KEGG   ENZYME: 1.1.1.289
Entry
EC 1.1.1.289                Enzyme                                 

Name
sorbose reductase;
Sou1p
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]
Reaction(KEGG)
R07346
Substrate
D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]
Product
L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
History
EC 1.1.1.289 created 2006
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K17742  sorbose reductase
K19633  sorbose reductase
Genes
QSU: 111983853 111993541 111994894 112002464 112003553 112014868 112032708 112033672
KLA: KLLA0_E22397g KLLA0_E24003g
KMX: KLMA_10715(SOU2) KLMA_10783(SOU1)
LTH: KLTH0E13134g KLTH0F18062g KLTH0H14564g
ZRO: ZYRO0A11902g ZYRO0G22440g
TDL: TDEL_0B02360(TDEL0B02360) TDEL_0H00150(TDEL0H00150) TDEL_0H04540(TDEL0H04540)
PPA: PAS_chr4_0754 PAS_chr4_0988
DHA: DEHA2A12386g DEHA2A14322g DEHA2A14344g DEHA2E08910g DEHA2E24244g DEHA2F00990g
PIC: PICST_38255(SOU1)
PGU: PGUG_05385 PGUG_05388 PGUG_05464 PGUG_05466
CDU: CD36_32760 CD36_45870(SOU2) CD36_45880(SOU1)
SLB: AWJ20_2382(SPS19) AWJ20_3417(SPS19)
NTE: NEUTE1DRAFT115988(NEUTE1DRAFT_115988) NEUTE1DRAFT117650(NEUTE1DRAFT_117650)
MGR: MGG_07455
ANG: ANI_1_1178074(An08g08480) ANI_1_1276074(An08g09360) ANI_1_2328074(An08g09340) ANI_1_438064(An07g03570) ANI_1_450094(An11g03260) ANI_1_736134(An15g05450)
ABE: ARB_02722
TVE: TRV_00610
PNO: SNOG_01607 SNOG_15488(AY788902)
ABP: AGABI1DRAFT114569(AGABI1DRAFT_114569)
ABV: AGABI2DRAFT194752(AGABI2DRAFT_194752)
MGL: MGL_3023
MRT: MRET_3631
GOX: GOX1432
GOH: B932_1684
GDI: GDI0886(mtlK)
GDJ: Gdia_1133
GXY: GLX_20590
GXL: H845_2922
KSC: CD178_00846(por_1)
BPRO: PMF13cell1_02465(fabG_4)
MTUR: CFBS_2025
MTD: UDA_1928c
MTUE: J114_10280
MTUT: HKBT1_2022
MTUU: HKBT2_2023
MBT: JTY_1951
MBX: BCGT_1759
MAF: MAF_19510
MMIC: RN08_2143
MAO: MAP4_2189
MAVI: RC58_10895
MAVU: RE97_10905
MIT: OCO_26060
MIA: OCU_25920
MID: MIP_03640
MYO: OEM_24550
MIR: OCQ_24640
MMI: MMAR_2849
MMM: W7S_12655
MHAD: B586_11245
MSHG: MSG_02718
BADL: BADO_0956
BKS: BBKW_1136
BCAT: BBCT_1008
BPSC: BBPC_1010
BSCA: BBSC_1118
BPJ: B2904_orf1255(sou1)
 » show all
Reference
1  [PMID:16134116]
  Authors
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E
  Title
Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:957-69 (2005)
DOI:10.1002/yea.1282
  Sequence
Reference
2
  Authors
Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.
  Title
Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:1171 (2005)
Reference
3
  Authors
Sugisawa, T., Hoshino, T. and Fujiwara, A.
  Title
Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.
  Journal
Agric Biol Chem 55:2043-2049 (1991)
Reference
4  [PMID:11790761]
  Authors
Shinjoh M, Tazoe M, Hoshino T
  Title
NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.
  Journal
J Bacteriol 184:861-3 (2002)
DOI:10.1128/JB.184.3.861-863.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.289
IUBMB Enzyme Nomenclature: 1.1.1.289
ExPASy - ENZYME nomenclature database: 1.1.1.289
BRENDA, the Enzyme Database: 1.1.1.289
CAS: 138440-90-1

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