KEGG   ENZYME: 1.1.1.308
Entry
EC 1.1.1.308                Enzyme                                 

Name
sulfopropanediol 3-dehydrogenase;
DHPS 3-dehydrogenase (sulfolactate forming);
2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming);
dihydroxypropanesulfonate 3-dehydrogenase;
hpsN (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(R)-2,3-dihydroxypropane-1-sulfonate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
(R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD+ + H2O = (R)-3-sulfolactate + 2 NADH + 2 H+ [RN:R09545]
Reaction(KEGG)
R09545
Substrate
(R)-2,3-dihydroxypropane-1-sulfonate [CPD:C19675];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
(R)-3-sulfolactate [CPD:C11537];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme is involved in degradation of (R)-2,3-dihydroxypropanesulfonate.
History
EC 1.1.1.308 created 2011
Orthology
K15509  sulfopropanediol 3-dehydrogenase
Genes
ECLX: LI66_17165 LI66_17190
ECLY: LI62_18750 LI62_18775
ECLO: ENC_28830
EXF: BFV63_16780 BFV63_16805
ECAN: CWI88_05315(hisD) CWI88_05340(hisD)
EAE: EAE_05825
EAR: CCG32834
GQU: AWC35_21415
LAX: APT61_12775 APT61_12800
LEI: C2U54_14965(hisD) C2U54_14990(hisD)
LEH: C3F35_01725(hisD)
LEE: DVA44_13790(hisD)
LER: GNG29_09810(hisD) GNG29_09835(hisD)
LEA: GNG26_09515(hisD) GNG26_09540(hisD)
LEW: DAI21_16950(hisD)
BAGE: BADSM9389_23870(hisD) BADSM9389_23920(hisD)
AHN: NCTC12129_02753(hisD_1)
SGOE: A8O29_004590(hisD) A8O29_004615(hisD)
EAME: GXP68_05000(hisD)
PANS: FCN45_18875(hisD) FCN45_18905(hisD)
VCA: M892_00680(hisD)
VAG: N646_3369
VNL: D3H41_23030(hisD)
GHO: AL542_00750(hisD) AL542_03485(hisD)
PFS: PFLU_1949
PSYC: DABAL43B_1044(hisD1)
ABAU: IX87_19995
THT: E2K93_07265(hisD)
THAP: FNC98_06420(hisD)
PART: PARC_a1302(hpsN)
PAGA: PAGA_a2523(hpsN)
AMAC: MASE_15385
ALR: DS731_00845(hisD)
GPS: C427_0082
GAI: IMCC3135_20750(hpsN_1) IMCC3135_26035(hpsN_2) IMCC3135_30885(hpsN_3)
HCO: LOKO_03376(hpsN)
HHH: CLM76_02795(hisD)
HBE: BEI_0845(hpsN1) BEI_1107(hpsN2)
HAF: C8233_03385(hisD)
KUY: FY550_15220(hisD)
PAUR: FGL86_17225(hisD)
LLP: GH975_08280(hisD)
SALN: SALB1_1666
THIN: CRN91_00450(hisD) CRN91_00980(hisD)
REH: H16_A1694(h16_A1694)
CPAU: EHF44_26110(hisD)
BCN: Bcen_1517
BGO: BM43_40(hisD)
BGP: BGL_2c18430(hisD)
BXE: Bxe_C0309
BXB: DR64_8125(hisD)
BPH: Bphy_7422
PMEG: FNZ07_08965(hisD)
BHZ: ACR54_00804(hpsN)
BTRM: SAMEA390648700451(hisD_1)
AXY: AXYL_01399(hisD2)
ASW: CVS48_08695(hisD)
AMIM: MIM_c09530(hisD2)
VEI: Veis_0769
RTA: Rta_27270(hisD)
LIH: L63ED372_00902(hpsN)
HYN: F9K07_28790(hisD)
HHF: E2K99_23220(hisD)
XYK: GT347_15510(hisD)
ACOM: CEW83_08425(hisD)
AZR: CJ010_08300(hisD)
DAT: HRM2_03140(hisD1)
