KEGG   ENZYME: 1.1.1.288
Entry
EC 1.1.1.288                Enzyme                                 
Name
xanthoxin dehydrogenase;
xanthoxin oxidase;
ABA2
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
xanthoxin:NAD+ oxidoreductase
Reaction(IUBMB)
xanthoxin + NAD+ = abscisic aldehyde + NADH + H+ [RN:R06954]
Reaction(KEGG)
R06954
Substrate
xanthoxin [CPD:C13453];
NAD+ [CPD:C00003]
Product
abscisic aldehyde [CPD:C13455];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Requires a molybdenum cofactor for activity. NADP+ cannot replace NAD+ and short-chain alcohols such as ethanol, isopropanol, butanol and cyclohexanol cannot replace xanthoxin as substrate [3]. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.2.3.14 (abscisic-aldehyde oxidase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase]. Abscisic acid is a sesquiterpenoid plant hormone that is involved in the control of a wide range of essential physiological processes, including seed development, germination and responses to stress [3].
History
EC 1.1.1.288 created 2005
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09841  xanthoxin dehydrogenase
Genes
ATHAT1G52340(ABA2)
ALY9327753
CRB17896886
CSAT104758555 104778156
EUSEUTSA_v10011636mg
BRP103832798 103871215
BNA106345736 106390565
BOE106300040
RSZ108860834
THJ104821959
CPAP110815871
CIT102577974(ABA2)
CICCICLE_v10012415mg
PVY116143607
MINC123215053
TCC18585758
GRA105783205
GHI107920536 107933310
GAB108461096
DZI111295129 111310084
EGR104454559
GMX100786658 100801691
GSJ114374582 114376976
PVUPHAVU_005G031500g PHAVU_005G031600g
VRA106760860 106761417
VAR108333217 108333278
VUN114162538 114176348
CCAJ109809099 109815886
APRC113867779
MTR11414690
CAM101515018
LJALj0g3v0091119.1(Lj0g3v0091119.1)
ADU107471843
AIP107622404
AHF112717010 112782563
LANG109335868
FVE101292810
RCN112179057
PPER18785370
PMUM103343399
PAVI110747964 110770832
PDUL117620278
MDM103431475 103446486 114819149
PXB103945571 103957656 103957657
ZJU107417757
MNT21391964
CSV101219413
CMO103503321
BHJ120092550
MCHA111024504
CMAX111489670
CMOS111445228
CPEP111808179
RCU8270915 8280319
JCU105631198
HBR110661036
MESC110613693
POP7487015
PEU105107390
PALZ118061218
JRE108988748 108988790 108988885 108989891
QSU112022992 112022997 112023002
QLO115986376 115986377 115986378
TWL119988731 119989639 119989664 119989851 120006222 120006223
VVI100265470
VRI117927554
SLY101254297 101254591
SPEN107015744 107018349 107019321
SOT102577811 102584670
SSTN125856475 125856853
CANN107855067 107855068
NTA107760487 107765743 107765752 107778136
NSY104235616 104237462
NTO104121195 104121196
NAU109207455 109209388
INI109155970
ITR115997558
SIND105172159
OEU111410241
EGT105951798 105957017
SSPL121756256 121759247
HAN110925709
ECAD122603241 122605147
LSV111876124 111916298
CCAV112515797
DCR108206649
CSIN114297049
BVG104888541 104888542 104888543
SOE110784079 110784166
CQI110697046 110729644
NNU104612004
MING122090896
TSS122648330 122672765 122672766
PSOM113312628
NCOL116257606 116257618
OSA4334535
DOSAOs03t0810800-01(Os03g0810800)
OBR102708142
BDI100827045
ATS109784728
TDC119303737 119312419 119350087
TAES123105588 123113898 123123404
TUA125511092
SBI8057083
ZMA100282128
SITA101756331 101757665
SVS117836315 117838061
PVIR120649344 120687980
PHAI112874733 112874734
PDA103720715 103720728
EGU105045553 105045554 105052461
MUS103981080
DCT110111993
PEQ110031715
AOF109848475
ATR18433242
 » show all
Reference
1  [PMID:16666262]
  Authors
Sindhu RK, Walton DC.
  Title
Xanthoxin Metabolism in Cell-free Preparations from Wild Type and Wilty Mutants of Tomato.
  Journal
Plant Physiol 88:178-182 (1988)
DOI:10.1104/pp.88.1.178
Reference
2  [PMID:9159947]
  Authors
Schwartz SH, Leon-Kloosterziel KM, Koornneef M, Zeevaart JA.
  Title
Biochemical characterization of the aba2 and aba3 mutants in Arabidopsis thaliana.
  Journal
Plant Physiol 114:161-6 (1997)
DOI:10.1104/pp.114.1.161
  Sequence
[ath:AT1G52340]
Reference
3  [PMID:12172025]
  Authors
Gonzalez-Guzman M, Apostolova N, Belles JM, Barrero JM, Piqueras P, Ponce MR, Micol JL, Serrano R, Rodriguez PL
  Title
The short-chain alcohol dehydrogenase ABA2 catalyzes the conversion of xanthoxin to abscisic aldehyde.
  Journal
Plant Cell 14:1833-46 (2002)
DOI:10.1105/tpc.002477
  Sequence
[ath:AT1G52340]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.288
IUBMB Enzyme Nomenclature: 1.1.1.288
ExPASy - ENZYME nomenclature database: 1.1.1.288
BRENDA, the Enzyme Database: 1.1.1.288
CAS: 129204-37-1

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