KEGG   ENZYME: 1.1.1.305
Entry
EC 1.1.1.305                Enzyme                                 
Name
UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating);
UDP-GlcUA decarboxylase;
ArnADH;
UDP-glucuronate:NAD+ oxidoreductase (decarboxylating)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
UDP-alpha-D-glucuronate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
UDP-alpha-D-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+ [RN:R07658]
Reaction(KEGG)
R07658
Substrate
UDP-alpha-D-glucuronate [CPD:C00167];
NAD+ [CPD:C00003]
Product
UDP-beta-L-threo-pentapyranos-4-ulose [CPD:C16155];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The activity is part of a bifunctional enzyme also performing the reaction of EC 2.1.2.13 (UDP-4-amino-4-deoxy-L-arabinose formyltransferase).
History
EC 1.1.1.305 created 2010
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K10011  UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)
Genes
ECOb2255(arnA)
ECJJW2249(yfbG)
ECDECDH10B_2415(arnA)
EBWBWG_2028(arnA)
ECOKECMDS42_1825(yfbG)
ECEZ3513
ECSECs_3143(arnA)
ECFECH74115_3396(arnA)
ETWECSP_3132(arnA)
ELXCDCO157_2906
EOJECO26_3245(arnA)
EOHECO103_2721(arnA)
ECOOECRM13514_3011
ECOHECRM13516_2956
ESLO3K_08215
ESOO3O_17420
ESMO3M_08165
ECKEC55989_2501(yfbG)
ECGE2348C_2399(arnA)
EOKG2583_2795(arnA)
ELRECO55CA74_13835
ELHETEC_2389
ECWEcE24377A_2550(arnA)
EUNUMNK88_2807
ECPECP_2298
ENAECNA114_2348(yfbG)
ECOSEC958_2593(yfbG)
ECVAPECO1_4306(yfbG)
ECOAAPECO78_15095
ECXEcHS_A2400(arnA)
ECMEcSMS35_2409(arnA)
ECYECSE_2514
ECRECIAI1_2331(yfbG)
ECQECED1_2721(yfbG)
EUMECUMN_2596(yfbG)
ECTECIAI39_2402(yfbG)
EOCCE10_2638(arnA)
EBRECB_02181(yfbG)
EBLECD_02181(arnA)
EBEB21_02140(arnA)
EBDECBD_1404
ECIUTI89_C2537(yfbG)
EIHECOK1_2491(arnA)
ECZECS88_2404(yfbG)
ECCc2797(yfbG)
ELOEC042_2498(arnA)
ELNNRG857_11435
ESEECSF_2135
ECLEcolC_1394
EKOEKO11_1509
EKFKO11_11410(arnA)
EABECABU_c25890(arnA)
EDHEcDH1_1403
EDJECDH1ME8569_2191(arnA)
ELUUM146_05525
ELWECW_m2446(arnA)
ELLWFL_11970(arnA)
ELCi14_2596(yfbG)
ELDi02_2596(yfbG)
ELPP12B_c2349(arnA)
ELFLF82_0136(arnA)
ECOLLY180_11710
ECOIECOPMV1_02416(arnA)
ECOJP423_12625
EFEEFER_0914(yfbG)
EALEAKF1_ch3724c(arnA)
EMAC1192_00610
ESZFEM44_01470(arnA)
STYSTY2529
STTt0564
SEXSTBHUCCB_6050
SENTTY21A_02870
STMSTM2299(yfbG)
SEOSTM14_2837(yfbG)
SEVSTMMW_23231
SEYSL1344_2268(yfbG)
SEMSTMDT12_C23200
SEJSTMUK_2329(yfbG)
