KEGG   ENZYME: 1.1.1.289Help
Entry
EC 1.1.1.289                Enzyme                                 

Name
sorbose reductase;
Sou1p
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]
Reaction(KEGG)
Substrate
D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]
Product
L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
History
EC 1.1.1.289 created 2006
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K17742  sorbose reductase
K19633  sorbose reductase
Genes
QSU: 111983853 111994894 112002464 112003553 112032708 112033672
KLA: KLLA0_E22397g KLLA0_E24003g
KMX: KLMA_10715(SOU2) KLMA_10783(SOU1)
LTH: KLTH0E13134g KLTH0F18062g KLTH0H14564g
ZRO: ZYRO0A11902g ZYRO0G22440g
TDL: TDEL_0B02360(TDEL0B02360) TDEL_0H00150(TDEL0H00150) TDEL_0H04540(TDEL0H04540)
PPA: PAS_chr4_0754
DHA: DEHA2E08910g
PIC: PICST_38255(SOU1)
PGU: PGUG_05385 PGUG_05388 PGUG_05464 PGUG_05466
SPAA: SPAPADRAFT_148284 SPAPADRAFT_58963 SPAPADRAFT_60851 SPAPADRAFT_61649 SPAPADRAFT_62532
LEL: LELG_05725 LELG_05727
CAL: CAALFM_C406380WA(SOU2) CAALFM_C406390WA(SOU1) CAALFM_CR07170WA(CaO19.732)
CTP: CTRG_03131 CTRG_03800 CTRG_03801
COT: CORT_0B01330 CORT_0D05940
CDU: CD36_32760 CD36_45870(SOU2) CD36_45880(SOU1)
CTEN: CANTEDRAFT_102630 CANTEDRAFT_103164 CANTEDRAFT_112997 CANTEDRAFT_113000 CANTEDRAFT_113822 CANTEDRAFT_119297 CANTEDRAFT_119904
YLI: YALI0B16192g
CLU: CLUG_03390 CLUG_03744
CLUS: A9F13_01g04004 A9F13_01g07997
CAUR: CJI97_001279 CJI97_002470 CJI97_003341 CJI97_003343
SLB: AWJ20_3417(SPS19)
PKZ: C5L36_0A13160
NCR: NCU03803 NCU09041
NTE: NEUTE1DRAFT115988(NEUTE1DRAFT_115988) NEUTE1DRAFT117650(NEUTE1DRAFT_117650)
SMP: SMAC_02649 SMAC_05842
PAN: PODANSg2618 PODANSg9038
TTT: THITE_2108357
MTM: MYCTH_2302150
CTHR: CTHT_0067490
MGR: MGG_07455
TMN: UCRPA7_3047 UCRPA7_6054 UCRPA7_6057 UCRPA7_7028 UCRPA7_8020
SSCK: SPSK_07897 SPSK_10284
FGR: FGSG_04248 FGSG_04826 FGSG_06104 FGSG_10025
FPU: FPSE_04052(MTDH1) FPSE_04260 FPSE_04546 FPSE_08740
FVR: FVEG_02746 FVEG_03510 FVEG_04737 FVEG_10438 FVEG_13843
FOX: FOXG_05383 FOXG_05657 FOXG_07815 FOXG_11379 FOXG_13570
NHE: NECHADRAFT_105339 NECHADRAFT_37143 NECHADRAFT_42050 NECHADRAFT_42069 NECHADRAFT_63861 NECHADRAFT_69214 NECHADRAFT_81004 NECHADRAFT_85474
TRE: TRIREDRAFT_54086 TRIREDRAFT_60033 TRIREDRAFT_69840 TRIREDRAFT_74194(lxr1)
TRR: M419DRAFT_121678 M419DRAFT_134365 M419DRAFT_34830 M419DRAFT_4602
MAW: MAC_06617 MAC_08952
MAJ: MAA_01627 MAA_08417 MAA_09034
CMT: CCM_06357 CCM_07859 CCM_08784 CCM_09007
PLJ: VFPFJ_06456 VFPFJ_06521 VFPFJ_08088 VFPFJ_11024
VAL: VDBG_02657
VDA: VDAG_03582
CFJ: CFIO01_06096 CFIO01_06114 CFIO01_09197 CFIO01_10017 CFIO01_10020 CFIO01_11827 CFIO01_13671
ELA: UCREL1_4732 UCREL1_5183 UCREL1_7416 UCREL1_8867
PFY: PFICI_04519 PFICI_05410 PFICI_05413 PFICI_06515 PFICI_07972 PFICI_10486 PFICI_11801 PFICI_14636
SSL: SS1G_01500
BFU: BCIN_02g00470 BCIN_16g03380
MBE: MBM_02748 MBM_04022
PSCO: LY89DRAFT_595817 LY89DRAFT_656415 LY89DRAFT_656420 LY89DRAFT_781929
GLZ: GLAREA_05217 GLAREA_06523
ANI: AN8113.2 AN8819.2
AFM: AFUA_2G15430 AFUA_5G09400 AFUA_6G13830
AOR: AO090009000092 AO090012000287 AO090020000558 AO090103000206 AO090103000359
