KEGG   ENZYME: 1.1.1.196
Entry
EC 1.1.1.196                Enzyme                                 
Name
15-hydroxyprostaglandin-D dehydrogenase (NADP+);
prostaglandin-D 15-dehydrogenase (NADP+);
dehydrogenase, prostaglandin D2;
NADP+-PGD2 dehydrogenase;
dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate);
15-hydroxy PGD2 dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NADP+);
NADP+-dependent 15-hydroxyprostaglandin dehydrogenase;
prostaglandin D2 dehydrogenase;
NADP+-linked 15-hydroxyprostaglandin dehydrogenase;
NADP+-specific 15-hydroxyprostaglandin dehydrogenase;
NADP+-linked prostaglandin D2 dehydrogenase;
15-hydroxyprostaglandin-D dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+ = (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H+ [RN:R02800]
Reaction(KEGG)
R02800
Substrate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696];
NADP+ [CPD:C00006]
Product
(5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate [CPD:C04758];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Specific for prostaglandins D [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)].
History
EC 1.1.1.196 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
Reference
1  [PMID:7354056]
  Authors
Watanabe K, Shimizu T, Iguchi S, Wakatsuka H, Hayashi M, Hayaishi O.
  Title
An NADP-linked prostaglandin D dehydrogenase in swine brain.
  Journal
J Biol Chem 255:1779-82 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.196
IUBMB Enzyme Nomenclature: 1.1.1.196
ExPASy - ENZYME nomenclature database: 1.1.1.196
BRENDA, the Enzyme Database: 1.1.1.196
CAS: 84399-95-1

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Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (73)   
   UniProt (57)   
   SWISS-PROT (8)   
   RefSeq(pep) (8)   
DNA sequence (8)   
   RefSeq(nuc) (8)   
Protein domain (4)   
   InterPro (4)   
All databases (94)   

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