Entry |
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Name |
isoeugenol synthase;
IGS1;
t-anol/isoeugenol synthase 1
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
eugenol:NADP+ oxidoreductase (coniferyl acetate reducing)
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Reaction(IUBMB) |
isoeugenol + acetate + NADP+ = coniferyl acetate + NADPH + H+ [RN: R09931]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme acts in the opposite direction. In Ocimum basilicum (sweet basil), Clarkia breweri and Petunia hybrida only isoeugenol is formed [1,2]. However in Pimpinella anisum (anise) only anol is formed in vivo, although the cloned enzyme does produce isoeugenol [3].
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History |
EC 1.1.1.319 created 2012
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Pathway |
ec00940 | Phenylpropanoid biosynthesis |
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Orthology |
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Reference |
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Authors |
Koeduka T, Fridman E, Gang DR, Vassao DG, Jackson BL, Kish CM, Orlova I, Spassova SM, Lewis NG, Noel JP, Baiga TJ, Dudareva N, Pichersky E |
Title |
Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester. |
Journal |
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Sequence |
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Reference |
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Authors |
Koeduka T, Louie GV, Orlova I, Kish CM, Ibdah M, Wilkerson CG, Bowman ME, Baiga TJ, Noel JP, Dudareva N, Pichersky E |
Title |
The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. |
Journal |
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Reference |
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Authors |
Koeduka T, Baiga TJ, Noel JP, Pichersky E |
Title |
Biosynthesis of t-anethole in anise: characterization of t-anol/isoeugenol synthase and an O-methyltransferase specific for a C7-C8 propenyl side chain. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.319 |
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