KEGG   ENZYME: 1.1.1.226
Entry
EC 1.1.1.226                Enzyme                                 
Name
trans-4-hydroxycyclohexanecarboxylate dehydrogenase;
4-hydroxycyclohexanecarboxylate dehydrogenase (ambiguous);
chcB1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
trans-4-hydroxycyclohexane-1-carboxylate:NAD+ 4-oxidoreductase
Reaction(IUBMB)
trans-4-hydroxycyclohexane-1-carboxylate + NAD+ = 4-oxocyclohexane-1-carboxylate + NADH + H+ [RN:R04307]
Reaction(KEGG)
R04307
Substrate
trans-4-hydroxycyclohexane-1-carboxylate [CPD:C04404];
NAD+ [CPD:C00003]
Product
4-oxocyclohexane-1-carboxylate [CPD:C03767];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Corynebacterium cyclohexanicum is highly specific for the trans-4-hydroxy derivative. cf. EC 1.1.1.438, cis-4-hydroxycyclohexanecarboxylate dehydrogenase.
History
EC 1.1.1.226 created 1990, modified 2024
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K27673  trans-4-hydroxycyclohexanecarboxylate dehydrogenase
Genes
CGT: cgR_0065
CKP: ckrop_1446
CVT: B843_09960
CCJZ: ccrud_00215
CSUR: N24_0048
CFAC: CFAEC_12710(fabG2)
CGF: CGUA_00480(fabG1)
ARY: ATC04_00435
ACAO: NF551_15345
GPR: JQN66_00245
SATK: SA2016_1179
CCYC: SCMU_09900(chcB1)
GHM: CJ187_008785
 » show all
Reference
1  [PMID:3292236]
  Authors
Obata H, Uebayasi M, Kaneda T.
  Title
Purification and properties of 4-hydroxycyclohexanecarboxylate dehydrogenase from Corynebacterium cyclohexanicum.
  Journal
Eur J Biochem 174:451-8 (1988)
DOI:10.1111/j.1432-1033.1988.tb14119.x
Reference
2  [PMID:34583900]
  Authors
Yamamoto T, Hasegawa Y, Lau PCK, Iwaki H
  Title
Identification and characterization of a chc gene cluster responsible for the aromatization pathway of cyclohexanecarboxylate degradation in Sinomonas cyclohexanicum ATCC 51369.
  Journal
J Biosci Bioeng 132:621-629 (2021)
DOI:10.1016/j.jbiosc.2021.08.013
  Sequence
[ccyc:SCMU_09900]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.226
IUBMB Enzyme Nomenclature: 1.1.1.226
ExPASy - ENZYME nomenclature database: 1.1.1.226
BRENDA, the Enzyme Database: 1.1.1.226
CAS: 67272-36-0

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (13)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   InterPro (2)   
All databases (29)   

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