Entry
Name
histidinol dehydrogenase;
L-histidinol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-histidinol:NAD+ oxidoreductase
Reaction(IUBMB)
L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 3 H+ [RN:
R01158 ]
Reaction(KEGG)
Substrate
Product
Comment
Also oxidizes L-histidinal. The Neurospora enzyme also catalyses the reactions of EC
3.5.4.19 (phosphoribosyl-AMP cyclohydrolase) and EC
3.6.1.31 (phosphoribosyl-ATP diphosphatase).
History
EC 1.1.1.23 created 1961
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K00013 histidinol dehydrogenase
K14152 phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase / histidinol dehydrogenase
Genes
CSAT : 104727018 104741887 109124436
BNA : 106347943 106348076 106366261 106406908
MINC : 123205295 123205297 123205315 123205341 123218024 123227082 123227126
HSYR : 120121503 120128865 120191190 120205388
GMX : 100793496 100802665 100816684
GSJ : 114367969 114388645 114421454
PVU : PHAVU_002G198300g PHAVU_006G126900g
CCAJ : 109811473 109813211
APRC : 113846523 113857441
AIP : 107631544 107638862 107638863
AHF : 112734568 112741481 112741483 112792356 112796190
PCIN : 129285829 129305684
QSA : O6P43_013095 O6P43_013138
MSYL : 126587697 126624722
CMOS : 111434101 111456679
CPEP : 111783531 111802337
PALZ : 118029483 118035898
CAVE : 132167072 132187955
NTA : 107763421 107770793 107779522 107807270 107823137
SSPL : 121805884 121806782
CSIN : 114256734 114320957
PSOM : 113312606 113324145 113358546
TAES : 123045379 123053221 123189134
MFLO : 136477882 136516796 136534390
PVIR : 120649545 120690736
PHAI : 112877072 112884580
ZOF : 121970558 121975631 122001691 122005987 122023017 122026698 122026785 122038254 122038584 122043666 122044299 122054924 122055073
MSIN : 131230786 131249438 131249818
SMO : SELMODRAFT_107041 SELMODRAFT_417335 SELMODRAFT_96933
NCS : NCAS_0B08820(NCAS0B08820)
NDI : NDAI_0A00450(NDAI0A00450)
TPF : TPHA_0E03690(TPHA0E03690)
TDL : TDEL_0C06570(TDEL0C06570)
KAF : KAFR_0D00420(KAFR0D00420)
KNG : KNAG_0C00510(KNAG0C00510)
SPAA : SPAPADRAFT_141809(HIS2)
LBG : 92210178(LODBEIA_P49820)
CAL : CAALFM_C400140CA(HIS4)
YLI : 2905745(YALI2_A00250g)
NTE : NEUTE1DRAFT150173(NEUTE1DRAFT_150173)
SMP : 10805831(SMAC4_02870)
FPOA : FPOAC1_000917(HIS3)
FFC : NCS54_00142500 NCS54_00891200
FKR : NCS57_00139700 NCS57_00823900 NCS57_01472000
FMU : J7337_001357(HIS3) J7337_003500
TATV : 25774999(TrAtP1_006517)
PLJ : 28891237(PLICBS_004464)
CLUP : CLUP02_02032 CLUP02_13698
CDET : 87948785(CDEST_12285)
BFU : BCIN_05g05260(Bchis4)
ANI : ANIA_00797 ANIA_02723
