KEGG   ENZYME: 1.1.1.276
Entry
EC 1.1.1.276                Enzyme                                 
Name
serine 3-dehydrogenase (NADP+);
serine 3-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-serine:NADP+ 3-oxidoreductase
Reaction(IUBMB)
L-serine + NADP+ = 2-aminoacetaldehyde + CO2 + NADPH + H+ (overall reaction) [RN:R10984];
(1a) L-serine + NADP+ = 2-aminomalonate semialdehyde + NADPH + H+ [RN:R06126];
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) [RN:R06830]
Reaction(KEGG)
Substrate
L-serine [CPD:C00065];
NADP+ [CPD:C00006];
2-aminomalonate semialdehyde [CPD:C11822]
Product
2-aminoacetaldehyde [CPD:C06735];
CO2 [CPD:C00011];
NADPH [CPD:C00005];
H+ [CPD:C00080];
2-aminomalonate semialdehyde [CPD:C11822]
Comment
NAD+ cannot replace NADP+ [cf. EC 1.1.1.387, serine 3-dehydrogenase (NAD+)].
History
EC 1.1.1.276 created 2003, modified 2015
Orthology
K05886  serine 3-dehydrogenase (NADP+)
Genes
XFAXF_0145
XFTPD_0114(ydfG)
XFMXfasm12_0122
XFNXfasM23_0107
XFFXFLM_05845
XFHXFHB_00585
XTWAB672_00635
XCCXCC3864
XCBXC_3948
XCAxcc-b100_4048
XCPXCR_0425
XCVXCV4032
XAXXACM_3813
XACXAC3919
XCIXCAW_00360
XCTJ151_04098
XCJJ158_04074
XCUJ159_04070
XCNJ169_04095
XCWJ162_04075
XCRJ163_04070
XCMJ164_04071
XCFJ172_04088
XFUXFF4834R_chr38070
XAOXAC29_19880
XOMXOO0458(XOO0458)
XOOXOO0491
XOPPXO_02915
XOYAZ54_22610
XORXOC_4237
XOZBE73_03000
XALXALC_0369
XSASB85_14920
XTNFD63_01840
XFRBER92_18435
XVEBJD12_10450
XPEBJD13_19365
XHRXJ27_13620
XGABI317_02930
XPHXppCFBP6546_14805(XppCFBP6546P_14805)
XVAC7V42_20155
XANAC801_19560
XARXB05_14555
XHYFZ025_08265
XCZEBN15_18405
XTHG4Q83_20735
XEUXSP_003720
XHDLMG31886_40540(sdh)
XPRMUG10_12380
SMLSmlt0396
SMTSmal_0278
BUJBurJV3_0307
SMZSMD_0316
SACZAOT14_05580
STEKAXG53_07940
SRHBAY15_0484
SLMBIZ42_10960
STENCCR98_01605
STEMCLM74_01520
STESMG068_01380
SINCDAIF1_03230(sdh)
SPAQSTNY_R03250
PSUPsesu_0150
PSUWWQ53_07100
PSDDSC_00090
PMEXH4W19_14930
PJPLAG73_16415
PDDMNQ95_05630
LUEDCD74_09470
LSXH8B22_06535
LHXLYSHEL_13940
LCASLYSCAS_13940
LUMCNR27_02955
LUSE5843_01275
THESFHQ07_09460
THEHG7079_02105
TCNH9L16_04025
TBVH9L17_10125
RHDR2APBS1_3857
RGLCS053_18200
RTHLRK53_17925
DTXATSB10_30620
RBDALSL_0063
BTDBTI_4935
BOKDM82_6368
BOCBG90_4306
BULBW21_4463
BUDAQ610_30805
CTESO987_22040
SAMYDB32_002188
ATUAtu4110(sdh)
ATAAWN88_05295
AGRAGROH133_12938
ATFAch5_38890(sdh)
AROB0909_17205
AGTEYD00_19850
ALFCFBP5473_18950
ARUIG6M88_18585
AVQHRR99_17120
RIRBN877_II1239(ydfG)
