Entry
Name
1-deoxy-D-xylulose-5-phosphate reductoisomerase;
DXP-reductoisomerase;
1-deoxy-D-xylulose-5-phosphate isomeroreductase;
2-C-methyl-D-erythritol 4-phosphate (MEP) synthase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)
Reaction(IUBMB)
2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+ [RN:
R05688 ]
Reaction(KEGG)
Substrate
2-C-methyl-D-erythritol 4-phosphate [CPD:
C11434 ];
NADP+ [CPD:
C00006 ]
Product
Comment
The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with the first being most effective. The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, {terp/nonMVA}). The mechanism has been shown to be a retroaldol/aldol reaction [2].
History
EC 1.1.1.267 created 2001
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K00099 1-deoxy-D-xylulose-5-phosphate reductoisomerase
Genes
CSAT : 104726878 104726881 104740299 104740429 104740436 104762411 104762412
BNA : 106347856 106366165 106401597 106424859 125598866
CIC : CICLE_v10019836mg CICLE_v10020004mg
GHI : 107890888 107922972 107933661
HSYR : 120191883 120204581 120214032
GMX : 100784845 100790607(DXR1) 100805316(DXR2)
GSJ : 114390769 114393917 114411960
CCAJ : 109791516 109812240
TPRA : 123884272 123923890
PSAT : 127073918 127076536
VVO : 131605330 131616360 131616362 131622366
AHF : 112695470 112710318 112722349 112775209
LANG : 109351900 109357425 109362493 109362650
PCIN : 129291167 129320903
QSA : O6P43_022717 O6P43_030872
MSYL : 126600287 126626187
PCOX : 137710626 137713455
CSAV : 115709371 115709372
MESC : 110617990 110630849
PALZ : 118044823 118057406
NTA : 107779016 107818871(DXR)
SIND : 105157212 105179409
OEU : 111385010 111389272 111402205
SSPL : 121746704 121762143 121765821 121787431
SHIS : 125202019 125215382
APAN : 127246105 127255230
HAN : 110879810 110918635 110941574
CCAV : 112508794 112514390
PSOM : 113340997 113355796
TDC : 119266567 119274240 119289804 119331262
TAES : 123068145 123083354 123150893 123166476 123172048 123172496
LRD : 124659059 124659071 124659364
MFLO : 136449704 136461917
PVIR : 120676392 120706259
PHAI : 112893013 112898287
PAUA : 133895171 133908410
PDA : 103701988 103705855 120113311
ZOF : 121981915 121985755 122010235 122016433 122037593 122037826
MSIN : 131234812 131237718
ACAK : 137936020 137941903
SMO : SELMODRAFT_229487 SELMODRAFT_229643
CVR : CHLNCDRAFT_29723(DXR)
PLAG : 39744608(PADL01_1467200)
PMAL : PMUG01_12049600(DXR)
PBRS : 92372507(MKS88_004420)
PREL : PRELSG_1213500(DXR)
PTI : PHATRDRAFT_43204(DXR)
FCY : FRACYDRAFT_177652(DXR)
EHX : EMIHUDRAFT_68547(DXPR1)
ECOO : ECRM13514_0180(yaeM)
ECOH : ECRM13516_0182(yaeM)
EDJ : ECDH1ME8569_0166(dxr)
REE : electrica_04160(dxr)
RTG : NCTC13098_06080(dxr)
CLAP : NCTC11466_03754(dxr)
KIE : NCTC12125_02851(dxr)
AHN : NCTC12129_00968(dxr)
METY : MRY16398_46260(dxr)
PSHI : SAMEA2665130_2486(dxr)
