KEGG   ENZYME: 1.1.1.289
Entry
EC 1.1.1.289                Enzyme                                 

Name
sorbose reductase;
Sou1p
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]
Reaction(KEGG)
R07346
Substrate
D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]
Product
L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
History
EC 1.1.1.289 created 2006
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K17742  sorbose reductase
K19633  sorbose reductase
Genes
QSU: 111983853 111993541 111994894 112002464 112003553 112014868 112032708 112033672
KLA: KLLA0_E22397g KLLA0_E24003g
KMX: KLMA_10715(SOU2) KLMA_10783(SOU1)
LTH: KLTH0E13134g KLTH0F18062g KLTH0H14564g
ZRO: ZYRO0A11902g ZYRO0G22440g
TDL: TDEL_0B02360(TDEL0B02360) TDEL_0H00150(TDEL0H00150) TDEL_0H04540(TDEL0H04540)
ZMK: HG535_0F05860
PPA: PAS_chr4_0754 PAS_chr4_0988
DHA: DEHA2A12386g DEHA2A14322g DEHA2A14344g DEHA2E08910g DEHA2E24244g DEHA2F00990g
PIC: PICST_38255(SOU1)
PGU: PGUG_05385 PGUG_05388 PGUG_05464 PGUG_05466
SPAA: SPAPADRAFT_148284 SPAPADRAFT_58963 SPAPADRAFT_60851 SPAPADRAFT_61649 SPAPADRAFT_62532
LEL: LELG_03159 LELG_05725 LELG_05727
CAL: CAALFM_C406380WA(SOU2) CAALFM_C406390WA(SOU1) CAALFM_CR07170WA(CaO19.732)
CTP: CTRG_03131 CTRG_03800 CTRG_03801
COT: CORT_0B01330 CORT_0D05940
CDU: CD36_32760 CD36_45870(SOU2) CD36_45880(SOU1)
CTEN: CANTEDRAFT_102630 CANTEDRAFT_103164 CANTEDRAFT_112997 CANTEDRAFT_113000 CANTEDRAFT_113822 CANTEDRAFT_119297 CANTEDRAFT_119904
YLI: YALI0B16192g YALI0D18964g YALI0E05643g
CLU: CLUG_03390 CLUG_03744
CLUS: A9F13_01g04004 A9F13_01g07997
CAUR: CJI97_001279 CJI97_002470 CJI97_003341 CJI97_003343
SLB: AWJ20_2382(SPS19) AWJ20_3417(SPS19)
PKZ: C5L36_0A13160
BNN: FOA43_003778
BBRX: BRETT_004557
NCR: NCU03803 NCU09041
NTE: NEUTE1DRAFT115988(NEUTE1DRAFT_115988) NEUTE1DRAFT117650(NEUTE1DRAFT_117650)
SMP: SMAC_02649 SMAC_05842
PAN: PODANSg2618 PODANSg9038
TTT: THITE_2108357
MTM: MYCTH_2302150
CTHR: CTHT_0067490
MGR: MGG_07455
TMN: UCRPA7_3047 UCRPA7_3397 UCRPA7_6054 UCRPA7_6057 UCRPA7_7028 UCRPA7_8020
SSCK: SPSK_07897 SPSK_10284
FGR: FGSG_04248 FGSG_04826 FGSG_06104 FGSG_10025
FPU: FPSE_04052(MTDH1) FPSE_04260 FPSE_04546 FPSE_08740
FVR: FVEG_02746 FVEG_03510 FVEG_04737 FVEG_10438 FVEG_13843
FOX: FOXG_05383 FOXG_05657 FOXG_07815 FOXG_11379 FOXG_13570
NHE: NECHADRAFT_105339 NECHADRAFT_37143 NECHADRAFT_42050 NECHADRAFT_42069 NECHADRAFT_63861 NECHADRAFT_69214 NECHADRAFT_81004 NECHADRAFT_85474
TRE: TRIREDRAFT_54086 TRIREDRAFT_60033 TRIREDRAFT_69840 TRIREDRAFT_74194(lxr1)
TRR: M419DRAFT_121678 M419DRAFT_134365 M419DRAFT_34830 M419DRAFT_4602
MAW: MAC_06617 MAC_08952
MAJ: MAA_01627 MAA_08417 MAA_09034
CMT: CCM_06357 CCM_07859 CCM_08784 CCM_09007
PLJ: VFPFJ_06456 VFPFJ_06521 VFPFJ_08088 VFPFJ_11024
VAL: VDBG_02657
VDA: VDAG_03582
CFJ: CFIO01_06096 CFIO01_06114 CFIO01_09197 CFIO01_10017 CFIO01_10020 CFIO01_11827 CFIO01_13671
SAPO: SAPIO_CDS7997
