KEGG ENZYME: 1.1.1.307

ENZYME: 1.1.1.307

Entry

EC 1.1.1.307 Enzyme

Name

D-xylose reductase;
XylR;
XyrA;
msXR;
dsXR;
monospecific xylose reductase;
dual specific xylose reductase;
NAD(P)H-dependent xylose reductase;
xylose reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

xylitol:NAD(P)+ oxidoreductase

Reaction(IUBMB)

xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+ [RN:R01431 R09477]

Reaction(KEGG)

R01431 R09477

Substrate

xylitol [CPD:C00379];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

D-xylose [CPD:C00181];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.

History

EC 1.1.1.307 created 2010

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K17743

D-xylose reductase

Genes

SASA:

100196319(xyl1)

QSU:	112005872 112027707

MIS:	MICPUN_98293

SCE:	YHR104W(GRE3)

AGO:	AGOS_ACL107C

ERC:

Ecym_5508

KLA:	KLLA0_E21627g

KMX:	KLMA_10683(XYL1)

LTH:	KLTH0F16610g

ZRO:	ZYRO0A06336g

CGR:	CAGL0I01122g

NCS:	NCAS_0A06660(NCAS0A06660)

NDI:	NDAI_0D01600(NDAI0D01600)

TPF:	TPHA_0E01860(TPHA0E01860)

TBL:	TBLA_0A00630(TBLA0A00630) TBLA_0F01720(TBLA0F01720)

TDL:	TDEL_0E02150(TDEL0E02150)

KAF:	KAFR_0C05320(KAFR0C05320)

PPA:	PAS_chr3_0744

DHA:	DEHA2F13068g

PIC:	PICST_89614(XYL1)

PGU:	PGUG_00922 PGUG_02290

SPAA:

SPAPADRAFT_61339(XYL1.2) SPAPADRAFT_61341(XYL1.1)

CAL:	CAALFM_C502930CA(GRE3)

CTP:	CTRG_05978 CTRG_05993

COT:	CORT_0F01440

CDU:	CD36_52690(XYRA)

CTEN:

CANTEDRAFT_95032

YLI:	YALI0D07634g

CLU:	CLUG_01135

CLUS:

A9F13_09g01958

CAUR:

CJI97_000813

SLB:	AWJ20_3140(GRE3)

NCR:	NCU08384(xr)

NTE:	NEUTE1DRAFT133088(NEUTE1DRAFT_133088)

SMP:	SMAC_04649

PAN:	PODANSg09635

TTT:	THITE_2121064

MTM:	MYCTH_43671

CTHR:

CTHT_0056950

MGR:	MGG_01404 MGG_03648

TMN:	UCRPA7_3687 UCRPA7_6874

SSCK:

SPSK_06315

FGR:	FGSG_01523

FPU:	FPSE_05024

FVR:	FVEG_08194 FVEG_09602

FOX:	FOXG_01819 FOXG_11189

NHE:	NECHADRAFT_102983 NECHADRAFT_38020

TRE:	TRIREDRAFT_107776(xyl1)

MAJ:

MAA_00542

PLJ:	VFPFJ_08966

VAL:	VDBG_00802 VDBG_03846 VDBG_06547

VDA:	VDAG_00411 VDAG_01073 VDAG_05087

CFJ:	CFIO01_01300 CFIO01_01602

ELA:	UCREL1_14 UCREL1_6453

PFY:	PFICI_01687 PFICI_04525 PFICI_07157

SSL:	SS1G_05911

MBE:	MBM_04242 MBM_09727

PSCO:

LY89DRAFT_599386 LY89DRAFT_657917

GLZ:	GLAREA_03723

ANI:

AN0423.2

AFM:	AFUA_1G04820

AOR:	AO090003000859

ANG:	ANI_1_2444014(An01g03740)

AFV:	AFLA_029600

ACT:	ACLA_029850

NFI:	NFIA_019940

PCS:	Pc16g09600

PDP:	PDIP_20350

CIM:	CIMG_04915

CPW:	CPC735_069630

URE:	UREG_06636

ABE:

ARB_06141

TVE:

TRV_03808

AJE:	HCAG_04822

PNO:	SNOG_12824

PTE:

PTT_08729

BZE:	COCCADRAFT_7101

BSC:	COCSADRAFT_90781

BOR:	COCMIDRAFT_103379

AALT:

CC77DRAFT_925768

ZTR:	MYCGRDRAFT_56833

PFJ:	MYCFIDRAFT_187110

BCOM:

BAUCODRAFT_374705

NPA:	UCRNP2_5917

TML:	GSTUM_00005097001

TVS:	TRAVEDRAFT_161569 TRAVEDRAFT_68124

DSQ:	DICSQDRAFT_152560 DICSQDRAFT_95722

PCO:	PHACADRAFT_214614 PHACADRAFT_266555 PHACADRAFT_82194

SHS:	STEHIDRAFT_117277 STEHIDRAFT_124813

HIR:	HETIRDRAFT_59016

PSQ:	PUNSTDRAFT_95399

ADL:	AURDEDRAFT_181771

FME:	FOMMEDRAFT_145959

GTR:	GLOTRDRAFT_113068 GLOTRDRAFT_71965

MPR:	MPER_01564

MRR:	Moror_16424

CCI:	CC1G_12853

SCM:	SCHCODRAFT_13604

CPUT:

CONPUDRAFT_96186

SLA:	SERLADRAFT_455569

SRE:	PTSG_10029

FCY:	FRACYDRAFT_182665

EHX:	EMIHUDRAFT_460747 EMIHUDRAFT_464332

PEA:	PESP_a3828

AMAC:

MASE_18010

AMB:	AMBAS45_18435

AMG:	AMEC673_18140

ALT:	ambt_20095

AAL:	EP13_18110

AAUS:

EP12_18925

ASP:	AOR13_3808

ASQ:	AVL57_19640

AAW:	AVL56_18455

ALE:	AV939_18610

ALZ:	AV940_18305

GPS:

C427_1732

GAI:	IMCC3135_21385

ERK:	CD351_15130

PIR:	VN12_20240(ytbE)

PBS:	Plabr_2838

PLS:	VT03_22870(ytbE)

FMR:	Fuma_05200(dkgA)

SACI:

Sinac_2429

» show all

Reference

1 [PMID:9307017]

Authors

Neuhauser W, Haltrich D, Kulbe KD, Nidetzky B

Title

NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme.

Journal

Biochem J 326 ( Pt 3):683-92 (1997)

Reference

2 [PMID:14690376]

Authors

Nidetzky B, Bruggler K, Kratzer R, Mayr P

Title

Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies.

Journal

J Agric Food Chem 51:7930-5 (2003)
DOI:10.1021/jf034426j

Reference

3 [PMID:14526534]

Authors

Iablochkova EN, Bolotnikova OI, Mikhailova NP, Nemova NN, Ginak AI

Title

[The activity of xylose reductase and xylitol dehydrogenase in yeasts]

Journal

Mikrobiologiia 72:466-9 (2003)

Reference

4 [PMID:19342796]

Authors

Chen LC, Huang SC, Chuankhayan P, Chen CD, Huang YC, Jeyakanthan J, Pang HF, Men LC, Chen YC, Wang YK, Liu MY, Wu TK, Chen CJ

Title

Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis.

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun 65:419-21 (2009)
DOI:10.1107/S1744309109008719

Sequence

[ctp:CTRG_05993]

Reference

5 [PMID:3921014]

Authors

Verduyn C, Van Kleef R, Frank J, Schreuder H, Van Dijken JP, Scheffers WA

Title

Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis.

Journal

Biochem J 226:669-77 (1985)
DOI:10.1042/bj2260669

Sequence

[pic:PICST_89614]

Reference

6 [PMID:20093741]

Authors

Fernandes S, Tuohy MG, Murray PG

Title

Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity.

Journal

J Biosci 34:881-90 (2009)

Reference

7 [PMID:14532079]

Authors

Lee JK, Koo BS, Kim SY

Title

Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis.

Journal

Appl Environ Microbiol 69:6179-88 (2003)
DOI:10.1128/AEM.69.10.6179-6188.2003

Sequence

[ag:AAO91803]

Reference

8 [PMID:15746370]

Authors

Woodyer R, Simurdiak M, van der Donk WA, Zhao H

Title

Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa.

Journal

Appl Environ Microbiol 71:1642-7 (2005)
DOI:10.1128/AEM.71.3.1642-1647.2005