DALK: DSCA_18210(hisD_1)
MLO: mlr6649
MES: Meso_1928
RPOD: E0E05_11230(hisD)
ORM: HTY61_12010(hisD)
RHI: NGR_b04410 NGR_b16070(hisD1)
SFH: SFHH103_01284(hisD2)
SIX: BSY16_5513(hisD)
SAME: SAMCFNEI73_pC1468(hisD)
EAD: OV14_b0880(hisD1)
REI: IE4771_PB00243(hisD-2)
RLE: pRL80041(hisD2)
RHR: CKA34_28430(hisD)
RGR: FZ934_23660(hisD)
BOS: BSY19_1289(hisD)
BOF: FQV39_18635(hisD)
VGO: GJW-30_1_00907(hpsN_1) GJW-30_1_01965(hpsN_2)
STAR: G3545_11255(hisD) G3545_24870(hisD)
LNE: FZC33_00875(hisD) FZC33_14695(hisD)
APRA: G3A50_21635(hisD)
MNO: Mnod_4267
MMES: MMSR116_01585(hisD)
RHJ: HZY79_09725(hisD)
DEI: C4375_12335(hisD) C4375_12360(hisD)
MMED: Mame_04313(hpsN_1) Mame_05173(hpsN_2) Mame_05185(hpsN_3)
AALA: IGS74_17450(hisD)
BRN: D1F64_19415(hisD)
HDI: HDIA_3170(hpsN)
CFH: C1707_01990(hisD)
SIL: SPO0594(hpsN) SPO0981
RUA: D1823_05095(hisD) D1823_18835(hisD)
RUT: FIU92_07910(hpsN1) FIU92_18225(hpsN2)
RDE: RD1_3808(hisD) RD1_3948(hisD)
RLI: RLO149_c004880(hisD2) RLO149_c006370(hisD3)
RPON: G3256_03870(hisD) G3256_13775(hisD)
PYE: A6J80_16310(hisD) A6J80_16410(hisD)
PZH: CX676_13155(hisD) CX676_13200(hisD)
PARO: CUV01_13375(hisD) CUV01_13420(hisD)
PARU: CYR75_12595(hisD)
PPAN: ESD82_00940(hisD) ESD82_16450(hisD)
DSH: Dshi_2034(hisD2) Dshi_2242(hisD3)
PGA: PGA1_c07750(hisD1) PGA1_c25490(hisD2) PGA1_c27370(hisD3)
PGL: PGA2_c07530(hisD2) PGA2_c25390(hisD3)
PHP: PhaeoP97_01086(hisD3)
PPIC: PhaeoP14_00696(hisD1) PhaeoP14_02480(hisD3)
PHQ: D1820_08400(hisD) D1820_16950(hisD)
OAT: OAN307_c35180(hisD2) OAN307_c48490(hisD3)
OAR: OA238_160p0290(hisD) OA238_c24160(hisD1) OA238_c29640(hisD2) OA238_c48370(hisD4)
OTM: OSB_32490(hpsN)
OCT: FTO60_12465(hisD) FTO60_13760(hisD)
LEJ: ETW24_02325(hisD) ETW24_15625(hisD)
LAQU: R2C4_00650(hisD) R2C4_03535(hisD)
PTP: RCA23_c21930(hisD2) RCA23_c26870(hisD3)
RSU: NHU_04453(hisD)
LABR: CHH27_12040(hisD) CHH27_16760(hisD)
LABP: FJ695_27790(hisD)
LABT: FIU93_30275(hpsN1) FIU93_30335(hpsN2)
YPAC: CEW88_04375(hisD) CEW88_22695(hisD)
SULZ: C1J03_04920(hisD) C1J03_11915(hisD)
SULI: C1J05_06910(hisD) C1J05_16090(hisD)
SPOT: G6548_16730(hisD)
RID: RIdsm_00494(hpsN)
ROM: EI983_02800(hisD) EI983_18900(hisD)
ROH: FIU89_02610(hpsN1) FIU89_13955(hpsN2)
RBG: BG454_15370(hisD)
SAGU: CDO87_14620(hisD) CDO87_18475(hisD) CDO87_18520(hisD)
THAA: CFI11_07280(hisD) CFI11_22175(hisD)
GEH: HYN69_00370(hisD)
TAW: EI545_04905(hisD) EI545_04925(hisD) EI545_14725(hisD)
SEDI: EBB79_03180(hisD) EBB79_14275(hisD)
BOO: E2K80_12245(hisD) E2K80_12270(hisD)
PSEB: EOK75_01145(hisD) EOK75_18460(hisD)
MARU: FIU81_03585(hpsN)
ROT: FIV09_00080(hpsN)
PAED: G5B38_17045(hisD)
MALU: KU6B_37700(hisD_1) KU6B_37810(hisD_2) KU6B_40350(hisD_3)
THAS: C6Y53_06700(hisD)
