KEGG   ENZYME: 1.1.1.270
Entry
EC 1.1.1.270                Enzyme                                 
Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R12402]
Reaction(KEGG)
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09827  3-keto steroid reductase
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA51478(HSD17B7) 79154(DHRS11)
PTR454598(DHRS11) 466046 747814(HSD17B7)
PPS100985156 100989828(DHRS11) 117974256(HSD17B7)
GGO101133645(DHRS11) 101137638(HSD17B7)
PON100446761(HSD17B7) 100450428(DHRS11)
NLE100580130(DHRS11) 100587120(HSD17B7)
HMH116473311(HSD17B7) 116474548(DHRS11)
MCC713823(DHRS11) 720399
MCF102127673(HSD17B7) 102133734(DHRS11)
MTHB126939340
MNI105476877(DHRS11) 105498235(HSD17B7)
CSAB103223654(HSD17B7) 103242795(DHRS11)
CATY105583369(DHRS11) 105589219(HSD17B7)
PANU101007886(DHRS11) 101019563(HSD17B7)
TGE112610332(DHRS11)
MLEU105546902(DHRS11) 105550995(HSD17B7)
RRO104656967(HSD17B7) 104672997(DHRS11)
RBB108526295(DHRS11) 108535633
TFN117067355(DHRS11) 117074787(HSD17B7)
PTEH111525046(HSD17B7) 111537680(DHRS11)
CANG105519588(HSD17B7) 105520057(DHRS11)
CJC100410416(HSD17B7) 100415468(DHRS11)
SBQ101047238(HSD17B7) 101049784(DHRS11)
CIMI108293633(HSD17B7) 108312102(DHRS11)
CSYR103250515(HSD17B7) 103269368(DHRS11)
MMUR105873582(HSD17B7) 105879451(DHRS11)
LCAT123620379(DHRS11) 123635243(HSD17B7)
PCOQ105806403(HSD17B7) 105813872(DHRS11)
OGA100950944(DHRS11) 100957601(HSD17B7)
MMU15490(Hsd17b7) 192970(Dhrs11)
MCAL110292934(Hsd17b7) 110304998(Dhrs11)
MPAH110322287(Hsd17b7) 110332326(Dhrs11)
RNO29540(Hsd17b7) 360583(Dhrs11)
MCOC116078372(Dhrs11) 116103156(Hsd17b7)
ANU117711819(Dhrs11) 117716536(Hsd17b7)
MUN110550630(Hsd17b7) 110555253(Dhrs11)
CGE100763193(Dhrs11) 100767580(Hsd17b7)
MAUA101828473(Dhrs11) 101836885(Hsd17b7)
PROB127221629(Dhrs11) 127223546(Hsd17b7)
PLEU114689903(Hsd17b7) 114707715(Dhrs11)
MORG121441976 121455259 121457070(Dhrs11)
MFOT126487000 126511195
AAMP119813383(Dhrs11) 119827319(Hsd17b7)
NGI103732605(Dhrs11) 103746788(Hsd17b7)
HGL101704213(Dhrs11) 101712707(Hsd17b7)
CPOC100729809(Hsd17b7) 100733505(Dhrs11)
CCAN109690973(Hsd17b7) 109691233(Dhrs11)
DORD105983235(Dhrs11) 105989680(Hsd17b7) 106002656
DSP122103721(Hsd17b7) 122119919(Dhrs11)
PLOP125359559(Hsd17b7) 125366000(Dhrs11)
NCAR124980099 124990069
MMMA107147446(Hsd17b7) 107150365(Dhrs11)
OCU100008778 100349261 100350282
OPI101524723(HSD17B7) 101526339(DHRS11)
TUP102473205(HSD17B7) 102481007(DHRS11)
GVR103589874(HSD17B7) 103595175(DHRS11)
CFA491129(DHRS11) 609364(HSD17B7)
CLUD112643059(HSD17B7) 112655062(DHRS11)
VVP112914306(HSD17B7) 112917964(DHRS11)
VLG121473558(DHRS11) 121501279(HSD17B7)
NPO129512126(DHRS11) 129515344(HSD17B7)
AML100477716(HSD17B7) 100483445(DHRS11)
UMR103658287(HSD17B7) 103667445(DHRS11)
UAH113268675(HSD17B7) 113268922(DHRS11)
UAR123776919(DHRS11) 123800151(HSD17B7)
ELK111151061 111151673
LLV125086086 125086982
MPUF101688526(DHRS11) 101689203(HSD17B7)
MNP132003715(DHRS11) 132025742(HSD17B7)
MLK131814597(HSD17B7) 131816091(DHRS11)
NVS122906486(DHRS11) 122918391(HSD17B7)
ORO101368538(HSD17B7) 101372465(DHRS11)
EJU114210516(HSD17B7) 114213877(DHRS11)