ELA: UCREL1_1116 UCREL1_4732 UCREL1_5183 UCREL1_7416 UCREL1_8867
PFY: PFICI_04519 PFICI_05410 PFICI_05413 PFICI_06515 PFICI_07972 PFICI_10486 PFICI_10609 PFICI_11801 PFICI_14636
SSL: SS1G_01500 SS1G_08799 SS1G_09310
BFU: BCIN_02g00470 BCIN_06g04730 BCIN_13g04760 BCIN_16g03380
MBE: MBM_02748 MBM_04022
PSCO: LY89DRAFT_582420 LY89DRAFT_595817 LY89DRAFT_656415 LY89DRAFT_656420 LY89DRAFT_677887 LY89DRAFT_717013 LY89DRAFT_781929
GLZ: GLAREA_05217 GLAREA_06523 GLAREA_06706 GLAREA_08131
ANI: AN7590.2 AN8113.2 AN8819.2
AFM: AFUA_2G15430 AFUA_5G09400 AFUA_6G13830
ACT: ACLA_011160 ACLA_074390 ACLA_087030
NFI: NFIA_059700 NFIA_077930 NFIA_090670
AOR: AO090009000092 AO090012000287 AO090020000558 AO090103000206 AO090103000359 AO090701000415
ANG: ANI_1_1178074(An08g08480) ANI_1_1276074(An08g09360) ANI_1_2328074(An08g09340) ANI_1_438064(An07g03570) ANI_1_450094(An11g03260) ANI_1_736134(An15g05450)
AFV: AFLA_002003 AFLA_004926 AFLA_004930 AFLA_010099 AFLA_011270 AFLA_013173 AFLA_013316
PCS: Pc12g00830 Pc16g10970 Pc16g11010 Pc16g13310 Pc21g18520 Pc22g00670 Pc22g01350
PDP: PDIP_04500 PDIP_45660 PDIP_50980 PDIP_65860
TMF: PMAA_079570 PMAA_088200 PMAA_088300
TRG: TRUGW13939_00052 TRUGW13939_01338 TRUGW13939_01729 TRUGW13939_09110 TRUGW13939_09267 TRUGW13939_09270 TRUGW13939_10687
CIM: CIMG_06663
CPW: CPC735_031160
PBL: PAAG_04181
PBN: PADG_07435
URE: UREG_03776
ABE: ARB_02722
TVE: TRV_00610
AJE: HCAG_00626
BGH: BDBG_01254
PNO: SNOG_01607 SNOG_15488(AY788902)
PTE: PTT_06742 PTT_07726 PTT_09906
BZE: COCCADRAFT_108299 COCCADRAFT_26499 COCCADRAFT_32637 COCCADRAFT_36831
BSC: COCSADRAFT_142026 COCSADRAFT_32603 COCSADRAFT_34195 COCSADRAFT_41505
BOR: COCMIDRAFT_29087 COCMIDRAFT_31692 COCMIDRAFT_93520 COCMIDRAFT_97193
AALT: CC77DRAFT_1054735 CC77DRAFT_1091062 CC77DRAFT_931278 CC77DRAFT_935368 CC77DRAFT_942593 CC77DRAFT_964195
ZTR: MYCGRDRAFT_31902 MYCGRDRAFT_64923 MYCGRDRAFT_74599 MYCGRDRAFT_84831
PFJ: MYCFIDRAFT_209507 MYCFIDRAFT_211363 MYCFIDRAFT_38554 MYCFIDRAFT_71664
BCOM: BAUCODRAFT_29448 BAUCODRAFT_64133 BAUCODRAFT_74440
NPA: UCRNP2_3500 UCRNP2_5371
TML: GSTUM_00000686001 GSTUM_00002833001
SPO: SPAC22A12.17c SPAC8E11.10 SPCC1739.08c
CNE: CNH02950 CNK02860 CNL05930
CNB: CNBI0900 CNBK0650 CNBL3020
CGI: CGB_D1070C CGB_K0731C CGB_L3660C
TASA: A1Q1_04349 A1Q1_05496
PSQ: PUNSTDRAFT_83219
FME: FOMMEDRAFT_123887
GTR: GLOTRDRAFT_108403 GLOTRDRAFT_133516
LBC: LACBIDRAFT_256071
CCI: CC1G_15600
ABP: AGABI1DRAFT114569(AGABI1DRAFT_114569)
ABV: AGABI2DRAFT194752(AGABI2DRAFT_194752)
CPUT: CONPUDRAFT_138022
SLA: SERLADRAFT_436806 SERLADRAFT_457635(oxr1)
WSE: WALSEDRAFT_31566 WALSEDRAFT_32727 WALSEDRAFT_63204
WIC: J056_002472 J056_003684 J056_004249
UMA: UMAG_05252 UMAG_10938
PFP: PFL1_02969 PFL1_04231 PFL1_04817
MGL: MGL_3023
MRT: MRET_3631
MSYM: MSY001_1257
PGR: PGTG_01366 PGTG_16113
MLR: MELLADRAFT_55312 MELLADRAFT_77343
GOX: GOX1432
GOH: B932_1684
GOY: GLS_c15490
GAL: A0U94_10565
GTI: FXF46_02985
GSP: IGS75_08345
