KEGG   ENZYME: 1.1.1.225
Entry
EC 1.1.1.225                Enzyme                                 

Name
chlordecone reductase;
CDR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
chlordecone-alcohol:NADP+ 2-oxidoreductase
Reaction(IUBMB)
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ [RN:R03716]
Reaction(KEGG)
R03716
Substrate
chlordecone alcohol [CPD:C02817];
NADP+ [CPD:C00006]
Product
chlordecone [CPD:C01792];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Chlordecone is an organochlorine pesticide.
History
EC 1.1.1.225 created 1989
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Genes
HSA: 1109(AKR1C4)
PTR: 450274(AKR1C4)
PPS: 100987989
GGO: 101148343
PON: 100434557(AKR1C4)
NLE: 100605385
MCC: 711440 722490(AKR1C4)
MCF: 102117205(AKR1C4) 102142023(HSD17B5)
CSAB: 103237814
RRO: 104674748
RBB: 108521035
CJC: 100405255 100405615(AKR1C4)
SBQ: 101041915
ECB: 100057251
EPZ: 103540777
EAI: 106827243
LAV: 100660861
XLA: 108712557(akr1c4.S)
XTR: 496490(akr1c4)
NPR: 108799292
 » show all
Reference
1  [PMID:2427522]
  Authors
Molowa DT, Shayne AG, Guzelian PS.
  Title
Purification and characterization of chlordecone reductase from human liver.
  Journal
J Biol Chem 261:12624-7 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.225
IUBMB Enzyme Nomenclature: 1.1.1.225
ExPASy - ENZYME nomenclature database: 1.1.1.225
BRENDA, the Enzyme Database: 1.1.1.225
CAS: 102484-73-1

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