SEBSTM474_2395(yfbG)
SEFUMN798_2481
SETUSTU288_07870
SETCCFSAN001921_05300
SENRSTMDT2_22681
SENDDT104_23571
SENICY43_12320
SEENSE451236_17690
SPTSPA0564(yfbG)
SEKSSPA0528
SPQSPAB_00682
SEISPC_1412(yfbG)
SEHSeHA_C2539
SHBSU5_02894
SENHCFSAN002069_20350
SEEHSEEH1578_20770
SEESNSL254_A2484
SENNSN31241_34040
SEWSeSA_A2527
SEASeAg_B2435
SENSQ786_11335
SEDSeD_A2643
SEGSG2328(yfbG)
SELSPUL_0591(yfbG)
SEGASPUCDC_0591(yfbG)
SETSEN2281(yfbG)
SENAAU38_11530
SENOAU37_11540
SENVAU39_11540
SENQAU40_12920
SENLIY59_11855
SENJCFSAN001992_22080
SEECCFSAN002050_18420
SEEBSEEB0189_008075
SEEPI137_02725
SENBBN855_23800
SENEIA1_11450
SENCSEET0819_18585
SBGSBG_2088
SBZA464_2413
SBVN643_10210
SALZEOS98_07550
SFXS2467(ybfG)
SFVSFV_2325
SFESFxv_2577(arnA)
SFNSFy_3321
SFSSFyv_3396
SFTNCTC1_02567(arnA)
SSNSSON_2316
SBOSBO_2292
SBCSbBS512_E2631(arnA)
SDZAsd1617_03305
SHQA0259_15095
ENCECL_04861
ENLA3UG_21620
ECLGEC036_42110
ECLEECNIH2_22145
ECLNECNIH4_01690
ECLYLI62_23410
ECLOENC_26920
EHMAB284_03400
EAUDI57_19845
EKBBFV64_22140
ENOECENHK_20885
EECEcWSU1_04282(arnA)
ELGBH714_14215
ECANCWI88_21375
ERNBFV67_20790
ECLSLI67_022825
ECHGFY206_22985(arnA)
ESHC1N69_21595
ENTEnt638_2077
EASEntas_4174
ENRH650_13745
ENXNI40_020910
ENFAKI40_0312
LNICWR52_13980(arnA)
EBGFAI37_08130(arnA)
ENDA4308_05625
ENZG0034_21540(arnA)
EHUD5067_0001335(arnA)
EMORL6Y89_21005(arnA)
ENBELK40_21280(arnA)
KPNKPN_03845(yfbG)
KPUKP1_5182
KPMKPHS_50000
KPPA79E_0271
KPHKPNIH24_24920
KPZKPNIH27_23840
KPVKPNIH29_24760
KPWKPNIH30_25210
KPYKPNIH31_24265
KPGKPNIH32_26080
KPCKPNIH10_24885
KPQKPR0928_24405
KPTVK055_3625(arnA)
KPOKPN2242_22235
KPRKPR_5072(arnA)
KPJN559_0309
KPID364_19670
KPAKPNJ1_00281
KPSKPNJ2_00283
KPXPMK1_01347(arnA)
KPBFH42_15560
KPNEKU54_001385
KPNULI86_01380
KPNKBN49_0272(arnA)
KVAKvar_0256
KPEKPK_0268(arnA)
KPKA593_09430
KVDKR75_06785
KVQSP68_13375
KOXKOX_05070
KOEA225_5481
KOYJ415_04690
KOMHR38_03545
KMIVW41_09735
KOKKONIH1_27595
KOCAB185_08785
KQUAVR78_03065
EAEEAE_05690
EARCCG32860
KQVB8P98_01400
KLLBJF97_27260
KLWDA718_01740(arnA)
KARLGL98_01375(arnA)
KGRJJJ10_01555(arnA)
RORRORB6_20125
RONTE10_00870
RPLNB1209_01360
RAODSD31_01460
RTGNCTC13098_00333(arnA)
REEelectrica_00259(arnA)
CFDCFNIH1_22840
CBRAA6J81_24925
CWECO701_06615
CYOCD187_07865
CPOTFOB25_18990(arnA)
CFQC2U38_16795
CAMAF384_12075
CAFAL524_10820
CIFAL515_15745
CFARCI104_17410
CIRC2U53_27260
CIEAN232_12520
CPARCUC49_11795