ZCA113933397(HSD17B7) 113936410(DHRS11)
MLX118014038(HSD17B7) 118025129(DHRS11)
NSU110588123(HSD17B7) 110592971(DHRS11)
LWW102748211(DHRS11)
FCA101083482(HSD17B7) 101083724(DHRS11)
PYU121017066(DHRS11) 121020915(HSD17B7)
PCOO112854121(DHRS11) 112864813(HSD17B7)
PBG122475607(HSD17B7) 122485272(DHRS11)
LRUF124509916 124512930
PTG102953856(DHRS11) 102968316(HSD17B7)
PPAD109251987(DHRS11) 109276652(HSD17B7)
PUC125925561 125927464
AJU106980443 106986761
HHV120241069(HSD17B7) 120248116(DHRS11)
BTA505212(HSD17B7) 510264(DHRS11)
BOM102266348(HSD17B7) 102267490(DHRS11)
BIU109574096(DHRS11) 109577890(HSD17B7)
BBUB102389083(HSD17B7) 102414485(DHRS11)
BBIS104999168(HSD17B7) 105004053(DHRS11)
CHX102176160(DHRS11) 102179058(HSD17B7)
OAS101109465(DHRS11) 101110013(HSD17B7)
BTAX128045446(HSD17B7) 128064812(DHRS11)
ODA120855521(HSD17B7) 120866412(DHRS11)
CCAD122429981(HSD17B7) 122432561 122449929(DHRS11)
MBEZ129539649(DHRS11) 129541062(HSD17B7)
SSC100155418(HSD17B7) 100513307(DHRS11)
CFR102507556(DHRS11) 102512546(HSD17B7)
CBAI105064308(DHRS11) 105068038(HSD17B7)
CDK105092702(HSD17B7) 105097850(DHRS11)
VPC102531229(HSD17B7) 102531560(DHRS11)
BACU103011691(DHRS11) 103014331(HSD17B7)
LVE103069867(DHRS11) 103084050(HSD17B7)
OOR101278328(DHRS11) 101286750(HSD17B7)
DLE111163734(DHRS11) 111169243(HSD17B7)
PCAD102984493(HSD17B7) 102995379(DHRS11)
PSIU116743840(HSD17B7) 116746440(DHRS11)
NASI112403909(HSD17B7) 112408016(DHRS11)
ECB100059061(HSD17B7) 100071416(DHRS11)
EPZ103554456(DHRS11) 103559639(HSD17B7)
EAI106823694(HSD17B7) 106844689(DHRS11)
MYB102251181(HSD17B7) 102262752(DHRS11)
MYD102765268(DHRS11) 102767046(HSD17B7)
MMYO118671682(DHRS11) 118673077(HSD17B7)
MLF102428751(HSD17B7) 102439019(DHRS11)
MNA107530816(DHRS11) 107535110(HSD17B7)
PKL118712029(HSD17B7) 118726466(DHRS11)
EFUS103293195(DHRS11) 103296492(HSD17B7)
HAI109379798(DHRS11) 109392309(HSD17B7)
DRO112298817(HSD17B7) 112316505(DHRS11)
SHON118979201(HSD17B7) 119003587(DHRS11)
AJM119052313(HSD17B7) 119062640(DHRS11)
PDIC114502689(DHRS11) 114511975(HSD17B7)
PHAS123817235(DHRS11) 123818535(HSD17B7)
MMF118633927(DHRS11) 118637572(HSD17B7)
RFQ117013304(DHRS11) 117015421(HSD17B7)
PPAM129071593(DHRS11) 129081919(HSD17B7)
PALE102892079(HSD17B7) 102894290(DHRS11)
PGIG120584178(HSD17B7) 120620857(DHRS11)
PVP105303413(HSD17B7) 105305000(DHRS11)
RAY107510114(DHRS11)
MJV108396655(HSD17B7)
TOD119231930(DHRS11) 119241348(HSD17B7)
SARA101551054(HSD17B7) 101551118(DHRS11)
LAV100676060 100676239(DHRS11) 100676343(HSD17B7)
TMU101350976 101361551
ETF101649501(DHRS11) 101663414(HSD17B7)
DNM101418508(HSD17B7) 101420664(DHRS11)
MDO100016071(HSD17B7) 100618596(DHRS11)
GAS123243907(DHRS11) 123244846(HSD17B7)
SHR100926227(HSD17B7) 100933320(DHRS11)
AFZ127559926 127562983
PCW110209887(HSD17B7) 110212020(DHRS11)
OAA100077820(DHRS11) 114817513(HSD17B7)
GGA395172(DHRS11) 424367(HSD17B7)
PCOC116227942(DHRS11) 116230531(HSD17B7)
MGP100542399(DHRS11) 100542640(HSD17B7)
CJO107317140(HSD17B7) 107322636(DHRS11)
TPAI128072514(HSD17B7) 128083545(DHRS11)
LMUT125693253(HSD17B7) 125702996(DHRS11)
NMEL110402344(HSD17B7)
APLA101796287(DHRS11) 101799136(HSD17B7)