FAQ: G5B39_15400(hisD)
NAR: Saro_3423
NOV: TQ38_020025(hisD)
NOT: C7W88_17740(hisD)
NOR: FA702_20075(hisD) FA702_20105(hisD)
NOG: GKE62_07885(hisD) GKE62_11150(hisD)
SPHI: TS85_23210
SPHR: BSY17_83(hisD)
BLAS: BSY18_3965(hisD)
RDI: CMV14_09780(hisD)
PALG: HFP57_16015(hisD)
SAND: H3309_03500(hisD)
SHUM: STHU_10300(hisD_1)
SVC: STVA_44230(hisD_2)
THAC: CSC3H3_22895(hisD)
NAO: Y958_19140(hisD)
NCB: C0V82_13695(hisD)
HTQ: FRZ44_36780(hisD1) FRZ44_43920(hisD)
HADH: FRZ61_35830(hisD1) FRZ61_41810(hisD)
PUB: SAR11_0801(hisD2)
PEG: E5R92_01975(hisD)
BMD: BMD_1657(hisD)
BMEG: BG04_3973(hisD)
BEO: BEH_11410
BCL: ABC1168
BKO: CKF48_05215(hisD)
LYG: C1N55_20065(hisD)
PASA: BAOM_4816(hpsN)
PSYH: D0S48_10150(hisD)
RUE: DT065_17120(hisD)
SALE: EPH95_03675(hisD)
STEA: C0679_01115(hisD)
SSCU: CEP64_13375(hisD)
PPSC: EHS13_22085(hisD)
BTS: Btus_2894
PLX: CW734_04305(hisD)
CACE: CACET_c12870(hisD1)
CRS: FQB35_14815(hisD)
BLAU: DQQ01_02240(hisD)
PDC: CDIF630_01753(hisD)
CDC: CD196_1504(hisD)
CDL: CDR20291_1479(hisD)
PDF: CD630DERM_15820(hisD)
TAE: TepiRe1_1115(hisD)
MGRO: FZ046_01425(hisD)
MSM: MSMEG_2012(hisD) MSMEG_5656(hisD)
MVQ: MYVA_3092(hisD2)
MAUU: NCTC10437_01640(hpsN)
CGT: cgR_0116
CGY: CGLY_10805(hisD1) CGLY_10865(hpsN)
RHA: RHA1_ro04557(hisD2)
ROP: ROP_44710(hisD)
SCB: SCAB_89041(hisD)
SMAL: SMALA_1386
SGE: DWG14_02657(hpsN)
SAST: CD934_07485(hisD) CD934_07505(hisD)
MLV: CVS47_01021(hpsN_1) CVS47_01027(hpsN_2)
PLAP: EAO79_05850(hisD)
AGG: C1N71_13130(hisD)
ARTH: C3B78_17490(hisD)
PSEY: GU243_21335(hisD)
AEB: C6I20_02945(hisD)
ACTW: F7P10_23120(hisD) F7P10_23160(hisD)
KRA: Krad_2498
SEN: SACE_3119(hisD2)
AMYC: CU254_18835(hisD) CU254_18870(hisD)
AMYY: YIM_21405(hpsN1) YIM_21450(hpsN2)
PSEA: WY02_28305
BSOL: FSW04_24235(hisD)
CWO: Cwoe_0128
MRB: Mrub_2545
PLH: VT85_11070(hpsN)
SACI: Sinac_7380
PBOR: BSF38_01252(hpsN)
AGV: OJF2_30990(hpsN)
TAI: Taci_0033
FGG: FSB75_00075(hisD)
PGIN: FRZ67_05840(hisD)
RUN: DR864_23085(hisD)
RUP: DTQ70_06245(hisD)
RHOZ: GXP67_01645(hisD)
HYJ: FHG12_20705(hisD)
HALJ: G9465_23315(hisD)
HAER: DU502_08815(hisD)
HALU: HUG12_14850(hisD)
NVR: FEJ81_21100(hisD)
 » show all
Reference
1  [PMID:20150239]
  Authors
Mayer J, Huhn T, Habeck M, Denger K, Hollemeyer K, Cook AM
  Title
2,3-Dihydroxypropane-1-sulfonate degraded by Cupriavidus pinatubonensis JMP134: purification of dihydroxypropanesulfonate 3-dehydrogenase.
  Journal
Microbiology 156:1556-64 (2010)
DOI:10.1099/mic.0.037580-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.308
IUBMB Enzyme Nomenclature: 1.1.1.308
ExPASy - ENZYME nomenclature database: 1.1.1.308
BRENDA, the Enzyme Database: 1.1.1.308

DBGET integrated database retrieval system