CTELGBC03_13055(arnA)
CITZE4Z61_01455(arnA)
CARSE1B03_18230(arnA)
HDEHDEF_0857(arnA)
SECTA359_07480
SEHCA35E_00191
EBTEBL_c14160(arnA)
CNTJT31_02770
CEMLH23_15425
CENLH86_14575
CLAPNCTC11466_02466(arnA)
PGELG71_17165
ESCEntcl_0249
KLEAO703_20170
KSAC813_16860
KORAWR26_01315(arnA)
KRDA3780_23415
KCOBWI95_09185
KOTEH164_01280(arnA)
KPSEIP581_21855(arnA)
KGOCEW81_01535
KIENCTC12125_04155(arnA)
KASKATP_02600(arnA)
LEFLJPFL01_4009
LEWDAI21_05805
BUFD8682_04200(arnA)
BAGEBADSM9389_18930
BFTMNO13_11290(arnA)
SYMK6K13_03645(arnA)
METYMRY16398_42510(arnA)
AHNNCTC12129_01387(arnA_1)
YREHEC60_16740(arnA)
SGOEA8O29_001750(arnA)
KINAB182_18760
PDZHHA33_21215(arnA)
PSGCG163CM_02790(arnA)
EBFD782_1295
EBCC2U52_29970
YPEYPO2420
YPKy1919
YPHYPC_2055
YPAYPA_1764
YPNYPN_1874
YPMYP_2207(wcaG9)
YPPYPDSF_0730
YPGYpAngola_A2610(arnA)
YPZYPZ3_1467
YPTA1122_14040
YPDYPD4_1432
YPXYPD8_1513
YPWCH59_4254
YPJCH55_496
YPVBZ15_1105
YPLCH46_2685
YPSYPTB2328(pmrI)
YPOBZ17_126
YPIYpsIP31758_1727(arnA)
YPYYPK_1833
YPBYPTS_2403
YPQDJ40_4257
YPUBZ21_1616
YPRBZ20_3915
YPCBZ23_1902
YPFBZ19_1693
YENYE2190
YEPYE105_C2003
YEYY11_08001
YELLC20_02959
YEWCH47_1625
YETCH48_3631
YEFFORC2_2213
YEEYE5303_20321
YSIBF17_20740
YALAT01_262
YFRAW19_1396
YINCH53_4133
YKRCH54_266
YROCH64_735
YRUBD65_479
YRBUGYR_02450
YMADA391_12025
YHID5F51_07870(arnA)
YCAF0T03_10080(arnA)
YMOHRD69_16410(arnA)
SMARSM39_1617(arnA)
SMACSMDB11_1430(arnA)
SMWSMWW4_v1c21850(arnA)
SPESpro_2156
SRRSerAS9_2098
SRLSOD_c19700(arnA)
SRYM621_10855
SPLYQ5A_010900(arnA)
SRSSerAS12_2098
SRASerAS13_2099
SMAFD781_1987
SLQM495_10685
SERFL085_17840
SERSSERRSCBI_10245
SFWWN53_19960
SFGAV650_15780
SRZAXX16_3142
SERASer39006_002825
SERQCWC46_02825
SERMCLM71_09860
SQUE4343_05430(arnA)
SFJSAMEA4384070_2214(arnA)
SOFNCTC11214_04679(arnA)
SSURATE40_007630
SURIJ0X03_13095(arnA)
SRHZFO014_23580(arnA)
SENPKHA73_10950(arnA)
SFOZ042_26220
RAHRahaq_2821
RACEJHW33_08070(arnA)
RAQRahaq2_2851
RAAQ7S_14230
ROXBV494_08900
RVCJ9880_20975(arnA)
GQUAWC35_22975
FSMCCS41_07075
EAMEGXP68_08320(arnA)
RBADH2866_15890(arnA)
ECAECA3144
PATREV46_15565
PATOGZ59_31540
PCTPC1_2926
PCCPCC21_029640
PCVBCS7_14885
PWAPecwa_1352
PPARA8F97_12115
PECW5S_1258
PWSA7983_01545
PPOABJK05_09745
PBRAB5S52_07015
PPUJE2566_15105(arnA)
PARII2D83_06975(arnA)
PVZOA04_31390(arnA)
PPAVLOZ86_14660(arnA)
DDDDda3937_01078(yfbG)
DZEDd1591_4226
DDCDd586_4198
DZCW909_20290
DSOA4U42_09035
