KEGG   ENZYME: 1.1.1.188
Entry
EC 1.1.1.188                Enzyme                                 
Name
prostaglandin-F synthase;
prostaglandin-D2 11-reductase;
reductase, 15-hydroxy-11-oxoprostaglandin;
PGD2 11-ketoreductase;
PGF2alpha synthetase;
prostaglandin 11-ketoreductase;
prostaglandin D2-ketoreductase;
prostaglandin F synthase;
prostaglandin F synthetase;
synthetase, prostaglandin F2alpha;
PGF synthetase;
NADPH-dependent prostaglandin D2 11-keto reductase;
prostaglandin 11-keto reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R02684]
Reaction(KEGG)
R02684;
(other) R02799
Substrate
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD:C00639];
NADP+ [CPD:C00006]
Product
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
History
EC 1.1.1.188 created 1984, modified 1989, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K04119  aldo-keto reductase family 1 member C3
Genes
HSA8644(AKR1C3)
PTR100612718(AKR1C3) 100612887 746545
PPS100986388 100987632 100988315
GGO101144878 101147265 101152195
PON100174617(AKR1C3) 100432652 100461633 100462259
NLE100593325 100604844 100606512
MCC100430336 722485 722496
MCF102116465 102142023(HSD17B5) 102143072 102144231
CSAB103237812 103237813 103237816
CATY105587690 105597446 105597481
PANU100997485 101022585 101024707
TGE112631307 112631750
RRO104674747
RBB108521036 108532990
TFN117082052 117082118 117083437
PTEH111528130 111528985 113224919
CJC100406962 100409025 100409384
SBQ101041594 101042225 101049957
CSYR103261879 103261880 103261882 103261883 103263298 103263300
MMUR105858219 105858220 105858221 105858224
LCAT123623043 123623044
OGA100942491 100967071
MCAL110308148
MPAH110333839 110333848
RNO361267(Akr1c15)
MCOC116081731
MUN110560700
CGE100768090 100768376
MAUA101841267
PLEU114708096
MORG121432600 121432606 121432658 121432668
AAMP119816160 119816243 119826549
NGI103725884 103725890 103725892 103746652
HGL101702106
CPOC100727454
CCAN109678869 109680334 109680990
DSP122113031
NCAR124961142 124961655
OPI101524567 101525842 101526664 101526901 101527313 101527569 101527977
TUP102478063 102478495 102491222 102491650
CFA497070(AKR1C3)
CLUD112658979
VVP112933725
VLG121496638
AML100483758
UMR103676234
UAH113241124
UAR123802294(AKR1C8)
ELK111158636
LLV125107753
MPUF101678776
ORO101377633 101379669
EJU114217720
ZCA113921662
MLX118021623 118021905
FCA100510801(AKR1C3)
PYU121014878
PBG122473163
PTG102963188
PPAD109273789
AJU106988139
HHV120237198
BTA100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
BOM102267155 102269337 102271037 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205
BIU109567627 109567629 109568074 109568076 109568077 109568079 109568080 109568087
BBUB102389138 102395293 102395635 102396460 102396772 102398476 102399119 102400645 102404780 102415234 102416534
CHX102176340 102176622 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498
OAS101106610 101107119 101107541 101107809 101109111 101109377 101109633 101110434 101110693 105614315 106990122 114108656 443108(PGFS)
ODA120860627 120868601 120869467 120869469 120869471
CCAD122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512
SSC654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
CFR102511678 116656624 116661570
CBAI105074137 105074417 105074427 105074728
CDK105104488 105104489 105105880
VPC102531609 102541232 102541486
BACU103002145 103003050
LVE103069218
OOR101273575 101281536
DLE111170128 111170129
PCAD102978533
PSIU116748968 116749098
ECB100057212 100070491 100070501 100070509 100070616 111771771 111771772
EPZ103541472 103541473 103542048
EAI106824650 106827241 106827468 106846832 106846833 106846834 123281999
MYB102254990 102255491
MYD102751586 102763642
MMYO118672630 118672665
MLF102421358 102428982
MNA107542430 107542432
PKL118702292 118702295
HAI109378613
DRO112321159 112323007
SHON118977133
AJM119057712
PDIC114492418
PHAS123824859 123831227(AKR1C8)
MMF118632067 118632135
PALE102889546
PGIG120608988
PVP105299187
MJV108383288 108384939 108393830 108407235 108407237 108407238
TOD119244650 119245260
SARA101543981 101545704 101551007 101551999 101555320 101555749
LAV100659630 100659914
TMU101342771 101360332
DNM101428157 101433437
OAA100085065 100085965 100085983
PSS102446010 102446253 102446483
CMY102946053
CPIC101940001 101940260 101940524
TST117882842
CABI116815619
MRV120395343 120395494 120395542
PVT110070400 110071420 110088827
PMUA114590236 114604979 114604980 114604981 114605230 114605592
ZVI118090693 118090694 118090915
GJA107108026
XLA100049750(XB5895996.L) 443571(akr1c3.L)
XTR100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 734139 779627(akr1c3)
NPR108789947 108789949 108799287 108799288 108799289 108799290 108799291
RTEM120921832 120932840
PPYR116168970
DMK116918341
PMAX117329343 117329344 117331065
MMER123536211
 » show all
Reference
1  [PMID:7248318]
  Authors
Reingold DF, Kawasaki A, Needleman P.
  Title
A novel prostaglandin 11-keto reductase found in rabbit liver.
  Journal
Biochim Biophys Acta 659:179-88 (1981)
DOI:10.1016/0005-2744(81)90282-5
Reference
2
  Authors
Watanabe, K., Shimizu, T. and Hayaishi, O.
  Title
Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2alpha in the rat lung.
  Journal
Biochem Int 2:603-610 (1981)
Reference
3  [PMID:3858278]
  Authors
Watanabe K, Yoshida R, Shimizu T, Hayaishi O.
  Title
Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.
  Journal
J Biol Chem 260:7035-41 (1985)
Reference
4  [PMID:7248317]
  Authors
Wong PY.
  Title
Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver.
  Journal
Biochim Biophys Acta 659:169-78 (1981)
DOI:10.1016/0005-2744(81)90281-3
Reference
5  [PMID:7132748]
  Authors
Wong PY.
  Title
Purification of PGD2 11-ketoreductase from rabbit liver.
  Journal
Methods Enzymol 86:117-25 (1982)
DOI:10.1016/0076-6879(82)86179-x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.188
IUBMB Enzyme Nomenclature: 1.1.1.188
ExPASy - ENZYME nomenclature database: 1.1.1.188
BRENDA, the Enzyme Database: 1.1.1.188
CAS: 55976-95-9

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