KEGG   ENZYME: 1.1.1.315
Entry
EC 1.1.1.315                Enzyme                                 

Name
11-cis-retinol dehydrogenase;
RDH5 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
11-cis-retinol:NAD+ oxidoreductase
Reaction(IUBMB)
11-cis-retinol---[retinal-binding-protein] + NAD+ = 11-cis-retinal---[retinol-binding-protein] + NADH + H+
Reaction(KEGG)
(other) R03048 R08382
Substrate
11-cis-retinol---[retinal-binding-protein];
NAD+ [CPD:C00003]
Product
11-cis-retinal---[retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal [1] while the substrate is bound to the retinal-binding protein [4]. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol [2].
History
EC 1.1.1.315 created 2011
Orthology
K00061  11-cis-retinol dehydrogenase
Genes
HSA: 5959(RDH5)
PTR: 467029(RDH5)
PPS: 100988391(RDH5)
GGO: 101125878(RDH5)
PON: 100437933(RDH5)
NLE: 100598708(RDH5)
MCC: 709644(RDH5)
MCF: 107126391(RDH5)
CSAB: 103238482(RDH5)
CATY: 105587331(RDH5)
PANU: 101020375(RDH5)
RRO: 104673711(RDH5)
RBB: 108516026(RDH5)
TFN: 117089975(RDH5)
PTEH: 111541884(RDH5)
CJC: 100402026(RDH5)
SBQ: 101051979(RDH5)
MMUR: 109729192(RDH5)
MMU: 19682(Rdh5)
MCAL: 110303548(Rdh5)
MPAH: 110327089(Rdh5)
RNO: 366791(Rdh5)
MCOC: 116075885(Rdh5)
MUN: 110563162(Rdh5)
CGE: 100772460(Rdh5)
PLEU: 114681765(Rdh5)
NGI: 103738827(Rdh5)
HGL: 101701578(Rdh5)
CCAN: 109696229(Rdh5)
OCU: 100346443(RDH5)
OPI: 101534881(RDH5)
TUP: 102492697(RDH5)
CFA: 481098(RDH5)
VVP: 112922414(RDH5)
VLG: 121491616(RDH5)
AML: 100477613(RDH5)
UMR: 103682388(RDH5)
UAH: 113256460(RDH5)
ORO: 101378842(RDH5)
ELK: 111160231
MPUF: 101694013(RDH5)
EJU: 114215022(RDH5)
MLX: 118008746(RDH5)
FCA: 101090450(RDH5)
PYU: 121040964(RDH5)
PBG: 122473719(RDH5)
PTG: 102955802(RDH5)
PPAD: 109270294(RDH5)
AJU: 106986902(RDH5)
HHV: 120219944(RDH5)
BTA: 281448(RDH5)
BOM: 102281461(RDH5)
BIU: 109559397(RDH5)
BBUB: 102405059(RDH5)
CHX: 102179453(RDH5)
OAS: 101115199(RDH5)
ODA: 120857407(RDH5)
CCAD: 122427804(RDH5)
SSC: 100517586(RDH5)
CFR: 102522460(RDH5)
CBAI: 105075923(RDH5)
CDK: 105086399(RDH5)
BACU: 103013640(RDH5)
LVE: 103070515(RDH5)
OOR: 101272361(RDH5)
DLE: 111173906(RDH5)
PCAD: 102981003(RDH5)
ECB: 100051379(RDH5)
EPZ: 103560206(RDH5)
EAI: 106841311(RDH5)
MYB: 102250054(RDH5)
MYD: 102752637(RDH5)
MMYO: 118650216(RDH5)
MNA: 107538219(RDH5)
PKL: 118730397(RDH5)
HAI: 109396898(RDH5)
DRO: 112319078(RDH5)
SHON: 118975846(RDH5)
AJM: 119048530(RDH5)
MMF: 118624197(RDH5)
PALE: 102890960(RDH5)
PGIG: 120604875(RDH5)
RAY: 107521261(RDH5)
MJV: 108395935(RDH5)
TOD: 119248026(RDH5)
LAV: 100665758(RDH5)
TMU: 101359207
SHR: 100926680(RDH5)
PCW: 110210897(RDH5)
OAA: 100077776(RDH5)
GGA: 395452(RDH5)
PCOC: 116235212(RDH5)
MGP: 100551395
CJO: 107325819(RDH5)
NMEL: 110391116(RDH5)
LSR: 110483543
PMOA: 120503923(RDH5)
OTC: 121338757(RDH5)