CEDLH89_12335
DFNCVE23_22445
DDQDDI_4291
DAQDAQ1742_04456(arnA)
DICDpoa569_003891(arnA)
DDADd703_4017
BGJAWC36_13855
BIZHC231_18665(arnA)
SGLSG1843
SODSant_1032(arnA)
PESSOPEG_3209(arnA)
SLIGGTU79_03960(arnA)
EAMEAMY_1085(yfbG)
EAYEAM_1092(arnA)
ETAETA_23810(arnA)
EPYEpC_25160(arnA)
EPREPYR_02726(yfbG)
EBIEbC_12130(arnA)
ERJEJP617_22110(arnA)
EGEEM595_p0068(arnA)
EPECI789_12800
ERWIGN242_15080(arnA)
ETPLU633_08580(arnA)
ERPLJN55_05940(arnA)
WBRb2255
WGLWIGMOR_0622(arnA)
PAMPANA_4004(arnA)
PLFPANA5342_p10122(arnA)
PAJPAJ_p0005(arnA)
PAQPAGR_p093
PVAPvag_pPag10070(yfbG)
PAGGAL522_03075
PAOPat9b_5646
PAGCBEE12_23615
PSTWDSJ_25425
PANSFCN45_22930(arnA)
PEYEE896_21540(arnA)
PDISD8B20_18360(arnA) D8B20_20975(arnA)
TCIA7K98_14380
TPTYNCTC11468_02692(arnA)
PLUplu2658(pbgP3)
PLUMA4R40_13235
PAYPAU_01877(arnA)
PTTVY86_18210
PAKHB0X70_13545
PLUICE143_13540
PMRPMI1045(arnA)
PMIBBB2000_1082(arnA)
PVLAOB99_07275
PVGCRN77_13920
PHAUPH4a_14255
PROTBTA34_06475
PCOLF1325_08400(arnA)
PCIBF9282_08350(arnA)
PPEEI6G31_01860(arnA)
XBOXBJ1_2534(arnA)
XBVXBW1_3010(pbgP)
XNEXNC1_1837(pbgP3)
XNMXNC2_1782(pbgP)
XDOXDD1_1781(pbgP)
XPOXPG1_1548(pbgP)
XHOA9255_06875
XBUHGO23_09000(arnA)
PSIS70_19365
PSXDR96_2785
PSTABGK56_01430
PRGRB151_019250(arnA)
PALACO695_16000
PHEINCTC12003_02332(arnA)
PRQCYG50_07550(arnA)
PRJNCTC6933_01643(arnA)
PVCG3341_11935(arnA)
PMAGJI723_11840(arnA)
MMKMU9_2436
ANSArsFIN_16500(arnA)
AEDE3U36_11970(arnA)
AETLDL57_09095(arnA)
MWIMNY66_06895(arnA)
EICNT01EI_1415
ETRETAE_1293
ETDETAF_1205
ETEETEE_3268(arnA)
ETCETAC_06130
EDWQY76_13725
EDLAAZ33_06730(arnA)
EHOA9798_10285
HAVAT03_10625
HPARAL518_15205
OPODSM2777_16850
LPVHYN51_11420
PFQQQ39_15925
VSHBSZ05_00680
PAEPA3554(arnA)
PAEVN297_3677
PAEIN296_3677
PAUPA14_18350(fmt)
PAPPSPA7_1591
PAGPLES_14791
PAFPAM18_1432
PNCNCGM2_4680(fmt)
PAEBNCGM1900_2729(fmt)
PDKPADK2_06595
PSGG655_07030
PRPM062_18825
PAEPPA1S_07650
PAERPA1R_gp1373
PAEMU769_07125
PAELT223_07365
PAESSCV20265_1508
PAEUBN889_03925
PAEGAI22_26255
PAECM802_3674
PAEOM801_3542
PCQPcP3B5_10970(arnA)
PMUIG4G71_27470(arnA)
PORAPT59_21350
PSBPsyr_2691
PSYRN018_13795
PSPPSPPH_2804(arnA)
PAVLBKM03_14600
PVDCFBP1590_0593(arnA)
PCABJGS08_12945(arnA)
PCOFPOR16_12505(arnA)
PTREI9H09_12560(arnA)
PSYIMME58_14000(arnA)
PFLPFL_3045(arnA)
PPRCPFLCHA0_c30730(arnA)
PPROPPC_3073
PFNHZ99_09570
PFOPfl01_2843
PFSPFLU_3041
PFCPflA506_2684(arnA)
PPZH045_08710
