KEGG ENZYME: 1.1.1.263

ENZYME: 1.1.1.263

Entry

EC 1.1.1.263                Enzyme

Name

1,5-anhydro-D-fructose reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

1,5-anhydro-D-glucitol:NADP+ oxidoreductase

Reaction(IUBMB)

1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+ [RN:R05682]

Reaction(KEGG)

R05682

Substrate

1,5-anhydro-D-glucitol [CPD:C07326];
NADP+ [CPD:C00006]

Product

1,5-anhydro-D-fructose [CPD:C06485];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also reduces pyridine-3-aldehyde and 2,3-butanedione. Acetaldehyde, 2-dehydroglucose (glucosone) and glucuronate are poor substrates, but there is no detectable action on glucose, mannose and fructose.

History

EC 1.1.1.263 created 2000

Orthology

K13981

1,5-anhydro-D-fructose reductase

Genes

HSA:	83592(AKR1E2)

PPS:	100985849(AKR1E2)

GGO:	101143645(AKR1E2)

PON:	100462621(AKR1E2)

PPYG:

129006868(AKR1E2)

NLE:	100603254(AKR1E2)

HMH:	116474586(AKR1E2)

SSYN:

129491836(AKR1E2)

MCC:	711035(AKR1E2)

MCF:	101925198(AKR1E2)

MTHB:

126963011

MNI:	105490785(AKR1E2)

CSAB:

103237804(AKR1E2)

CATY:

105587692(AKR1E2)

PANU:

101021644 116268518(AKR1E2)

TGE:	112631310(AKR1E2)

MLEU:

105532492(AKR1E2)

RRO:	104678923(AKR1E2)

RBB:	108513974(AKR1E2)

TFN:	117082287(AKR1E2)

PTEH:

111527012(AKR1E2)

CANG:

105521706(AKR1E2)

CJC:	100404287(AKR1E2)

SBQ:	101050607(AKR1E2)

CIMI:

108285105(AKR1E2)

ANAN:

105710888(AKR1E2)

MMUR:

105858223(AKR1E2)

LCAT:

123623048(AKR1E2)

ERUF:

138375339(AKR1E2)

PCOQ:

105826914(AKR1E2)

OGA:	100942807(AKR1E2)

MMU:	56043(Akr1e1)

MCAL:

110307827(Akr1e2)

MPAH:

110333880(Akr1e2)

RNO:	307091(Akr1e2)

MCOC:

116081948(Akr1e2)

ANU:	117713847(Akr1e2)

ASYL:

127665031(Akr1e2)

MUN:	110563027(Akr1e2)

CGE:	100750439(Akr1e2)

MAUA:

101843859(Akr1e2)

PROB:

127229797(Akr1e2)

PLEU:

114707994(Akr1e2)

PMAV:

102915602(Akr1e2)

MORG:

121432662(Akr1e2)

MFOT:

126501691

AAMP:

119817584

CNL:	130886182(Akr1e2)

NGI:	103725894(Akr1e2)

CPOC:

100725167(Akr1e2)

CCAN:

109678870(Akr1e2)

DORD:

105980518(Akr1e2)

DSP:	122113032(Akr1e2)

DMER:

138805666(Akr1e2)

PLOP:

125366787(Akr1e2)

NCAR:

124961755

MMMA:

107150199(Akr1e2)

ITI:	101955263(Akr1e2)

OCU:

100345389

OPI:	101521319(AKR1E2)

OCZ:

121151971

TUP:	102478936(AKR1E2)

GVR:

103607547

CFA:	608809(AKR1E2)

CLUD:

112658941(AKR1E2)

VVP:	112933735(AKR1E2)

VLG:	121498000(AKR1E2)

NPO:	129513992(AKR1E2)

AML:	100464743(AKR1E2)

UMR:	103676233(AKR1E2)

UAH:	113241123(AKR1E2)

UAR:	123802308(AKR1E2)

ELK:

111158637

LLV:

125107257

MPUF:

101674921(AKR1E2) 101687856

MNP:	132020014(AKR1E2) 132025126

MLK:	131812858 131838052(AKR1E2)

NVS:	122891224(AKR1E2)

ORO:	101372660 101377286 101377908(AKR1E2)

EJU:	114217688(AKR1E2)

ZCA:	113922699(AKR1E2)

MLX:	118021624(AKR1E2)

MANO:

123844263

NSU:	110586490(AKR1E2)

LWW:

102725983

FCA:	101097814(AKR1E2)

PYU:	121014879(AKR1E2)

PCOO:

112867310

PBG:	122473929(AKR1E2)

PVIV:

125170959(AKR1E2)

LRUF:

124502198

LGF:	123590149(AKR1E2)

AJU:

106988131

PTG:	102968954(AKR1E2)

PPAD:

109273790(AKR1E2)

PUC:

125918567

PLEZ:

122223816(AKR1E2)

HHV:

120237197

CCRU:

144227019(AKR1E2)

BTA:	615959(AKR1E2)

BOM:	102270889(AKR1E2)

BIU:	109567630(AKR1E2)

BJV:	133259264(AKR1E2)

BBUB:

102393589(AKR1E2)

BKE:	129625178(AKR1E2)

BBIS:

104986161(AKR1E2)

CHX:	102189770(AKR1E2)

OAS:	101110956(AKR1E2)

OCAN:

138417530(AKR1E2)

BTAX:

128058157(AKR1E2)

CSUM:

138091442(AKR1E2)

ODA:	120869465(AKR1E2)

CCAD:

122448192(AKR1E2)

MREE:

136159324(AKR1E2)

OVR:	110142565(AKR1E2)

MBEZ:

129559504(AKR1E2)

SSC:	733633(AKR1E2)

BMUS:

118891074

PCAD:

102978821(AKR1E2)

ECB:	100070632(AKR1E2)

EPZ:	103555590(AKR1E2)

EAI:

106827463

MYB:	102256598(AKR1E2)

MYD:	102752243(AKR1E2)

MMYO:

118672693(AKR1E2)

MLF:	102421063(AKR1E2)

MDT:	132215253(AKR1E2)

MYUM:

138992465(AKR1E2)

PKL:	118702298(AKR1E2)

EFUS:

103300839(AKR1E2)

MNA:	107542425(AKR1E2)

DRO:	112321166(AKR1E2)

SHON:

118977169(AKR1E2)

AJM:	119057883(AKR1E2)

PHAS:

123806948(AKR1E2)

MMF:	118632036(AKR1E2)

PPAM:

129084903(AKR1E2)

PALE:

102889300(AKR1E2)

PGIG:

120608989(AKR1E2)

PVP:	105299188(AKR1E2)

RAY:

107501640

MJV:	108393832(AKR1E2)

SARA:

101555047(AKR1E2)

SFUM:

130024033(AKR1E2)

SETR:

126013303 126013591

LAV:

100661345

TMU:

101356649

ETF:	101653887(AKR1E2)

DNM:	101433242(AKR1E2)

MDO:	100018228(AKR1E2)

GAS:	123250424(AKR1E2)

SHR:

100927444

AFZ:

127539131

PCW:	110218695(AKR1E2)

TVP:	118850800 118851175 118851179 118851182

PBRV:

138165894(AKR1E2)

MLAO:

141493490(AKR1E2)

BCOO:

119073220 119080509 119083626

OTU:

111419676

CCRN:

123297856

PTRU:

123510143

PMEO:

129585393 129585959 129590479

LSAX:

138982063

HRF:

124149804

HRJ:	124267665 124280637

HCRA:

139451889 139452746

CRG:

105345761

CANU:

128181978

OED:

125646396

PMAX:

117335390

YBA:

132548446

MCAF:

127705095

DPOL:

127851148

» show all

Reference

1 [PMID:9504428]

Authors

Sakuma M, Kametani S, Akanuma H

Title

Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose.

Journal

J Biochem 123:189-93 (1998)
DOI:10.1093/oxfordjournals.jbchem.a021909

Sequence

[ssc:733633]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.263

IUBMB Enzyme Nomenclature:

1.1.1.263

ExPASy - ENZYME nomenclature database:

1.1.1.263

UM-BBD (Biocatalysis/Biodegradation Database):

1.1.1.263

BRENDA, the Enzyme Database:

1.1.1.263

CAS:	206138-19-4

All links

Gene (4)   
   MGENES (1)   
   RefGene (3)   
Protein sequence (176)   
   UniProt (158)   
   SWISS-PROT (5)   
   RefSeq(pep) (7)   
   PDBSTR (6)   
DNA sequence (9)   
   RefSeq(nuc) (7)   
   GenBank (2)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   InterPro (1)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (192)   

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