PRUF: 121352058
PHI: 102110114(RDH5)
ETL: 114070099(RDH5)
CLV: 102088293(RDH5)
NPD: 112954223(RDH5)
ASN: 102385802(RDH5)
AMJ: 102572099(RDH5)
PSS: 102452664(RDH5)
CMY: 119564299(RDH5)
CPIC: 101937595(RDH5)
TST: 117888703(RDH5)
CABI: 116827762(RDH5)
ACS: 100561257(rdh5)
PVT: 110073773(RDH5)
PBI: 103065660(RDH5)
PMUR: 107294926(RDH5)
TSR: 106544310(RDH5)
PGUT: 117662852(RDH5)
PMUA: 114587482(RDH5)
ZVI: 118079582(RDH5)
GJA: 107121726(RDH5)
XLA: 444623(rdh5.L) 447549(rdh5.S)
XTR: 496830(rdh5)
NPR: 108796498(RDH5)
DRE: 556528(rdh5)
SANH: 107653177
IPU: 108281000(rdh5)
PHYP: 113538008(rdh5)
AMEX: 103042897(rdh5)
EEE: 113580614
TRU: 101069778
LCO: 104922032(rdh5)
NCC: 104964277
CGOB: 115007744(rdh5)
ELY: 117256620(rdh5)
PLEP: 121954371(rdh5)
SLUC: 116051415 116051418(rdh5)
ECRA: 117943470(rdh5)
PFLV: 114554590
GAT: 120834586(rdh5)
PPUG: 119229689(rdh5)
MSAM: 119886406(rdh5)
CUD: 121507237(rdh5)
MZE: 101481430
ONL: 100710882(rdh5)
OAU: 116326849(rdh5)
OLA: 100125503(rdh5)
OML: 112145338(rdh5)
XMA: 102227238
XCO: 114135012
XHE: 116710304
PRET: 103464826
CVG: 107103450(rdh5)
CTUL: 119797824(rdh5)
NFU: 107385384(rdh5)
KMR: 108231532(rdh5)
ALIM: 106517650(rdh5)
AOCE: 111576058(rdh5)
CSEM: 103386710(rdh5)
POV: 109635450(rdh5)
LCF: 108902106
SDU: 111233581(rdh5)
SLAL: 111655098(rdh5)
XGL: 120783021(rdh5)
HCQ: 109521663(rdh5)
BPEC: 110173750(rdh5)
MALB: 109969798(rdh5)
OTW: 112246300
SALP: 111970500
ELS: 105007069
AANG: 118211649(rdh5)
LOC: 102694797
PSPA: 121307122
LCM: 102365116
CMK: 103180707(rdh5)
VDE: 111247750
VJA: 111264885
OSN: 115215065
PDAM: 113684761
SPIS: 111327939
 » show all
Reference
1  [PMID:7836368]
  Authors
Simon A, Hellman U, Wernstedt C, Eriksson U
  Title
The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases.
  Journal
J Biol Chem 270:1107-12 (1995)
DOI:10.1074/jbc.270.3.1107
  Sequence
[bta:281448]
Reference
2  [PMID:9931293]
  Authors
Wang J, Chai X, Eriksson U, Napoli JL
  Title
Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.
  Journal
Biochem J 338 ( Pt 1):23-7 (1999)
  Sequence
[hsa:5959]
Reference
3  [PMID:11675386]
  Authors
Liden M, Romert A, Tryggvason K, Persson B, Eriksson U
  Title
Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus.
  Journal
J Biol Chem 276:49251-7 (2001)
DOI:10.1074/jbc.M107337200
  Sequence
[hsa:5959]
Reference
4  [PMID:12536149]
  Authors
Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW
  Title
Mapping the ligand binding pocket in the cellular retinaldehyde binding protein.
  Journal
J Biol Chem 278:12390-6 (2003)
DOI:10.1074/jbc.M212775200
  Sequence
[hsa:5959]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.315
IUBMB Enzyme Nomenclature: 1.1.1.315
ExPASy - ENZYME nomenclature database: 1.1.1.315
BRENDA, the Enzyme Database: 1.1.1.315

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