Entry |
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Name |
(R)-3-hydroxyacid-ester dehydrogenase;
3-oxo ester (R)-reductase
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
Sysname |
ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase
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Reaction(IUBMB) |
ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + NADPH + H+ [RN: R04105]
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Reaction(KEGG) |
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Substrate |
ethyl (R)-3-hydroxyhexanoate [CPD: C03864];
NADP+ [CPD: C00006]
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Product |
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Comment |
Also acts on ethyl (R)-3-oxobutanoate and some other (R)-3-hydroxy acid esters. The (R)- symbol is allotted on the assumption that no substituents change the order of priority from O-3 > C-2 > C-4. A subunit of yeast fatty acid synthase EC 2.3.1.86, fatty-acyl-CoA synthase system. cf. EC 1.1.1.280, (S)-3-hydroxyacid ester dehydrogenase.
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History |
EC 1.1.1.279 created 1990 as EC 1.2.1.55, transferred 2003 to EC 1.1.1.279, modified 2018
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Reference |
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Authors |
Heidlas J, Engel KH, Tressl R. |
Title |
Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.279 |
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