Entry
Name
8-hydroxygeraniol dehydrogenase;
8-hydroxygeraniol oxidoreductase;
CYP76B10;
G10H;
CrG10H;
SmG10H;
acyclic monoterpene primary alcohol:NADP+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(6E)-8-hydroxygeraniol:NADP+ oxidoreductase
Reaction(IUBMB)
(6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction) [RN:
R08499 ];
(1a) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-hydroxygeranial + NADPH + H+ [RN:
R09926 ];
(1b) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-oxogeraniol + NADPH + H+ [RN:
R09927 ];
(1c) (6E)-8-hydroxygeranial + NADP+ = (6E)-8-oxogeranial + NADPH + H+ [RN:
R09928 ];
(1d) (6E)-8-oxogeraniol + NADP+ = (6E)-8-oxogeranial + NADPH + H+ [RN:
R09929 ]
Reaction(KEGG)
Substrate
(6E)-8-hydroxygeraniol [CPD:
C17621 ];
NADP+ [CPD:
C00006 ];
(6E)-8-hydroxygeranial [CPD:
C20222 ];
(6E)-8-oxogeraniol [CPD:
C20223 ]
Product
Comment
Contains Zn2+. The enzyme catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol. Also acts on geraniol, nerol and citronellol. May be identical to EC
1.1.1.183 geraniol dehydrogenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol as used by references 1 and 2. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}.
History
EC 1.1.1.324 created 2012
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K23232 8-hydroxygeraniol dehydrogenase
Genes
CIC : CICLE_v10025755mg CICLE_v10025933mg CICLE_v10026185mg
PVY : 116129781 116131356 116133638 116143840 116143842 116143843 116146377
MINC : 123192061 123210469 123213697 123214839 123216740 123221905 123229782
GRA : 105761267 105763514 105787742 105787743 105804130
GHI : 107925779 107940605 107940871 107943783 107947223 107950489 121209950 121223428
GAB : 108462294 108466633 108472514 108474204 108478314 108478630
HSYR : 120125616 120126736 120130479 120138239 120166901 120216530
DZI : 111288725 111291756 111291757 111311783 111311785 111317014
EGR : 104418344 104429416 104444737 104453744
PVU : 137811290 137811293 137811294
VUM : 124828766 124845809 124845836
CCAJ : 109800431 109800810
APRC : 113868521 113868522 113868523
MTR : 11405461 11405462 11405463 11407842 11407843 11411933 11413451 11416510 11423701 11426262 11441675 25494598
TPRA : 123903767 123903768 123903769 123903771 123903772 123903777 123903778
CAM : 101510015 101510334 101510666 101511296
PSAT : 127076054 127118937 127118943
VVO : 131646099 131646100 131650205 131650206 131650210 131650211 131650219 131650220
ADU : 107480985 107487232 107487233 107487234 107487235 107487238
AIP : 107642290 107642291 107642292 107642293 107642295
AHF : 112747353 112747354 112747355 112747356 112747358 112791712 112799968 112799969 112799970 112799971 112799973
LANG : 109331771 109333059 109333060 109349124
PCIN : 129311339 129311340 129322367 129322368
QSA : O6P43_025191 O6P43_025192 O6P43_025193 O6P43_025194 O6P43_033266 O6P43_033267 O6P43_033268 O6P43_033269
FVE : 101293136 101293434 101297378 101305018 105352586
RCN : 112170111 112170112 112170113 112170114 112173332 112187218 112190872 112190873 112197344 112197352 112197358 112197375
PPER : 109949827 109949828 18772394 18772397 18772399 18773163 18773263 18773379 18773431 18774545 18774850 18775537 18775625
PMUM : 103335223 103335236 103335246 103335256 103335267 103335277 103335288 103335298 103335314 103335323
PAVI : 110744604 110755099 110772149 110772150 110772157 110772158 110773133 110773134 110773136 110773885
PDUL : 117629577 117629578 117630081 117630082 117630719 117630894 117630895 117631210 117633135 117633136 117633137 117633139 117633225
MDM : 103415151 103416068 103446799 103448758 103448898 114821662
MSYL : 126584379 126587089 126605425 126605426 126620821 126621014 126623237 126623261
PXB : 103927900 103954148(SAD) 103954149 103954695 103954696
ZJU : 107425062 107425065 107425070 107425101 107425106 107425124 112492598 112492600 125418176
MNT : 21385909 21385910 21409376 21409442
CSAV : 115712847 115712849 115712850 115725521
RCU : 8260964 8260966 8261810
JCU : 105641679 105641717 105641719 105641751
HBR : 110651640 110657190 110657297 110658829 110664407 110664408 110671751
MESC : 110604932 110604940 110608488 110608489 110608520 110608725 110627677 110627737 110629448 110629837 110629839 110630354
