Entry
Name
hydroxyphenylpyruvate reductase;
HPPR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ oxidoreductase
Reaction(IUBMB)
(1) (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ = 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:
R03337 R03339 ];
(2) (R)-3-(3,4-dihydroxyphenyl)lactate + NAD(P)+ = 3-(3,4-dihydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:
R03373 R12252 ]
Reaction(KEGG)
Substrate
(R)-3-(4-hydroxyphenyl)lactate [CPD:
C03964 ];
NAD+ [CPD:
C00003 ];
NADP+ [CPD:
C00006 ];
(R)-3-(3,4-dihydroxyphenyl)lactate [CPD:
C22038 ]
Product
Comment
The enzyme participates in the biosynthesis of rosmarinic acid. It belongs to the family of D-isomer-specific 2-hydroxyacid dehydrogenases, and prefers NADPH to NADH.
History
EC 1.1.1.237 created 1992, modified 2018
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec00960 Tropane, piperidine and pyridine alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13574 hydroxycarboxylate dehydrogenase B
K18606 hydroxyphenylpyruvate reductase
Genes
HSYR : 120131849 120195953 120204201
CSAV : 115697455 115707836
MEAN : 126679816 126683219
SSPL : 121768515 121771586 121795126 121795127 121795132 121795133 121797828
SHIS : 125190168 125207200
ECAD : 122588587 122595340 122596024
CSIN : 114279513 114323921
MING : 122066597 122066860 122082675 122082676
TSS : 122653576 122666837 122667233
PSOM : 113348278 113349087
ECOO : ECRM13514_0878(ybiC)
ECOH : ECRM13516_0833(ybiC)
EDJ : ECDH1ME8569_0754(ybiC)
ECOI : ECOPMV1_00803(ybiC)
KOY : J415_15110 J415_18885
KOM : HR38_17100 HR38_20840
KOK : KONIH1_12525 KONIH1_16575
REE : electrica_01980(ybiC_1) electrica_02154(ybiC_2)
RTG : NCTC13098_02582(ybiC_1) NCTC13098_03134(ybiC_2)
AHN : NCTC12129_02563(ybiC)
KIN : AB182_12390 AB182_18530
PDZ : HHA33_15075 HHA33_21005
METY : MRY16398_29140(ybiC) MRY16398_42030
EBC : C2U52_23280 C2U52_29745
SMW : SMWW4_v1c20410(ybiC)
SFJ : SAMEA4384070_2085(ybiC_2)
SOF : NCTC11214_04882(ybiC)
GQU : AWC35_00900 AWC35_03550
PWA : Pecwa_1798 Pecwa_2132
PPAR : A8F97_08210 A8F97_09785
PWS : A7983_18130 A7983_22515
PPOA : BJK05_02250 BJK05_04260
PARI : I2D83_10070 I2D83_14995
PVZ : OA04_24140 OA04_28810
PPOO : LW347_07580 LW347_09670
PACB : M9782_09525 M9782_11760
PARL : PEC302110_13720 PEC302110_18450
DDD : Dda3937_02253 Dda3937_02692
DSO : A4U42_00945 A4U42_16640
CED : LH89_04530 LH89_21165
DFN : CVE23_08230 CVE23_13820
DIC : Dpoa569_001506 Dpoa569_002383
DDA : Dd703_1300 Dd703_1601
BGJ : AWC36_08580 AWC36_10535
BNG : EH206_12170 EH206_14470
GAI : IMCC3135_12715(ybiC)
REH : H16_B0942(h16_B0942)
BCON : NL30_01730 NL30_16180
BUO : BRPE64_BCDS06860(ybiC)
PVAC : HC248_02881(hcxB_2)
LIM : L103DPR2_00626(ybiC)
LIH : L63ED372_02625(ybiC)
BJU : BJ6T_67890 BJ6T_68480
BJP : RN69_32930 RN69_33220
BRC : BCCGELA001_13060 BCCGELA001_13315
BRAD : BF49_1720 BF49_1774
BSYM : CIT39_08165 CIT39_08460
BDG : LPJ38_17615 LPJ38_17875
BBAN : J4G43_016705 J4G43_016990
BCAN : BcanWSM471_13885 BcanWSM471_14145
BROS : QUH67_11825 QUH67_30270
VGO : GJW-30_1_02181(ybiC)
SRF : LHU95_03030 LHU95_11910
RAP : RHOA_0566(hcxB) RHOA_1359(hcxB)
SHUM : STHU_18420 STHU_40300 STHU_51190
SVC : STVA_34900 STVA_51100
STEL : STAQ_17320 STAQ_46330
AZL : AZL_a00760 AZL_a06180
AZM : DM194_19645 DM194_22170
AZS : E6C72_16090 E6C72_23440
ELIO : KO353_01085 KO353_03675 KO353_05605
NACI : NUH88_01885 NUH88_11400
THAR : T8K17_02885 T8K17_19110
GAZ : Pan241w_17250(ybiC_1)
» show all
Taxonomy
Reference
1
Authors
Petersen M, Alfermann AW.
Title
Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.
Journal
Z Naturforsch C: Biosci 43:501-504 (1988)
Reference
Authors
Kim KH, Janiak V, Petersen M
Title
Purification, cloning and functional expression of hydroxyphenylpyruvate reductase involved in rosmarinic acid biosynthesis in cell cultures of Coleus blumei.
Journal
Sequence
Reference
Authors
Kim YB, Uddina MR, Kim Y, Park CG, Park SU
Title
Molecular cloning and characterization of tyrosine aminotransferase and hydroxyphenylpyruvate reductase, and rosmarinic acid accumulation in Scutellaria baicalensis.
Journal
Nat Prod Commun 9:1311-4 (2014)
Reference
Authors
Wang GQ, Chen JF, Yi B, Tan HX, Zhang L, Chen WS
Title
HPPR encodes the hydroxyphenylpyruvate reductase required for the biosynthesis of hydrophilic phenolic acids in Salvia miltiorrhiza.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.237