KEGG   ENZYME: 1.1.1.315
Entry
EC 1.1.1.315                Enzyme                                 
Name
11-cis-retinol dehydrogenase;
RDH5 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
11-cis-retinol:NAD+ oxidoreductase
Reaction(IUBMB)
11-cis-retinol---[retinal-binding-protein] + NAD+ = 11-cis-retinal---[retinol-binding-protein] + NADH + H+
Reaction(KEGG)
(other) R03048 R08382
Substrate
11-cis-retinol---[retinal-binding-protein];
NAD+ [CPD:C00003]
Product
11-cis-retinal---[retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal [1] while the substrate is bound to the retinal-binding protein [4]. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol [2].
History
EC 1.1.1.315 created 2011
Orthology
K00061  11-cis-retinol dehydrogenase
Genes
HSA5959(RDH5)
PTR467029(RDH5)
PPS100988391(RDH5)
GGO101125878(RDH5)
PON100437933(RDH5)
NLE100598708(RDH5)
MCC709644(RDH5)
MCF107126391(RDH5)
CSAB103238482(RDH5)
CATY105587331(RDH5)
PANU101020375(RDH5)
TGE112634360(RDH5)
RRO104673711(RDH5)
RBB108516026(RDH5)
TFN117089975(RDH5)
PTEH111541884(RDH5)
CJC100402026(RDH5)
SBQ101051979(RDH5)
CSYR103266789(RDH5)
MMUR109729192(RDH5)
LCAT123639691(RDH5)
OGA100962477(RDH5)
MMU19682(Rdh5)
MCAL110303548(Rdh5)
MPAH110327089(Rdh5)
RNO366791(Rdh5)
MCOC116075885(Rdh5)
MUN110563162(Rdh5)
CGE100772460(Rdh5)
MAUA101842006(Rdh5)
PLEU114681765(Rdh5)
MORG121462246(Rdh5)
AAMP119803379(Rdh5)
NGI103738827(Rdh5)
HGL101701578(Rdh5)
CPOC100716482(Rdh5)
CCAN109696229(Rdh5)
DORD105990761(Rdh5)
DSP122124150(Rdh5)
NCAR124983578
OCU100346443(RDH5)
OPI101534881(RDH5)
TUP102492697(RDH5)
CFA481098(RDH5)
CLUD112678051(RDH5)
VVP112922414(RDH5)
VLG121491616(RDH5)
AML100477613(RDH5)
UMR103682388(RDH5)
UAH113256460(RDH5)
UAR123787282(RDH5)
ELK111160231
LLV125107375
MPUF101694013(RDH5)
ORO101378842(RDH5)
EJU114215022(RDH5)
ZCA113922945(RDH5)
MLX118008746(RDH5)
FCA101090450(RDH5)
PYU121040964(RDH5)
PBG122473719(RDH5)
PTG102955802(RDH5)
PPAD109270294(RDH5)
AJU106986902(RDH5)
HHV120219944(RDH5)
BTA281448(RDH5)
BOM102281461(RDH5)
BIU109559397(RDH5)
BBUB102405059(RDH5)
CHX102179453(RDH5)
OAS101115199(RDH5)
ODA120857407(RDH5)
CCAD122427804(RDH5)
SSC100517586(RDH5)
CFR102522460(RDH5)
CBAI105075923(RDH5)
CDK105086399(RDH5)
VPC102536073(RDH5)
BACU103013640(RDH5)
LVE103070515(RDH5)
OOR101272361(RDH5)
DLE111173906(RDH5)
PCAD102981003(RDH5)
PSIU116761093(RDH5)
ECB100051379(RDH5)
EPZ103560206(RDH5)
EAI106841311(RDH5)
MYB102250054(RDH5)
MYD102752637(RDH5)
MMYO118650216(RDH5)
MLF102418468(RDH5)
MNA107538219(RDH5)
PKL118730397(RDH5)
HAI109396898(RDH5)
DRO112319078(RDH5)
SHON118975846(RDH5)
AJM119048530(RDH5)
PDIC118496626(RDH5)
PHAS123812926(RDH5)
MMF118624197(RDH5)
RFQ117029459(RDH5)
PALE102890960(RDH5)
PGIG120604875(RDH5)
PVP105302612(RDH5)
RAY107521261(RDH5)
MJV108395935(RDH5)
TOD119248026(RDH5)
SARA101546945(RDH5)
LAV100665758(RDH5)
TMU101359207
DNM101444166(RDH5)
GAS123249031(RDH5)
SHR100926680(RDH5)
PCW110210897(RDH5)
OAA100077776(RDH5)
GGA395452(RDH5)
PCOC116235212(RDH5)
MGP100551395
CJO107325819(RDH5)
NMEL110391116(RDH5)
AFUL116500006(RDH5)
LSR110483543
PMOA120503923(RDH5)
OTC121338757(RDH5)
PRUF121352058
PHI102110114(RDH5)
ETL114070099(RDH5)
CLV102088293(RDH5)
TALA116961526(RDH5)
ACHC115350876(RDH5)
NPD112954223(RDH5)
ASN102385802(RDH5)
AMJ102572099(RDH5)
PSS102452664(RDH5)
CMY119564299(RDH5)
CPIC101937595(RDH5)
TST117888703(RDH5)
CABI116827762(RDH5)
