EC                Enzyme                                 

long-chain-3-hydroxyacyl-CoA dehydrogenase;
beta-hydroxyacyl-CoA dehydrogenase;
long-chain 3-hydroxyacyl coenzyme A dehydrogenase;
3-hydroxyacyl-CoA dehydrogenase;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
a long-chain (S)-3-hydroxyacyl-CoA + NAD+ = a long-chain 3-oxoacyl-CoA + NADH + H+ [RN:R01778]
long-chain (S)-3-hydroxyacyl-CoA;
NAD+ [CPD:C00003]
long-chain 3-oxoacyl-CoA;
NADH [CPD:C00004];
H+ [CPD:C00080]
This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 3-hydroxyacyl-CoA dehydrogenase).
EC created 1986
ec00062  Fatty acid elongation
ec00071  Fatty acid degradation
ec01100  Metabolic pathways
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase
HSA: 3030(HADHA)
PTR: 459079(HADHA)
PPS: 100973698 100978217(HADHA)
GGO: 101143053(HADHA)
PON: 100172963(HADHA)
NLE: 100593214 100593233(HADHA)
MCC: 695975(HADHA)
MCF: 102142372(HADHA)
CSAB: 103220642(HADHA)
RRO: 104677892(HADHA)
RBB: 108532679(HADHA)
CJC: 100390439(HADHA)
SBQ: 101047074(HADHA)
MMU: 97212(Hadha)
MCAL: 110294690(Hadha)
MPAH: 110324206(Hadha)
RNO: 170670(Hadha)
MUN: 110547680(Hadha)
CGE: 100757947(Hadha)
NGI: 103735655(Hadha)
HGL: 101724137(Hadha)
CCAN: 109685831(Hadha)
OCU: 100355022(HADHA)
TUP: 102471941(HADHA) 102478660
CFA: 100856745(HADHA)
VVP: 112908532(HADHA)
AML: 100469654(HADHA)
UMR: 103671672(HADHA)
UAH: 113270772(HADHA)
ORO: 101364854(HADHA)
ELK: 111154088
FCA: 101084701(HADHA)
PTG: 102966470(HADHA)
PPAD: 109267284(HADHA)
AJU: 106967830(HADHA)
BTA: 281810(HADHA)
BOM: 102287426(HADHA)
BIU: 109566315(HADHA)
BBUB: 102398211(HADHA)
CHX: 102189046(HADHA)
OAS: 100192316(HADHA)
SSC: 397012(HADHA)
CFR: 102516648(HADHA)
CDK: 105098509(HADHA)
BACU: 103001885(HADHA)
LVE: 103086620(HADHA)
OOR: 101286957(HADHA)
DLE: 111174988(HADHA)
PCAD: 102996843(HADHA)
ECB: 100071381(HADHA)
EPZ: 103546462(HADHA)
EAI: 106840921(HADHA)
MYB: 102263028(HADHA)
MYD: 102751724(HADHA)
MNA: 107534200(HADHA)
HAI: 109383051(HADHA)
DRO: 112297764(HADHA)
PALE: 102889313(HADHA)
RAY: 107498535(HADHA)
MJV: 108392159(HADHA)
LAV: 100675857(HADHA)
TMU: 101353485
MDO: 100030776(HADHA)
SHR: 100928252(HADHA)
PCW: 110206510(HADHA)
OAA: 100077524(HADHA)
GGA: 395929(HADHA)
MGP: 100548080(HADHA)
CJO: 107312378(HADHA)
NMEL: 110397114(HADHA)
ACYG: 106048383(HADHA)
LSR: 110478445(HADHA)
SCAN: 103824695(HADHA)
GFR: 102032411(HADHA)
FAB: 101815112(HADHA)
PHI: 102103703(HADHA)
PMAJ: 107198787(HADHA)
CCAE: 111927468(HADHA)
CCW: 104683133(HADHA)
ETL: 114071979(HADHA)
FPG: 101918262(HADHA)
FCH: 102045684(HADHA)
CLV: 102093055(HADHA)
EGZ: 104130955(HADHA)
NNI: 104014780(HADHA)
ACUN: 113478819(HADHA)
PADL: 103923913(HADHA)
AAM: 106499621(HADHA)
ASN: 102387874(HADHA)
AMJ: 102559143(HADHA)
PSS: 102461507(HADHA)
CMY: 102938765(HADHA)
CPIC: 101942783(HADHA)
ACS: 100553746(hadha)
PVT: 110090547(HADHA)
PBI: 103053277(HADHA)
