KEGG   ENZYME: 1.1.1.263
Entry
EC 1.1.1.263                Enzyme                                 
Name
1,5-anhydro-D-fructose reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
1,5-anhydro-D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+ [RN:R05682]
Reaction(KEGG)
R05682
Substrate
1,5-anhydro-D-glucitol [CPD:C07326];
NADP+ [CPD:C00006]
Product
1,5-anhydro-D-fructose [CPD:C06485];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also reduces pyridine-3-aldehyde and 2,3-butanedione. Acetaldehyde, 2-dehydroglucose (glucosone) and glucuronate are poor substrates, but there is no detectable action on glucose, mannose and fructose.
History
EC 1.1.1.263 created 2000
Orthology
K13981  1,5-anhydro-D-fructose reductase
Genes
HSA83592(AKR1E2)
PTR746502(AKR1E2)
PPS100985849(AKR1E2)
GGO101143645(AKR1E2)
PON100462621(AKR1E2)
NLE100603254(AKR1E2)
MCC711035(AKR1E2)
MCF101925198(AKR1E2)
CSAB103237804(AKR1E2)
CATY105587692(AKR1E2)
PANU101021644 116268518(AKR1E2)
TGE112631310(AKR1E2)
RRO104678923(AKR1E2)
RBB108513974(AKR1E2)
TFN117082287(AKR1E2)
PTEH111527012(AKR1E2)
CJC100404287(AKR1E2)
SBQ101050607(AKR1E2)
MMUR105858223(AKR1E2)
LCAT123623048(AKR1E2)
OGA100942807(AKR1E2)
MMU56043(Akr1e1)
MCAL110307827(Akr1e2)
MPAH110333880(Akr1e2)
RNO307091(Akr1e2)
MCOC116081948(Akr1e2)
MUN110563027(Akr1e2)
CGE100750439(Akr1e2)
MAUA101843859(Akr1e2)
PLEU114707994(Akr1e2)
MORG121432662(Akr1e2)
AAMP119817584
NGI103725894(Akr1e2)
CPOC100725167(Akr1e2)
CCAN109678870(Akr1e2)
DORD105980518(Akr1e2)
DSP122113032(Akr1e2)
NCAR124961755
OCU100345389(AKR1E2)
OPI101521319(AKR1E2)
TUP102478936(AKR1E2)
CFA608809(AKR1E2)
VVP112933735(AKR1E2)
VLG121498000(AKR1E2)
AML100464743(AKR1E2)
UMR103676233(AKR1E2)
UAH113241123(AKR1E2)
UAR123802308(AKR1E2)
ELK111158637
LLV125107257
MPUF101674921(AKR1E2) 101687856
ORO101372660 101377286 101377908(AKR1E2)
EJU114217688(AKR1E2)
ZCA113922699(AKR1E2)
MLX118021624(AKR1E2)
FCA101097814(AKR1E2)
PYU121014879(AKR1E2)
PBG122473929(AKR1E2)
PTG102968954(AKR1E2)
PPAD109273790(AKR1E2)
AJU106988131(AKR1E2)
HHV120237197
BTA615959
BOM102270889(AKR1E2)
BIU109567630(AKR1E2)
BBUB102393589(AKR1E2)
CHX102189770(AKR1E2)
OAS101110956(AKR1E2)
ODA120869465(AKR1E2)
CCAD122448192(AKR1E2)
SSC733633(AKR1E2)
PCAD102978821(AKR1E2)
ECB100070632(AKR1E2)
EPZ103555590(AKR1E2)
EAI106827463
MYB102256598(AKR1E2)
MYD102752243(AKR1E2)
MMYO118672693(AKR1E2)
MLF102421063(AKR1E2)
MNA107542425(AKR1E2)
PKL118702298(AKR1E2)
DRO112321166(AKR1E2)
SHON118977169(AKR1E2)
AJM119057883
PHAS123806948(AKR1E2)
MMF118632036(AKR1E2)
PALE102889300(AKR1E2)
PGIG120608989(AKR1E2)
PVP105299188(AKR1E2)
RAY107501640
MJV108393832(AKR1E2)
SARA101555047(AKR1E2)
LAV100661345
TMU101356649
DNM101433242(AKR1E2)
MDO100018228(AKR1E2)
GAS123250424(AKR1E2)
SHR100927444
PCW110218695(AKR1E2)
BCOO119073220 119080509 119083626
OTU111419676
PTRU123510143
HRF124149804
HRJ124267665 124280637
CRG105345761
PMAX117335390
 » show all
Reference
1  [PMID:9504428]
  Authors
Sakuma M, Kametani S, Akanuma H
  Title
Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose.
  Journal
J Biochem 123:189-93 (1998)
DOI:10.1093/oxfordjournals.jbchem.a021909
  Sequence
[ssc:733633]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.263
IUBMB Enzyme Nomenclature: 1.1.1.263
ExPASy - ENZYME nomenclature database: 1.1.1.263
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.263
BRENDA, the Enzyme Database: 1.1.1.263
CAS: 206138-19-4

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