KEGG   ENZYME: 1.1.1.337
Entry
EC 1.1.1.337                Enzyme                                 
Name
L-2-hydroxycarboxylate dehydrogenase (NAD+);
(R)-sulfolactate:NAD+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
L-2-hydroxyacid dehydrogenase (NAD+);
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase
Reaction(IUBMB)
a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+ [RN:R10189]
Reaction(KEGG)
R10189 > R07136
Substrate
(2S)-2-hydroxycarboxylate [CPD:C15565];
NAD+ [CPD:C00003]
Product
2-oxocarboxylate [CPD:C00161];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
History
EC 1.1.1.337 created 2012
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K05884  L-2-hydroxycarboxylate dehydrogenase (NAD+)
Genes
VSHBSZ05_08715
WBOMIS45_08080
CNCCNE_BB1p05710(comC)
CUHBJN34_35490
PACSFAZ98_33455
PNRAT302_16585
BFZBAU07_07535
ADYHLG70_07725
PUSCKA81_13830
PIGEGT29_10430
LIML103DPR2_01654(yjmC)
HYNF9K07_00765
BPRCD521_0584
BEBABWI17_02740
SMKSinme_5353
SMQSinmeB_5546
SMXSM11_pC1598
SMIBN406_04935
SMEGC770_GR4pC1290
SMELSM2011_a0265
SMERDU99_24705
SFHSFHH103_06683(mdh)
SIXBSY16_5575
RELREMIM1_PF00544
REIIE4771_PD00374
RLBRLEG3_08205
RLURLEG12_11130
RIRBN877_p0363
RGARGR602_PC00441
RJGCCGE525_30300
RLNJ0663_23680
SHZshn_26825
APOLK9D25_08275
RHZRHPLAN_59280
DEQXM25_09010
DEIC4375_14185
YTIFNA67_12740
MMEDMame_04860(yjmC_2)
PSINCAK95_00810
TSOIZ6_03830(mdh_2)
OTMOSB_08100(yjmC)
SUAMBOO69_02845
DAAAKL17_3266
SEDIEBB79_05045
LITFPZ52_15805
PALWPSAL_017020(allD)
GCEKYE46_09560
SPPHKFK14_10825
SCIBHUG20_05110
SCIAHUG15_07015
LRUHMPREF0538_21967
LRTLRI_1196
LRRN134_04225
LMULBLM1_05130
LORAYI71_01210
LCYLC20004_10680
THLTEH_05010(mdh)
TOOC7K38_02045
TKRC7K43_11960
CRNCAR_c14810(mdh)
CVDLHA31_11755
CACCA_C0566
CAESMB_G0579(mdh)
CAYCEA_G0580
CKLCKL_2769(mdh)
CKRCKR_2460
CLJCLJU_c05920(mdh)
CLSCXIVA_05030
CPASClopa_1152
CPATCLPA_c31190(mdh)
CPAECPAST_c31190(mdh)
CAHCAETHG_2689
CTYKCTK_C26970(mdh)
CARGRSJ17_10995
CFERD4Z93_02490
CLOSDMR38_02690
RUMCK1_23260 CK1_39560
PFAAMM59RIKEN_02120
CCTCC1_29650
ROBCK5_14170
BYLA4V09_10375
BHANCGC63_01920
BPROPMF13cell1_03197(yjmC_2)
BLABEYS05_03090
CSHClosa_3084
ACHTbsdcttw_20390
QDOH9Q78_05115
WHJH9Q79_05195
EACEAL2_808p02730(mdh)
FWADCMF_19385
AWOAwo_c16770(mdh)
AWICHL1_001481
ALKAJ0B03_10230
CBARPATL70BA_1096(mdh)
MDVC5Q96_04090
TEPTepRe1_1808
TAETepiRe1_1949(mdh)
VNKVEIT17_15940
ERMEYR00_09930
TBKHF295_08465
MTYMTOK_02180
SLEsle_01170(sle_01170)
SGEDWG14_06080(dpkA)
SVDCP969_00545
DDTAAY81_05455
OLSOlsu_0270
ERZER308_02550
LCREPla8534_16970(yjmC)
SDYNMal52_06970(yjmC)
TAERGT409_05910
TPITREPR_3329
SPEREW093_13865
OCKEXM22_12545
SBUSpiBuddy_0633
SCCSpico_1555
SGPSpiGrapes_1364
SASSMUG09_03720 MUG09_13845
TAZTREAZ_1631
ACOAmico_1325 Amico_1663
CBAECOR50_00710
CHITFW415_08115
COYHF329_20415
CFILMYF79_30070
NKONiako_5052
NSONIASO_00405
FGGFSB75_01485
AGIFSB73_14960
ATEEK9M52_14285
