KEGG   ENZYME: 1.1.1.251
Entry
EC 1.1.1.251                Enzyme                                 
Name
galactitol-1-phosphate 5-dehydrogenase;
gatD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
galactitol-1-phosphate:NAD+ oxidoreductase
Reaction(IUBMB)
galactitol 1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+ [RN:R05571]
Reaction(KEGG)
R05571
Substrate
galactitol 1-phosphate [CPD:C06311];
NAD+ [CPD:C00003]
Product
D-tagatose 6-phosphate [CPD:C01097];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Escherichia coli is involved in a galactitol degradation pathway. It contains two zinc atoms per subunit.
History
EC 1.1.1.251 created 1999
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K00094  galactitol-1-phosphate 5-dehydrogenase
Genes
ECOb2091(gatD)
ECJJW2075(gatD)
ECDECDH10B_2244(gatD)
EBWBWG_1877(gatD)
ECEZ3254(gatD)
ECSECs_2894(gatD)
ECFECH74115_3070(gatD)
ETWECSP_2886(gatD)
ELXCDCO157_2671
EOIECO111_2807(gatD)
EOHECO103_2565(gatD)
ECOOECRM13514_2806(gatD)
ECOHECRM13516_2720(gatD)
ESLO3K_08995
ESOO3O_16625
ESMO3M_08960
ECKEC55989_2345(gatD)
ECGE2348C_2236(gatD)
EOKG2583_2623(gatD)
ELRECO55CA74_12625
ECWEcE24377A_2379(gatD)
ECPECP_2129
ENAECNA114_2182(gatD)
ECOSEC958_2425(gatD)
ECVAPECO1_4454(gatD)
ECOAAPECO78_14165
ECXEcHS_A2227(gatD)
ECMEcSMS35_0973(gatD)
ECYECSE_2360
ECRECIAI1_2165(gatD)
EUMECUMN_2423(gatD)
ECTECIAI39_0926(gatD)
EOCCE10_2405(gatD)
EBRECB_02017(gatD)
EBLECD_02017(gatD)
EBEB21_01983(gatD)
EBDECBD_1566
ECIUTI89_C2364(gatD)
EIHECOK1_2320
ECZECS88_2233(gatD)
ECCc2616(gatD)
ELOEC042_2323(gatD)
ELNNRG857_10615
ESEECSF_1973
ECLEcolC_1556
EKOEKO11_1663
EKFKO11_12165(gatD)
EABECABU_c24210(gatD)
EDHEcDH1_1567
EDJECDH1ME8569_2025(gatD)
ELUUM146_06335
ELWECW_m2292(gatD)
ELLWFL_11215(gatD)
ELCi14_2417(gatD)
ELDi02_2417(gatD)
ELPP12B_c2188(gatD)
ELFLF82_0811(gatD)
ECOLLY180_10935
ECOIECOPMV1_02249(tdh_3)
ECOJP423_11805
ESZFEM44_00670(gatD)
STYSTY3444(gatD)
STTt3181(gatD)
SEXSTBHUCCB_33650
SENTTY21A_16125
STMSTM3261
SEOSTM14_3943
SEVSTMMW_32611
SEYSL1344_3234(gatD)
SEMSTMDT12_C33180
SEJSTMUK_3245
SEBSTM474_3418
SEFUMN798_3549(gatD)
SETUSTU288_16510
SETCCFSAN001921_00705
SENRSTMDT2_31541(gatD)
SENDDT104_32561(gatD)
SENICY43_16985
SEENSE451236_22400
SPTSPA3130(gatD)
SEKSSPA2922
SPQSPAB_04071
SEISPC_3332(gadD)
SECSCH_3202(gadD)
SEHSeHA_C3556
SHBSU5_03749
SENHCFSAN002069_15860
SEEHSEEH1578_02425
SEESNSL254_A3519
SENNSN31241_43860
SEWSeSA_A3450
SEASeAg_B3448
SENSQ786_15885
SEDSeD_A3616
SEGSG3152
SELSPUL_3270
SEGASPUCDC_3256
SETSEN3096
SENAAU38_15765
SENOAU37_15965
SENVAU39_15960
SENQAU40_17770
SENLIY59_16365
SENJCFSAN001992_17230
