Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
morphine + NAD(P)+ = morphinone + NAD(P)H + H+ [RN:
Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analogue. Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol).
EC 184.108.40.206 created 1989, modified 1990
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
K03378 morphine 6-dehydrogenase
K13374 aldo-keto reductase family 1 member C13
MMU: 27384(Akr1c13) 622402(Akr1c12)
DORD: 105980361 105980413 105980416 105980418 Taxonomy
Yamano S, Kageura E, Ishida T, Toki S.
Purification and characterization of guinea pig liver morphine 6-dehydrogenase.
J Biol Chem 260:5259-64 (1985)
Yamano S, Nishida F, Toki S.
Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase.
ExPASy - ENZYME nomenclature database: 220.127.116.11