GDI: GDI0886(mtlK)
GDJ: Gdia_1133
GXY: GLX_20590
GXL: H845_2922
KNA: B0W47_08225
KEU: S101446_02540
KSC: CD178_00846(por_1)
KRE: GWK63_01240
KHA: IFJ82_15285
AACE: A0U92_16660
ABG: Asbog_02764
KBA: A0U89_13385
NCH: A0U93_13575
NTN: D5366_09545
SSAM: E3D00_06230
EBLA: JGUZn3_11270(por)
SPSY: AZE41_19100
NTR: B0W44_16760
KEB: GXN75_05805
CAPR: EQM14_03885
BPRO: PMF13cell1_02465(fabG_4)
MTV: RVBD_1928c
MTF: TBFG_11957
MTB: TBMG_02064
MTK: TBSG_02074
MTZ: TBXG_002046
MTG: MRGA327_11885
MTI: MRGA423_12005
MTE: CCDC5079_1783
MTUR: CFBS_2025
MTL: CCDC5180_1759
MTO: MTCTRI2_1961
MTD: UDA_1928c
MTJ: J112_10275
MTUE: J114_10280
MTX: M943_10015
MTUT: HKBT1_2022
MTUU: HKBT2_2023
MTQ: HKBS1_2026
MBO: BQ2027_MB1963C
MBT: JTY_1951
MBM: BCGMEX_1948c
MBK: K60_020200
MBX: BCGT_1759
MAF: MAF_19510
MMIC: RN08_2143
MCE: MCAN_19451
MCQ: BN44_40198
MCV: BN43_31078
MAO: MAP4_2189
MAVI: RC58_10895
MAVU: RE97_10905
MIT: OCO_26060
MIA: OCU_25920
MID: MIP_03640
MYO: OEM_24550
MCHI: AN480_13735
MIR: OCQ_24640
MMAL: CKJ54_11785
MMI: MMAR_2849
MMAE: MMARE11_27690
MMM: W7S_12655
MLI: MULP_02613
MHAD: B586_11245
MSHG: MSG_02718
MFJ: MFLOJ_04950
MSTO: MSTO_06290
MPAG: C0J29_16340
MBAI: MB901379_02635(gno)
MSEO: MSEO_15590
MALK: MalAC0309_0361
BADL: BADO_0956
BADO: BBMN23_1035
BKS: BBKW_1136
BCAT: BBCT_1008
BPSC: BBPC_1010
BSCA: BBSC_1118
BLEM: BL8807_01055
BEU: BE0216_10400
ABAO: BEQ56_02015
TAZ: TREAZ_3467
TPI: TREPR_0133
BPO: BP951000_2320
BPJ: B2904_orf1255(sou1)
BPIP: BPP43_03215
 » show all
Reference
1  [PMID:16134116]
  Authors
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E
  Title
Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:957-69 (2005)
DOI:10.1002/yea.1282
  Sequence
Reference
2
  Authors
Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.
  Title
Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:1171 (2005)
Reference
3
  Authors
Sugisawa, T., Hoshino, T. and Fujiwara, A.
  Title
Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.
  Journal
Agric Biol Chem 55:2043-2049 (1991)
Reference
4  [PMID:11790761]
  Authors
Shinjoh M, Tazoe M, Hoshino T
  Title
NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.
  Journal
J Bacteriol 184:861-3 (2002)
DOI:10.1128/JB.184.3.861-863.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.289
IUBMB Enzyme Nomenclature: 1.1.1.289
ExPASy - ENZYME nomenclature database: 1.1.1.289
BRENDA, the Enzyme Database: 1.1.1.289
CAS: 138440-90-1

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
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Gene (737)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (421)   
   KEGG MGENES (40)   
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Protein sequence (53)   
   UniProt (30)   
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   GenBank (5)   
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3D Structure (3)   
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