KEGG   ENZYME: 1.1.1.218
Entry
EC 1.1.1.218                Enzyme                                 
Name
morphine 6-dehydrogenase;
naloxone reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
morphine:NAD(P)+ 6-oxidoreductase
Reaction(IUBMB)
morphine + NAD(P)+ = morphinone + NAD(P)H + H+ [RN:R03591 R03592]
Reaction(KEGG)
R03591 R03592
Substrate
morphine [CPD:C01516];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
morphinone [CPD:C01735];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analogue. Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol).
History
EC 1.1.1.218 created 1989, modified 1990
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K03378  morphine 6-dehydrogenase
K13374  aldo-keto reductase family 1 member C13
Genes
MMU27384(Akr1c13) 622402(Akr1c12)
MCAL110288103
MPAH110333723
RNO361266(Akr1c13)
ANU117713703 117713780
CGE100769523
MAUA101839119 101842245 101842874
PROB127229805
MORG121432553 121432554 121432601 121432715
MFOT126501682 126501683 126501689
AAMP119816240 119816241 119816242
NGI103725887
CCAN109680003
DORD105980361 105980413 105980416 105980418
DSP122113029
PLOP125366784
 » show all
Reference
1  [PMID:2580834]
  Authors
Yamano S, Kageura E, Ishida T, Toki S.
  Title
Purification and characterization of guinea pig liver morphine 6-dehydrogenase.
  Journal
J Biol Chem 260:5259-64 (1985)
Reference
2  [PMID:3539118]
  Authors
Yamano S, Nishida F, Toki S.
  Title
Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase.
  Journal
Biochem Pharmacol 35:4321-6 (1986)
DOI:10.1016/0006-2952(86)90712-4
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.218
IUBMB Enzyme Nomenclature: 1.1.1.218
ExPASy - ENZYME nomenclature database: 1.1.1.218
BRENDA, the Enzyme Database: 1.1.1.218
CAS: 97002-71-6

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