ACYG106041628(HSD17B7) 106046860(DHRS11)
CATA118243454(HSD17B7) 118255160(DHRS11)
AFUL116491836(HSD17B7) 116497443(DHRS11)
TGU100222823(HSD17B7) 100230987(DHRS11)
LSR110467717(DHRS11) 110478897(HSD17B7)
SCAN103820184(DHRS11) 103824326(HSD17B7)
PMOA120497588(HSD17B7) 120507831(DHRS11)
OTC121344332(HSD17B7) 121347083(DHRS11)
PRUF121359833(HSD17B7) 121361824(DHRS11)
GFR102031952(DHRS11) 102042580(HSD17B7)
FAB101806967(DHRS11) 101818521(HSD17B7)
OMA130256324(HSD17B7) 130260929(DHRS11)
PHI102107312(HSD17B7) 102113937(DHRS11)
PMAJ107198613(HSD17B7) 107213026(DHRS11)
CCAE111932684(HSD17B7) 111937859(DHRS11)
CCW104690988(DHRS11) 104695594(HSD17B7)
CBRC103612739(HSD17B7) 103613383(DHRS11)
ETL114057489(DHRS11) 114067481(HSD17B7)
ZAB102061622(DHRS11) 102069841(HSD17B7)
ACHL103806603(DHRS11) 103807871(HSD17B7)
SVG106852300(HSD17B7) 106856087(DHRS11)
MMEA130577458(HSD17B7)
HRT120756417(HSD17B7) 120761400(DHRS11)
FPG101912846(DHRS11) 101919410(HSD17B7)
FCH102050282(DHRS11) 102059217(HSD17B7)
CLV102090168(DHRS11) 102097738(HSD17B7)
EGZ104121871(DHRS11) 104132130(HSD17B7)
NNI104010459(HSD17B7) 104016400(DHRS11)
PCRI104034337(DHRS11) 104034394(HSD17B7)
PLET104614462(HSD17B7) 104619859(DHRS11)
EHS104510302(DHRS11) 104516764(HSD17B7)
PCAO104043476(HSD17B7) 104052672(DHRS11)
ACUN113483111(HSD17B7) 113487258(DHRS11)
TALA104356976(HSD17B7) 104360740(DHRS11)
PADL103914076(HSD17B7) 103917037(DHRS11)
AFOR103898043(DHRS11) 103904020(HSD17B7)
ACHC115347497(DHRS11) 115349487(HSD17B7)
HALD104314838(HSD17B7) 104315802(DHRS11)
HLE104835677(DHRS11) 104840783(HSD17B7)
AGEN126039349 126041842
GCL127019153 127024359
CCRI104155453(HSD17B7) 104156066(DHRS11)
CSTI104549393(HSD17B7) 104559481(DHRS11)
CMAC104474625(DHRS11) 104482200(HSD17B7)
MUI104533594(HSD17B7) 104539474(DHRS11)
BREG104629966(HSD17B7) 104639096(DHRS11)
FGA104078589(HSD17B7) 104082797(DHRS11)
GSTE104258108(DHRS11) 104260822(HSD17B7)
LDI104340165(HSD17B7) 104343602(DHRS11)
MNB103769161(HSD17B7) 103780383(DHRS11)
OHA104329421(DHRS11) 104333725(HSD17B7)
NNT104399910(HSD17B7) 104404606(DHRS11)
SHAB115601803(DHRS11) 115611783(HSD17B7)
DPUB104307784(DHRS11) 104307990(HSD17B7)
PGUU104458613(HSD17B7) 104461659(DHRS11)
ACAR104518582(HSD17B7) 104525116(DHRS11)
CPEA104390729(HSD17B7) 104398892(DHRS11)
AVIT104268103(HSD17B7) 104276911(DHRS11)
CVF104291882(DHRS11) 104293312(HSD17B7)
RTD128913087(DHRS11) 128914298(HSD17B7)
CUCA104054748(HSD17B7) 104064969(DHRS11)
TEO104370260(HSD17B7) 104383420(DHRS11)
BRHI104491591(DHRS11) 104499853(HSD17B7)
AAM106494687(DHRS11) 106499711(HSD17B7)
AROW112968787(DHRS11) 112977170(HSD17B7)
NPD112951140(HSD17B7) 112954713(DHRS11)
TGT104567919(DHRS11) 104581010(HSD17B7)
DNE112987422(DHRS11) 112997417(HSD17B7)
SCAM104140832(HSD17B7)
ASN102374189(HSD17B7) 112551119(DHRS11)
AMJ102561890(DHRS11) 102565865(HSD17B7)
CPOO109307069(HSD17B7) 109317147(DHRS11)
GGN109287068(HSD17B7) 109293262(DHRS11)
PSS102452802(DHRS11) 102461698(HSD17B7)
CMY102944731(HSD17B7) 102944881(DHRS11)
CCAY125623998(DHRS11) 125640778(HSD17B7)
DCC119844873(DHRS11) 119860497(HSD17B7)
CPIC101936463(DHRS11) 101953232(HSD17B7)
TST117867488(DHRS11) 117881449(HSD17B7)
