KEGG   ENZYME: 1.1.1.289
Entry
EC 1.1.1.289                Enzyme                                 

Name
sorbose reductase;
Sou1p
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]
Reaction(KEGG)
R07346
Substrate
D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]
Product
L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
History
EC 1.1.1.289 created 2006
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K17742  sorbose reductase
K19633  sorbose reductase
Genes
QSU: 111983853 111993541 111994894 112002464 112003553 112014868 112032708 112033672
KLA: KLLA0_E22397g KLLA0_E24003g
KMX: KLMA_10715(SOU2) KLMA_10783(SOU1)
LTH: KLTH0E13134g KLTH0F18062g KLTH0H14564g
ZRO: ZYRO0A11902g ZYRO0G22440g
TDL: TDEL_0B02360(TDEL0B02360) TDEL_0H00150(TDEL0H00150) TDEL_0H04540(TDEL0H04540)
PPA: PAS_chr4_0754 PAS_chr4_0988
DHA: DEHA2A12386g DEHA2A14322g DEHA2A14344g DEHA2E08910g DEHA2E24244g DEHA2F00990g
PIC: PICST_38255(SOU1)
PGU: PGUG_05385 PGUG_05388 PGUG_05464 PGUG_05466
SPAA: SPAPADRAFT_148284 SPAPADRAFT_58963 SPAPADRAFT_60851 SPAPADRAFT_61649 SPAPADRAFT_62532
LEL: LELG_03159 LELG_05725 LELG_05727
CAL: CAALFM_C406380WA(SOU2) CAALFM_C406390WA(SOU1) CAALFM_CR07170WA(CaO19.732)
CTP: CTRG_03131 CTRG_03800 CTRG_03801
COT: CORT_0B01330 CORT_0D05940
CDU: CD36_32760 CD36_45870(SOU2) CD36_45880(SOU1)
CTEN: CANTEDRAFT_102630 CANTEDRAFT_103164 CANTEDRAFT_112997 CANTEDRAFT_113000 CANTEDRAFT_113822 CANTEDRAFT_119297 CANTEDRAFT_119904
YLI: YALI0B16192g YALI0D18964g YALI0E05643g
CLU: CLUG_03390 CLUG_03744
CLUS: A9F13_01g04004 A9F13_01g07997
CAUR: CJI97_001279 CJI97_002470 CJI97_003341 CJI97_003343
SLB: AWJ20_2382(SPS19) AWJ20_3417(SPS19)
PKZ: C5L36_0A13160
NCR: NCU03803 NCU09041
NTE: NEUTE1DRAFT115988(NEUTE1DRAFT_115988) NEUTE1DRAFT117650(NEUTE1DRAFT_117650)
SMP: SMAC_02649 SMAC_05842
PAN: PODANSg2618 PODANSg9038
TTT: THITE_2108357
MTM: MYCTH_2302150
CTHR: CTHT_0067490
MGR: MGG_07455
TMN: UCRPA7_3047 UCRPA7_3397 UCRPA7_6054 UCRPA7_6057 UCRPA7_7028 UCRPA7_8020
SSCK: SPSK_07897 SPSK_10284
FGR: FGSG_04248 FGSG_04826 FGSG_06104 FGSG_10025
FPU: FPSE_04052(MTDH1) FPSE_04260 FPSE_04546 FPSE_08740
FVR: FVEG_02746 FVEG_03510 FVEG_04737 FVEG_10438 FVEG_13843
FOX: FOXG_05383 FOXG_05657 FOXG_07815 FOXG_11379 FOXG_13570
NHE: NECHADRAFT_105339 NECHADRAFT_37143 NECHADRAFT_42050 NECHADRAFT_42069 NECHADRAFT_63861 NECHADRAFT_69214 NECHADRAFT_81004 NECHADRAFT_85474
TRE: TRIREDRAFT_54086 TRIREDRAFT_60033 TRIREDRAFT_69840 TRIREDRAFT_74194(lxr1)
TRR: M419DRAFT_121678 M419DRAFT_134365 M419DRAFT_34830 M419DRAFT_4602
MAW: MAC_06617 MAC_08952
MAJ: MAA_01627 MAA_08417 MAA_09034
CMT: CCM_06357 CCM_07859 CCM_08784 CCM_09007
PLJ: VFPFJ_06456 VFPFJ_06521 VFPFJ_08088 VFPFJ_11024
VAL: VDBG_02657
VDA: VDAG_03582
CFJ: CFIO01_06096 CFIO01_06114 CFIO01_09197 CFIO01_10017 CFIO01_10020 CFIO01_11827 CFIO01_13671
SAPO: SAPIO_CDS7997
