2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase;
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase;
alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+ [RN:
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal;
The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate . However, later studies showed that the substrate is the hemiacetal form , and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].
EC 126.96.36.1992 created 1978 as EC 188.8.131.52, transferred 2011 to EC 184.108.40.2062
ec01120 Microbial metabolism in diverse environments
K10219 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
ACIP: CBP36_05705 CBP36_20295
DEL: DelCs14_1674 DelCs14_2360
NOV: TQ38_025015 TQ38_028420
NDR: HT578_08925 HT578_09615
SHYD: CJD35_16830 CJD35_19590
SHUN: DWB77_01946(ligC_2) » show all
Maruyama K, Ariga N, Tsuda M, Deguchi K.
Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase.
Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase.
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
Masai E, Momose K, Hara H, Nishikawa S, Katayama Y, Fukuda M
Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6.
ExPASy - ENZYME nomenclature database: 220.127.116.112