KEGG   ENZYME: 1.1.1.252
Entry
EC 1.1.1.252                Enzyme                                 
Name
tetrahydroxynaphthalene reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
scytalone:NADP+ Delta5-oxidoreductase
Reaction(IUBMB)
scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+ [RN:R02906]
Reaction(KEGG)
R02906;
(other) R03322
Substrate
scytalone [CPD:C00779];
NADP+ [CPD:C00006]
Product
1,3,6,8-tetrahydroxynaphthalene [CPD:C04033];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC 4.2.1.94 scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi.
History
EC 1.1.1.252 created 1992 as EC 1.3.1.50, transferred 1999 to EC 1.1.1.252
Orthology
K17739  tetrahydroxynaphthalene reductase
Genes
QSU111996407 112020408 112030256 112033622
NCRNCU09390(tnr-1)
NTENEUTE1DRAFT102704(NEUTE1DRAFT_102704)
SMPSMAC_05650(tih)
PANPODANS72p035 PODANSg1142
TTTTHITE_2145571
MTMMYCTH_2064803 MYCTH_2127410
CTHRCTHT_0020210 CTHT_0037040
MGRMGG_02252
PPEIPpBr36_06854
TMNUCRPA7_2613
SSCKSPSK_02654
VALVDBG_02748
VDAVDAG_03665 VDAG_05181
CFJCFIO01_05916
CLUPCLUP02_04511
CHIGCH63R_03364 CH63R_09544
ELAUCREL1_5427 UCREL1_5776
PFYPFICI_05460 PFICI_06726
SSLSS1G_10677
BFUBCIN_04g04800(Bcbrn1) BCIN_10g00140
MBEMBM_00285
PSCOLY89DRAFT_581099 LY89DRAFT_689141
GLZGLAREA_02255
ANIAN0146.2
NFINFIA_101580
APUUAPUU_12003S APUU_22040A
PDPPDIP_50160
TMFPMAA_031660 PMAA_100520
TRGTRUGW13939_00030
PNOSNOG_11990
PTEPTT_12898 PTT_20021
BZECOCCADRAFT_105268 COCCADRAFT_21397
BSCCOCSADRAFT_275042 COCSADRAFT_33820 COCSADRAFT_37812
BORCOCMIDRAFT_106821 COCMIDRAFT_22732 COCMIDRAFT_26577
AALTCC77DRAFT_528893
ZTRMYCGRDRAFT_87994
PFJMYCFIDRAFT_145765
FFUCLAFUR5_12822 CLAFUR5_12910
BCOMBAUCODRAFT_30716 BAUCODRAFT_61485
NPAUCRNP2_5079
GTRGLOTRDRAFT_114557
 » show all
Reference
1
  Authors
Wheeler, M.H. and Greenblatt, G.A.
  Title
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
  Journal
Exp Mycol 12:151-160 (1988)
Reference
2  [PMID:8112349]
  Authors
Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M
  Title
Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing.
  Journal
Eur J Biochem 219:985-92 (1994)
DOI:10.1111/j.1432-1033.1994.tb18581.x
  Sequence
[mgr:MGG_02252]
Reference
3  [PMID:9048570]
  Authors
Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB.
  Title
Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism.
  Journal
Biochemistry 36:1852-60 (1997)
DOI:10.1021/bi962355u
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.252
IUBMB Enzyme Nomenclature: 1.1.1.252
ExPASy - ENZYME nomenclature database: 1.1.1.252
BRENDA, the Enzyme Database: 1.1.1.252
CAS: 141350-13-2

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