CABI116824223(DHRS11) 116831149(HSD17B7)
MRV120370584(HSD17B7) 120387076(DHRS11)
ACS100556465(hsd17b7)
ASAO132774342(HSD17B7)
PVT110075560(DHRS11) 110081655(HSD17B7)
SUND121929890(HSD17B7)
PBI103063132(HSD17B7) 103065679(DHRS11)
PMUR107294873(DHRS11) 107302880(HSD17B7)
CTIG120310515(HSD17B7) 120310987(DHRS11)
TSR106539066(DHRS11)
PGUT117661207(HSD17B7) 117675673(DHRS11)
APRI131188703(DHRS11) 131195814(HSD17B7)
PTEX113438132(HSD17B7) 113442594(DHRS11)
NSS113422043(DHRS11)
VKO123023595(DHRS11) 123027952(HSD17B7)
PMUA114585448(DHRS11) 114598525(HSD17B7)
PRAF128402582(DHRS11) 128415224(HSD17B7)
ZVI118078620 118089365(HSD17B7) 118097242(DHRS11)
HCG128324135(HSD17B7) 128336072(DHRS11)
GJA107108933(DHRS11) 107121042(HSD17B7)
STOW125425213 125425220 125433115(HSD17B7)
EMC129331384(HSD17B7) 129344428(DHRS11)
XLA108704561(dhrs11.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR496708(dhrs11) 548963(hsd17b7)
NPR108801354(HSD17B7)
RTEM120945526(HSD17B7)
BBUF120979196(HSD17B7)
BGAR122943861(HSD17B7)
MUO115456781(DHRS11) 115472964(HSD17B7)
GSH117348752(DHRS11) 117368162(HSD17B7)
DRE436969(dhrs11b.2) 768185(hsd17b7) 791578(dhrs11a) 791770(dhrs11b.1)
SRX107724130 107724135 107725165 107731464 107734374 107752375 107752377 107758362 107758673 107758683
SANH107654319 107665172 107672389 107672391 107672392 107683210 107684349(hsd17b7) 107692446 107694033
SGH107551038 107562199 107582609 107582610 107591475 107592755 107592792 107594628
CCAR109066392 109066456 109067119 109091408
CAUA113051185 113058281 113068034 113070053 113073543 113100989 113115232
CGIB127958863 127960108 127972186 128014885 128029356 128029358 128029359 128029360
PTET122345090(dhrs11a) 122346431(hsd17b7) 122359049(dhrs11b.1) 122359050 122359051
LROH127165413(dhrs11a) 127167393(hsd17b7) 127177294 127177296 127177297(dhrs11b.1)
OMC131541000(dhrs11a) 131542039(hsd17b7) 131554280 131554281 131554282(dhrs11b.1) 131554283
PPRM120460132(hsd17b7) 120471601(dhrs11a) 120471622 120478528 120478530
RKG130077833(dhrs11b.2) 130077834 130077835 130091641(hsd17b7)
MAMB125249621 125249622 125249623 125249624 125249625 125249628 125266309(dhrs11a) 125274024(hsd17b7)
CIDE127495018 127495020 127513110 127514762
MASI127422492 127423629 127429594 127440047 127445644
TROS130557250(hsd17b7) 130564979 130564980 130564981(dhrs11b.1) 130571732(dhrs11a)
TDW130419645(dhrs11a) 130424202(hsd17b7) 130428592(dhrs11b.1) 130428593
MANU129437796 129437797 129437798(dhrs11b.1) 129437799 129437800 129437801 129437802 129439505(dhrs11a) 129450993(hsd17b7)
IPU108260417(dhrs11a) 108271889
IFU128603678(dhrs11a) 128614572(hsd17b7)
PHYP113531061(dhrs11) 113538418(hsd17b7)
SMEO124379484(dhrs11a) 124388015(hsd17b7)
TFD113634115(dhrs11a) 113647617(hsd17b7)
TVC132841280(dhrs11a) 132844268(hsd17b7)
AMEX103021948 103023849 103035681(hsd17b7) 103042381 103042688 103043000
CMAO118799376 118808188(hsd17b7) 118814776(dhrs11a)
EEE113570462(hsd17b7) 113577576(dhrs11)
CHAR105906061(hsd17b7) 105911027 122129995
TRU101072277 101075534 101079626(hsd17b7) 101079674(dhrs11) 115248690
TFS130529155(hsd17b7) 130534822 130538000(dhrs11a) 130538525
