Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
dTDP-alpha-D-fucopyranose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NAD(P)H + H+ [RN:
The enzymes from the Gram-negative bacteria Aggregatibacter actinomycetemcomitans and Escherichia coli O52 are involved in activation of fucose for incorporation into capsular polysaccharide O-antigens [1,3]. The enzyme from the Gram-positive bacterium Anoxybacillus tepidamans (Geobacillus tepidamans) is involved in activation of fucose for incorporation into the organism's S-layer . The enzyme from Escherichia coli O52 has a higher catalytic efficiency with NADH than with NADPH .
EC 220.127.116.116 created 2001, modified 2013
ec00523 Polyketide sugar unit biosynthesis
ec00541 O-Antigen nucleotide sugar biosynthesis
ec01110 Biosynthesis of secondary metabolites
K13306 dTDP-4-dehydro-6-deoxyglucose reductase
Yoshida Y, Nakano Y, Nezu T, Yamashita Y, Koga T.
A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose.
Zayni S, Steiner K, Pfostl A, Hofinger A, Kosma P, Schaffer C, Messner P
The dTDP-4-dehydro-6-deoxyglucose reductase encoding fcd gene is part of the surface layer glycoprotein glycosylation gene cluster of Geobacillus tepidamans GS5-97T.
Wang Q, Ding P, Perepelov AV, Xu Y, Wang Y, Knirel YA, Wang L, Feng L
Characterization of the dTDP-D-fucofuranose biosynthetic pathway in Escherichia coli O52.
ExPASy - ENZYME nomenclature database: 18.104.22.1686