ANG: ANI_1_1178074(An08g08480) ANI_1_2328074(An08g09340) ANI_1_438064(An07g03570) ANI_1_736134(An15g05450)
AFV: AFLA_008740 AFLA_010170 AFLA_015580 AFLA_053630 AFLA_058700 AFLA_058740 AFLA_098700
ACT: ACLA_011160 ACLA_074390 ACLA_087030
NFI: NFIA_059700 NFIA_077930 NFIA_090670
PCS: Pc16g10970 Pc21g18520
PDP: PDIP_04500 PDIP_45660 PDIP_50980 PDIP_65860
CIM: CIMG_06663
CPW: CPC735_031160
PBL: PAAG_04181
PBN: PADG_07435
URE: UREG_03776
ABE: ARB_02722
TVE: TRV_00610
AJE: HCAG_00626
PNO: SNOG_01607 SNOG_15488(AY788902)
PTE: PTT_06742 PTT_07726
BZE: COCCADRAFT_26499 COCCADRAFT_32637 COCCADRAFT_36831
BSC: COCSADRAFT_32603 COCSADRAFT_34195 COCSADRAFT_41505
BOR: COCMIDRAFT_31692 COCMIDRAFT_93520 COCMIDRAFT_97193
AALT: CC77DRAFT_1054735 CC77DRAFT_1091062 CC77DRAFT_931278
ZTR: MYCGRDRAFT_31902 MYCGRDRAFT_64923 MYCGRDRAFT_74599 MYCGRDRAFT_84831
PFJ: MYCFIDRAFT_209507 MYCFIDRAFT_211363 MYCFIDRAFT_38554 MYCFIDRAFT_71664
BCOM: BAUCODRAFT_29448 BAUCODRAFT_64133 BAUCODRAFT_74440
NPA: UCRNP2_3500 UCRNP2_5371
TML: GSTUM_00000686001
SPO: SPAC22A12.17c SPAC8E11.10 SPCC1739.08c
CNE: CNL05930
CNB: CNBI0900
CGI: CGB_D1070C CGB_K0731C
PSQ: PUNSTDRAFT_83219
FME: FOMMEDRAFT_123887
GTR: GLOTRDRAFT_108403 GLOTRDRAFT_133516
LBC: LACBIDRAFT_256071
CCI: CC1G_15600
CPUT: CONPUDRAFT_138022
WSE: WALSEDRAFT_32727
WIC: J056_003684
UMA: UMAG_05252
PFP: PFL1_04231
MRT: MRET_3631
PGR: PGTG_16113
MLR: MELLADRAFT_77343
GOX: GOX1432
GOH: B932_1684
GOY: GLS_c15490
GAL: A0U94_10565
GTI: FXF46_02985
GDI: GDI0886(mtlK)
GDJ: Gdia_1133
GXY: GLX_20590
GXL: H845_2922
KNA: B0W47_08225
KEU: S101446_02540
KSC: CD178_00846(por_1)
AACE: A0U92_16660
ABG: Asbog_02764
KBA: A0U89_13385
NCH: A0U93_13575
NTN: D5366_09545
SSAM: E3D00_06230
 » show all
Taxonomy
Reference
1  [PMID:16134116]
  Authors
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E.
  Title
Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:957-69 (2005)
DOI:10.1002/yea.1282
  Sequence
Reference
2
  Authors
Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.
  Title
Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:1171 (2005)
Reference
3
  Authors
Sugisawa, T., Hoshino, T. and Fujiwara, A.
  Title
Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.
  Journal
Agric Biol Chem 55:2043-2049 (1991)
Reference
4  [PMID:11790761]
  Authors
Shinjoh M, Tazoe M, Hoshino T.
  Title
NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.
  Journal
J Bacteriol 184:861-3 (2002)
DOI:10.1128/JB.184.3.861-863.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.289
IUBMB Enzyme Nomenclature: 1.1.1.289
ExPASy - ENZYME nomenclature database: 1.1.1.289
BRENDA, the Enzyme Database: 1.1.1.289
CAS: 138440-90-1

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (548)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (266)   
   KEGG MGENES (6)   
   RefGene (274)   
Protein sequence (50)   
   UniProt (27)   
   SWISS-PROT (2)   
   RefSeq(pep) (7)   
   PDBSTR (14)   
DNA sequence (20)   
   RefSeq(nuc) (14)   
   GenBank (3)   
   EMBL (3)   
3D Structure (3)   
   PDB (3)   
All databases (632)   

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