TNGGSTEN00016280G001 GSTEN00024682G001 GSTEN00030120G001
LCO104923446(dhrs11) 104925933 104930791 104933511
NCC104948248(hsd17b7) 104963923(dhrs11) 104967182 104967580
TBEN117469415(dhrs11a) 117488349 117495818(hsd17b7)
CGOB115007156(hsd17b7) 115017925 115018914(dhrs11)
PGEO117445711(hsd17b7) 117457343 117458385(dhrs11a) 117462512
GACU117540400 117545516 117555039(hsd17b7) 117557251(dhrs11a)
ELY117253561(hsd17b7) 117260047 117268096(dhrs11a) 117271615
EFO125888937 125895999(hsd17b7) 125898571(dhrs11a) 125902137
PLEP121940863(hsd17b7) 121943315 121951731 121952976(dhrs11a) 121963835
SLUC116045810 116048477 116058070(dhrs11a) 116063209(hsd17b7)
ECRA117942184 117950534(hsd17b7) 117954002 117955964(dhrs11a)
ESP116674109 116696129 116698600(hsd17b7) 116700528(dhrs11)
PFLV114553336 114561703 114565046 114566471(dhrs11)
GAT120816127(hsd17b7) 120822622(dhrs11a)
PPUG119202648(hsd17b7) 119215510(dhrs11a) 119216850
AFB129088998 129090885 129095026(hsd17b7) 129113967(dhrs11a)
CLUM117729959(hsd17b7) 117741510 117743192(dhrs11a) 117746243
MSAM119882883 119895317(dhrs11a) 119900960(hsd17b7) 119902362
SCHU122878253(hsd17b7) 122878435 122887524 122888447(dhrs11a)
CUD121511992(hsd17b7) 121516037 121516905 121518057 121518430(dhrs11a) 121520534 121521235 121521242
ALAT119010615 119028523(hsd17b7) 119031909(dhrs11a) 119033593
MZE101475164(dhrs11) 101475712 101476044 101480987 101482452 101483095 106674540 106675057 106675058 112430056 112435947
ONL100694215 100694479 100695275 100695806 100696595 100698653 100698819 100698923 100699728 100701254 100706590(dhrs11) 100708654 102082640 106097863 109194269 112841634
OAU116313876 116313883 116316375 116316390 116318426 116321239 116321691(dhrs11a) 116326992 116327922(hsd17b7) 116331994 120432826 120443504 120443558 120443559 120443560 120443564
OLA101156119 101158433 101160498 101167642(dhrs11)
OML112138999(dhrs11a) 112147206 112149002 112150931(hsd17b7)
XMA102219736(dhrs11) 102223080(hsd17b7) 102225591 102238341 102238369
XCO114133176 114133177 114146459 114150325 114153301(dhrs11)
XHE116708005 116708105 116708307 116721503 116725522 116728461(dhrs11)
PRET103463731 103474141 103474142 103476050(dhrs11) 103479029
PFOR103133850(dhrs11) 103139996 103148525 103155178
PLAI106946498 106949687 106952787 106956657(dhrs11)
PMEI106907488 106917775 106922829 106933207(dhrs11)
GAF122832192 122832193 122838419(hsd17b7) 122840633 122845217(dhrs11a)
PPRL129361993 129368820(dhrs11a) 129368968(hsd17b7) 129369852 129369856
CVG107082613 107090012 107090028 107090353(dhrs11) 107099593
CTUL119789912 119790042(hsd17b7) 119791476(dhrs11a) 119795338 119795346
GMU124866110 124870458 124873591(hsd17b7) 124876497(dhrs11a) 124880193 124880948 124883585 124884217 124884218 124884265
NFU107379993 107379994 107384420 107387055(dhrs11) 107393363
KMR108230837(hsd17b7) 108233843(dhrs11a) 108235955 108236012 108236013 108238258 108247279
ALIM106511588 106525408(dhrs11) 106528419(hsd17b7) 106528841 106529742
NWH119407462(hsd17b7) 119411326 119411327 119414502 119420614(dhrs11a)
AOCE111563582 111567499 111567500 111572719(dhrs11) 111580065 111586999
MCEP125009772(hsd17b7) 125011278 125014138 125014139 125021225(dhrs11a)
