KEGG   ENZYME: 1.1.1.19
Entry
EC 1.1.1.19                 Enzyme                                 
Name
glucuronate reductase;
L-hexonate:NADP dehydrogenase;
TPN-L-gulonate dehydrogenase;
NADP-L-gulonate dehydrogenase;
D-glucuronate dehydrogenase;
D-glucuronate reductase;
L-glucuronate reductase (incorrect)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-gulonate:NADP+ 6-oxidoreductase
Reaction(IUBMB)
L-gulonate + NADP+ = D-glucuronate + NADPH + H+ [RN:R01481]
Reaction(KEGG)
R01481
Substrate
L-gulonate [CPD:C00800];
NADP+ [CPD:C00006]
Product
D-glucuronate [CPD:C00191];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also reduces D-galacturonate. May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)].
History
EC 1.1.1.19 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13913518]
  Authors
SIVAK A, HOFFMANN-OSTENHOF O.
  Title
Enzymes of mesoinositol catabolism in the yeast Schwanniomyces accidentalis.
  Journal
Biochim Biophys Acta 53:426-8 (1961)
DOI:10.1016/0006-3002(61)90462-0
Reference
2
  Authors
von Wartburg JP, Wermoth B.
  Title
Aldehyde reductase.
  Journal
In: Jakoby WB (ed). Enzymatic Basis of Detoxication. Vol. 1. New York: Academic Press; 1980. p. 249-260.
Reference
3  [PMID:13787380]
  Authors
YORK JL, GROLLMAN AP, BUBLITZ C.
  Title
TPN-L-gluonate dehydrogenase.
  Journal
Biochim Biophys Acta 47:298-306 (1961)
DOI:10.1016/0006-3002(61)90290-6
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.19
IUBMB Enzyme Nomenclature: 1.1.1.19
ExPASy - ENZYME nomenclature database: 1.1.1.19
BRENDA, the Enzyme Database: 1.1.1.19
CAS: 9028-29-9

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