MPHG : MPHASIOC01_004445(ispC)
YPI : YpsIP31758_1017(dxr)
SFJ : SAMEA4384070_3900(dxr)
SOF : NCTC11214_02856(dxr_2)
SSAR : SSARUM_003768(ispC)
PAQU : DMB82_0015720(ispC)
PARL : PEC302110_09250(ispC)
DIC : Dpoa569_0002812(ispC)
EHD : ERCIPSTX3056_189(dxr)
BAPF : BUMPF009_CDS00359(dxr)
BAPG : BUMPG002_CDS00360(dxr)
BAPU : BUMPUSDA_CDS00359(dxr)
BAPW : BUMPW106_CDS00359(dxr)
TPTY : NCTC11468_03024(dxr)
PHEI : NCTC12003_03052(dxr)
LRI : NCTC12151_00719(dxr)
HPIT : NCTC13334_00952(dxr)
HHZ : NCTC10839_00292(dxr)
HAEG : NCTC8502_00196(dxr)
ADP : NCTC12871_00192(dxr)
ALIG : NCTC10568_01113(dxr)
ASEG : NCTC10977_00771(dxr)
RPNE : NCTC8284_03756(dxr_1)
PAET : NCTC13378_00338(dxr)
XFU : XFF4834R_chr30820(dxr)
XPH : XppCFBP6546_04330(XppCFBP6546P_04330)
DJA : HY57_12620 HY57_18230
DTL : H8F01_04565 H8F01_19275
DTA : DYST_00497 DYST_04483
VAU : VANGNB10_cI2041c(dxr)
VPL : SA104470976_00558(dxr)
VIB : VspSTUT11_06550(dxr)
VIS : VspSTUT16_07500(dxr)
PPUD : DW66_1142 DW66_1476
PPRC : PFLCHA0_c12020(dxr)
PMUD : NCTC8068_01188(dxr)
PFW : PF1751_v1c12230(dxr)
PCH : EY04_05245 EY04_14525
PTRT : HU722_0007440(ispC)
PTAE : NCTC10697_03451(dxr)
PSNC : C0058_06260 C0058_14160
MCUN : NCTC10297_01091(dxr)
SCAA : TUM17387_27450(dxr)
MISZ : MishRS11D_38240(dxr)
HAAH : HALA3H3_210113(dxr)
ALCA : ASALC70_00496(dxr_2)
AEL : NCTC12917_03205(dxr)
NMM : NMBM01240149_1901(dxr)
NMS : NMBM01240355_0187(dxr)
NMQ : NMBM04240196_0191(dxr)
NWE : SAMEA3174300_1541(dxr)
NZO : SAMEA4504057_0491(dxr)
NCI : NCTC10296_00134(dxr)
NCZ : NCTC10294_01701(dxr)
NANI : NCTC12227_02110(dxr)
ECOR : SAMEA4412678_1272(dxr)
BPM : BURPS1710b_2577(dxr)
BPL : BURPS1106A_2487(dxr)
POLT : TUM22923_11170(dxr)
PLG : NCTC10937_01473(dxr)
LMIR : NCTC12852_01660(dxr)
BUO : BRPE64_ACDS11950(dxr)
BUE : BRPE67_ACDS11000(dxr)
BTRM : SAMEA390648703412(dxr)
AXX : ERS451415_02486(dxr)
VBO : CKY39_16390 CKY39_30070
VAV : IG196_13725 IG196_27940
VAE : RZE79_14300(ispC) RZE79_27970(ispC)
SMIO : CATMQ487_36690(dxr)
URU : DSM104443_01036(dxr)
UPL : DSM104440_00945(dxr)
THAG : CKCBHOJB_02032(dxr)
RBS : RHODOSMS8_00884(dxr)
SAME : SAMCFNEI73_Ch3433(dxr)
ASAL : CFBP5507_11830(dxr)
ALEG : CFBP4996_11875(dxr)
REC : RHECIAT_CH0004120(dxr)
RTR : RTCIAT899_CH16575(dxr)
RLW : RlegWSM1455_19730(dxr)
BCAN : BcanWSM471_21655(dxr)
MTUN : MTUNDRAET4_0379(dxr)
TSV : DSM104635_02051(dxr)
PPIC : PhaeoP14_01328(dxr)
SINL : DSM14862_01339(dxr)
SPSE : SULPSESMR1_01708(dxr)
RMM : ROSMUCSMR3_00967(dxr)
AHT : ANTHELSMS3_03612(dxr)
LALG : LentiSH36_01342(dxr)
LVS : LOKVESSMR4R_01403(dxr)
SFLA : SPHFLASMR4Y_01293(dxr)
HPO : HMPREF4655_20457(dxr)
HPX : HMPREF0462_0271(dxr)
HAC : Hac_1502(dxr_fragment_2)
HCL : NCTC13205_00075(dxr)
HSH : NHP194022_02020(dxr)
HPUL : NCTC13154_00272(dxr)
CCOC : CCON33237_1365(dxr)
CPIN : CPIN18020_0123(dxr)
CAMZ : CVIC12175_1396(dxr)
