KEGG   ENZYME: 1.1.1.292
Entry
EC 1.1.1.292                Enzyme                                 
Name
1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming);
1,5-anhydro-D-fructose reductase (ambiguous);
AFR (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
1,5-anhydro-D-mannitol:NADP+ oxidoreductase
Reaction(IUBMB)
1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+ [RN:R08194]
Reaction(KEGG)
R08194
Substrate
1,5-anhydro-D-mannitol [CPD:C16538];
NADP+ [CPD:C00006]
Product
1,5-anhydro-D-fructose [CPD:C06485];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme is present in some but not all Rhizobium species and belongs in the GFO/IDH/MocA protein family [2]. This enzyme differs from hepatic 1,5-anhydro-D-fructose reductase, which yields 1,5-anhydro-D-glucitol as the product (see EC 1.1.1.263). In Sinorhizobium morelense, the product of the reaction, 1,5-anhydro-D-mannitol, can be further metabolized to D-mannose [1]. The enzyme also reduces 1,5-anhydro-D-erythro-hexo-2,3-diulose and 2-ketoaldoses (called osones), such as D-glucosone (D-arabino-hexos-2-ulose) and 6-deoxy-D-glucosone. It does not reduce common aldoses and ketoses, or non-sugar aldehydes and ketones [1].
History
EC 1.1.1.292 created 2007
Orthology
K19181  1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming)
Genes
ABERBSR55_01160
MARSA8C75_09770
PHSC2L64_35315
PTERC2L65_31225
PCAFDSC91_001449
VEIVeis_3569
DELDelCs14_2523
DTSBI380_07350
DHKBO996_19295
DLAI6G47_02760
LCHLcho_4310
JALBZG29_17705
JSVCNX70_17885
JASFJQ89_07950
JLVG3257_18360
JAHJAB4_036170(afr)
JRIP9875_18320
MLOmll6645 mlr3046
MLNA9174_09665
MOPMesop_1903
MAMMesau_01925
MAMOA6B35_28055
MESMEJ066_02260
MHUAMCHK_4557
MJREB229_09830
MERDEB233_10040
MOHIHQ72_10165
MMEILRP31_11660 LRP31_30595
AAKAA2016_1985
AMIHCO731_02111(afr_2)
AMISAmn_43470
ANJAMD1_1992(afr)
PHTBLM14_17665
PHYLHB779_05535
SMESMc04400(afr)
SMKSinme_3297
SMQSinmeB_3072
SMXSM11_chr3428(afr)
SMIBN406_03101(afr)
SMEGC770_GR4Chr3397
SMELSM2011_c04400(afr)
SMERDU99_17800
SMDSmed_3174
RHINGR_b16110 NGR_c33010
SFHSFHH103_01280 SFHH103_03458
SFDUSDA257_c58200(afr)
SIXBSY16_3752(afr) BSY16_5517
SAMESAMCFNEI73_Ch3678(afr) SAMCFNEI73_pC1472
SINOSS05631_c35520 SS05631_c37170
ESJSJ05684_c33320
EAKEKH55_3235
EMXFKV68_20355
ENUPYH37_005777
EGIPZN02_001285
SKMPZL22_003575
STEGQA637_16525
EADOV14_0832
EAHFA04_17520
ECAAJ3R84_17490
ENPJVX98_22720
AVQHRR99_20200
RECRHECIAT_PC0000793
RHLLPU83_2038
RGARGR602_CH02580(afr)
RJGCCGE525_18655
RHRCKA34_28390
RGRFZ934_21800
ROYG3A56_23470
RSULN2599_04870
NGLRG1141_PA11210
SHZshn_15890 shn_29210
SZOK8M09_14315
SOJK6301_12410 K6301_19645
SSUMQ9314_14145 Q9314_20305
PDESFE840_019810
BMEBMEI0020
BMELDK63_1414(afr)
BMIBMEA_A2109
BMZBM28_A2034
BMGBM590_A2033
BMWBMNI_I1948
BMEEDK62_1534(afr)
BMFBAB1_2049
BMBBruAb1_2023
BMCBAbS19_I19190
BAABAA13334_I00717
BABODK55_1982(afr)
BABRDO74_1993(afr)
BABTDK49_1739(afr)
BABBDK48_137(afr)
BABUDK53_1967(afr)
BABSDK51_1575(afr)
BABCDO78_1886(afr)
BMSBR2048
BSIBS1330_I2042
BSFBSS2_I1982
BSUIBSSP1_I1848
BSUPBSPT1_I1864
BSUVBSPT2_I1848
BSUCBSSP2_I1853
BMTBSUIS_A1890
BSZDK67_318(afr)
BSVBSVBI22_A2044
