NAD+ cannot replace NADP+ [3]. In higher organisms, this enzyme forms part of a multienzyme complex with EC
4.2.1.10, 3-dehydroquinate dehydratase [4]. cf. EC
1.1.1.24, quinate/shikimate dehydrogenase (NAD+), EC
1.1.5.8, quinate/shikimate dehydrogenase (quinone), and EC
1.1.1.282, quinate/shikimate dehydrogenase [NAD(P)+].