POP : 7455614 7463857 7465262 7475058 7475061 7488065
PEU : 105110689 105126043 105126294 105138196 105141572
PALZ : 118027679 118027681 118027682 118043831 118047063 118049851 118062493
PNZ : 133676694 133677345 133679118 133679703 133688703 133701482
JRE : 108984582 108986809 108986824 108994227 108999669 109003642 109003644 109003645 118349266
CILL : 122274147 122315253 122319192 122319194 122319195 122319297 122319298 122319299 122319300
CAVE : 132192152 132192286
QSU : 111999434 112006220 112006221 112006233 112006238 112021214
QLO : 115950657 115950658 115989470 115994249 115994250 115994453 115994455 115995220 115995349 115995451
TWL : 119986839 119995270 119998191 120012309
VVI : 100247559 100255907 100260964 100261642 100264687 100854583 100855415
VRI : 117907661 117918382 117918383 117918384 117918386 117919413 117919415
SLY : 101253340 101259903 101265396 104644298 543602
SPEN : 107003304 107003351 107003484 107004699 107004886
SOT : 102581654 102581912 102589424 102589753(drd-1) 102595339 102595669 102598492 102599810 102600145 102604900 107061631
SSTN : 125843529 125843531 125843532 125843885 125843886 125843887 125843893 125843898 125844414 125846084 125846086 125856828 125864456 125866244
SDUL : 129871570 129884974 129896857 129896882 129897360 129897376 129897438 129897470 129900419
CANN : 107849611 107850273 107850275 107850276 107850278 107850545 107850546 107851765
LBB : 132614181 132614242 132614243 132614851 132615022 132616209 132617051
NTA : 107772795(SAD4) 107773242 107773552
NSY : 104216597 104216598 104216600 104218512 104232065 104247345
NTO : 104089646 104103376 104108069 104114759 104114760
NAU : 109208903 109208905 109208906 109215604 109220179
INI : 109172720 109172721 109180300 109180302 109180303 109180304 109180305 109180306 109180307 109180308
ITR : 116012170 116012599 116012600 116012806 116012807 116013707 116013949 116013985 116014506 116021186 116025915
SIND : 105165971 105176369 105176370 105176372 105176373 105176374 105178229 105178286
OEU : 111373464 111373465 111373466 111376665 111376667 111385603
EGT : 105959003 105959013 105965126 105973276
SSPL : 121760094 121767408 121768607 121770429 121770797 121772668 121781933 121783176 121783317 121784594 121784595 121784596 121784598 121785111 121785252 121785270 121785512 121785680 121787553 121787593
SMIL : 131001627 131011140 131021871 131021872 131021874 131021875 131021877 131021878 131021920 131021921 131021922
SHIS : 125200881 125208267 125213256 125213257 125213258 125213279 125213280 125213618 125213619 125215972 125218779
APAN : 127242092 127248753 127248879 127256931 127256932 127258528
HAN : 110867821 110867822 110867824 110909241 110909243 110909244 110909246 110909257 110909259 110923586 110938113
ECAD : 122596050 122602767 122603005 122603035 122603360 122603475 122603917
LSV : 111883427 111883478 111913318
CCAV : 112507461 112510743 112522980
DCR : 108194533 108198616 108202765 108211204
CSIN : 114256186 114256196 114256206 114274899 114274964 114285850 114302967 114302972 114309783 114312840 114312846 114320821
RVL : 131304268 131304269 131304270 131304271 131304272 131304273 131304274 131331472 131331476 131331477
AEW : 130751817 130776906 130781834 130784599 130784965
CQI : 110682111 110695277 110713893 110725202
ATRI : 130820263 130820265
MOF : 131147218 131153794 131153802 131153831 131165296 131165303 131165312 131165318 131165323 131165331
MING : 122067465 122070770 122070780 122070781 122083248 122083250
TSS : 122645617 122660519 122660520 122660521 122660522 122660523 122661590
PSOM : 113286661 113310981
MSIN : 131229328 131229329 131229330 131229333 131229335
ACAK : 137952802 137952883 137952954 137953129 137954010
ATR : 105421195 18441230 18441231
» show all
Taxonomy
Reference
Authors
Ikeda H, Esaki N, Nakai S, Hashimoto K, Uesato S, Soda K, Fujita T
Title
Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols.
Journal
J Biochem 109:341-7 (1991)
Reference
Authors
Hallahan DL, West JM, Wallsgrove RM, Smiley DW, Dawson GW, Pickett JA, Hamilton JG
Title
Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa).
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.324