Entry |
|
Name |
15-hydroxyprostaglandin-D dehydrogenase (NADP+);
prostaglandin-D 15-dehydrogenase (NADP+);
dehydrogenase, prostaglandin D2;
NADP+-PGD2 dehydrogenase;
dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate);
15-hydroxy PGD2 dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NADP+);
NADP+-dependent 15-hydroxyprostaglandin dehydrogenase;
prostaglandin D2 dehydrogenase;
NADP+-linked 15-hydroxyprostaglandin dehydrogenase;
NADP+-specific 15-hydroxyprostaglandin dehydrogenase;
NADP+-linked prostaglandin D2 dehydrogenase;
15-hydroxyprostaglandin-D dehydrogenase (NADP+)
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
Sysname |
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase
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Reaction(IUBMB) |
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+ = (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH + H+ [RN: R02800]
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Reaction(KEGG) |
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Substrate |
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD: C00696];
NADP+ [CPD: C00006]
|
Product |
(5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate [CPD: C04758];
NADPH [CPD: C00005];
H+ [CPD: C00080]
|
Comment |
Specific for prostaglandins D [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)].
|
History |
EC 1.1.1.196 created 1984, modified 1990
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Pathway |
ec00590 | Arachidonic acid metabolism |
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Reference |
|
Authors |
Watanabe K, Shimizu T, Iguchi S, Wakatsuka H, Hayashi M, Hayaishi O. |
Title |
An NADP-linked prostaglandin D dehydrogenase in swine brain. |
Journal |
J Biol Chem 255:1779-82 (1980) |
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.196 |
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