KEGG ENZYME: 1.1.1.188

ENZYME: 1.1.1.188

Entry

EC 1.1.1.188                Enzyme

Name

prostaglandin-F synthase;
prostaglandin-D2 11-reductase;
reductase, 15-hydroxy-11-oxoprostaglandin;
PGD2 11-ketoreductase;
PGF2alpha synthetase;
prostaglandin 11-ketoreductase;
prostaglandin D2-ketoreductase;
prostaglandin F synthase;
prostaglandin F synthetase;
synthetase, prostaglandin F2alpha;
PGF synthetase;
NADPH-dependent prostaglandin D2 11-keto reductase;
prostaglandin 11-keto reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase

Reaction(IUBMB)

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R02684]

Reaction(KEGG)

R02684;
(other) R02799

Substrate

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD:C00639];
NADP+ [CPD:C00006]

Product

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.

History

EC 1.1.1.188 created 1984, modified 1989, modified 1990

Pathway

ec00590

Arachidonic acid metabolism

Orthology

K04119

aldo-keto reductase family 1 member C3

Genes

HSA:	340811(AKR1C8) 8644(AKR1C3)

PTR:	100612718(AKR1C3) 100612887 746545

PPS:	100971300 100986388(AKR1C3) 100987632 100988315

GGO:	101144878(AKR1C3) 101147265(AKR1C8) 101152195

PON:	100174617(AKR1C3) 100432652 100461633 100462259

PPYG:

129006137 129006869 129006873 129006874(AKR1C8)

NLE:	100593325 100604844 100606512

HMH:	116457717 116460197(AKR1C8)

SSYN:

129491831 129491837 129491838

MCC:	100430336 711440 722485 722496

MCF:	102116465 102142023(HSD17B5) 102143072 102144231

MTHB:

126963005 126963008 126963422

MNI:	105490778 105490780 105490783 105494391 112428206

CSAB:

103237812 103237813 103237816

CATY:

105587690 105597446 105597481

PANU:

100997485 101022585 101024707

TGE:	112631307 112631750

MLEU:

105532496 105535734 105535762

RRO:	104674747 104678924

RBB:	108521036 108532990

TFN:	117082052 117082118 117083437

PTEH:

111528130 111528985 113224919

CANG:

105521700 105521704

CJC:	100406962 100409025 100409384

SBQ:	101041594 101042225 101049957

CIMI:

108285106 108292323 108292357

ANAN:

105710839 105710887 105710891

CSYR:

103261879 103261880 103261882 103261883 103263298 103263300

MMUR:

105858219 105858220 105858221 105858224

LCAT:

123623042 123623043 123623044 123623047

PCOQ:

105826891 105826910 105826913

OGA:	100942491 100967071

MCAL:

110308148

MPAH:

110333839 110333848

RNO:	361267(Akr1c15)

MCOC:

116081731

ANU:

117713832

MUN:

110560700

CGE:	100768090 100768376

MAUA:

101841267

PROB:

127229800

PLEU:

114708096

MORG:

121432600 121432606 121432658 121432668

MFOT:

126501679 126501680 126501681 126506800

AAMP:

119816160 119816243 119826549

NGI:	103725884 103725890 103725892 103746652

HGL:

101702106

CPOC:

100727454

CCAN:

109678869 109680334 109680990

DSP:

122113031

PLOP:

125366785

NCAR:

124961142 124961655

OCU:

108176284

OPI:	101524567 101525842 101526664 101526901 101527313 101527569 101527977

TUP:	102478063 102478495 102491222 102491650

GVR:	103602898 103610229 103610426

CFA:	497070(AKR1C3)

CLUD:

112658979

VVP:

112933725

VLG:

121496638

NPO:

129514265

AML:

100483758

UMR:

103676234

UAH:

113241124

UAR:	123802294(AKR1C8)

ELK:

111158636

LLV:

125107753

MPUF:

101678776

MNP:

132020017

MLK:

131838054

NVS:	122891768(AKR1C4)

ORO:	101377633 101379669

EJU:

114217720

ZCA:

113921662

MLX:	118021623 118021905

LWW:	102748666 102748964

FCA:	100510801(AKR1C3)

PYU:

121014878

PCOO:

112867557

PBG:

122473163

PVIV:

125169528

LRUF:

124502362

PTG:

102963188

PPAD:

109273789

PUC:

125918575

AJU:

106988139

HHV:

120237198

BTA:	100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884

BOM:	102267155 102269337 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205

BIU:	109567627 109568074 109568076 109568077 109568079 109568080 109568087

BBUB:

102389138 102395293 102395635 102396460 102396772 102399119 102400645 102404780 102415234

BBIS:

104985980 104985985 104985990 104985991 104985992 104985994 104985995 104985998 104985999 104986133