CSEM103376747 103394917(dhrs11) 103395808
POV109625649(hsd17b7) 109628284(dhrs11) 109644359
SSEN122779439(dhrs11a) 122780473 122780509(hsd17b7)
HHIP117760842(hsd17b7) 117774058(dhrs11a) 117778754
HSP118118430 118121021(hsd17b7) 118122571(dhrs11a)
LCF108875972 108876053 108879148 108883797 108893892(dhrs11a)
SDU111222241(dhrs11) 111228986 111231932 111232315
SLAL111650668 111653771 111663897(dhrs11) 111670521
XGL120790306(hsd17b7) 120792442 120798840 120803065(dhrs11a)
HCQ109521128 109521129 109531160(dhrs11) 109532086
SSCV125976239 125982720 125984682
SBIA133491545(dhrs11a) 133504969 133510600(hsd17b7)
PEE133405426 133406482 133411357 133416315(dhrs11a)
PTAO133467572(dhrs11a) 133481333 133482409 133489461
BPEC110163629 110165106(dhrs11) 110173518(hsd17b7) 110174039
MALB109951354(hsd17b7) 109960466(dhrs11) 109966957
BSPL114844067(hsd17b7) 114868694 114869112(dhrs11a)
SJO128360321 128361357(hsd17b7) 128368776 128371193(dhrs11a)
SASA100196011(dhr11) 106567994 106568727 106603495
STRU115148835 115154304 115156632 115163408
OTW112228556 112257875 112260221(hsd17b7) 112265505
OMY110507750 110530031(hsd17b7) 110533618 110537508
OGO123993925 123994594 124000655 124009932(hsd17b7)
ONE115105516 115114123(hsd17b7) 115135930 115137610
OKI109873497 109875116(hsd17b7) 109892760 109906081
OKE118390063 118391142 118397440 118402323(hsd17b7)
SALP111950509 111957119(hsd17b7) 111981656 111982530
SNH120018199 120030392 120055749(hsd17b7) 120057046
CCLU121573530 121580208 121580679
ELS105024805 105025666(dhrs11) 105030986
SFM108921710(dhrs11) 108935177(hsd17b7) 108938265
PKI111841069(hsd17b7) 111854721(dhrs11) 111859701
AANG118209261 118230844(hsd17b7) 118236726(dhrs11a)
LOC102694052(dhrs11) 102696390(hsd17b7)
PSPA121308431(dhrs11a) 121327382
ARUT117400178 117416602 117429929 117430868
PSEX120514537(hsd17b7) 120531425(dhrs11a) 120539831
LCM102348492(HSD17B7) 102362545(DHRS11)
CMK103180036(hsd17b7) 103180635(dhrs11a)
RTP109920236(dhrs11) 109925128(hsd17b7)
CPLA122554583(hsd17b7) 122564066(dhrs11a)
HOC132818673(hsd17b7) 132830445(dhrs11a)
LERI129701205(hsd17b7) 129710819(dhrs11a)
PMRN116951668(HSD17B7)
LRJ133347485(HSD17B7)
BFO118408332 118408333 118408418 118421569 118421586 118426285
BBEL109467187 109467200 109482730 109482774
CIN100175937 100179068 100180521 100183772 104266129 104266131 104266156
SCLV120325859 120336480 120346622
SPU574625 574750 574825 588363 752858
LPIC129260484 129260485 129262387 129262388 129262389 129275133 129277634
APLC110976300 110976571 110976608 110976634 110976654 110976655 110976666
AJC117109980 117113032 117113034 117113040 117113055
SKO100374990 100375140 100375283 102804082
RZE108380627
ACER107993351
ADR102671249
BBIF117205728
BVK117230776
BVAN117157352
BAFF126923835
BPAS132912182
NMEA116424013
CGIG122405241
FEX115240720
PFUC122523913
CCIN107266625
DSM124407108
NPT124214573 124215756
NFB124177982
NLO107223159 107223187
NVG124300532
AGRG126743178
CSET123307195
PPYR116171680
OTU111415407 111416771 111420830 111423098
CCRN123293274 123293340 123295752
ACOO126834250 126835627 126836152 126838656 126838657 126841220 126842939 126843007 126846845