AFM : AFUA_1G14570 AFUA_1G17660
NFI : NFIA_007520 NFIA_010850
AOR : AO090003000477 AO090005000146
AFV : AFLA_001209 AFLA_002931
ALUC : AKAW2_10357A(HIS4) AKAW2_41327S
ACHE : ACHE_30635A(HIS4) ACHE_70166S
APUU : APUU_11196A(HIS4) APUU_40672S
PTRR : 6342900(PtrM4_115850) 6350345(PtrM4_134150)
CDEP : 91088063(L203_103853)
KMG : 30166319(I203_102385)
KNE : 92179906(IAR55_002648)
CCAC : CcaHIS019_0202180(HIS4)
ABP : AGABI1DRAFT72979(AGABI1DRAFT_72979)
ABV : AGABI2DRAFT184772(AGABI2DRAFT_184772)
SCM : SCHCO_02621953(SCHCODRAFT_02621953)
PSTR : Pst134EA_005041 Pst134EA_032370
ECOO : ECRM13514_2741(hisD)
ECOH : ECRM13516_2609(hisD)
ELR : ECO55CA74_12215(hisD)
ECW : EcE24377A_2311(hisD)
ECOA : APECO78_13835(hisD)
EDJ : ECDH1ME8569_1956(hisD)
ECOI : ECOPMV1_02175(hisD)
SEM : STMDT12_C20940(hisD)
SETC : CFSAN001921_06425(hisD)
SEEN : SE451236_16570(hisD)
SENH : CFSAN002069_21460(hisD)
SEEH : SEEH1578_19640(hisD)
SENJ : CFSAN001992_01070(hisD)
SEEC : CFSAN002050_17320(hisD)
SEEB : SEEB0189_009105(hisD)
SENC : SEET0819_17505(hisD)
KPK : A593_02230(hisD) A593_26090
REE : electrica_01706(hisD)
RTG : NCTC13098_02357(hisD)
CLAP : NCTC11466_01534(hisD)
KIE : NCTC12125_00649(hisD_2)
BAGE : BADSM9389_15150(hisD)
AHN : NCTC12129_03332(hisD_2)
METY : MRY16398_18250(hisD)
PSHI : SAMEA2665130_2139(hisD)
YPG : YpAngola_A3170(hisD)
YPI : YpsIP31758_2429(hisD)
SMW : SMWW4_v1c15980(hisD)
SRR : SerAS9_1586 SerAS9_2030
SRL : SOD_c14850(hisD) SOD_c19050(hisD2)
SRY : M621_08280(hisD) M621_10505
SPLY : Q5A_008035(hisD_1) Q5A_010545(hisD_2)
SRS : SerAS12_1586 SerAS12_2030
SRA : SerAS13_1587 SerAS13_2031
SERS : SERRSCBI_07595(hisD)
SFJ : SAMEA4384070_1657(hisD)
SOF : NCTC11214_05297(hisD)
SSAR : SSARUM_001552(hisD)
RAH : Rahaq_1766 Rahaq_2170
RACE : JHW33_03105(hisD) JHW33_05970(hisD)
RAQ : Rahaq2_1842 Rahaq2_2276
ROX : BV494_06220 BV494_08070
GQU : AWC35_04015(hisD) AWC35_22690
NIG : C1N62_06470(hisD) C1N62_22175(hisD)
SERA : Ser39006_008155(hisD) Ser39006_015690(hisD)
SERQ : CWC46_08150(hisD) CWC46_15685(hisD)
PAQU : DMB82_0008990(hisD)
PARL : PEC302110_17380(hisD)
DIC : Dpoa569_002096(hisD)
PROD : PCO85_09305(hisD) PCO85_17655(hisD)
BAPF : BUMPF009_CDS00495(hisd)
BAPG : BUMPG002_CDS00496(hisd)
BAPU : BUMPUSDA_CDS00494(hisd)
BAPW : BUMPW106_CDS00495(hisd)
PAO : Pat9b_2563 Pat9b_4925
PPHO : CTZ24_15775(hisD) CTZ24_23540(hisD)
TCI : A7K98_09605 A7K98_13065
TPTY : NCTC11468_02374(hisD)
PHEI : NCTC12003_02824(hisD)
PRJ : NCTC6933_01250(hisD)
LRI : NCTC12151_01570(hisD)
HIC : NTHIC486_00517(hisD)
HPIT : NCTC13334_01125(hisD)
HAEG : NCTC8502_00665(hisD)