PGINFRZ67_22035
LACSH4075_07420
FEIK9M53_13855
FLPLK994_01670
FLCKJS93_10890
FLVKJS94_08280
PSNPedsa_2198
CAMUCA2015_1167
BBDBelba_1791
EVIEchvi_0162
ESTDN752_07350
ECHIFKX85_00785
MDAIPZ59_00985
SPIKEXU85_28470
SPIBG8759_30960
SRHOHH216_11020
DSNHWI92_12955
RSIRunsl_0559
RUNDR864_22800
RUPDTQ70_27545
HSWHsw_3558
HYMN008_11585
HYPA0257_10070
HYZAXW84_17735
HRSHER32_07605
HTSHMJ29_03810
HMTMTP16_02030
HTBMTX78_19255
RUFTH63_01270
RTIDC20_19730
RUDTH61_09780
ADDHUW48_20385
ASWUHUW51_03165
FPFDCC35_04490
FLMMY04_2484 MY04_2897
FYAKMW28_01625 KMW28_03820
FKAKM029_13735 KM029_15620
CHKD4L85_06045
FUVJR347_01350
SHYRLA303_06570
CACICLOAM1159(mdh)
KPFIX53_06400
MPGTheba_0594
MINFMESINF_0035(mdh) MESINF_1540(mdh)
BANABARAN1_1319(mdh)
MJAMJ_1425
MFEMefer_1396
MVUMetvu_0738
MFSMFS40622_0628
MIFMetin_0176
MJHJH146_0548
MESGMLAUSG7_0644(comC)
MESAMLASG1_0181(comC)
MIGMetig_0716
MMPMMP1133(comC)
MMQMmarC5_0451
MMXMmarC6_1534
MMZMmarC7_0385
MMDGYY_06515
MMAKMMKA1_13120(comC)
MMAOMMOS7_12420(comC)
MMADMMJJ_17120(yjmC)
MAEMaeo_1015
MVNMevan_0455
MVOMvol_0905
MOKMetok_0546
METFCFE53_04010
MTHMTH_1205
MMGMTBMA_c15830(comC)
MWOMWSIV6_1598(comC)
MTEEMTTB_02220
METCMTCT_1098
METEtca_01162(yjmC)
METZMETMT2_1207
METKFVF72_05595
MTHMFZP57_07660
METJFZP68_03015
MSTMsp_0279(comC)
METBAW729_05750
MRUmru_1980(comC)
MSIMsm_1040
MEBAbm4_1552(comC)
MMILsm9_2052(comC)
MEYETL18_09445
MOLYLM1_1417
MAROMarbSA_15040
METVK4897_06265
MELMetbo_0320
MEWMSWAN_2101
METHMBMB1_1726(comC)
MFCBRM9_0342(comC)
MFIDSM1535_0956(comC)
MCUBMCBB_2038(comC)
MSUBBK009_07660
METNBK008_03315
METTCIT01_03895
METOCIT02_09230
MEMEHYG87_05175
MFVMfer_0389
MKAMK0392(comC)
HALXM0R89_21370
STOSTK_20900
SOHD1869_11455
SULLEWF20_12610
AMANB6F84_09265
ABRIDFR85_02480 DFR85_02750
ASULDFR86_07970
AAMBD1866_00065 D1866_09410
ACIHHS5_24340
SACDHS1genome_1813
SAZOD1868_06535
CSTYKN1_08830
STEPIC006_0144
LOKILokiarch_23620(mdh_3) Lokiarch_23630(mdh_4)
PSYTDSAG12_01758(mdh)
 » show all
Reference
1  [PMID:10850983]
  Authors
Graupner M, Xu H, White RH
  Title
Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:3688-92 (2000)
DOI:10.1128/JB.182.13.3688-3692.2000
  Sequence
[mja:MJ_1425]
Reference
2  [PMID:11451450]
  Authors
Graupner M, White RH.
  Title
The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea.
  Journal
Biochim Biophys Acta 1548:169-73 (2001)
DOI:10.1016/S0167-4838(01)00220-5
  Sequence
[mja:MJ_1425]
Reference
3  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat Prod Rep 19:133-47 (2002)
DOI:10.1039/b103714p
Reference
4  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology 151:737-47 (2005)
DOI:10.1099/mic.0.27548-0
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.337
IUBMB Enzyme Nomenclature: 1.1.1.337
ExPASy - ENZYME nomenclature database: 1.1.1.337
BRENDA, the Enzyme Database: 1.1.1.337
CAS: 81210-65-3

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