DVT126894595 126895800 126895975 126905896
HHAL106680119 106680121 106687257 106687260 106687261 106687264 106691770 106691802 112210398
NLU111054592 111054596 111054598
HVI124357177 124357178 124357983 124362815 124362816 124362817 124362818 124362819 124363316 124363317 124363318 124363319 124363320 124363976
MQU128988481 128988482 128988483 128991100 128991101 128991103 128991104
CSEC111867801 111868321 111868327 111873476 111873478 111873484 111873485 111873486 111873934 111875540
SGRE126281641 126284328 126284627 126284842 126285012 126291426 126335599 126335600 126335618 126335743 126336109 126336110 126336111 126336121 126336130 126336182 126336247 126336249 126336254 126336360 126336361 126336364 126336366 126336368 126336370 126336473 126336646 126336670 126336671 126336672 126336673 126336787 126336789 126336790 126336791
IEL124154655 124161564 124162245 124166842
FCD110845300 110848537
DPXDAPPUDRAFT_306348
DMK116930984
DPZ124349059
PVM113817572 113823180
PJA122245754 122247374
PCHN125046859 125046860
PMOO119591282 119591283
HAME121862366 121865924
PCLA123767671 123767673 123767674 123767675
CQD128697819 128697928
PTRU123515477 123515543 123515544 123515545 123515937 123515938
ESN127001865 127001867 127001869 127001873 127001874 127001875 127001891 127001892 127001893 127002262 127002276 127002277 127006126 127006127
LSM121116144 121122687 121123209
TCF131877969 131886641
PPOI119090724 119090775 119092040 119105906 119107105 119107124 119112263 119112466 119112985
CSCU111616124 111618745 111618759
PTEP107437425
UDV129217739 129235096
SDM118180812 118195543
LPOL106457516 106457517
PMEO129586192 129587824 129590626 129590627 129591500 129592606 129592619 129592668 129592700 129592800 129592838 129593018 129594555 129594812 129595605 129596117
HROHELRODRAFT_76698
LGILOTGIDRAFT_201976 LOTGIDRAFT_205793
PVUL126807655 126810764 126810765 126819554 130010299
PCAN112561798 112564142 112575325
BGT106062648 106063212
GAE121366783 121376023 121380252 121381187
HRF124113772 124114009 124114011 124114014 124143791 124146756
HRJ124260971 124264874 124288111 124288131 124288132
CRG105331538 105332739 105338891 117680536
CVN111118141 111120983 111121045 111121101 111134862
CANU128165847 128166353 128166960 128166961 128166962
OED125671117 125671651 125671671 125683102
MYI110447365 110457107
PMAX117328501 117328541 117343915
MCAF127710000 127725360 127725560 127731229
MMER123524121 123531642
RPHI132713834 132722683 132735393 132741072 132744644 132760319
DPOL127855231 127862479
OSN115223516 115223538 115231651
LAK106150742 106152479 106155453 106155948 106155949 106155960 106157462 106158358 106160574 106162367 106165644 106166261 106166737 106167094 106170933 106170936 106176414
TADTRIADDRAFT_53215
AQU100632069 100632185 100633565 100638506 100640506
SCEYLR100W(ERG27)
SEUBDI49_3627
SPAOSPAR_L01540
AGOAGOS_AGR068W
ERCEcym_4279
KLAKLLA0_F19756g
KMXKLMA_40163(ERG27)
LTHKLTH0G13046g
VPOKpol_1033p20
ZROZYRO0D06534g
CGRCAGL0M11506g
NCSNCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDINDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPFTPHA_0C01040(TPHA0C01040)