CHX:	102176340 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498

OAS:	101107119 101107541 101109111 101109377 101110434 101110693 105614315 106990122 114108656

BTAX:

128058197 128058202 128058203 128058208 128058211 128058212 128058213 128058216

CSUM:

138091116 138091651 138091745 138091796 138091808 138091833 138091836 138091865 138091869

ODA:	120860627 120868601 120869467 120869469 120869471

CCAD:

122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512 122448583

MREE:

136157847 136157852 136157854 136157856 136157857 136159311 136159313 136159314 136159316 136159318

MBEZ:

129547517 129555459 129559457 129559483 129559564 129559569 129559578 129559602 129559618 129559630 129559646

SSC:	654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)

CFR:	102511678 116656624 116661570

CBAI:

105074137 105074417 105074427 105074728

CDK:	105104488 105104489 105105880

VPC:	102531609 102541232 102541486

BACU:

103002145 103003050

BMUS:

118891073 118891271

LVE:

103069218

OOR:	101273575 101281536

DLE:	111170128 111170129

PCAD:

102978533

PSIU:

116748968 116749098

NASI:

112407550 112407551

ECB:	100057212 100070491 100070501 100070509 100070616 111771771 111771772

EPZ:	103541472 103541473 103542048

EAI:	106824650 106827241 106827468 106846832 106846833 106846834 123281999

MYB:	102254990 102255491

MYD:	102751586 102763642

MMYO:

118672630 118672665

MLF:	102421358 102428982

MDT:	132215226 132215243

PKL:	118702292 118702295

EFUS:

103300835 103300840

MNA:	107542430 107542432

DRO:	112321159 112323007

SHON:

118977133

AJM:

119057712

PDIC:

114492418

PHAS:

123824859 123831227(AKR1C8)

MMF:	118632067 118632135

PPAM:

129084610 129084627

HAI:

109378613

PALE:

102889546

PGIG:

120608988

PVP:

105299187

MJV:	108384939 108393830 108407235 108407237 108407238

TOD:	119244650 119245260

SARA:

101543981 101545704 101551007 101551999 101555320 101555749

SFUM:

130024001 130024071 130024072 130024073 130024074

SETR:

126013285

LAV:	100659630 100659914

TMU:	101342771 101360332

ETF:	101653259 101653576

DNM:	101428157 101433437

PBRV:

138165825

OAA:	100085065 100085983

PSS:	102446010 102446253 102446483

CMY:	102946053 119563672

CCAY:

125625831

DCC:	119843778 119849865

CPIC:

101940001 101940260 101940524

TST:

117882842

CABI:

116815619

MRV:	120395343 120395491 120395494 120395542

PVT:	110070400 110071420 110088827

PMUA:

114590236 114604979 114604980 114604981 114605230 114605592

PRAF:

128421905 128421906 128421907 128421908 128421909 128422029

ZVI:	118090693 118090694 118090915

GJA:

107108026

EMC:

129335705

XLA:	100049750(XB5895996.L) 443571(akr1c3.L)

XTR:	100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 734139 779627(akr1c3)

NPR:	108789947 108789949 108799287 108799288 108799289 108799290 108799291

RTEM:

120921832 120932840

CPLA:

122559456

HOC:

132825023

PPYR:

116168970

DMK:

116918341

PMEO:

129593135

PVUL:

126823863 130010387

HASI:

137266197

PMAX:

117329343 117329344 117331065

AIRR:

138327949

MCAF:

127727738

MMER:

123536211

» show all

Reference

1 [PMID:7248318]

Authors

Reingold DF, Kawasaki A, Needleman P.

Title

A novel prostaglandin 11-keto reductase found in rabbit liver.

Journal

Biochim Biophys Acta 659:179-88 (1981)
DOI:10.1016/0005-2744(81)90282-5

Reference

Authors

Watanabe K, Shimizu T, Hayaishi O.

Title

Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2alpha in the rat lung.

Journal

Biochem Int 2:603-610 (1981)

Reference

3 [PMID:3858278]

Authors

Watanabe K, Yoshida R, Shimizu T, Hayaishi O.

Title

Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.

Journal

J Biol Chem 260:7035-41 (1985)

Reference

4 [PMID:7248317]

Authors

Wong PY.

Title

Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver.

Journal

Biochim Biophys Acta 659:169-78 (1981)
DOI:10.1016/0005-2744(81)90281-3

Reference

5 [PMID:7132748]

Authors

Wong PY.

Title

Purification of PGD2 11-ketoreductase from rabbit liver.

Journal

Methods Enzymol 86:117-25 (1982)
DOI:10.1016/0076-6879(82)86179-x

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.188

IUBMB Enzyme Nomenclature:

1.1.1.188

ExPASy - ENZYME nomenclature database:

1.1.1.188

BRENDA, the Enzyme Database:

1.1.1.188

CAS:	55976-95-9

DBGET integrated database retrieval system