KEGG   ENZYME: 1.1.1.289
Entry
EC 1.1.1.289                Enzyme                                 
Name
sorbose reductase;
Sou1p
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]
Reaction(KEGG)
R07346
Substrate
D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]
Product
L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
History
EC 1.1.1.289 created 2006
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K17742  sorbose reductase
K19633  sorbose reductase
Genes
QSU111983853 111993541 111994894 112002464 112003553 112032708 112033672
KLAKLLA0_E22397g KLLA0_E24003g
KMXKLMA_10715(SOU2) KLMA_10783(SOU1)
LTHKLTH0E13134g KLTH0F18062g KLTH0H14564g
ZROZYRO0A11902g ZYRO0G22440g
TDLTDEL_0B02360(TDEL0B02360) TDEL_0H00150(TDEL0H00150) TDEL_0H04540(TDEL0H04540)
TGBHG536_0F00190 HG536_0H02380
ZMKHG535_0F05860
PPAPAS_chr4_0754 PAS_chr4_0988
DHADEHA2A12386g DEHA2A14322g DEHA2A14344g DEHA2E08910g DEHA2E24244g DEHA2F00990g
PICPICST_38255(SOU1)
PGUPGUG_05385 PGUG_05388 PGUG_05464 PGUG_05466
SPAASPAPADRAFT_148284 SPAPADRAFT_58963 SPAPADRAFT_60851 SPAPADRAFT_61649 SPAPADRAFT_62532
LELLELG_03159 LELG_05725 LELG_05727
CALCAALFM_C406380WA(SOU2) CAALFM_C406390WA(SOU1) CAALFM_CR07170WA(CaO19.732)
CTPCTRG_03131 CTRG_03800 CTRG_03801
COTCORT_0B01330 CORT_0D05940
CDUCD36_32760 CD36_45870(SOU2) CD36_45880(SOU1)
CTENCANTEDRAFT_102630 CANTEDRAFT_103164 CANTEDRAFT_112997 CANTEDRAFT_113000 CANTEDRAFT_113822 CANTEDRAFT_119297 CANTEDRAFT_119904
YLIYALI0B16192g YALI0D18964g YALI0E05643g
CLUCLUG_03390 CLUG_03744
CLUSA9F13_01g04004 A9F13_01g07997
CAURCJI97_001279 CJI97_002470 CJI97_003341 CJI97_003343
SLBAWJ20_2382(SPS19) AWJ20_3417(SPS19)
PKZC5L36_0A13160
BNNFOA43_003778
BBRXBRETT_004557
OPAHPODL_00132 HPODL_00133 HPODL_00159 HPODL_00206 HPODL_02372 HPODL_03552 HPODL_04542
SLUDSCDLUD_005287
NCRNCU03803 NCU09041
NTENEUTE1DRAFT115988(NEUTE1DRAFT_115988) NEUTE1DRAFT117650(NEUTE1DRAFT_117650)
SMPSMAC_02649 SMAC_05842
PANPODANSg2618 PODANSg9038
TTTTHITE_2108357
MTMMYCTH_2302150
CTHRCTHT_0067490
MGRMGG_07455
PPEIPpBr36_02364
TMNUCRPA7_3047 UCRPA7_3397 UCRPA7_6054 UCRPA7_6057 UCRPA7_7028 UCRPA7_8020
SSCKSPSK_07897 SPSK_10284
FGRFGSG_04248 FGSG_04826 FGSG_06104 FGSG_10025
FPUFPSE_04052(MTDH1) FPSE_04260 FPSE_04546 FPSE_08740
FVRFVEG_02746 FVEG_03510 FVEG_04737 FVEG_10438 FVEG_13843
FOXFOXG_05383 FOXG_05657 FOXG_07815 FOXG_11379 FOXG_13570
NHENECHADRAFT_105339 NECHADRAFT_37143 NECHADRAFT_42050 NECHADRAFT_42069 NECHADRAFT_63861 NECHADRAFT_69214 NECHADRAFT_81004 NECHADRAFT_85474
TRETRIREDRAFT_54086 TRIREDRAFT_60033 TRIREDRAFT_69840 TRIREDRAFT_74194(lxr1)
TRRM419DRAFT_121678 M419DRAFT_134365 M419DRAFT_34830 M419DRAFT_4602
MAWMAC_06617 MAC_08952
MAJMAA_01627 MAA_08417 MAA_09034
CMTCCM_06357 CCM_07859 CCM_08784 CCM_09007
PLJVFPFJ_06456 VFPFJ_06521 VFPFJ_08088 VFPFJ_11024
VALVDBG_02657
VDAVDAG_03582
CFJCFIO01_06096 CFIO01_06114 CFIO01_09197 CFIO01_10017 CFIO01_10020 CFIO01_11827 CFIO01_13671
