KEGG ENZYME: 1.1.1.289

ENZYME: 1.1.1.289

Entry

EC 1.1.1.289                Enzyme

Name

sorbose reductase;
Sou1p

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glucitol:NADP+ oxidoreductase

Reaction(IUBMB)

D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]

Reaction(KEGG)

R07346

Substrate

D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]

Product

L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.

History

EC 1.1.1.289 created 2006

Pathway

ec00051

Fructose and mannose metabolism

ec01100

Metabolic pathways

Orthology

K17742

sorbose reductase

K19633

sorbose reductase

Genes

QSU:	111983853 111993541 111994894 112002464 112003553 112032708 112033672

KLA:	KLLA0_E22397g KLLA0_E24003g

KMX:	KLMA_10715(SOU2) KLMA_10783(SOU1)

LTH:	KLTH0E13134g KLTH0F18062g KLTH0H14564g

ZRO:	ZYRO0A11902g ZYRO0G22440g

TDL:	TDEL_0B02360(TDEL0B02360) TDEL_0H00150(TDEL0H00150) TDEL_0H04540(TDEL0H04540)

TGB:	HG536_0F00190 HG536_0H02380

ZMK:	HG535_0F05860

PPA:	PAS_chr4_0754 PAS_chr4_0988

DHA:	DEHA2A12386g DEHA2A14322g DEHA2A14344g DEHA2E08910g DEHA2E24244g DEHA2F00990g

PIC:	PICST_38255(SOU1)

PGU:	PGUG_05385 PGUG_05388 PGUG_05464 PGUG_05466

SPAA:

SPAPADRAFT_148284 SPAPADRAFT_58963 SPAPADRAFT_60851 SPAPADRAFT_61649 SPAPADRAFT_62532

LEL:	LELG_03159 LELG_05725 LELG_05727

CAL:	CAALFM_C406380WA(SOU2) CAALFM_C406390WA(SOU1) CAALFM_CR07170WA(CaO19.732)

CTP:	CTRG_03131 CTRG_03800 CTRG_03801

COT:	CORT_0B01330 CORT_0D05940

CDU:	CD36_32760 CD36_45870(SOU2) CD36_45880(SOU1)

CTEN:

CANTEDRAFT_102630 CANTEDRAFT_103164 CANTEDRAFT_112997 CANTEDRAFT_113000 CANTEDRAFT_113822 CANTEDRAFT_119297 CANTEDRAFT_119904

YLI:	YALI0B16192g YALI0D18964g YALI0E05643g

CLU:	CLUG_03390 CLUG_03744

CLUS:

A9F13_01g04004 A9F13_01g07997

CAUR:

CJI97_001279 CJI97_002470 CJI97_003341 CJI97_003343

SLB:	AWJ20_2382(SPS19) AWJ20_3417(SPS19)

PKZ:	C5L36_0A13160

BNN:	FOA43_003778

BBRX:

BRETT_004557

OPA:	HPODL_00132 HPODL_00133 HPODL_00159 HPODL_00206 HPODL_02372 HPODL_03552 HPODL_04542

SLUD:

SCDLUD_005287

NCR:	NCU03803 NCU09041

NTE:	NEUTE1DRAFT115988(NEUTE1DRAFT_115988) NEUTE1DRAFT117650(NEUTE1DRAFT_117650)

SMP:	SMAC_02649 SMAC_05842

PAN:	PODANSg2618 PODANSg9038

TTT:	THITE_2108357

MTM:	MYCTH_2302150

CTHR:

CTHT_0067490

MGR:

MGG_07455

PPEI:

PpBr36_02364

TMN:	UCRPA7_3047 UCRPA7_3397 UCRPA7_6054 UCRPA7_6057 UCRPA7_7028 UCRPA7_8020

SSCK:

SPSK_07897 SPSK_10284

FGR:	FGSG_04248 FGSG_04826 FGSG_06104 FGSG_10025

FPU:	FPSE_04052(MTDH1) FPSE_04260 FPSE_04546 FPSE_08740

FVR:	FVEG_02746 FVEG_03510 FVEG_04737 FVEG_10438 FVEG_13843

FOX:	FOXG_05383 FOXG_05657 FOXG_07815 FOXG_11379 FOXG_13570

NHE:	NECHADRAFT_105339 NECHADRAFT_37143 NECHADRAFT_42050 NECHADRAFT_42069 NECHADRAFT_63861 NECHADRAFT_69214 NECHADRAFT_81004 NECHADRAFT_85474

TRE:	TRIREDRAFT_54086 TRIREDRAFT_60033 TRIREDRAFT_69840 TRIREDRAFT_74194(lxr1)

TRR:	M419DRAFT_121678 M419DRAFT_134365 M419DRAFT_34830 M419DRAFT_4602

MAW:	MAC_06617 MAC_08952

MAJ:	MAA_01627 MAA_08417 MAA_09034

CMT:	CCM_06357 CCM_07859 CCM_08784 CCM_09007

PLJ:	VFPFJ_06456 VFPFJ_06521 VFPFJ_08088 VFPFJ_11024

VAL:	VDBG_02657

VDA:	VDAG_03582

CFJ:	CFIO01_06096 CFIO01_06114 CFIO01_09197 CFIO01_10017 CFIO01_10020 CFIO01_11827 CFIO01_13671

CHIG:

CH63R_03138 CH63R_04126 CH63R_11374

SAPO:

SAPIO_CDS7997

ELA:	UCREL1_1116 UCREL1_4732 UCREL1_5183 UCREL1_7416 UCREL1_8867

PFY:	PFICI_04519 PFICI_05410 PFICI_05413 PFICI_06515 PFICI_07972 PFICI_10486 PFICI_10609 PFICI_11801 PFICI_14636

SSL:	SS1G_01500 SS1G_08799 SS1G_09310

BFU:	BCIN_02g00470 BCIN_06g04730 BCIN_13g04760 BCIN_16g03380

MBE:	MBM_02748 MBM_04022

PSCO:

LY89DRAFT_582420 LY89DRAFT_595817 LY89DRAFT_656415 LY89DRAFT_656420 LY89DRAFT_677887 LY89DRAFT_717013 LY89DRAFT_781929

GLZ:	GLAREA_05217 GLAREA_06523 GLAREA_06706 GLAREA_08131

ANI:	AN5547.2 AN7590.2 AN8113.2 AN8819.2

AFM:	AFUA_2G15430 AFUA_5G09400 AFUA_6G13830

ACT:	ACLA_011160 ACLA_074390 ACLA_087030

NFI:	NFIA_059700 NFIA_077930 NFIA_090670

AOR:	AO090009000092 AO090012000287 AO090020000558 AO090103000206 AO090103000359 AO090701000415

ANG:	ANI_1_1178074(An08g08480) ANI_1_1276074(An08g09360) ANI_1_2328074(An08g09340) ANI_1_438064(An07g03570) ANI_1_450094(An11g03260) ANI_1_736134(An15g05450)

AFV:	AFLA_002003 AFLA_004926 AFLA_004930 AFLA_010099 AFLA_011270 AFLA_013173 AFLA_013316

ALUC:

AKAW2_11826S(LXR3) AKAW2_51678S AKAW2_60217S(LXR1) AKAW2_80300S

ACHE:

ACHE_10084A ACHE_10087S ACHE_11906S ACHE_31392S ACHE_50422S ACHE_50426S ACHE_50429A(LXR1_1) ACHE_50556S(LXR1_2) ACHE_50561S ACHE_50662S ACHE_50760S

APUU:

APUU_10973S APUU_12355S(SOU1) APUU_20144S APUU_40897A APUU_60796S APUU_60913A APUU_60916A APUU_80356S(LXR1)

PCS:	Pc12g00830 Pc16g10970 Pc16g11010 Pc16g13310 Pc21g18520 Pc22g00670 Pc22g01350

