Entry |
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Name |
D-xylose reductase;
XylR;
XyrA;
msXR;
dsXR;
monospecific xylose reductase;
dual specific xylose reductase;
NAD(P)H-dependent xylose reductase;
xylose reductase
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
xylitol:NAD(P)+ oxidoreductase
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Reaction(IUBMB) |
xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+ [RN: R01431 R09477]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.
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History |
EC 1.1.1.307 created 2010
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Pathway |
ec00040 | Pentose and glucuronate interconversions |
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Orthology |
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Genes |
» show all
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Reference |
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Authors |
Neuhauser W, Haltrich D, Kulbe KD, Nidetzky B |
Title |
NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme. |
Journal |
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Reference |
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Authors |
Nidetzky B, Bruggler K, Kratzer R, Mayr P |
Title |
Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies. |
Journal |
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Reference |
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Authors |
Iablochkova EN, Bolotnikova OI, Mikhailova NP, Nemova NN, Ginak AI |
Title |
[The activity of xylose reductase and xylitol dehydrogenase in yeasts] |
Journal |
Mikrobiologiia 72:466-9 (2003) |
Reference |
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Authors |
Chen LC, Huang SC, Chuankhayan P, Chen CD, Huang YC, Jeyakanthan J, Pang HF, Men LC, Chen YC, Wang YK, Liu MY, Wu TK, Chen CJ |
Title |
Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis. |
Journal |
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Sequence |
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Reference |
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Authors |
Verduyn C, Van Kleef R, Frank J, Schreuder H, Van Dijken JP, Scheffers WA |
Title |
Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis. |
Journal |
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Sequence |
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Reference |
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Authors |
Fernandes S, Tuohy MG, Murray PG |
Title |
Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity. |
Journal |
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Reference |
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Authors |
Lee JK, Koo BS, Kim SY |
Title |
Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis. |
Journal |
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Sequence |
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Reference |
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Authors |
Woodyer R, Simurdiak M, van der Donk WA, Zhao H |
Title |
Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.307 |
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