PMUR: 107291031(HADHA) 107300505
TSR: 106541761(HADHA)
PMUA: 114594987(HADHA)
GJA: 107113769(HADHA)
XLA: 108717268(hadha.L) 444044(hadha.S)
XTR: 394832(hadha)
NPR: 108803249(HADHA)
DRE: 553401(hadhaa) 793834(hadhab)
IPU: 100304971 108257474(hadha)
TRU: 101073662(hadha)
LCO: 104929997(hadha)
NCC: 104942173(hadha)
OLA: 101155646(hadha)
XMA: 102229661(hadha)
XCO: 114133804(hadha)
PRET: 103458382(hadha)
CVG: 107095825(hadha)
NFU: 107392010(hadha)
KMR: 108239107(hadha)
ALIM: 106529789(hadha)
CSEM: 103380450(hadha)
POV: 109636387(hadha)
LCF: 108874899(hadha)
SDU: 111225708(hadha)
SLAL: 111673117(hadha)
MALB: 109964597(hadha)
SASA: 106603767 106611334(ECHA)
ELS: 105026863(hadha)
PKI: 111851531(hadha) 111857967
LCM: 102350823(HADHA)
CMK: 103183149(hadha)
RTP: 109910714(hadha)
BFO: 118404846
CIN: 100181980
SPU: 585357
APLC: 110978691
SKO: 100369576(HADHA)
DME: Dmel_CG4389(Mtpalpha)
DER: 6541344
DSE: 6611826
DSI: Dsimw501_GD22351(Dsim_GD22351)
DAN: 6504621
DSR: 110176800
DPE: 6589537
DMN: 108161786
DWI: 6641563
DAZ: 108610802
DNV: 108649592
DHE: 111603880
DVI: 6634031
MDE: 101889137
LCQ: 111679665
AAG: 5572923
AME: 410325
BIM: 100741897
BTER: 100642892
CCAL: 108623987
OBB: 114875921
SOC: 105201374
MPHA: 105837947
AEC: 105152057
ACEP: 105621618
PBAR: 105434016
VEM: 105567443
HST: 105189285
DQU: 106748121
CFO: 105254374
LHU: 105673815
PGC: 109863893
OBO: 105279823
PCF: 106784609
NVI: 100121740
CSOL: 105361087
MDL: 103579736
TCA: 662336
ATD: 109603223
NVL: 108558831
BMOR: 692820
BMAN: 114248364
PMAC: 106719824
PRAP: 110999633
HAW: 110371935
TNL: 113493488
PXY: 105387328
API: 100165657
DNX: 107168916
AGS: 114130103
RMD: 113555782
BTAB: 109036133
CLEC: 106670657
ZNE: 110827146
FCD: 110854334
PVM: 113805029
TUT: 107359547
DPTE: 113799485
CSCU: 111616495
CEL: CELE_C29F3.1(ech-1.1) CELE_T08B2.7(ech-1.2)
CBR: CBG12562
BMY: Bm1_51120
PCAN: 112574360
CRG: 105342066
OBI: 106883270
LAK: 106173898
EPA: 110254396
ADF: 107334024
AMIL: 114957985
PDAM: 113673361
SPIS: 111326946
DGT: 114535097
HMG: 100197152(hadha)
AQU: 100631983
ATH: AT3G06860(MFP2) AT4G29010(AIM1)
CPAP: 110819879
LJA: Lj0g3v0340609.1(Lj0g3v0340609.1) Lj4g3v2310310.1(Lj4g3v2310310.1) Lj6g3v1465030.1(Lj6g3v1465030.1)
DOSA: Os01t0348600-01(Os01g0348600) Os02t0274100-01(Os02g0274100) Os05t0155000-01(Os05g0155000) Os05t0362100-01(Os05g0362100)
ATS: 109733511(LOC109733511) 109739968(LOC109739968) 109751016(LOC109751016) 109760663(LOC109760663) 109773312(LOC109773312)
APRO: F751_2626
SPAR: SPRG_06557
 » show all
1  [PMID:7150615]
El-Fakhri M, Middleton B.
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
Biochim Biophys Acta 713:270-9 (1982)
Other DBs
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IUBMB Enzyme Nomenclature:
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BRENDA, the Enzyme Database:
CAS: 84177-52-6

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