RPUSCFBP5875_20065
RHVBA939_20545
ROYG3A56_22740
RBANJ2J98_22615
NENNCHU2750_31200
BOSBSY19_4254(sdh)
BVVBHK69_17745
MAQUMaq22A_c21460
MINDmvi_53030
HDIHDIA_3275(sdh_2)
LAPACP90_18705
LABTFIU93_25365(sdh)
LAGGB0E33_02475
BNEDA69_09205
BDMEQG53_06900
BVYNCTC9239_02689(sdh)
CONTQ29_03530
THWBMG03_13915
TECAKL02_013090
HMLHmaOT1_12535
FAPGR316_03935
ZMOZMO0226
ZMNZa10_0988
ZMMZmob_0788
ZMBZZ6_0988
ZMIZCP4_1022
ZMCA265_01015(sdh)
ZMRA254_01014(sdh)
ZMPZymop_0943
NPPPP1Y_AT35775
NPNJI59_10405
NREBES08_15335
NOVTQ38_016215
NDRHT578_15590
SPHMG432_06740
STAXMC45_09530
SPHITS85_19360
SNJA7E77_03605
SMYBJP26_12630
SPANAWL63_12570
SKRBRX40_02980
SPLMBXU08_13235
SPLKAV944_02500
SPKCKC8_09575
SPHCCVN68_13690
SPHFDM480_07750
SPHAD3Y57_07500
SPAUDRN02_012910
SLUTH9L13_01930
SDHH9L15_05815
SSEDH9L14_13725
SXAFMM02_06400
SPIIG7077_07700
SSING7078_00875
SSAUH8M03_09085
SSUAFPZ54_14185
SMORLHA26_11535
SGLCM1K48_09645
SJPSJA_C1-25880
SINBSIDU_02205
SCHSphch_1393
SYBTZ53_14220 TZ53_18295
SBDATN00_06455 ATN00_17655
SPHTK426_15085 K426_24024
SHYDCJD35_15660
SYAA6768_17950
SCLOSCLO_1016560
SUFLFIL70_00745 FIL70_06665
SBARH5V43_01065
CIJWG74_02290
BLASBSY18_2503
BFWB5J99_07950
SPHJBSL82_14285
SPHSETR14_12220
AMXAM2010_2089
PMASNCF86_12170
ANHA6F65_00294(sdh)
ADOA6F68_00572(sdh)
TFVIDJ81_04050
CNAAB433_03585
CMANA9D14_00390
EFVCHH26_01715
QCINCF85_14090
ERRDVR09_03340
EMVHQR01_06355
PNSA9D12_03800
PORLBG023_11191
PHZCHX26_01545
POTE2E27_02380
AZLAZL_b03320
ALIAZOLI_p20658(ydfG)
ATIAL072_26695
AZMDM194_19005 DM194_21170
AOZHUE56_07535
HJOAY555_10515
TIIDY252_07915
THAIIT893_13345
ARTArth_1787
ARRARUE_c37180
ARZAUT26_17060
ARXARZXY2_171
AAUAAur_3589
 » show all
Reference
1  [PMID:12092831]
  Authors
Fujisawa H, Nagata S, Chowdhury EK, Matsumoto M, Misono H
  Title
Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens.
  Journal
Biosci Biotechnol Biochem 66:1137-9 (2002)
DOI:10.1271/bbb.66.1137
  Sequence
[atu:Atu4110]
Reference
2  [PMID:9028042]
  Authors
Chowdhury EK, Higuchi K, Nagata S, Misono H
  Title
A novel NADP(+)-dependent serine dehydrogenase from Agrobacterium tumefaciens.
  Journal
Biosci Biotechnol Biochem 61:152-7 (1997)
DOI:10.1271/bbb.61.152
  Sequence
[atu:Atu4110]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.276
IUBMB Enzyme Nomenclature: 1.1.1.276
ExPASy - ENZYME nomenclature database: 1.1.1.276
BRENDA, the Enzyme Database: 1.1.1.276
CAS: 9038-55-5

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