PFBVO64_0275
PMANOU5_0511(arnA)
PTVAA957_29330
PCGAXG94_01710
PVRPverR02_15960
PAZOAYR47_22455
POIBOP93_12505
PRXHRH33_14000(arnA)
PFWPF1751_v1c26890(arnA)
PFFPFLUOLIPICF722870
PFXA7318_13375
PDRH681_05040
PSKU771_15900
PKCPKB_4721(arnA)
PCHEY04_14440
PCZPCL1606_30720
PCPJM49_15600
PFZAV641_11485
PPVNJ69_08675
PSEMTO66_15070
PPSYAOC04_08565
PSOSPOS17_3049
PANRA7J50_2964
PPSLBJP27_15085
PYMAK972_2830
PKEDLD99_14965
PGGFX982_03612
PPSHG5J76_14665(arnA)
PGYAWU82_13400
PEZHWQ56_11375(arnA)
PZEHU754_015370(arnA)
PMOEHV782_015475(arnA)
PSEPC4K39_5051
PVWHU752_017360(arnA)
PTRTHU722_0015210(arnA)
PSAMHU731_001845(arnA)
PTZHU718_015610(arnA)
PSHHHU773_014130(arnA)
PASGKSS96_15130(arnA)
PTAENCTC10697_02216(arnA)
PGFJ0G10_15710(arnA)
SSESsed_0924
SMAIEXU30_10565(arnA)
AGZM0C34_01280(arnA)
ZPLZBT109_1561
AHAAHA_0990
AHYAHML_05290
AHDAI20_14310
AHRV428_05510
AHPV429_05515
AHJV469_17840
AHHRY45_05455
AHIVU14_17560
AAJBOQ57_04915
ASAASA_3309(arnA)
AEOO23A_p2676
ASRWL1483_257(arnA)
ADHCK627_21275
AJDI6H43_09520(arnA)
SALNSALB1_1040
SADEGFK82_00483(arnA)
BHGI6G56_25840
DBKDGMP_23970(arnA)
DAXFDQ92_14880(arnA)
SECHB18_00735
AMUCPan181_15280(arnA)
BPITBPIT_06360
VBCC5Q97_16955
 » show all
Reference
1  [PMID:15695810]
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
  Sequence
[eco:b2255]
Reference
2  [PMID:15491143]
  Authors
Gatzeva-Topalova PZ, May AP, Sousa MC
  Title
Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain. A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance.
  Journal
Biochemistry 43:13370-9 (2004)
DOI:10.1021/bi048551f
  Sequence
[eco:b2255]
Reference
3  [PMID:15809294]
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
  Sequence
[eco:b2255]
Reference
4  [PMID:15939024]
  Authors
Gatzeva-Topalova PZ, May AP, Sousa MC
  Title
Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance.
  Journal
Structure 13:929-42 (2005)
DOI:10.1016/j.str.2005.03.018
  Sequence
[eco:b2255]
Reference
5  [PMID:17928292]
  Authors
Yan A, Guan Z, Raetz CR
  Title
An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli.
  Journal
J Biol Chem 282:36077-89 (2007)
DOI:10.1074/jbc.M706172200
  Sequence
[eco:b2255]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.305
IUBMB Enzyme Nomenclature: 1.1.1.305
ExPASy - ENZYME nomenclature database: 1.1.1.305
BRENDA, the Enzyme Database: 1.1.1.305

DBGET integrated database retrieval system