ELA: UCREL1_1116 UCREL1_4732 UCREL1_5183 UCREL1_7416 UCREL1_8867
PFY: PFICI_04519 PFICI_05410 PFICI_05413 PFICI_06515 PFICI_07972 PFICI_10486 PFICI_10609 PFICI_11801 PFICI_14636
SSL: SS1G_01500 SS1G_08799 SS1G_09310
BFU: BCIN_02g00470 BCIN_06g04730 BCIN_13g04760 BCIN_16g03380
MBE: MBM_02748 MBM_04022
PSCO: LY89DRAFT_582420 LY89DRAFT_595817 LY89DRAFT_656415 LY89DRAFT_656420 LY89DRAFT_677887 LY89DRAFT_717013 LY89DRAFT_781929
GLZ: GLAREA_05217 GLAREA_06523 GLAREA_06706 GLAREA_08131
ANI: AN8113.2 AN8819.2
AFM: AFUA_2G15430 AFUA_5G09400 AFUA_6G13830
ACT: ACLA_011160 ACLA_074390 ACLA_087030
NFI: NFIA_059700 NFIA_077930 NFIA_090670
AOR: AO090009000092 AO090012000287 AO090020000558 AO090103000206 AO090103000359 AO090701000415
ANG: ANI_1_1178074(An08g08480) ANI_1_1276074(An08g09360) ANI_1_2328074(An08g09340) ANI_1_438064(An07g03570) ANI_1_450094(An11g03260) ANI_1_736134(An15g05450)
AFV: AFLA_008740 AFLA_010170 AFLA_015580 AFLA_053630 AFLA_058700 AFLA_058740 AFLA_098700
PCS: Pc12g00830 Pc16g10970 Pc16g11010 Pc16g13310 Pc21g18520 Pc22g00670 Pc22g01350
PDP: PDIP_04500 PDIP_45660 PDIP_50980 PDIP_65860
TMF: PMAA_079570 PMAA_088200 PMAA_088300
TRG: TRUGW13939_00052 TRUGW13939_01338 TRUGW13939_01729 TRUGW13939_09110 TRUGW13939_09267 TRUGW13939_09270 TRUGW13939_10687
CIM: CIMG_06663
CPW: CPC735_031160
PBL: PAAG_04181
PBN: PADG_07435
URE: UREG_03776
ABE: ARB_02722
TVE: TRV_00610
AJE: HCAG_00626
BGH: BDBG_01254
PNO: SNOG_01607 SNOG_15488(AY788902)
PTE: PTT_06742 PTT_07726 PTT_09906
BZE: COCCADRAFT_108299 COCCADRAFT_26499 COCCADRAFT_32637 COCCADRAFT_36831
BSC: COCSADRAFT_142026 COCSADRAFT_32603 COCSADRAFT_34195 COCSADRAFT_41505
BOR: COCMIDRAFT_29087 COCMIDRAFT_31692 COCMIDRAFT_93520 COCMIDRAFT_97193
AALT: CC77DRAFT_1054735 CC77DRAFT_1091062 CC77DRAFT_931278 CC77DRAFT_935368 CC77DRAFT_942593 CC77DRAFT_964195
ZTR: MYCGRDRAFT_31902 MYCGRDRAFT_64923 MYCGRDRAFT_74599 MYCGRDRAFT_84831
PFJ: MYCFIDRAFT_209507 MYCFIDRAFT_211363 MYCFIDRAFT_38554 MYCFIDRAFT_71664
BCOM: BAUCODRAFT_29448 BAUCODRAFT_64133 BAUCODRAFT_74440
NPA: UCRNP2_3500 UCRNP2_5371
TML: GSTUM_00000686001 GSTUM_00002833001
SPO: SPAC22A12.17c SPAC8E11.10 SPCC1739.08c
CNE: CNH02950 CNK02860 CNL05930
CNB: CNBI0900 CNBK0650 CNBL3020
CGI: CGB_D1070C CGB_K0731C CGB_L3660C
TASA: A1Q1_04349 A1Q1_05496
PSQ: PUNSTDRAFT_83219
FME: FOMMEDRAFT_123887
GTR: GLOTRDRAFT_108403 GLOTRDRAFT_133516
LBC: LACBIDRAFT_256071
CCI: CC1G_15600
ABP: AGABI1DRAFT114569(AGABI1DRAFT_114569)
ABV: AGABI2DRAFT194752(AGABI2DRAFT_194752)
CPUT: CONPUDRAFT_138022
SLA: SERLADRAFT_436806 SERLADRAFT_457635(oxr1)
WSE: WALSEDRAFT_31566 WALSEDRAFT_32727 WALSEDRAFT_63204
WIC: J056_002472 J056_003684 J056_004249
UMA: UMAG_05252 UMAG_10938
PFP: PFL1_02969 PFL1_04231 PFL1_04817
MGL: MGL_3023
MRT: MRET_3631
MSYM: MSY001_1257
PGR: PGTG_01366 PGTG_16113
MLR: MELLADRAFT_55312 MELLADRAFT_77343
GOX: GOX1432
GOH: B932_1684
