KEGG ENZYME: 1.1.1.263

ENZYME: 1.1.1.263

Entry

EC 1.1.1.263                Enzyme

Name

1,5-anhydro-D-fructose reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

1,5-anhydro-D-glucitol:NADP+ oxidoreductase

Reaction(IUBMB)

1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+ [RN:R05682]

Reaction(KEGG)

R05682

Substrate

1,5-anhydro-D-glucitol [CPD:C07326];
NADP+ [CPD:C00006]

Product

1,5-anhydro-D-fructose [CPD:C06485];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also reduces pyridine-3-aldehyde and 2,3-butanedione. Acetaldehyde, 2-dehydroglucose (glucosone) and glucuronate are poor substrates, but there is no detectable action on glucose, mannose and fructose.

History

EC 1.1.1.263 created 2000

Orthology

K13981

1,5-anhydro-D-fructose reductase

Genes

HSA:	83592(AKR1E2)

PTR:	746502(AKR1E2)

PPS:	100985849(AKR1E2)

GGO:	101143645(AKR1E2)

PON:	100462621(AKR1E2)

NLE:	100603254(AKR1E2)

HMH:	116474586(AKR1E2)

MCC:	711035(AKR1E2)

MCF:	101925198(AKR1E2)

MTHB:

126963011

MNI:	105490785(AKR1E2)

CSAB:

103237804(AKR1E2)

CATY:

105587692(AKR1E2)

PANU:

101021644 116268518(AKR1E2)

TGE:	112631310(AKR1E2)

MLEU:

105532492(AKR1E2)

RRO:	104678923(AKR1E2)

RBB:	108513974(AKR1E2)

TFN:	117082287(AKR1E2)

PTEH:

111527012(AKR1E2)

CANG:

105521706(AKR1E2)

CJC:	100404287(AKR1E2)

SBQ:	101050607(AKR1E2)

CIMI:

108285105(AKR1E2)

MMUR:

105858223(AKR1E2)

LCAT:

123623048(AKR1E2)

PCOQ:

105826914(AKR1E2)

OGA:	100942807(AKR1E2)

MMU:	56043(Akr1e1)

MCAL:

110307827(Akr1e2)

MPAH:

110333880(Akr1e2)

RNO:	307091(Akr1e2)

MCOC:

116081948(Akr1e2)

ANU:	117713847(Akr1e2)

MUN:	110563027(Akr1e2)

CGE:	100750439(Akr1e2)

MAUA:

101843859(Akr1e2)

PROB:

127229797(Akr1e2)

PLEU:

114707994(Akr1e2)

MORG:

121432662(Akr1e2)

MFOT:

126501691

AAMP:

119817584

NGI:	103725894(Akr1e2)

CPOC:

100725167(Akr1e2)

CCAN:

109678870(Akr1e2)

DORD:

105980518(Akr1e2)

DSP:	122113032(Akr1e2)

PLOP:

125366787(Akr1e2)

NCAR:

124961755

OCU:

100345389

OPI:	101521319(AKR1E2)

TUP:	102478936(AKR1E2)

GVR:

103607547

CFA:	608809(AKR1E2)

CLUD:

112658941(AKR1E2)

VVP:	112933735(AKR1E2)

VLG:	121498000(AKR1E2)

NPO:	129513992(AKR1E2)

AML:	100464743(AKR1E2)

UMR:	103676233(AKR1E2)

UAH:	113241123(AKR1E2)

UAR:	123802308(AKR1E2)

ELK:

111158637

LLV:

125107257

MPUF:

101674921(AKR1E2) 101687856

NVS:	122891224(AKR1E2)

ORO:	101372660 101377286 101377908(AKR1E2)

EJU:	114217688(AKR1E2)

ZCA:	113922699(AKR1E2)

MLX:	118021624(AKR1E2)

NSU:	110586490(AKR1E2)

LWW:

102725983

FCA:	101097814(AKR1E2)

PYU:	121014879(AKR1E2)

PCOO:

112867310

PBG:	122473929(AKR1E2)

LRUF:

124502198

PTG:	102968954(AKR1E2)

PPAD:

109273790(AKR1E2)

PUC:

125918567

AJU:

106988131

HHV:

120237197

BTA:

615959

BOM:	102270889(AKR1E2)

BIU:	109567630(AKR1E2)

BBUB:

102393589(AKR1E2)

BBIS:

104986161(AKR1E2)

CHX:	102189770(AKR1E2)

OAS:	101110956(AKR1E2)

BTAX:

128058157(AKR1E2)

ODA:	120869465(AKR1E2)

CCAD:

122448192(AKR1E2)

SSC:	733633(AKR1E2)

PCAD:

102978821(AKR1E2)

ECB:	100070632(AKR1E2)

EPZ:	103555590(AKR1E2)

EAI:

106827463

MYB:	102256598(AKR1E2)

MYD:	102752243(AKR1E2)

MMYO:

118672693(AKR1E2)

MLF:	102421063(AKR1E2)

MNA:	107542425(AKR1E2)

PKL:	118702298(AKR1E2)

DRO:	112321166(AKR1E2)

SHON:

118977169(AKR1E2)

AJM:

119057883

PHAS:

123806948(AKR1E2)

MMF:	118632036(AKR1E2)

PALE:

102889300(AKR1E2)

PGIG:

120608989(AKR1E2)

PVP:	105299188(AKR1E2)

RAY:

107501640

MJV:	108393832(AKR1E2)

SARA:

101555047(AKR1E2)

LAV:

100661345

TMU:

101356649

ETF:	101653887(AKR1E2)

DNM:	101433242(AKR1E2)

MDO:	100018228(AKR1E2)

GAS:	123250424(AKR1E2)

SHR:

100927444

AFZ:

127539131

PCW:	110218695(AKR1E2)

BCOO:

119073220 119080509 119083626

OTU:

111419676

PTRU:

123510143

PMEO:

129585393 129585959 129590479

HRF:

124149804

HRJ:	124267665 124280637

CRG:

105345761

PMAX:

117335390

MCAF:

127705095

DPOL:

127851148

» show all

Reference

1 [PMID:9504428]

Authors

Sakuma M, Kametani S, Akanuma H

Title

Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose.

Journal

J Biochem 123:189-93 (1998)
DOI:10.1093/oxfordjournals.jbchem.a021909

Sequence

[ssc:733633]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.263

IUBMB Enzyme Nomenclature:

1.1.1.263

ExPASy - ENZYME nomenclature database:

1.1.1.263

UM-BBD (Biocatalysis/Biodegradation Database):

1.1.1.263

BRENDA, the Enzyme Database:

1.1.1.263

CAS:	206138-19-4

DBGET integrated database retrieval system