CHIGCH63R_03138 CH63R_04126 CH63R_11374
SAPOSAPIO_CDS7997
ELAUCREL1_1116 UCREL1_4732 UCREL1_5183 UCREL1_7416 UCREL1_8867
PFYPFICI_04519 PFICI_05410 PFICI_05413 PFICI_06515 PFICI_07972 PFICI_10486 PFICI_10609 PFICI_11801 PFICI_14636
SSLSS1G_01500 SS1G_08799 SS1G_09310
BFUBCIN_02g00470 BCIN_06g04730 BCIN_13g04760 BCIN_16g03380
MBEMBM_02748 MBM_04022
PSCOLY89DRAFT_582420 LY89DRAFT_595817 LY89DRAFT_656415 LY89DRAFT_656420 LY89DRAFT_677887 LY89DRAFT_717013 LY89DRAFT_781929
GLZGLAREA_05217 GLAREA_06523 GLAREA_06706 GLAREA_08131
ANIAN5547.2 AN7590.2 AN8113.2 AN8819.2
AFMAFUA_2G15430 AFUA_5G09400 AFUA_6G13830
ACTACLA_011160 ACLA_074390 ACLA_087030
NFINFIA_059700 NFIA_077930 NFIA_090670
AORAO090009000092 AO090012000287 AO090020000558 AO090103000206 AO090103000359 AO090701000415
ANGANI_1_1178074(An08g08480) ANI_1_1276074(An08g09360) ANI_1_2328074(An08g09340) ANI_1_438064(An07g03570) ANI_1_450094(An11g03260) ANI_1_736134(An15g05450)
AFVAFLA_002003 AFLA_004926 AFLA_004930 AFLA_010099 AFLA_011270 AFLA_013173 AFLA_013316
ALUCAKAW2_11826S(LXR3) AKAW2_51678S AKAW2_60217S(LXR1) AKAW2_80300S
ACHEACHE_10084A ACHE_10087S ACHE_11906S ACHE_31392S ACHE_50422S ACHE_50426S ACHE_50429A(LXR1_1) ACHE_50556S(LXR1_2) ACHE_50561S ACHE_50662S ACHE_50760S
APUUAPUU_10973S APUU_12355S(SOU1) APUU_20144S APUU_40897A APUU_60796S APUU_60913A APUU_60916A APUU_80356S(LXR1)
PCSPc12g00830 Pc16g10970 Pc16g11010 Pc16g13310 Pc21g18520 Pc22g00670 Pc22g01350
PDPPDIP_04500 PDIP_45660 PDIP_50980 PDIP_65860
TMFPMAA_079570 PMAA_088200 PMAA_088300
TRGTRUGW13939_00052 TRUGW13939_01338 TRUGW13939_01729 TRUGW13939_09110 TRUGW13939_09267 TRUGW13939_09270 TRUGW13939_10687
CIMCIMG_06663
CPWCPC735_031160
UREUREG_03776
PBLPAAG_04181
PBNPADG_07435
ABEARB_02722
TVETRV_00610
AJEHCAG_00626
BGHBDBG_01254
PNOSNOG_01607 SNOG_15488(AY788902)
PTEPTT_06742 PTT_07726 PTT_09906
BZECOCCADRAFT_108299 COCCADRAFT_26499 COCCADRAFT_32637 COCCADRAFT_36831
BSCCOCSADRAFT_142026 COCSADRAFT_32603 COCSADRAFT_34195 COCSADRAFT_41505
BORCOCMIDRAFT_29087 COCMIDRAFT_31692 COCMIDRAFT_93520 COCMIDRAFT_97193
AALTCC77DRAFT_1054735 CC77DRAFT_1091062 CC77DRAFT_931278 CC77DRAFT_935368 CC77DRAFT_942593 CC77DRAFT_964195
ZTRMYCGRDRAFT_31902 MYCGRDRAFT_64923 MYCGRDRAFT_74599 MYCGRDRAFT_84831
PFJMYCFIDRAFT_209507 MYCFIDRAFT_211363 MYCFIDRAFT_38554 MYCFIDRAFT_71664
FFUCLAFUR5_04588 CLAFUR5_07014 CLAFUR5_09329
BCOMBAUCODRAFT_29448 BAUCODRAFT_64133 BAUCODRAFT_74440
NPAUCRNP2_3500 UCRNP2_5371
TMLGSTUM_00000686001 GSTUM_00002833001
SPOSPAC22A12.17c SPAC8E11.10 SPCC1739.08c
CNECNH02950 CNK02860 CNL05930
CNBCNBI0900 CNBK0650 CNBL3020
CNGCNAG_01947 CNAG_05024 CNAG_05657 CNAG_06978
CGICGB_D1070C CGB_K0731C CGB_L3660C
TASAA1Q1_04349 A1Q1_05496
PSQPUNSTDRAFT_83219
FMEFOMMEDRAFT_123887
GTRGLOTRDRAFT_108403 GLOTRDRAFT_133516
LBCLACBIDRAFT_256071
CCICC1G_15600
ABPAGABI1DRAFT114569(AGABI1DRAFT_114569)
ABVAGABI2DRAFT194752(AGABI2DRAFT_194752)