PDP:	PDIP_04500 PDIP_45660 PDIP_50980 PDIP_65860

TMF:	PMAA_079570 PMAA_088200 PMAA_088300

TRG:	TRUGW13939_00052 TRUGW13939_01338 TRUGW13939_01729 TRUGW13939_09110 TRUGW13939_09267 TRUGW13939_09270 TRUGW13939_10687

CIM:	CIMG_06663

CPW:	CPC735_031160

URE:	UREG_03776

PBL:	PAAG_04181

PBN:	PADG_07435

ABE:

ARB_02722

TVE:

TRV_00610

AJE:	HCAG_00626

BGH:	BDBG_01254

PNO:	SNOG_01607 SNOG_15488(AY788902)

PTE:	PTT_06742 PTT_07726 PTT_09906

BZE:	COCCADRAFT_108299 COCCADRAFT_26499 COCCADRAFT_32637 COCCADRAFT_36831

BSC:	COCSADRAFT_142026 COCSADRAFT_32603 COCSADRAFT_34195 COCSADRAFT_41505

BOR:	COCMIDRAFT_29087 COCMIDRAFT_31692 COCMIDRAFT_93520 COCMIDRAFT_97193

AALT:

CC77DRAFT_1054735 CC77DRAFT_1091062 CC77DRAFT_931278 CC77DRAFT_935368 CC77DRAFT_942593 CC77DRAFT_964195

ZTR:	MYCGRDRAFT_31902 MYCGRDRAFT_64923 MYCGRDRAFT_74599 MYCGRDRAFT_84831

PFJ:	MYCFIDRAFT_209507 MYCFIDRAFT_211363 MYCFIDRAFT_38554 MYCFIDRAFT_71664

FFU:	CLAFUR5_04588 CLAFUR5_07014 CLAFUR5_09329

BCOM:

BAUCODRAFT_29448 BAUCODRAFT_64133 BAUCODRAFT_74440

NPA:	UCRNP2_3500 UCRNP2_5371

TML:	GSTUM_00000686001 GSTUM_00002833001

SPO:	SPAC22A12.17c SPAC8E11.10 SPCC1739.08c

CNE:	CNH02950 CNK02860 CNL05930

CNB:	CNBI0900 CNBK0650 CNBL3020

CNG:	CNAG_01947 CNAG_05024 CNAG_05657 CNAG_06978

CGI:	CGB_D1070C CGB_K0731C CGB_L3660C

TASA:

A1Q1_04349 A1Q1_05496

PSQ:	PUNSTDRAFT_83219

FME:	FOMMEDRAFT_123887

GTR:	GLOTRDRAFT_108403 GLOTRDRAFT_133516

LBC:	LACBIDRAFT_256071

CCI:	CC1G_15600

ABP:	AGABI1DRAFT114569(AGABI1DRAFT_114569)

ABV:	AGABI2DRAFT194752(AGABI2DRAFT_194752)

CPUT:

CONPUDRAFT_138022

SLA:	SERLADRAFT_436806 SERLADRAFT_457635(oxr1)

WSE:	WALSEDRAFT_31566 WALSEDRAFT_32727 WALSEDRAFT_63204

WIC:	J056_002472 J056_003684 J056_004249

UMA:	UMAG_05252 UMAG_10938

PFP:	PFL1_02969 PFL1_04231 PFL1_04817

MGL:

MGL_3023

MRT:

MRET_3631

MSYM:

MSY001_1257

PGR:	PGTG_01366 PGTG_16113

MLR:	MELLADRAFT_55312 MELLADRAFT_77343

LIZ:	LGH83_17090

GOX:

GOX1432

GOH:

B932_1684

GOY:	GLS_c15490

GAL:	A0U94_10565

GTI:	FXF46_02985

GSP:	IGS75_08345

GFA:	MKW11_02970

GDI:	GDI0886(mtlK)

GDJ:

Gdia_1133

GXY:

GLX_20590

GXL:

H845_2922

KNA:	B0W47_08225

KEU:	S101446_02540

KSC:	CD178_00846(por_1)

KRE:	GWK63_01240

AACE:

A0U92_16660

ABG:	Asbog_02764

KBA:	A0U89_13385

NCH:	A0U93_13575

NTN:	D5366_09545

SSAM:

E3D00_06230

EBLA:

JGUZn3_11270(por)

KHA:	IFJ82_15285

PARZ:

DTQ13_03645

SPSY:

AZE41_19100

NTR:	B0W44_16760

KEB:	GXN75_05805

CAPR:

EQM14_03885

BPRO:

PMF13cell1_02465(fabG_4)

MTV:	RVBD_1928c

MTF:	TBFG_11957

MTB:	TBMG_02064

MTK:	TBSG_02074

MTZ:	TBXG_002046

MTG:	MRGA327_11885

MTI:	MRGA423_12005

MTE:	CCDC5079_1783

MTUR:

CFBS_2025

MTL:	CCDC5180_1759

MTO:	MTCTRI2_1961

MTD:

UDA_1928c

MTJ:	J112_10275

MTUE:

J114_10280

MTX:	M943_10015

MTUT:

HKBT1_2022

MTUU:

HKBT2_2023

MTQ:	HKBS1_2026

MBO:	BQ2027_MB1963C

MBT:

JTY_1951

MBM:	BCGMEX_1948c

MBK:	K60_020200

MBX:

BCGT_1759

MAF:

MAF_19510

MMIC:

RN08_2143

MCE:	MCAN_19451

MCQ:	BN44_40198

MCV:	BN43_31078

MAO:

MAP4_2189

MAVI:

RC58_10895

MAVU:

RE97_10905

MIT:

OCO_26060

MIA:

OCU_25920

MID:

MIP_03640

MYO:

OEM_24550

MCHI:

AN480_13735

MIR:

OCQ_24640

MMAL:

CKJ54_11785

MMAN:

MMAN_12980

MMI:

MMAR_2849

MMAE:

MMARE11_27690

MMM:

W7S_12655

MLI:	MULP_02613

MHAD:

B586_11245

MSHG:

MSG_02718

MFJ:	MFLOJ_04950

MSTO:

MSTO_06290

MSIM:

MSIM_50320

MSAK:

MSAS_08190

MKU:	I2456_13950

MPAG:

C0J29_16340

MGOR:

H0P51_15280

MBAI:

MB901379_02635(gno)

MSEO:

MSEO_15590

MPSE:

MPSD_29380

MSHO:

MSHO_42610

MSPG:

F6B93_11755

MALK:

MalAC0309_0361

BADL:

BADO_0956

BADO:

BBMN23_1035

BKS:

BBKW_1136

BCAT:

BBCT_1008

BPSC:

BBPC_1010

BSCA:

BBSC_1118

BLEM:

BL8807_01055

BEU:	BE0216_10400

ABAO:

BEQ56_02015

TPI:	TREPR_0133

TAZ:	TREAZ_3467

BPO:	BP951000_2320

BPJ:	B2904_orf1255(sou1)

BPIP:

BPP43_03215

» show all

Reference

1 [PMID:16134116]

Authors

Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E

Title

Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.

Journal

Yeast 22:957-69 (2005)
DOI:10.1002/yea.1282

Sequence

[cal:CAALFM_C406390WA]

Reference

Authors

Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.

Title

Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.

Journal

Yeast 22:1171 (2005)

Reference

Authors

Sugisawa, T., Hoshino, T. and Fujiwara, A.

Title

Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.

Journal

Agric Biol Chem 55:2043-2049 (1991)

Reference

4 [PMID:11790761]

Authors

Shinjoh M, Tazoe M, Hoshino T

Title

NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.

Journal

J Bacteriol 184:861-3 (2002)
DOI:10.1128/JB.184.3.861-863.2002

Sequence

[ag:BAB83933]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.289

IUBMB Enzyme Nomenclature:

1.1.1.289

ExPASy - ENZYME nomenclature database:

1.1.1.289

BRENDA, the Enzyme Database:

1.1.1.289

CAS:	138440-90-1

DBGET integrated database retrieval system