MRV120391110(RDH5)
ACS100561257(rdh5)
PVT110073773(RDH5)
SUND121921108(RDH5)
PBI103065660(RDH5)
PMUR107294926(RDH5)
TSR106544310(RDH5)
PGUT117662852(RDH5)
VKO123033167(RDH5)
PMUA114587482(RDH5)
ZVI118079582(RDH5)
GJA107121726(RDH5)
STOW125427669(RDH5)
XLA444623(rdh5.L) 447549(rdh5.S)
XTR496830(rdh5)
NPR108796498(RDH5)
RTEM120929556(RDH5)
BBUF120993663(RDH5)
BGAR122931032(RDH5)
DRE556528(rdh5)
SRX107736472 107745400
SANH107653177
SGH107573570 107586996
CCAR109062934 109063464
CAUA113039486 113039514 113040775 113064698 113080109
PPRM120492909(rdh5)
MAMB125263575(rdh5)
IPU108281000(rdh5)
PHYP113538008(rdh5)
SMEO124402340(rdh5)
TFD113639090(rdh5)
AMEX103042897(rdh5)
EEE113580614
TRU101069778
TNGGSTEN00037625G001
LCO104922032(rdh5)
NCC104964277
CGOB115007744(rdh5)
ELY117256620(rdh5)
EFO125892935(rdh5)
PLEP121954371(rdh5)
SLUC116051415 116051418(rdh5)
ECRA117943470(rdh5)
ESP116687746(rdh5)
PFLV114554590
GAT120834586(rdh5)
PPUG119229689(rdh5)
MSAM119886406(rdh5)
CUD121507237(rdh5)
ALAT119021367(rdh5)
MZE101481430
ONL100710882(rdh5)
OAU116326849(rdh5)
OLA100125503(rdh5)
OML112145338(rdh5)
XMA102227238
XCO114135012
XHE116710304
PRET103464826
PFOR103150135(rdh5)
PLAI106952142(rdh5)
PMEI106923335(rdh5)
GAF122833903(rdh5)
CVG107103450(rdh5)
CTUL119797824(rdh5)
GMU124857132(rdh5)
NFU107385384(rdh5)
KMR108231532(rdh5)
ALIM106517650(rdh5)
NWH119411860(rdh5)
AOCE111576058(rdh5)
MCEP125006507(rdh5)
CSEM103386710(rdh5)
POV109635450(rdh5)
SSEN122768312(rdh5)
HHIP117761343(rdh5)
HSP118104741(rdh5)
LCF108902106
SDU111233581(rdh5)
SLAL111655098(rdh5)
XGL120783021(rdh5)
HCQ109521663(rdh5)
BPEC110173750(rdh5)
MALB109969798(rdh5)
BSPL114856142(rdh5)
SASA106566157 106583706
OTW112246300
OMY110519410 110529045
OGO124003926 124018490
ONE115122218
SALP111970500
SNH120023979 120065517
CCLU121574737(rdh5)
ELS105007069
SFM108928371 114909360
AANG118211649(rdh5)
LOC102694797
PSPA121307122
ARUT117401139 117966981
LCM102365116
CMK103180707(rdh5)
DSV119463870 119463874
RSAN119401518 119402626
VDE111247750
VJA111264885
MMER123531040
OSN115215065
EPA110231798 110254791
PDAM113684761
SPIS111327939
BBIGBBBOND_0107740
EHXEMIHUDRAFT_310752
 » show all
Reference
1  [PMID:7836368]
  Authors
Simon A, Hellman U, Wernstedt C, Eriksson U
  Title
The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases.
  Journal
J Biol Chem 270:1107-12 (1995)
DOI:10.1074/jbc.270.3.1107
  Sequence
[bta:281448]
Reference
2  [PMID:9931293]
  Authors
Wang J, Chai X, Eriksson U, Napoli JL
  Title
Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.
  Journal
Biochem J 338 ( Pt 1):23-7 (1999)
  Sequence
[hsa:5959]
Reference
3  [PMID:11675386]
  Authors
Liden M, Romert A, Tryggvason K, Persson B, Eriksson U
  Title
Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus.
  Journal
J Biol Chem 276:49251-7 (2001)
DOI:10.1074/jbc.M107337200
  Sequence
[hsa:5959]
Reference
4  [PMID:12536149]
  Authors
Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW
  Title
Mapping the ligand binding pocket in the cellular retinaldehyde binding protein.
  Journal
J Biol Chem 278:12390-6 (2003)
DOI:10.1074/jbc.M212775200
  Sequence
[hsa:5959]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.315
IUBMB Enzyme Nomenclature: 1.1.1.315
ExPASy - ENZYME nomenclature database: 1.1.1.315
BRENDA, the Enzyme Database: 1.1.1.315

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