PDAG : 4362423_02110(hisD)
ALIG : NCTC10568_02419(hisD)
AVT : NCTC3438_00687(hisD)
RPNE : NCTC8284_00219(hisD)
PAET : NCTC13378_00469(hisD)
XFU : XFF4834R_chr19740(hisD)
XPH : XppCFBP6546_19945(hisD)
XHD : LMG31886_24760(hisD)
LLZ : LYB30171_01629(hisD)
VAU : VANGNB10_cI1068(hisD)
VPL : SA104470976_00884(hisD)
VIB : VspSTUT11_19050(hisD)
VIS : VspSTUT16_19990(hisD)
PAEB : NCGM1900_2278(hisD)
PVD : CFBP1590__1140(hisD)
PPRC : PFLCHA0_c09440(hisD)
PMUD : NCTC8068_04408(hisD)
PFW : PF1751_v1c08630(hisD)
PPUU : PputUW4_00791(hisD)
PTRT : HU722_0005705(hisD)
PTW : TUM18999_13020(hisD)
PTAE : NCTC10697_03623(hisD)
MSHE : MAALD49_26780(hisD)
PSYC : DABAL43B_2499(hisD3)
MCAT : MC25239_01661(hisD)
MCUN : NCTC10297_00541(hisD)
SCAA : TUM17387_18140(hisD)
CPS : CPS_2061(hisD1) CPS_3890(hisD2)
PLZ : S4054249_22375(hisD)
PSMM : PspMM1_37280(hisD_2)
SALH : HMF8227_00973(hisD)
LLG : 44548918_01238(hisD)
LJR : NCTC11533_01693(hisD)
LCJ : NCTC11976_02565(hisD)
LWA : SAMEA4504053_1422(hisD)
LSS : NCTC12082_00879(hisD)
MISZ : MishRS11D_14390(hisD)
TIB : THMIRHAM_05900(hisD)
TSE : THMIRHAS_06830(hisD)
TZO : THMIRHAT_09690(hisD)
TFRI : Thiofri_04740(hisD)
TNI : TVNIR_2626(hisD_[H])
GAI : IMCC3135_06965(hisD_1) IMCC3135_19760(hisD_2)
THIC : TspCOW1_16220(hisD)
HAAH : HALA3H3_950078(hisD)
COBE : CLAM6_07040(hisD_1)
ALCA : ASALC70_01205(hisD)
AEL : NCTC12917_02052(hisD)
CHJ : NCTC10426_01091(hisD)
CDIZ : CEDIAZO_01924(hisD_1) CEDIAZO_03329(hisD_2)
NMQ : NMBM04240196_0647(hisD)
NMZ : NMBNZ0533_1555(hisD)
NMX : NMA510612_1994(hisD)
NWE : SAMEA3174300_1102(hisD)
NZO : SAMEA4504057_2070(hisD)
NCI : NCTC10296_02093(hisD)
NANI : NCTC12227_00368(hisD)
CCUP : BKK81_00130 BKK81_18495
BMV : BMASAVP1_A3239(hisD)
BML : BMA10229_A1788(hisD)
BPM : BURPS1710b_3693(hisD)
BPL : BURPS1106A_3724(hisD)
BUE : BRPE67_ACDS24530(hisD)
POLY : PSHI2_01130(hisD_1)
POLN : PSHI8_01130(hisD_1)
PLG : NCTC10937_01038(hisD)
LMIR : NCTC12852_00140(hisD)
VTR : MYVALT_E_00440(hisD)
BTRM : SAMEA390648701074(hisD_2)
AXX : ERS451415_00195(hisD)
LIM : L103DPR2_00735(hisD)
LIH : L63ED372_02592(hisD)
SMIO : CATMQ487_39520(hisD)
URU : DSM104443_03684(hisD)
UPL : DSM104440_03212(hisD)
THAG : CKCBHOJB_00629(hisD)
FPHO : SHINM1_013340(hisD)
MLN : A9174_12660 A9174_30065
MCI : Mesci_2368 Mesci_2664
MCIC : A4R28_14295 A4R28_29025
MOP : Mesop_2512 Mesop_5951
MAM : Mesau_02398 Mesau_05417
MESW : A9K65_012425 A9K65_014595
MESM : EJ066_00040(hisD) EJ066_17205(hisD)
MHUA : MCHK_0144(hisD) MCHK_0621(hisD)
MJR : EB229_12525(hisD) EB229_30655(hisD)
MERD : EB233_26795(hisD) EB233_28935(hisD)
