KEGG   ENZYME: 1.1.1.333
Entry
EC 1.1.1.333                Enzyme                                 

Name
decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase;
decaprenylphospho-beta-D-ribofuranose 2'-epimerase;
Rv3791;
DprE2
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase
Reaction(IUBMB)
trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+ = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+ [RN:R10113]
Reaction(KEGG)
R10113
Substrate
trans,octacis-decaprenylphospho-beta-D-arabinofuranose [CPD:C20370];
NAD+ [CPD:C00003]
Product
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose [CPD:C20369];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The reaction is catalysed in the reverse direction. The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.98.3, decaprenylphospho-beta-D-ribofuranose 2-oxidase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.
History
EC 1.1.1.333 created 2012
Orthology
K16652  decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
Genes
PAO: Pat9b_2996
XAX: XACM_3486
XCI: XCAW_04291(fabG)
XCT: J151_03776
XCJ: J158_03752
XCU: J159_03748
XCN: J169_03773
XCW: J162_03753
XCR: J163_03748
XCM: J164_03749
XOR: XOC_3852
XPH: XppCFBP6546_16380(XppCFBP6546P_16380)
SML: Smlt0632
SMT: Smal_0498
FBL: Fbal_2185
HHA: Hhal_1550
SALN: SALB1_3581
RSE: F504_181
BDL: AK34_2287
BUB: BW23_846
BXB: DR64_1461
PNU: Pnuc_0327
AAA: Acav_0082
MEH: M301_1232
GCA: Galf_2856
AZA: AZKH_0574
DALK: DSCA_01340
RLG: Rleg_5791
RIR: BN877_p0341(noeO)
BBT: BBta_7180
BRS: S23_01230
RPC: RPC_4216
MPO: Mpop_1597
BID: Bind_1026
MSL: Msil_2164
BVR: BVIR_2415
HDI: HDIA_4437
CAK: Caul_4798
JAN: Jann_2832
OTM: OSB_07400
LAQU: R2C4_10110
MARU: FIU81_11060(isfD1)
MALU: KU6B_39300
BTS: Btus_3155
MTU: Rv3791(dprE2)
MTV: RVBD_3791
MTC: MT3899
MRA: MRA_3831
MTUR: CFBS_4020
MTD: UDA_3791
MTUB: MT7199_3860(dprE2)
MTUC: J113_26460
MTUE: J114_20245
MTUH: I917_26620
MTUL: TBHG_03729
MTUT: HKBT1_4003
MTUU: HKBT2_4013
MBO: BQ2027_MB3820(dpre2)
MBB: BCG_3853
MBT: JTY_3855
MBX: BCGT_3652
MAF: MAF_38060
MMIC: RN08_4180
MLE: ML0108
MLB: MLBr00108
MPA: MAP_0234c
MAO: MAP4_3637
MAVI: RC58_18080
MAVU: RE97_18115
MAV: MAV_0231
MIT: OCO_02360
MIA: OCU_02420
MID: MIP_00567
MYO: OEM_02470
MIR: OCQ_02360
MLP: MLM_0177
MUL: MUL_4970
MMC: Mmcs_5001
MKM: Mkms_5089
MJL: Mjls_5382
MMI: MMAR_5353
MMM: W7S_01160
MHAD: B586_03110
MSHG: MSG_04855(dprE2)
MFJ: MFLOJ_36680(dprE2)
MXE: MYXE_02630(dprE2)
MVA: Mvan_5628
MGI: Mflv_1177
MPHL: MPHLCCUG_00214(phbB_1)
MVQ: MYVA_5557
MHAS: MHAS_04505(dprE2)
MDU: MDUV_45970(dprE2)
MDR: MDOR_35150(dprE2)
MAB: MAB_0191c
MABB: MASS_0189
MCHE: BB28_00985
MSTE: MSTE_00190
MSAL: DSM43276_00168(phbB)
MTER: 4434518_04037(actIII)