HCJ : HCR_11860(dxr_1) HCR_13030(dxr_2)
PPOR : JCM14722_29070(dxr)
ABIW : Abiwalacus_25050(dxr)
TRC : DYE49_01850 DYE49_05595
PSPC : Strain318_001651(dxr)
BTHO : Btheta7330_01043(dxr)
BCEL : BcellWH2_01401(dxr)
PCRE : NCTC12858_01153(dxr)
PCAG : NCTC12856_00621(dxr)
PSOE : CE91St14_16290(dxr)
COPR : Cop2CBH44_10750(dxr)
PMZ : HMPREF0659_A5252(dxr)
PDN : HMPREF9137_0835(dxr)
POC : NCTC13071_00799(dxr)
CBAM : PIECOFPK_01910(dxr)
SDJ : NCTC13534_03686(dxr)
STHA : NCTC11429_04934(dxr)
BAN : BA_3409(dxr1) BA_3959(dxr2)
BAR : GBAA_3409(dxr1) GBAA_3959(dxr2)
BAH : BAMEG_0673(dxr2) BAMEG_1219(dxr1)
BAI : BAA_3442(dxr1) BAA_3982(dxr2)
BAX : H9401_3243 H9401_3770
BANT : A16_34220 A16_39650
BANR : A16R_34650 A16R_40110
BANS : BAPAT_3261 BAPAT_3792
BANH : HYU01_16710 HYU01_19345
BANV : DJ46_2140(dxr) DJ46_2660(dxr)
BCZ : BCE33L3054(dxr) BCE33L3580(dxr)
BCB : BCB4264_A3354(dxr1) BCB4264_A3919(dxr2)
BCU : BCAH820_3379(dxr1) BCAH820_3833(dxr2)
BCG : BCG9842_B1325(dxr2) BCG9842_B1872(dxr1)
BAL : BACI_c33050 BACI_c37720(dxr)
BCER : BCK_16145 BCK_18405
BCY : Bcer98_2128 Bcer98_2473
BTK : BT9727_3144(dxr) BT9727_3562(dxr)
BTB : BMB171_C3028(dxr1) BMB171_C3486(dxr2)
BTHR : YBT1520_17745 YBT1520_20290
BTHI : BTK_17735 BTK_20190
BTC : CT43_CH3270(dxr1) CT43_CH3819(dxr2)
BTM : MC28_2487(dxr1) MC28_3044(dxr)
BTG : BTB_c34050(dxr1) BTB_c39460(dxr2)
BTN : BTF1_14150 BTF1_17395
BTHT : H175_ch3326 H175_ch3880
BTHU : YBT1518_18145 YBT1518_20955
BTW : BF38_4522(dxr) BF38_4990(dxr)
BTHY : AQ980_10825 AQ980_13280
BWE : BcerKBAB4_3082 BcerKBAB4_3644
BMYO : BG05_2203(dxr) BG05_2658(dxr)
BTY : Btoyo_0576 Btoyo_1056
BBY : CY96_15745 CY96_18180
BTRO : FJR70_02560 FJR70_12490
BMOB : MLA2C4_17570 MLA2C4_19975
BALU : QRY64_02275 QRY64_18105 QRY64_21990(dxr)
BARD : QRY57_16290 QRY57_18875(dxr)
BMQ : BMQ_4159(dxr) BMQ_pBM70158(dxr)
BLEN : NCTC4824_02634(dxr)
PARG : PspKH34_25780(dxr2)
SDP : NCTC12225_01754(dxr)
SSTE : SAMEA4384403_1549(dxr)
LMOC : LMOSLCC5850_1376(dxr)
LMW : LMOSLCC2755_1319(dxr)
LMX : LMOSLCC2372_1378(dxr)
LMZ : LMOSLCC2482_1368(dxr)
LMON : LMOSLCC2376_1271(dxr)
LMOS : LMOSLCC7179_1287(dxr)
LMOO : LMOSLCC2378_1330(dxr)
LMOY : LMOSLCC2479_1377(dxr)
LMOT : LMOSLCC2540_1367(dxr)
LMOA : LMOATCC19117_1324(dxr)
LGZ : NCTC10812_01257(dxr)
COHN : KCTCHS21_38010(dxr2)
CCOH : SAMEA4530647_1085(dxr)
CGEL : psyc5s11_41030(dxr)
CLO : HMPREF0868_0939(dxr)
PFAA : MM59RIKEN_28870(dxr)
VFA : MM35RIKEN_02060(dxr)
VCOP : MM50RIKEN_05910(dxr)
BPRO : PMF13cell1_04511(dxr)
CSCI : HDCHBGLK_02752(dxr)
CHYL : CE91St63_13740(dxr)
PDF : CD630DERM_21300(dxr)
FAA : HMPREF0389_00923(dxr)
VDN : NCTC11831_01082(dxr)
DHO : Dia5BBH33_10590(dxr2)
SELM : TAMA11512_06950(dxr)
PFAC : PFJ30894_01558(dxr)
AARG : Aargi30884_06880(dxr2)
ABSI : A9CBEGH2_08720(dxr2)
FIT : Fi14EGH31_15520(dxr2)
CDIA : CaldiYA01_07210(dxr)