MOH : IHQ72_08245(hisD) IHQ72_28265(hisD)
MMEI : LRP31_28195(hisD) LRP31_31995(hisD)
MESJ : MJ8_11100 MJ8_28410
PHT : BLM14_14840 BLM14_28690
KMN : HW532_07365(hisD) HW532_09060(hisD)
RBS : RHODOSMS8_00001(hisD)
SME : SMa0398(hisD2) SMc02307(hisD1)
SMQ : SinmeB_0213 SinmeB_6485
SMX : SM11_chr0220(hisD) SM11_pC1570(hisD2)
SMI : BN406_00228(hisD1) BN406_03634(hisD2)
SMEG : C770_GR4Chr0597 C770_GR4pC0182
SMEL : SM2011_a0398(hisD2) SM2011_c02307(hisD1)
SMER : DU99_03120 DU99_19110
SFD : USDA257_c02100(hisD)
SAME : SAMCFNEI73_Ch0580(hisD)
SKM : PZL22_004198(hisD) PZL22_005379(hisD)
AGR : AGROH133_03921(hisD)
ALF : CFBP5473_12825(hisD)
AVV : RvVAT039_21510(hisD)
AVF : RvVAR031_08810(hisD)
ASAL : CFBP5507_00895(hisD)
RPUS : CFBP5875_00890(hisD)
ALEG : CFBP4996_00855(hisD)
REC : RHECIAT_CH0000656(hisD)
REL : REMIM1_CH00592(hisD)
REP : IE4803_CH00622(hisD)
REI : IE4771_CH00648(hisD-1)
RLT : Rleg2_0239 Rleg2_5007
RTR : RTCIAT899_CH15865(hisD)
RGA : RGR602_CH00628(hisD-1) RGR602_PC00487(hisD-2)
RPHA : AMC79_CH00619(hisD)
RGR : FZ934_00295(hisD) FZ934_26590(hisD)
RLW : RlegWSM1455_01250(hisD)
RBW : RLCC275e_01195(hisD)
NEN : NCHU2750_02210(hisD)
OIN : IAR37_04330(hisD) IAR37_18335(hisD)
BIO : BR141012304_10289(hisD)
OAH : DR92_2615(hisD) DR92_2906(hisD)
BPSN : NIK97_10625(hisD) NIK97_12890(hisD)
BRUC : LJ361_01360(hisD) LJ361_06290(hisD)
OCR : HGK82_00900(hisD) HGK82_20385(hisD)
OCL : GTN27_01350(hisD) GTN27_17480(hisD)
BSEP : HAP48_0011530(hisD)
BCAN : BcanWSM471_34725(hisD)
VGO : GJW-30_1_01347(hisD)
STAR : G3545_14280(hisD) G3545_20495(hisD)
LNE : FZC33_08930(hisD) FZC33_26995(hisD)
APRA : G3A50_10740(hisD) G3A50_12915(hisD)
MAQU : Maq22A_c00445(hisD)
MMES : MMSR116_30715(hisD)
MTUN : MTUNDRAET4_3389(hisD)
FIL : BN1229_v1_1977(hisD)
FIY : BN1229_v1_1981(hisD)
PLEO : OHA_1_01520(hisD_1) OHA_1_03843(hisD_2)
AALA : IGS74_16180(hisD) IGS74_18780(hisD)
AALM : LUX29_18270(hisD) LUX29_20990(hisD)
AUZ : Sa4125_02990(hisD_1) Sa4125_27080(hisD_3)
JAV : OXU80_00775(hisD) OXU80_25350(hisD)
NOH : G5V57_08805(hisD) G5V57_29345(hisD)
ACUT : MRB58_12545(hisD) MRB58_13540(hisD)
BVY : NCTC9239_00356(hisD)
TSV : DSM104635_00440(hisD)
RLI : RLO149_c002700(hisD1)
PHP : PhaeoP97_03116(hisD4)
PPIC : PhaeoP14_00127(hisD4)
OAT : OAN307_c29140(hisD1)
SINL : DSM14862_02644(hisD)
SPSE : SULPSESMR1_00224(hisD)
RMM : ROSMUCSMR3_02758(hisD)
AHT : ANTHELSMS3_04383(hisD)
LALG : LentiSH36_02285(hisD4)
RMAI : MACH21_10130(hisD1)
RSP : RSP_0632(hisD1) RSP_2155(hisD)
RSH : Rsph17029_0829 Rsph17029_2284
RSK : RSKD131_0466 RSKD131_1986
PALS : PAF20_04980(hisD) PAF20_11190(hisD)