CPUTCONPUDRAFT_138022
SLASERLADRAFT_436806 SERLADRAFT_457635(oxr1)
WSEWALSEDRAFT_31566 WALSEDRAFT_32727 WALSEDRAFT_63204
WICJ056_002472 J056_003684 J056_004249
UMAUMAG_05252 UMAG_10938
PFPPFL1_02969 PFL1_04231 PFL1_04817
MGLMGL_3023
MRTMRET_3631
MSYMMSY001_1257
PGRPGTG_01366 PGTG_16113
MLRMELLADRAFT_55312 MELLADRAFT_77343
LIZLGH83_17090
GOXGOX1432
GOHB932_1684
GOYGLS_c15490
GALA0U94_10565
GTIFXF46_02985
GSPIGS75_08345
GFAMKW11_02970
GDIGDI0886(mtlK)
GDJGdia_1133
GXYGLX_20590
GXLH845_2922
KNAB0W47_08225
KEUS101446_02540
KSCCD178_00846(por_1)
KREGWK63_01240
AACEA0U92_16660
ABGAsbog_02764
KBAA0U89_13385
NCHA0U93_13575
NTND5366_09545
SSAME3D00_06230
EBLAJGUZn3_11270(por)
KHAIFJ82_15285
PARZDTQ13_03645
SPSYAZE41_19100
NTRB0W44_16760
KEBGXN75_05805
CAPREQM14_03885
BPROPMF13cell1_02465(fabG_4)
MTVRVBD_1928c
MTFTBFG_11957
MTBTBMG_02064
MTKTBSG_02074
MTZTBXG_002046
MTGMRGA327_11885
MTIMRGA423_12005
MTECCDC5079_1783
MTURCFBS_2025
MTLCCDC5180_1759
MTOMTCTRI2_1961
MTDUDA_1928c
MTJJ112_10275
MTUEJ114_10280
MTXM943_10015
MTUTHKBT1_2022
MTUUHKBT2_2023
MTQHKBS1_2026
MBOBQ2027_MB1963C
MBTJTY_1951
MBMBCGMEX_1948c
MBKK60_020200
MBXBCGT_1759
MAFMAF_19510
MMICRN08_2143
MCEMCAN_19451
MCQBN44_40198
MCVBN43_31078
MAOMAP4_2189
MAVIRC58_10895
MAVURE97_10905
MITOCO_26060
MIAOCU_25920
MIDMIP_03640
MYOOEM_24550
MCHIAN480_13735
MIROCQ_24640
MMALCKJ54_11785
MMANMMAN_12980
MMIMMAR_2849
MMAEMMARE11_27690
MMMW7S_12655
MLIMULP_02613
MHADB586_11245
MSHGMSG_02718
MFJMFLOJ_04950
MSTOMSTO_06290
MSIMMSIM_50320
MSAKMSAS_08190
MKUI2456_13950
MPAGC0J29_16340
MGORH0P51_15280
MBAIMB901379_02635(gno)
MSEOMSEO_15590
MPSEMPSD_29380
MSHOMSHO_42610
MSPGF6B93_11755
MALKMalAC0309_0361
BADLBADO_0956
BADOBBMN23_1035
BKSBBKW_1136
BCATBBCT_1008
BPSCBBPC_1010
BSCABBSC_1118
BLEMBL8807_01055
BEUBE0216_10400
ABAOBEQ56_02015
TPITREPR_0133
TAZTREAZ_3467
BPOBP951000_2320
BPJB2904_orf1255(sou1)
BPIPBPP43_03215
 » show all
Reference
1  [PMID:16134116]
  Authors
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E
  Title
Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:957-69 (2005)
DOI:10.1002/yea.1282
  Sequence
Reference
2
  Authors
Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.
  Title
Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:1171 (2005)
Reference
3
  Authors
Sugisawa, T., Hoshino, T. and Fujiwara, A.
  Title
Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.
  Journal
Agric Biol Chem 55:2043-2049 (1991)
Reference
4  [PMID:11790761]
  Authors
Shinjoh M, Tazoe M, Hoshino T
  Title
NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.
  Journal
J Bacteriol 184:861-3 (2002)
DOI:10.1128/JB.184.3.861-863.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.289
IUBMB Enzyme Nomenclature: 1.1.1.289
ExPASy - ENZYME nomenclature database: 1.1.1.289
BRENDA, the Enzyme Database: 1.1.1.289
CAS: 138440-90-1

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