SSYR : SSYRP_v1c03420(dxr)
STAI : STAIW_v1c08400(dxr)
SAPI : SAPIS_v1c07090(dxr)
SATR : SATRI_v1c08920(dxr)
SSAB : SSABA_v1c05780(dxr)
SERI : SERIO_v1c08690(dxr)
SCOU : SCORR_v1c02640(dxr)
SPRN : S100390_v1c03370(dxr)
SPIT : STU14_v1c03370(dxr)
STAB : STABA_v1c07590(dxr)
SMOO : SMONO_v1c05630(dxr)
SALX : SALLE_v1c05980(dxr)
SCHI : SCHIN_v1c08700(dxr)
MGAC : HFMG06CAA_0661(dxr)
MGAN : HFMG08NCA_0660(dxr)
MGNC : HFMG96NCA_0663(dxr)
MBAI : MB901379_01656(dxr)
MHEK : JMUB5695_03257(dxr)
MKY : IWGMT90018_39810(dxr)
MPHL : MPHLCCUG_02206(dxr)
MAUU : NCTC10437_02117(dxr)
MFLV : NCTC10271_03248(dxr)
MSAL : DSM43276_02963(dxr)
CDIP : ERS451417_01525(ispC)
CUJ : CUL131002_1403c(dxr)
CMIN : NCTC10288_00929(dxr)
CCYS : SAMEA4530656_0833(dxr)
NFR : ERS450000_05793(dxr)
NAD : NCTC11293_05327(dxr)
NWL : NWFMUON74_21920(dxr)
NSPU : IFM12276_15460(dxr)
RCR : NCTC10994_00923(dxr)
RANT : RHODO2019_04625(dxr)
SLE : sle_19870(sle_19870)
SGM : GCM10017557_21950(dxr)
SGV : B1H19_02755 B1H19_29045
SALJ : SMD11_1907(dxr) SMD11_6942(dxr)
SBRO : GQF42_24245 GQF42_31075
STUI : GCM10017668_51670(dxr)
SGOB : test1122_20635(dxr)
SXT : KPP03845_105400(dxr)
SPRF : K4G22_24235(dxr) K4G22_27435(dxr)
STII : DRB96_17740 DRB96_20005
STIC : DRB89_06805 DRB89_20025
MSUW : GCM10025863_12470(dxr)
FSB : GCM10025867_32520(dxr)
AMAU : DSM26151_10540(dxr)
AMAV : GCM10025877_28680(dxr)
MALK : MalAC0309_1815(dxr)
PSEV : USB125703_01592(dxr)
AAGI : NCTC2676_1_00937(dxr)
RDN : HMPREF0733_11540(dxr)
DCO : SAMEA4475696_1105(dxr)
DSS : GCM25873_12270(ispC)
PAK : HMPREF0675_4577(dxr)
PAUS : NCTC13651_01769(dxr)
PPC : HMPREF9154_1116(dxr)
NAQU : ENKNEFLB_01444(dxr)
MSAG : GCM10017556_40050(dxr)
ACTR : Asp14428_62260(dxr)
MCU : HMPREF0573_11344(dxr)
TBW : NCTC13354_00358(dxr)
ANE : ATCC27039_12870(dxr)
AHW : NCTC11636_00772(dxr)
ASLA : NCTC11923_02265(dxr)
AVC : NCTC10951_01132(dxr)
ACAP : MANAM107_01780(dxr)
BBV : HMPREF9228_1210(dxr)
BALA : DSM104299_02676(dxr)
PARQ : DSM112329_02424(dxr)
SBAE : DSM104329_02730(dxr)
SYY : SYNGTS_2218(sll0019)
SYT : SYNGTI_2217(sll0019)
SYS : SYNPCCN_2216(sll0019)
SYQ : SYNPCCP_2216(sll0019)
SYNW : SynWH8103_00800(dxr)
LET : O77CONTIG1_00485(dxr)
LEPT : JVX88_07965 JVX88_23025(dxr)
CHON : NIES4102_18080(dxr)
SYP : SYNPCC7002_A0818(dxr)
NFL : COO91_01278 COO91_02911
NSPH : BDGGKGIB_02153(dxr)
SCYS : NIES4073_28650 NIES4073_72270
NCN : BZZ01_00240 BZZ01_24740
PPIO : CE91St28_13480(dxr)
FPE : Ferpe_0696 Ferpe_1302
FPOL : ERS445057_00865(dxr)
» show all
Taxonomy
Reference
Authors
Takahashi S, Kuzuyama T, Watanabe H, Seto H
Title
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.
Journal
Sequence
Reference
Authors
Munos JW, Pu X, Mansoorabadi SO, Kim HJ, Liu HW
Title
A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangement.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.267