KEGG   ENZYME: 1.1.1.316Help
Entry
EC 1.1.1.316                Enzyme                                 

Name
L-galactose 1-dehydrogenase;
L-GalDH;
L-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+ [RN:R07675]
Reaction(KEGG)
Substrate
L-galactose [CPD:C01825];
NAD+ [CPD:C00003]
Product
L-galactono-1,4-lactone [CPD:C01115];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway). The activity with NADP+ is less than 10% of the activity with NAD+.
History
EC 1.1.1.316 created 2011
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17744  L-galactose dehydrogenase
Genes
BFO: BRAFLDRAFT_67662
CIN: 100186884
SPU: 115925958 577380 584746
SKO: 100374490
DER: 6553843
DSI: Dsimw501_GD20614(Dsim_GD20614) Dsimw501_GD20615(Dsim_GD20615) Dsimw501_GD20616(Dsim_GD20616)
DSR: 110176662
DPO: Dpse_GA14985
DPE: 6591872
DMN: 108155422
DNV: 108660375
MDE: 101898389
AAG: 5570890
AME: 551849
BIM: 100743530
BTER: 100647407
CCAL: 108623090
OBB: 114882923
SOC: 105195368
MPHA: 105829971
AEC: 105146035
ACEP: 105617475
PBAR: 105431050
VEM: 105560780
HST: 105188424
DQU: 106751467
CFO: 105251704
LHU: 105671315
PGC: 109855486
OBO: 105287047
PCF: 106791390
NVI: 100114845
CSOL: 105363065
MDL: 103573392
TCA: 658727
ATD: 109604375
NVL: 108567277
BMOR: 101746219
PRAP: 110999854
HAW: 110372471
TNL: 113495667
PXY: 105381293
BTAB: 109043618
CLEC: 106674209
ZNE: 110831800
FCD: 110848494
PVM: 113811226
DPTE: 113790066
CSCU: 111631941
PTEP: 107452303
PCAN: 112563680
MYI: 110459756
LAK: 106165444
NVE: 5515835
EPA: 110252852
ATH: AT4G33670
ALY: 9303236
CRB: 17878442
BRP: 103834464 103862253(GDH)
BOE: 106303708
THJ: 104807192
CPAP: 110818987
CIT: 102621043
TCC: 18607308
GRA: 105763009
GAB: 108479971
DZI: 111308642
EGR: 104453016
GMX: 100809400
GSJ: 114421349
VRA: 106765834
VAR: 108332744
VUN: 114176640
CCAJ: 109809791
CAM: 101495571
LJA: Lj0g3v0243739.1(Lj0g3v0243739.1) Lj4g3v0410570.2(Lj4g3v0410570.2)
ADU: 107480539
AIP: 107626271
LANG: 109331942
FVE: 101299720
RCN: 112173603
PPER: 18766583
PMUM: 103334968
PAVI: 110757233
MDM: 103436244
PXB: 103938180
ZJU: 107427462
CSV: 101206435
CMO: 103495364
MCHA: 111022462
CMAX: 111471025
CMOS: 111455013
CPEP: 111776398
RCU: 8279173
JCU: 105635996
MESC: 110619655
JRE: 108995719
QSU: 112040078
VVI: 100263479(GDH)
SLY: 101254135
SPEN: 107006598
SOT: 102599558
CANN: 107840121
NSY: 104219974
NTO: 104103548
NAU: 109213589
INI: 109165254
SIND: 105169328
OEU: 111388928
HAN: 110877998
LSV: 111881024
CCAV: 112500306
DCR: 108224817
BVG: 104904801
SOE: 110788012
NNU: 104607573
OSA: 4352223
DOSA: Os12t0482700-01(Os12g0482700)
OBR: 102719064
BDI: 100840848
ATS: 109753847(LOC109753847)
SBI: 8063259
ZMA: 732776(pco064579)
SITA: 101762145
PDA: 103707620
EGU: 105055920
MUS: 103979808
DCT: 110113925
AOF: 109834292
ATR: 18442443
APRO: F751_2396
DFA: DFA_04455(alrE)
SPAR: SPRG_00672
AXL: AXY_03780
PMW: B2K_20970
PRI: PRIO_5047(LGALDH)
RBA: RB203
PSL: Psta_0942
PIR: VN12_21745(fdh)
RUL: UC8_37580(fdh)
PLM: Plim_1644
PEH: Spb1_24960(fdh_1)
PLS: VT03_25970(fdh)
FMR: Fuma_05271(fdh)
GES: VT84_30385(fdh)
SACI: Sinac_2808
 » show all
Taxonomy
Reference
1  [PMID:15509850]
  Authors
Mieda T, Yabuta Y, Rapolu M, Motoki T, Takeda T, Yoshimura K, Ishikawa T, Shigeoka S
  Title
Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate.
  Journal
Plant Cell Physiol 45:1271-9 (2004)
DOI:10.1093/pcp/pch152
  Sequence
Reference
2  [PMID:12047629]
  Authors
Gatzek S, Wheeler GL, Smirnoff N
  Title
Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis.
  Journal
Plant J 30:541-53 (2002)
DOI:10.1046/j.1365-313X.2002.01315.x
  Sequence
[ath:AT4G33670]
Reference
3  [PMID:9620799]
  Authors
Wheeler GL, Jones MA, Smirnoff N
  Title
The biosynthetic pathway of vitamin C in higher plants.
  Journal
Nature 393:365-9 (1998)
DOI:10.1038/30728
Reference
4  [PMID:19297184]
  Authors
Oh MM, Carey EE, Rajashekar CB
  Title
Environmental stresses induce health-promoting phytochemicals in lettuce.
  Journal
Plant Physiol Biochem 47:578-83 (2009)
DOI:10.1016/j.plaphy.2009.02.008
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.316
IUBMB Enzyme Nomenclature: 1.1.1.316
ExPASy - ENZYME nomenclature database: 1.1.1.316
BRENDA, the Enzyme Database: 1.1.1.316

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