BSWIY71_10350
BSGIY72_10085
BOVBOV_1970
BCSBCAN_A2095
BSKBCA52141_I1931
BOLBCOUA_I2048
BCARDK60_2024(afr)
BCASDA85_09845
BMRBMI_I2070
BPPBPI_I2106
BPVDK65_1488(afr)
BCETV910_100019
BCEEV568_100022
BVLBF3285c1_0737
BRUBFS01_09755
BRJBKD03_11550
OINIAR37_01900
OANOant_0871
OAHDR92_409(afr)
OPSA8A54_17340
OCHCES85_2562(afr)
OCRHGK82_11625
OCLGTN27_11860
OCCKMS41_10625
PSCQKHQ08_10210
BSEPHAP48_0023770
BBANJ4G43_054155
LNEFZC33_00855 FZC33_28040
MEAMex_1p2875
MDIMETDI3441
MEXMext_2682
MCHMchl_2909
MPOMpop_2804
MZAB2G69_20945
MRDMrad2831_3595
METM446_2288
MORMOC_4117
METAY590_12890
MAQUMaq22A_1p30425(mviM)
MPHYMCBMB27_03080
MEEDA075_24800
METDC0214_15065
METXA3862_13485
METSDK389_00040 DK389_31750
METIDK427_16350
MMESMMSR116_03870
MTEADK419_20885
MINDmvi_03010(afr)
MOGMMB17_14765
MTADM6G65_29325
MOCBB934_41265
BIDBind_0626
BBARRHAL1_03672
DNPN8A98_01225
MEYTM49_05305
MAADAZF01_19825
MMEDMame_00846(afr_2)
MLUTJET14_00050
LAPACP90_03190
LABRCHH27_13625
LABPFJ695_05460
LABTFIU93_08820(afr1)
LAGGB0E33_14665
RPOPK1718_27180
LIZLGH83_15865
JANJann_3940
MALGMALG_00773
HATRC74_13775
RMAIMACH21_01810(afr)
RBLB6K69_13605
PZHCX676_13470
PAROCUV01_07765
PFISJHX87_16690
PAEZPAE61_07695
PALSPAF20_07515
TAWEI545_17620
BOOE2K80_03960
MONG8E03_08490
CACTHZ995_01905
GCEKYE46_03375
NSMJO391_02830
SINRO5O51_15395
RHOCQTA57_16245
GDIGDI1200 GDI3732
GDJGdia_1913 Gdia_2609
GXYGLX_01130
KNAB0W47_06500
KSCCD178_03511(afr)
LCKHN018_08750
KHAIFJ82_08805
SRFLHU95_14485
NGUQN315_11265
SKTIGS68_04555
SMUCJL100_004730
SROEJL101_004460
MFBMFUL124B02_11535
CCXCOCOR_00217(afr)
PPAKJY651_13860
SURSTAUR_3306
MBDMEBOL_002035
MDXBTO20_06220
MMATMMAGJ_22040
RHARHA1_ro02475
ROPROP_22020
ROAPd630_LPD06701
RHODAOT96_06365
RKOJWS14_12975
RPSKJWS13_32890
RHOPD8W71_11675
MALKMalAC0309_0175
ARTArth_1860
PUEFV140_09525
NMLNamu_4105
GOBGobs_1023
MMARMODMU_0874
KRAKrad_3430
ACTYOG774_13405
RRDRradSPS_2400
CALLOZ401_000895
CAPCLDAP_04320
RUVEC9_14630(afr_4)
RCFPoly24_14590(afr_3)
BREMPSR63_19595
TPLAElP_19970(afr_3)
PHMPSMK_19100
AQENBT05_09790
 » show all
Reference
1  [PMID:16461673]
  Authors
Kuhn A, Yu S, Giffhorn F
  Title
Catabolism of 1,5-anhydro-D-fructose in Sinorhizobium morelense S-30.7.5: discovery, characterization, and overexpression of a new 1,5-anhydro-D-fructose reductase and its application in sugar analysis and rare sugar synthesis.
  Journal
Appl Environ Microbiol 72:1248-57 (2006)
DOI:10.1128/AEM.72.2.1248-1257.2006
  Sequence
Reference
2  [PMID:16906761]
  Authors
Dambe TR, Kuhn AM, Brossette T, Giffhorn F, Scheidig AJ
  Title
Crystal structure of NADP(H)-dependent 1,5-anhydro-D-fructose reductase from Sinorhizobium morelense at 2.2 A resolution: construction of a NADH-accepting mutant and its application in rare sugar synthesis.
  Journal
Biochemistry 45:10030-42 (2006)
DOI:10.1021/bi052589q
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.292
IUBMB Enzyme Nomenclature: 1.1.1.292
ExPASy - ENZYME nomenclature database: 1.1.1.292
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.292
BRENDA, the Enzyme Database: 1.1.1.292

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