KEGG   ENZYME: 1.1.1.281
Entry
EC 1.1.1.281                Enzyme                                 

Name
GDP-4-dehydro-6-deoxy-D-mannose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous];
GDP-6-deoxy-D-lyxo-4-hexulose reductase;
Rmd;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming);
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03397 R03399]
Reaction(KEGG)
R03397 R03399
Substrate
GDP-alpha-D-rhamnose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
History
EC 1.1.1.281 created 2004
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K15856  GDP-4-dehydro-6-deoxy-D-mannose reductase
Genes
YPB: YPTS_1054
YPQ: DJ40_1349
YPU: BZ21_253
YPR: BZ20_1036
YPC: BZ23_529
XAL: XALC_2707(rmd)
XVA: C7V42_18455
LCP: LC55x_4380
LGU: LG3211_4185
LEZ: GLE_4243
LEM: LEN_0958
PAE: PA5454(rmd)
PAEV: N297_5642
PAEI: N296_5642
PAU: PA14_72000(rmd)
PAG: PLES_58491(rmd)
PAF: PAM18_5576(rmd)
PNC: NCGM2_6231(rmd)
PAEB: NCGM1900_6309(rmd)
PAEP: PA1S_29460
PAEM: U769_29965
PAEL: T223_29925
PAEU: BN889_06061(rmd)
PAEG: AI22_04525
PAEC: M802_5640
PAEO: M801_5507
PMK: MDS_1410
PCQ: PcP3B5_01740(rmd)
PSYR: N018_21315
PFE: PSF113_5885(rmd)
PMAN: OU5_3478
PSES: PSCI_5345
PSEM: TO66_31495
ASIP: AQUSIP_18140(rmd)
BMAL: DM55_1487
BMAE: DM78_2667
BMAQ: DM76_1465
BMAI: DM57_1072
BMAF: DM51_1938
BMAZ: BM44_1066
BMAB: BM45_2463
BPM: BURPS1710b_3293(wcbK)
BPSE: BDL_2648
BPSM: BBQ_512
BPSU: BBN_640
BPSD: BBX_1046
BPZ: BP1026B_I0513(wcbK)
BPK: BBK_2133
BPSH: DR55_1721
BPSA: BBU_2765
BPSO: X996_1361
BUT: X994_3359
BTHA: DR62_530
PLG: NCTC10937_04677(gmd_1)
CFU: CFU_1116(rmd)
CARE: LT85_3694
NET: Neut_0156
MBAT: BN1208_0921(wcbK)
CJJ: CJJ81176_1426(wcbK)
CJS: CJS3_1519(wcbK)
CJER: H730_08150
CJQ: UC78_1367(rmd_2)
CJR: CJE1611(wcbK)
CCF: YSQ_01730
CLX: CLAN_0158
GEM: GM21_3399
DWD: DSCW_50670(rfbB)
MXA: MXAN_5328(rmd)
CCX: COCOR_02240(rmd)
SUR: STAUR_6036(rmd)
PLA: Plav_3348
RPA: RPA3952
RPD: RPD_1646
RPE: RPE_4260
RPT: Rpal_4473
NHA: Nham_2781
VGO: GJW-30_1_00102(rmd)
AZC: AZC_0053
MET: M446_5188
RVA: Rvan_2460
MSC: BN69_2011
PLEO: OHA_1_01728(rmd)
HDI: HDIA_0149(rmd_1)
RSU: NHU_00140
HNE: HNE_0794
ZMN: Za10_0101
ZMI: ZCP4_0102
ZMC: A265_00102(rfbE)
ZMR: A254_00102(rfbE)
GOH: B932_0830
ACR: Acry_0507
AMV: ACMV_05820(rmd)
MGRY: MSR1_06580(rmd)
MAGQ: MGMAQ_1159
AFR: AFE_3291
ACU: Atc_0208
BWW: bwei_1210
BMYO: BG05_2275
PPY: PPE_03826
PPM: PPSC2_20115(rmd)
PPO: PPM_4031(rmd)
PPOL: X809_36250
PPOY: RE92_17075
PSAB: PSAB_18880
PRI: PRIO_5575
RCH: RUM_03120
BPB: bpr_I0151(gmd1) bpr_I0396
BHU: bhn_I0589
STH: STH1372
MTU: Rv0112(gca)
MTV: RVBD_0112
MTC: MT0121
MRA: MRA_0118(gca)
MTUR: CFBS_0121(gca)
MTO: MTCTRI2_0115(gca)
MTD: UDA_0112(gca)
MTN: ERDMAN_0130(gca)
MTUB: MT7199_0114(gca)
MTUC: J113_00800
MTUE: J114_00620
MTUH: I917_00860
MTUL: TBHG_00112
MTUT: HKBT1_0121(gca)
MTUU: HKBT2_0121(gca)
MTQ: HKBS1_0121(gca)
MBO: BQ2027_MB0116(gca)
MBB: BCG_0145(gca)
MBT: JTY_0116(gca)
MBM: BCGMEX_0116(gca)
MBX: BCGT_3909
MAF: MAF_01130(gca)
MMIC: RN08_0130
MCE: MCAN_01151(gca)
MCQ: BN44_10135(gca)
MCV: BN43_10130(gca)
MCX: BN42_10151(gca)
MCZ: BN45_10128(gca)
MTS: MTES_0931
RXY: Rxyl_0568
AFO: Afer_0745
EYY: EGYY_07230(Gmd)
NSH: GXM_02821
TRO: trd_0916
STI: Sthe_1123
PBF: CFX0092_A0151(rmd)
TRA: Trad_2861
TTR: Tter_1710
TTF: THTE_3576
PLH: VT85_25320(rmd_3)
BVO: Pan97_02120(rmd)
GES: VT84_32605(rmd_2)
SACI: Sinac_0262
PBOR: BSF38_03321(rmd_3) BSF38_04700(rmd_4)
AGV: OJF2_00280(rmd_1)
LIL: LA_0235(rfbB)
LIE: LIF_A0204(rfbB)
LIC: LIC_10203(rmd)
LIS: LIL_10203(rfbB1)
LBF: LBF_3148
LST: LSS_04696
ABAC: LuPra_05853(rmd)
TLI: Tlie_1236
FSC: FSU_2786(rmd)
GAU: GAU_1969
GBA: J421_3572
MPI: Mpet_1407
PIS: Pisl_1490
TNE: Tneu_0491
LOKI: Lokiarch_35700(rmd)
 » show all
Reference
1  [PMID:11096116]
  Authors
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P.
  Title
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J Biol Chem 276:5577-83 (2001)
DOI:10.1074/jbc.M010027200
  Sequence
Reference
2  [PMID:11856318]
  Authors
Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R.
  Title
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose.
  Journal
Eur J Biochem 269:593-601 (2002)
DOI:10.1046/j.0014-2956.2001.02688.x
  Sequence
[pae:PA5454]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.281
IUBMB Enzyme Nomenclature: 1.1.1.281
ExPASy - ENZYME nomenclature database: 1.1.1.281
BRENDA, the Enzyme Database: 1.1.1.281

DBGET integrated database retrieval system