SEECCFSAN002050_23270
SEEBSEEB0189_003565
SEEPI137_15590
SENBBN855_33420
SENEIA1_15780
SENCSEET0819_23285
SBGSBG_2892(gatD)
SBZA464_3342
SBVN643_14245
SALZEOS98_02975
SFLSF2151(gatD)
SFXS2277(gatD)
SFESFxv_2380(gatD)
SFNSFy_3039
SFSSFyv_3112
SFTNCTC1_02367(gatD)
SSNSSON_2138(gatD)
SBOSBO_0912(gatD)
SBCSbBS512_E1147(gatD)
SDYSDY_2263(gatD)
SDZAsd1617_03056
SHQA0259_14270
ECLZLI64_18870
EKBBFV64_20615
ENOECENHK_19445
ECLSLI67_021190
LNICWR52_15430
ENDA4308_04110
CUIAFK65_02310
CMWAFK63_16220
CTUCTU_04350(gatD)
KPNKPN_03551(gatD)
KPUKP1_4855(gatD)
KPMKPHS_46880
KPPA79E_0562
KPHKPNIH24_05460
KPVKPNIH29_23290
KPWKPNIH30_23615
KPGKPNIH32_24495
KPCKPNIH10_23340
KPQKPR0928_22860
KPJN559_0616
KPAKPNJ1_00601
KPSKPNJ2_00639
KPBFH42_14055
KPNEKU54_002970
KPNULI86_02975
KVAKvar_0546
KVDKR75_05285
KVQSP68_11905
KOXKOX_03535
KOEA225_5157
KOYJ415_06230
KQUAVR78_01605
KQVB8P98_03030
KLLBJF97_25710
KLWDA718_03460
KARLGL98_02885(gatD)
KGRJJJ10_03085(gatD)
CWECO701_00800
CPOTFOB25_14240(gatD)
CFQC2U38_22630
CSEDJY391_03115(gatD)
CIFAL515_20555
CPARCUC49_16295
KORAWR26_02850(gatD)
KRDA3780_21870
KCOBWI95_07120
KOTEH164_02685
KIENCTC12125_04489(gutB_2)
LEHC3F35_14820
LAZA8A57_18540
METYMRY16398_06260
AHNNCTC12129_03669(gatD_2)
PSGCG163CM_41690(gatD)
PSTSE05_50960
SFWWN53_06580
SFGAV650_04325
RAHRahaq_3466
RACEJHW33_11550
RAQRahaq2_3542
RAAQ7S_17450
ROXBV494_12380
RVCJ9880_03040(gatD)
PHEINCTC12003_03174(tdh_2)
HSOHS_1141(gatD)
HSMHSM_1035
AAOANH9381_1628
AAND7S_02347
AAHCF65_02047
AACNAANUM_1585
AACTACT75_10800
GAPGAPWK_0183
OCKEXM22_18110
FULC4N20_03410
STRSterm_3384
 » show all
Reference
1  [PMID:13331868]
  Authors
WOLFF JB, KAPLAN NO
  Title
Hexitol metabolism in Escherichia coli.
  Journal
J Bacteriol 71:557-64 (1956)
DOI:10.1128/JB.71.5.557-564.1956
Reference
2  [PMID:7772602]
  Authors
Nobelmann B, Lengeler JW
  Title
Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli.
  Journal
Biochim Biophys Acta 1262:69-72 (1995)
DOI:10.1016/0167-4781(95)00053-J
  Sequence
[eco:b2091]
Reference
3  [PMID:26143925]
  Authors
Benavente R, Esteban-Torres M, Kohring GW, Cortes-Cabrera A, Sanchez-Murcia PA, Gago F, Acebron I, de las Rivas B, Munoz R, Mancheno JM
  Title
Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase from Escherichia coli.
  Journal
Acta Crystallogr D Biol Crystallogr 71:1540-54 (2015)
DOI:10.1107/S1399004715009281
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.251
IUBMB Enzyme Nomenclature: 1.1.1.251
ExPASy - ENZYME nomenclature database: 1.1.1.251
BRENDA, the Enzyme Database: 1.1.1.251
CAS: 60120-43-6

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