KEGG   ENZYME: 1.1.1.225
Entry
EC 1.1.1.225                Enzyme                                 
Name
chlordecone reductase;
CDR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
chlordecone-alcohol:NADP+ 2-oxidoreductase
Reaction(IUBMB)
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ [RN:R03716]
Reaction(KEGG)
R03716
Substrate
chlordecone alcohol [CPD:C02817];
NADP+ [CPD:C00006]
Product
chlordecone [CPD:C01792];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Chlordecone is an organochlorine pesticide.
History
EC 1.1.1.225 created 1989
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Genes
HSA1109(AKR1C4)
PTR450274(AKR1C4)
PPS100987989(AKR1C4)
GGO101148343
PON100434557(AKR1C4)
NLE100605385
MCC722483 722490(AKR1C4)
MCF102116844 102117205(AKR1C4)
MTHB126963007
CSAB103237814
CATY105597444 105597447
PANU101022938
TGE112631314
RRO104674748
RBB108521035
TFN117082119 117082359
CJC100405255 100405615(AKR1C4)
SBQ101041915
OGA100940488
GVR103581518
ECB100057251
EPZ103540777
EAI106827243
LAV100660861
DNM101426998
XLA108712557(akr1c4.S)
XTR496490(akr1c4)
NPR108799292
RTEM120932842
BBUF121003666
BGAR122926607
 » show all
Reference
1  [PMID:2427522]
  Authors
Molowa DT, Shayne AG, Guzelian PS.
  Title
Purification and characterization of chlordecone reductase from human liver.
  Journal
J Biol Chem 261:12624-7 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.225
IUBMB Enzyme Nomenclature: 1.1.1.225
ExPASy - ENZYME nomenclature database: 1.1.1.225
BRENDA, the Enzyme Database: 1.1.1.225
CAS: 102484-73-1

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