LVS : LOKVESSMR4R_00883(hisD)
GEH : HYN69_03065(hisD) HYN69_09995(hisD)
BOO : E2K80_04625(hisD) E2K80_12490(hisD)
PPRU : FDP22_08585(hisD) FDP22_18480(hisD)
CMAG : CBW24_05610 CBW24_17680
AALK : LGT41_0014450(hisD)
SKR : BRX40_06245 BRX40_08760
SPAU : DRN02_000115(hisD) DRN02_011565(hisD)
SBIN : SBA_ch1_07540(hisD)
SPAG : sphantq_01854(hisD)
SFLA : SPHFLASMR4Y_00031(hisD)
GAL : A0U94_00395 A0U94_12600
KEU : S101446_00267(hisD) S101446_01841
NGU : QN315_10060(hisD) QN315_18070(hisD)
TMO : TMO_0437 TMO_1002(hisD)
HPUL : NCTC13154_01421(hisD)
CJV : MTVDSCj20_1556(hisD)
CFV : CFVI03293_0515(hisD)
CAMP : CFT03427_0523(hisD)
CCOC : CCON33237_1267(hisD)
CLR : UPTC16701_0108(hisD)
CLM : UPTC16712_0109(hisD)
CAMR : CAQ16704_0098(hisD)
CHV : CHELV3228_0252(hisD)
CAMZ : CVIC12175_0623(hisD)
GEC : GEO60473_25150(hisD)
GBN : GEOBRER4_36130(hisD)
PPOR : JCM14722_06760(hisD)
DEK : DSLASN_34290(hisD_3)
BAZ : BAMTA208_17700(hisD)
BAE : BATR1942_15360(hisD)
BSON : S101395_00667(hisD)
BTHR : YBT1520_08125(hisD)
BTHU : YBT1518_08055(hisD)
BFD : NCTC4823_03062(hisD)
BACI : B1NLA3E_19360(hisD)
OON : NP440_05255(hisD) NP440_21655(hisD)
PARG : PspKH34_03900(hisD)
LYP : MTP04_09400(hisD_1) MTP04_30530(hisD_2)
HNZ : P9989_04055(hisD) P9989_15345(hisD)
NCM : QNK12_15445(hisD) QNK12_26670(hisD)
BLEN : NCTC4824_01218(hisD)
SAX : USA300HOU_2679(hisD)
SUQ : HMPREF0772_10508(hisD)
SUX : SAEMRSA15_25840(hisD)
SUF : SARLGA251_24510(hisD)
SAUT : SAI1T1_2020100(hisD)
SAUJ : SAI2T2_1020110(hisD)
SAUK : SAI3T3_1020100(hisD)
SAUQ : SAI4T8_1020110(hisD)
SAUV : SAI7S6_1020100(hisD)
SAUW : SAI5S5_1020040(hisD)
SAUX : SAI6T6_1020050(hisD)
SAUY : SAI8T7_1020080(hisD)
SDP : NCTC12225_00299(hisD)
SPIC : SAMEA4384060_1930(hisD)
SSH : NCTC13712_02634(hisD)
SSIM : SAMEA4384339_2473(hisD)
SSTE : SAMEA4384403_0776(hisD)
LMOC : LMOSLCC5850_0560(hisD)
LMW : LMOSLCC2755_0572(hisD)
LMX : LMOSLCC2372_0576(hisD)
LMZ : LMOSLCC2482_0569(hisD)
LMON : LMOSLCC2376_0546(hisD)
LMOS : LMOSLCC7179_0543(hisD)
LMOO : LMOSLCC2378_0591(hisD)
LMOY : LMOSLCC2479_0574(hisD)
LMOT : LMOSLCC2540_0572(hisD)
LMOA : LMOATCC19117_0597(hisD)
LGZ : NCTC10812_00672(hisD)
PPQ : PPSQR21_001690(hisD)
PBJ : VN24_05795 VN24_11085
PCHI : PC41400_03445(hisD)
PBK : Back11_38770 Back11_44890(hisD)
PAUN : MJA45_10220 MJA45_26005(hisD)
PKP : SK3146_03529(hisD_1) SK3146_06938(hisD_2)
CHEB : HH215_07265(hisD) HH215_25720(hisD)
SMC : SmuNN2025_0785(hisD)
SGG : SGGBAA2069_c14930(hisD)
SFER : NCTC12278_01242(hisD)
LHO : LOOC260_121530(hisD)
ECEC : NCTC12421_00911(hisD)
CGEL : psyc5s11_37110(hisD)