TBLTBLA_0D04010(TBLA0D04010)
TGBHG536_0C01650
TDLTDEL_0F04160(TDEL0F04160)
KAFKAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
KNGKNAG_0G02190(KNAG0G02190) KNAG_0I01040(KNAG0I01040)
ZMKHG535_0G04170
PPAPAS_chr2-1_0628
DHADEHA2E20130g
PICPICST_61325(ERG27)
PGUPGUG_05066
SPAASPAPADRAFT_59939
LELPVL30_000153(ERG27)
CALCAALFM_CR01140CA(ERG27)
CTPCTRG_00974
COTCORT_0A01630
CDUCD36_26140(ERG27)
CTENCANTEDRAFT_113050
YLIYALI0B17644g
CLUCLUG_05409
CLUSA9F13_23g00473
CAURCJI96_0005271
SLBAWJ20_1569(ERG27)
PKZC5L36_0A05120
BNNFOA43_001771
BBRXBRETT_004734
OPAHPODL_01047
NCRNCU05991
NTENEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SMPSMAC_07919
PANPODANSg3046
TTTTHITE_164350
MTMMYCTH_69410
CTHRCTHT_0040790
PPEIPpBr36_00814
PGRIPgNI_04229
TMNUCRPA7_4666
SSCKSPSK_07425
FGRFGSG_13596
FPUFPSE_10479
FPOAFPOAC1_012172
FVNFVRRES_13250
FVRFVEG_04041
FOXFOXG_06186
NHENECHADRAFT_91272
FFCNCS54_00293900
FKRNCS57_00289300
FMUJ7337_004046
TRETRIREDRAFT_2634
TRRM419DRAFT_72950
MAWMAC_02683
MAJMAA_02120
PCHMVFPPC_01571
CMTCCM_05105
AMUSLMH87_010992
PLJVFPFJ_03970
PTKZJDV02_004553(ERG27)
VALVDBG_08048
VDAVDAG_01545
CFJCFIO01_12216
CLUPCLUP02_00244
CHIGCH63R_08186
SAPOSAPIO_CDS8162
ELAUCREL1_2995
PFYPFICI_14173
SSLSS1G_00326
BFUBCIN_03g05110
MBEMBM_01041
PSCOLY89DRAFT_608282
GLZGLAREA_07003
ANIAN5585.2
AFMAFUA_4G11500
ACTACLA_050580
NFINFIA_104700
AORAO090003001070
ANGAn04g05000
AFVAFLA_000602
ALUCAKAW2_51484A(ERG27)
ACHEACHE_10583S(ERG27)
APUUAPUU_40944S(ERG27)
PCSN7525_005626
PDPPDIP_33960
POUPOX_a01511
TMFEYB26_005378
TRGTRUGW13939_02849
CIMCIMG_01575
CPWCPC735_048910
UREUREG_05299
PBLPAAG_02717
PBNPADG_01744
ABEARB_02354
TVETRV_04668
AJEHCAG_01553
BGHBDBG_07225
PNOSNOG_06194
PTEPTT_11743
BZECOCCADRAFT_22878
BSCCOCSADRAFT_32948
BORCOCMIDRAFT_4981
AALTCC77DRAFT_76456
ARABEKO05_0005817
ZTRMYCGRDRAFT_38293
PFJMYCFIDRAFT_82835
FFUCLAFUR5_04846 CLAFUR5_06261
CBETCB0940_08812
NPAUCRNP2_3103
TMLGSTUM_00003619001
SPOSPBC1709.07(erg27)
SOMSOMG_01374(erg27)
CNECND03020
CNBCNBD3330
CNGCNAG_07437
CGICGB_D5570C
TMSTREMEDRAFT_43600
TASAA1Q1_03186
CCACCcaHIS019_0101450(ERG27)
TVSTRAVEDRAFT_73290
DSQDICSQDRAFT_162108 DICSQDRAFT_88133
HIRHETIRDRAFT_312795
ADLAURDEDRAFT_80749
FMEFOMMEDRAFT_21336
GTRGLOTRDRAFT_103653
RSXRhiXN_04275
LBCLACBIDRAFT_303734
CCICC1G_09970
ABPAGABI1DRAFT79443(AGABI1DRAFT_79443)
ABVAGABI2DRAFT202140(AGABI2DRAFT_202140)
MRRMoror_13823
MOREE1B28_007285
SCMSCHCO_02624672(SCHCODRAFT_02624672)
CPUTCONPUDRAFT_103632
SLASERLADRAFT_333162
WSEWALSEDRAFT_70726
UMAUMAG_02895
PFPPFL1_04973
MGLMGL_2564
MRTMRET_0524
PGRPGTG_14396
PTRCPtA15_8A46
PSTRPst134EA_015010
MLRMELLADRAFT_64276
 » show all
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J Biol Chem 243:5546-55 (1968)
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch Biochem Biophys 211:430-8 (1981)
DOI:10.1016/0003-9861(81)90474-4
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.270
IUBMB Enzyme Nomenclature: 1.1.1.270
ExPASy - ENZYME nomenclature database: 1.1.1.270
BRENDA, the Enzyme Database: 1.1.1.270
CAS: 42616-29-5

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