KEGG   ENZYME: 1.1.1.292
Entry
EC 1.1.1.292                Enzyme                                 
Name
1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming);
1,5-anhydro-D-fructose reductase (ambiguous);
AFR (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
1,5-anhydro-D-mannitol:NADP+ oxidoreductase
Reaction(IUBMB)
1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+ [RN:R08194]
Reaction(KEGG)
R08194
Substrate
1,5-anhydro-D-mannitol [CPD:C16538];
NADP+ [CPD:C00006]
Product
1,5-anhydro-D-fructose [CPD:C06485];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme is present in some but not all Rhizobium species and belongs in the GFO/IDH/MocA protein family [2]. This enzyme differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro-D-mannitol, can be further metabolized to D-mannose [1]. The enzyme also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. It does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones [1].
History
EC 1.1.1.292 created 2007
Orthology
K19181  1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)
Genes
DJICH75_01615
DJAHY57_19505
DTXATSB10_21920
LRZBJI69_02960
LPYFIV34_16705
PFLPFL_3704
PPRCPFLCHA0_c37490(afr)
PPROPPC_3847
PFOPfl01_3165
PFCPflA506_2436
PPZH045_10685
PMANOU5_0029
PVRPverR02_17635
PAZOAYR47_19950
POIBOP93_14300
PFXA7318_14220
PLULFOB45_16230
PPUUPputUW4_02315
PSKU771_19130
PCHEY04_19105
PCPJM49_12120
PSOSPOS17_3866
PKRAYO71_14680
PFKPFAS1_23600
PANRA7J50_2502
PYMAK972_2343
PKEDLD99_16000
PGYAWU82_12370
PATAJWU58_15355
PDWBV82_3741
PZEHU754_017075
PMOEHV782_013200
PTZHU718_013435
PHVHU739_002260
PAZEKSS91_12680
PTKEXN22_18060
PIEHU724_012715
ABERBSR55_01160
CEBB0D95_09105
CELLCBR65_20555
CEKD0B88_17385
CEGD0C16_09610
MAGAMag101_17550
MHYDGTQ55_00230
MDHAYM39_20380
MKOMKLM6_4113
THIMKFB96_06480
MARSA8C75_09770
PHSC2L64_35315
PTERC2L65_31225
PCAFDSC91_001449
RHYRD110_02760
VEIVeis_3569
DELDelCs14_2523
DTSBI380_07350
DHKBO996_19295
DLAI6G47_02760
JALBZG29_17705
JSVCNX70_17885
JASFJQ89_07950
JLVG3257_18360
HEEhmeg3_14680
HHFE2K99_08090
LCHLcho_4310
RBNRBXJA2T_06530
MFBMFUL124B02_11535
CCXCOCOR_00217(afr)
SURSTAUR_3306
MBDMEBOL_002035
MRMA7982_02388
MLOmll6645 mlr3046
MLNA9174_09665
MOPMesop_1903
MAMMesau_01925
MAMOA6B35_28055
MESMEJ066_02260
MESPC1M53_18595
MHUAMCHK_4557
MJREB229_09830
MERDEB233_10040
AAKAA2016_0164 AA2016_1985
AMIHCO731_02111(afr_2)
PHTBLM14_17665
SMESMc04400(afr)
SMKSinme_3297
SMQSinmeB_3072
SMXSM11_chr3428(afr)
SMIBN406_03101(afr)
SMEGC770_GR4Chr3397
SMELSM2011_c04400(afr)
SMERDU99_17800
SMDSmed_3174
RHINGR_b16110 NGR_c33010
SFHSFHH103_01280 SFHH103_03458
SFDUSDA257_c58200(afr)
SIXBSY16_3752(afr) BSY16_5517
SAMESAMCFNEI73_Ch3678(afr) SAMCFNEI73_pC1472
SINOSS05631_c35520 SS05631_c37170
EADOV14_0832
EAHFA04_17520
ESJSJ05684_c33320
EAKEKH55_3235
EMXFKV68_20355
