KEGG   ENZYME: 1.1.1.279Help
Entry
EC 1.1.1.279                Enzyme                                 

Name
(R)-3-hydroxyacid-ester dehydrogenase;
3-oxo ester (R)-reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase
Reaction(IUBMB)
ethyl (R)-3-hydroxyhexanoate + NADP+ = ethyl 3-oxohexanoate + NADPH + H+ [RN:R04105]
Reaction(KEGG)
Substrate
ethyl (R)-3-hydroxyhexanoate [CPD:C03864];
NADP+ [CPD:C00006]
Product
ethyl 3-oxohexanoate [CPD:C02975];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on ethyl (R)-3-oxobutanoate and some other (R)-3-hydroxy acid esters. The (R)- symbol is allotted on the assumption that no substituents change the order of priority from O-3 > C-2 > C-4. A subunit of yeast fatty acid synthase EC 2.3.1.86, fatty-acyl-CoA synthase system. cf. EC 1.1.1.280, (S)-3-hydroxyacid ester dehydrogenase.
History
EC 1.1.1.279 created 1990 as EC 1.2.1.55, transferred 2003 to EC 1.1.1.279, modified 2018
Reference
1  [PMID:3280313]
  Authors
Heidlas J, Engel KH, Tressl R.
  Title
Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast.
  Journal
Eur J Biochem 172:633-9 (1988)
DOI:10.1111/j.1432-1033.1988.tb13936.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.279
IUBMB Enzyme Nomenclature: 1.1.1.279
ExPASy - ENZYME nomenclature database: 1.1.1.279
BRENDA, the Enzyme Database: 1.1.1.279
CAS: 114705-02-1

  All links  
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (7)   

Download RDF
DBGET integrated database retrieval system