GOY: GLS_c15490
GAL: A0U94_10565
GTI: FXF46_02985
GDI: GDI0886(mtlK)
GDJ: Gdia_1133
GXY: GLX_20590
GXL: H845_2922
KNA: B0W47_08225
KEU: S101446_02540
KSC: CD178_00846(por_1)
KRE: GWK63_01240
AACE: A0U92_16660
ABG: Asbog_02764
KBA: A0U89_13385
NCH: A0U93_13575
NTN: D5366_09545
SSAM: E3D00_06230
SPSY: AZE41_19100
NTR: B0W44_16760
KEB: GXN75_05805
CAPR: EQM14_03885
BPRO: PMF13cell1_02465(fabG_4)
MTV: RVBD_1928c
MTF: TBFG_11957
MTB: TBMG_02064
MTK: TBSG_02074
MTZ: TBXG_002046
MTG: MRGA327_11885
MTI: MRGA423_12005
MTE: CCDC5079_1783
MTUR: CFBS_2025
MTL: CCDC5180_1759
MTO: MTCTRI2_1961
MTD: UDA_1928c
MTJ: J112_10275
MTUE: J114_10280
MTX: M943_10015
MTUT: HKBT1_2022
MTUU: HKBT2_2023
MTQ: HKBS1_2026
MBO: BQ2027_MB1963C
MBT: JTY_1951
MBM: BCGMEX_1948c
MBK: K60_020200
MBX: BCGT_1759
MAF: MAF_19510
MMIC: RN08_2143
MCE: MCAN_19451
MCQ: BN44_40198
MCV: BN43_31078
MAO: MAP4_2189
MAVI: RC58_10895
MAVU: RE97_10905
MIT: OCO_26060
MIA: OCU_25920
MID: MIP_03640
MYO: OEM_24550
MIR: OCQ_24640
MCHI: AN480_13735
MMAL: CKJ54_11785
MMI: MMAR_2849
MMAE: MMARE11_27690
MMM: W7S_12655
MLI: MULP_02613
MHAD: B586_11245
MSHG: MSG_02718
MFJ: MFLOJ_04950
MPAG: C0J29_16340
MALK: MalAC0309_0361
BADL: BADO_0956
BADO: BBMN23_1035
BKS: BBKW_1136
BCAT: BBCT_1008
BPSC: BBPC_1010
BSCA: BBSC_1118
BLEM: BL8807_01055
ABAO: BEQ56_02015
TAZ: TREAZ_3467
TPI: TREPR_0133
BPO: BP951000_2320
BPJ: B2904_orf1255(sou1)
BPIP: BPP43_03215
 » show all
Reference
1  [PMID:16134116]
  Authors
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E
  Title
Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:957-69 (2005)
DOI:10.1002/yea.1282
  Sequence
Reference
2
  Authors
Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.
  Title
Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:1171 (2005)
Reference
3
  Authors
Sugisawa, T., Hoshino, T. and Fujiwara, A.
  Title
Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.
  Journal
Agric Biol Chem 55:2043-2049 (1991)
Reference
4  [PMID:11790761]
  Authors
Shinjoh M, Tazoe M, Hoshino T
  Title
NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.
  Journal
J Bacteriol 184:861-3 (2002)
DOI:10.1128/JB.184.3.861-863.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.289
IUBMB Enzyme Nomenclature: 1.1.1.289
ExPASy - ENZYME nomenclature database: 1.1.1.289
BRENDA, the Enzyme Database: 1.1.1.289
CAS: 138440-90-1

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (724)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (403)   
   KEGG MGENES (45)   
   RefGene (274)   
Protein sequence (51)   
   UniProt (28)   
   SWISS-PROT (2)   
   RefSeq(pep) (7)   
   PDBSTR (14)   
DNA sequence (22)   
   RefSeq(nuc) (14)   
   GenBank (5)   
   EMBL (3)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   InterPro (2)   
All databases (813)   

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