AVQHRR99_20200
RECRHECIAT_PC0000793
RHLLPU83_2038
RGARGR602_CH02580(afr)
RJGCCGE525_18655
RHRCKA34_28390
RGRFZ934_21800
ROYG3A56_23470
NGLRG1141_PA11210
SHZshn_15890 shn_29210
SZOK8M09_14315
SOJK6301_12410 K6301_19645
PDESFE840_019810
BMEBMEI0020
BMELDK63_1414(afr)
BMIBMEA_A2109
BMZBM28_A2034
BMGBM590_A2033
BMWBMNI_I1948
BMEEDK62_1534(afr)
BMFBAB1_2049
BMBBruAb1_2023
BMCBAbS19_I19190
BAABAA13334_I00717
BABODK55_1982(afr)
BABRDO74_1993(afr)
BABTDK49_1739(afr)
BABBDK48_137(afr)
BABUDK53_1967(afr)
BABSDK51_1575(afr)
BABCDO78_1886(afr)
BMSBR2048
BSIBS1330_I2042
BSFBSS2_I1982
BSUIBSSP1_I1848
BSUPBSPT1_I1864
BSUVBSPT2_I1848
BSUCBSSP2_I1853
BMTBSUIS_A1890
BSZDK67_318(afr)
BSVBSVBI22_A2044
BSWIY71_10350
BSGIY72_10085
BOVBOV_1970
BCSBCAN_A2095
BSKBCA52141_I1931
BOLBCOUA_I2048
BCARDK60_2024(afr)
BCASDA85_09845
BMRBMI_I2070
BPPBPI_I2106
BPVDK65_1488(afr)
BCETV910_100019
BCEEV568_100022
BVLBF3285c1_0737
BRUBFS01_09755
BRJBKD03_11550
OINIAR37_01900
OANOant_0871
OAHDR92_409(afr)
OPSA8A54_17340
OCHCES85_2562(afr)
OCRHGK82_11625
OCLGTN27_11860
PSCQKHQ08_10210
BSEPHAP48_0023770
LNEFZC33_00855 FZC33_28040
MEAMex_1p2875
MDIMETDI3441
MEXMext_2682
MCHMchl_2909
MPOMpop_2804
MZAB2G69_20945
MRDMrad2831_3595
METM446_2288
MORMOC_4117
METAY590_12890
MAQUMaq22A_1p30425(mviM)
MPHYMCBMB27_03080
MEEDA075_24800
METDC0214_15065
METXA3862_13485
METSDK389_00040 DK389_31750
METIDK427_16350
MMESMMSR116_03870
MTEADK419_20885
MINDmvi_03010(afr)
MOGMMB17_14765
MOCBB934_41265
BIDBind_0626
BBARRHAL1_03672
DEQXM25_05265
YTIFNA67_09035
MEYTM49_05305
MAADAZF01_19825
MMEDMame_00846(afr_2)
MLUTJET14_00050
LAPACP90_03190
LABRCHH27_13625
LABPFJ695_05460
LABTFIU93_08820(afr1)
LAGGB0E33_14665
LIZLGH83_15865
JANJann_3940
MALGMALG_00773
SULZC1J03_19545
RIDRIdsm_04030(afr)
HATRC74_13775
RBLB6K69_13605
PZHCX676_13470
PAROCUV01_07765
THWBMG03_13870
TAWEI545_17620
BOOE2K80_03960
MONG8E03_08490
CACTHZ995_01905
GCEKYE46_03375
NSMJO391_02830
SPHQBWQ93_10075
GDIGDI1200 GDI3732
GDJGdia_1913 Gdia_2609
GXYGLX_01130
KNAB0W47_06500
KSCCD178_03511(afr)
RGIRGI145_10210
ROSCTJ15_07120
LCKHN018_08750
KHAIFJ82_08805
SRFLHU95_14485
SKTIGS68_04555
SMUCJL100_004730
SROEJL101_004460
BCIRC2I06_16385
PJDPjdr2_1882
PMSKNP414_02556 KNP414_06781
PMQPM3016_6400
PMWB2K_32355
PAENP40081_06900 P40081_09645
PAEQR50912_06135 R50912_08950
PAEAR70723_27225
PAEER70331_26305
PBJVN24_14575
PIHUB51_10655
POWIJ21_30420
PXLBS614_17735
PYGAWM70_12805
PSWUSY83_04010 SY83_07590
PIBBBD41_24030 BBD41_27075
PPSCEHS13_05450
PALBEJC50_13775 EJC50_20640
PCHIPC41400_08280
PBKBack11_24850
PPRTET464_01350
PBACHUB98_00865
PRZGZH47_05250 GZH47_11380
PLYCGXP70_11045
PTRIKDC22_05910
COHEAV92_15005
COHNKCTCHS21_12440
SACAFFV09_03450
SIVSSIL_0513
SSILSOLI23_16190
CTCCTC_00910
CTETBN906_00959
RUKA4V00_06815
ACHTbsdcttw_06040
WHJH9Q79_05815