MMIN: MMIN_15440(dprE2)
ASD: AS9A_0117
MKR: MKOR_33020(dprE2)
CGL: NCgl0186(Cgl0189)
CGB: cg0237
CGU: WA5_0186
CGT: cgR_0268
CGM: cgp_0237
CGJ: AR0_01235
CEF: CE0163
CDI: DIP0161
CJK: jk2050
CUR: cu1957
CUA: CU7111_1879(dprE2)
CAR: cauri_0102(fabG3)
CPSE: CPTA_00630
CPSU: CPTB_00903
CPSF: CPTC_00565
CRD: CRES_2121(dprE2)
CUL: CULC22_00148(dprE2)
CUC: CULC809_00150(dprE2)
CUN: Cul210932_0151(dprE2)
CUS: CulFRC11_0146(dprE2)
CUQ: Cul210931_0145(dprE2)
CUZ: Cul05146_0151(dprE2)
CUJ: CUL131002_0135c(dprE2)
CVA: CVAR_2926(dprE2)
CTER: A606_00555
COA: DR71_1173
CMQ: B840_00770(dprE2)
CKU: UL82_00350(dprE2)
CCJ: UL81_00545(dprE2)
CMV: CMUST_00575(dprE2)
CTED: CTEST_00725(dprE2)
CDX: CDES_01090(dprE2)
CSP: WM42_1262
CPHO: CPHO_00625
CGV: CGLAU_00460(phbB)
CAQU: CAQU_00420
CAMG: CAMM_01045
CMIN: NCTC10288_02446(fabG3)
NFA: NFA_1960
NFR: ERS450000_04042(fabG_23)
RER: RER_02340
REY: O5Y_01180
ROP: ROP_39520
REQ: REQ_02320
RHB: NY08_3925
RFA: A3L23_02041(dprE2)
RHS: A3Q41_01322(dprE2)
RHU: A3Q40_03630(dprE2)
RRT: 4535765_00239(fabG1_1)
GBR: Gbro_0251
GOR: KTR9_0242
GRU: GCWB2_01065(phbB1)
GOM: D7316_03428(dprE2)
TPR: Tpau_4120
SRT: Srot_2817
SCO: SCO4841(SC5G8.09c)
SALB: XNR_3917
SGR: SGR_2700
SGB: WQO_22060
SFA: Sfla_2402
SHY: SHJG_5969
SVE: SVEN_4516
SALS: SLNWT_4765
STRP: F750_4396
SFI: SFUL_4634
SRW: TUE45_05364(sdh_3)
SLE: sle_28330(sle_28330)
STRD: NI25_14740
SLAU: SLA_4700
SALF: SMD44_05417(dprE2)
SFK: KY5_4943c
SGE: DWG14_03283(dprE2)
SRJ: SRO_2910
PFRE: RM25_1516
PAUS: NCTC13651_00709(fabG_3)
MPH: MLP_13370
MGG: MPLG2_2493(dprE)
TFU: Tfu_2462
NDA: Ndas_0271
NAL: B005_3139
STRR: EKD16_04945(sdh1)
MMAR: MODMU_4724
KRA: Krad_3873
SEN: SACE_0193
SACC: EYD13_00800(phbB)
AMD: AMED_0229
AMN: RAM_01160
AMM: AMES_0224
AMZ: B737_0225
AOI: AORI_0234
AJA: AJAP_01215(dprE2)
AMYY: YIM_01225(fabG3)
PDX: Psed_0194
PSEA: WY02_17160
PSEE: FRP1_25605
PSEH: XF36_24960
PAUT: Pdca_01830
ALO: CRK60916
CAI: Caci_5663
TBI: Tbis_0813
AFO: Afer_1741
STI: Sthe_2274
TRA: Trad_2707
LBF: LBF_1032
ABAS: ACPOL_1599
MUC: MuYL_3235
MGOT: MgSA37_03194(sdh_1)
RAI: RA0C_0707
RAR: RIA_1786
RAG: B739_1533
RAE: G148_1137
RAT: M949_1958
CTAK: 4412677_02568(fabG_2)
 » show all
Reference
1  [PMID:22188377]
  Authors
Trefzer C, Skovierova H, Buroni S, Bobovska A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikusova K, Johnsson K
  Title
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1.
  Journal
J Am Chem Soc 134:912-5 (2012)
DOI:10.1021/ja211042r
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.333
IUBMB Enzyme Nomenclature: 1.1.1.333
ExPASy - ENZYME nomenclature database: 1.1.1.333
BRENDA, the Enzyme Database: 1.1.1.333

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