KEGG   ENZYME: 1.1.1.324
Entry
EC 1.1.1.324                Enzyme                                 
Name
8-hydroxygeraniol dehydrogenase;
8-hydroxygeraniol oxidoreductase;
CYP76B10;
G10H;
CrG10H;
SmG10H;
acyclic monoterpene primary alcohol:NADP+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(6E)-8-hydroxygeraniol:NADP+ oxidoreductase
Reaction(IUBMB)
(6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction) [RN:R08499];
(1a) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-hydroxygeranial + NADPH + H+ [RN:R09926];
(1b) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-oxogeraniol + NADPH + H+  [RN:R09927];
(1c) (6E)-8-hydroxygeranial + NADP+ = (6E)-8-oxogeranial + NADPH + H+  [RN:R09928];
(1d) (6E)-8-oxogeraniol + NADP+ = (6E)-8-oxogeranial + NADPH + H+ [RN:R09929]
Reaction(KEGG)
Substrate
(6E)-8-hydroxygeraniol [CPD:C17621];
NADP+ [CPD:C00006];
(6E)-8-hydroxygeranial [CPD:C20222];
(6E)-8-oxogeraniol [CPD:C20223]
Product
(6E)-8-oxogeranial [CPD:C17622];
NADPH [CPD:C00005];
H+ [CPD:C00080];
(6E)-8-hydroxygeranial [CPD:C20222];
(6E)-8-oxogeraniol [CPD:C20223]
Comment
Contains Zn2+. The enzyme catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol. Also acts on geraniol, nerol and citronellol. May be identical to EC 1.1.1.183 geraniol dehydrogenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol as used by references 1 and 2. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}.
History
EC 1.1.1.324 created 2012
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23232  8-hydroxygeraniol dehydrogenase
Genes
MNT21385910
VVI100855415
SLY543602
SPEN107004699
SOT102581912 102589753(drd-1) 102599810 102600145
SSTN125843885 125843893 125843898 125846084 125864456 125866244
CANN107849611 107850273 107850275
NTA107772795(SAD4)
NSY104218512 104232065
NTO104089646 104103376
NAU109215604 109220179
INI109172721 109180302 109180303 109180305 109180306 109180307
ITR116012170 116012599 116012600 116012806 116012807 116013707 116013949 116013985 116014506 116021186 116025915
SIND105176373 105178286
OEU111373464 111385603
EGT105959003 105959013 105965126
SSPL121760094 121767408 121770429 121770797 121772668 121781933
HAN110867824
ECAD122602767 122603005 122603360
LSV111883478
CCAV112510743
MING122059761
 » show all
Reference
1  [PMID:1864846]
  Authors
Ikeda H, Esaki N, Nakai S, Hashimoto K, Uesato S, Soda K, Fujita T
  Title
Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols.
  Journal
J Biochem 109:341-7 (1991)
Reference
2  [PMID:7726550]
  Authors
Hallahan DL, West JM, Wallsgrove RM, Smiley DW, Dawson GW, Pickett JA, Hamilton JG
  Title
Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa).
  Journal
Arch Biochem Biophys 318:105-12 (1995)
DOI:10.1006/abbi.1995.1210
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.324
IUBMB Enzyme Nomenclature: 1.1.1.324
ExPASy - ENZYME nomenclature database: 1.1.1.324
BRENDA, the Enzyme Database: 1.1.1.324

DBGET integrated database retrieval system