HASHalsa_2362
MDXBTO20_06220
MMATMMAGJ_22040
RHARHA1_ro02475
RERRER_09450
ROPROP_22020
ROAPd630_LPD06701
RHODAOT96_06365
RKOJWS14_12975
SPLULK06_027525
SALFSMD44_07181 SMD44_07493(iolG)
SFKKY5_7290
SBATG4Z16_15070 G4Z16_15075
SSPBCP982_34595
MIXAB663_001014
MIPAXH82_07700
MOYCVS54_00213(gfo)
CUMNI26_02900
CUBBJK06_11950
CUGC1N91_02770
MALKMalAC0309_0175
HUWFPZ11_12055 FPZ11_14605
GRYD7I44_10495
AGXAGREI_0290
ARTArth_1860
PUEFV140_09215 FV140_09525
RSARSal33209_1036
BFABfae_01210
BRXBH708_14035
BGGCFK41_16235
BRRC1N80_10010
XCEXcel_2113 Xcel_2124
HALTIM660_19130
PPCHMPREF9154_2851
ACIJJS278_00456(iolX_1)
MICGGJV80_01575 GJV80_20850 GJV80_21240
PRVG7070_04915
KFLKfla_3402 Kfla_4930 Kfla_4931
KQIF1D05_01360 F1D05_07020 F1D05_31230
NMLNamu_4105
GOBGobs_1023
MMARMODMU_0874
KRAKrad_3430
AMNRAM_03135
AMMAMES_0611(rifS)
AMZB737_0612(rifS)
PFLAPflav_046640
RRDRradSPS_1845
ATQGH723_13090
RRSRoseRS_1364 RoseRS_3615
RCARcas_0520 Rcas_3571
CAPCLDAP_04320
KBSEPA93_32345
TTRTter_2602
DEINDAAJ005_13510
TRATrad_0667
CCZCCALI_00721
FGIOP10G_2895
BVOPan97_37330(afr_3)
AMUCPan181_35630(afr_2)
GOGC1280_06500
FTJFTUN_0104
ULIETAA1_10970(afr_3)
IPAIsop_2920
PHMPSMK_10360 PSMK_19100
PCORKS4_20200(afr_3)
VBCC5Q97_12665
SBUSpiBuddy_3014
SGPSpiGrapes_1975
ACAACP_2132
EDAGWR55_12145
ADINH7849_20770
ABACLuPra_02187(afr_3)
GBAJ421_4304
BTHOBtheta7330_03056(afr_2)
BHLBache_1691
BXYBXY_15300
BOABovatus_00164(afr)
BCELBcellWH2_04629(afr_2)
BCACCGC64_10260
BCAEA4V03_06445
BISDXK01_012470
BUNBun01g_33820
PMUCING2E5A_1728(afr)
PETPEIBARAKI_5692
MBASALGA_3915
FAEFAES_4139
FPSZAMR72_08495
FCMBIW12_05270
FPALHYN49_12840
FMGHYN48_09665
FALBHYN59_02765
FNKE1750_10065
MUTGVT53_15555
CAGGHYG79_09895
ASACATHSA_1604
DMUDesmu_0422
 » show all
Reference
1  [PMID:16461673]
  Authors
Kuhn A, Yu S, Giffhorn F
  Title
Catabolism of 1,5-anhydro-D-fructose in Sinorhizobium morelense S-30.7.5: discovery, characterization, and overexpression of a new 1,5-anhydro-D-fructose reductase and its application in sugar analysis and rare sugar synthesis.
  Journal
Appl Environ Microbiol 72:1248-57 (2006)
DOI:10.1128/AEM.72.2.1248-1257.2006
  Sequence
Reference
2  [PMID:16906761]
  Authors
Dambe TR, Kuhn AM, Brossette T, Giffhorn F, Scheidig AJ
  Title
Crystal structure of NADP(H)-dependent 1,5-anhydro-D-fructose reductase from Sinorhizobium morelense at 2.2 A resolution: construction of a NADH-accepting mutant and its application in rare sugar synthesis.
  Journal
Biochemistry 45:10030-42 (2006)
DOI:10.1021/bi052589q
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.292
IUBMB Enzyme Nomenclature: 1.1.1.292
ExPASy - ENZYME nomenclature database: 1.1.1.292
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.292
BRENDA, the Enzyme Database: 1.1.1.292

DBGET integrated database retrieval system