KEGG   ENZYME: 1.1.1.338
Entry
EC 1.1.1.338                Enzyme                                 
Name
(2R)-3-sulfolactate dehydrogenase (NADP+);
(R)-sulfolactate:NADP+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R)-3-sulfolactate:NADP+ oxidoreductase
Reaction(IUBMB)
(2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+ [RN:R07137]
Reaction(KEGG)
R07137
Substrate
(2R)-3-sulfolactate [CPD:C11537];
NADP+ [CPD:C00006]
Product
3-sulfopyruvate [CPD:C05528];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate.
History
EC 1.1.1.338 created 2012
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K16844  (2R)-3-sulfolactate dehydrogenase (NADP+)
Genes
ASUBNLZ15_10115
PPSLBJP27_04190
PTRTHU722_0015150
PZAHU749_019265
SSALSPISAL_05330
APRSBI364_08720
GAIIMCC3135_02485(dpkA)
CSACsal_1771
HBEBEI_0839(comC)
HCAMI4484_16840
HSXHNO51_16740
LLPGH975_02520
SVASVA_1861
TSNW908_08240
THINCRN91_01900
RPJN234_02640
CUHBJN34_26765
REUReut_B3531
CTIRALTA_B0842
CBWRR42_m0457
CGDCR3_0184(comC)
COXE0W60_13295
BCTGEM_4713
BYIBYI23_C008400
BUEBRPE67_CCDS02810
BGEBC1002_3744
BFNOI25_4405
BCAIK788_0007261
PARABTO02_21280
PGISI6I06_21475
PACSFAZ98_25220
PEWKZJ38_22635
PDQCL55_00014430
PANIDCO16_07890
PTXABW99_10900
PNRAT302_12480
PANDDRB87_03425
PFIBPI93_015610
CABASBC2_17590(comC)
BUOBRPE64_DCDS09650
BPARBN117_4156
BPABPP4084
BBHBN112_3867
BBRBB4555
BBMBN115_4232
BBXBBS798_4332
BPTBpet0408
BHOD560_1789
BHMD558_1780
BHZACR54_04291(comC)
BBROBAU06_18085
BFZBAU07_08195
BPDZBBN53_01625
BOHAKI39_17280
BGMCAL15_02260
AXYAXYL_00470
AXONH44784_017151
AXNAX27061_0476
AXXERS451415_00470(allD_1)
ADTAPT56_02485
AISBUW96_28010
ASWCVS48_03845
ACHRC2U31_07135
ACHBDVB37_02035
ADYHLG70_19615
AKATKWG_24430
AMIMMIM_c39390
PARKLSG25_12715
VEIVeis_0890
VAPVapar_3821
VPDVAPA_1c39340
HYNF9K07_27970
RGERGE_25200
ATERMW290_05755 MW290_18650
HARHEAR3341
URUDSM104443_03883(comC)
UPLDSM104440_03444(comC)
ACOMCEW83_08345
BPRCD521_1333
BEBABWI17_07600
DVMDvMF_1995
DALKDSCA_63910
MLOmll5197
MLNA9174_01530
MCIMesci_0321
MOPMesop_0303
MAMMesau_00292
MAMOA6B35_06245
MESWA9K65_001610 A9K65_032710
MESMEJ066_09840
MESPC1M53_10440
MHUAMCHK_6247
MJREB229_01555
MERDEB233_01620
MESRFGU64_14690
MESOBSQ44_12895 BSQ44_19610
AAKAA2016_0684 AA2016_5548
AMIHCO731_00781(comC)
PHTBLM14_27990
NIYFQ775_15300 FQ775_22310
KMNHW532_06425
SMESMa1459
SMKSinme_5990
SMQSinmeB_6310
SMXSM11_pC0853
SMIBN406_04533
SMEGC770_GR4pC0580
SMELSM2011_a1459
SMERDU99_22025
SMDSmed_5101
SFHSFHH103_04893(yjmC)
SIXBSY16_4749
SAMESAMCFNEI73_Ch0742
SINOSS05631_c03940
EAHFA04_30270
EMXFKV68_00580 FKV68_25165
ATUAtu0164
ARAArad_4516
ATAAWN88_20420
AGRAGROH133_03129(mdh)
ATFAch5_01490(comC)
AGCBSY240_4080
AROB0909_12670
AGTEYD00_13065
ALFCFBP5473_00210
ARUIG6M88_08520
AVQHRR99_00325
REPIE4803_PC00466
REIIE4771_PD00476
RLBRLEG3_07895
RTRRTCIAT899_CH17445
RIRBN877_I0162(comC)
RPUSCFBP5875_13395
RHLLPU83_4041
RGARGR602_CH03906
RHNAMJ98_PE00507
RPHAAMC79_PD00644
RHXAMK02_PD00370
RHVBA939_09550
REZAMJ99_PD00507
RJGCCGE525_20485 CCGE525_23430
RHRCKA34_00710
RGRFZ934_22360
RADCO657_27650
ROYG3A56_10685
RIIFFM53_027620
RLSHB780_24490
RROSD4A92_00210
NGLRG1141_CH42250
NGGRG540_CH42620
NEOCYG48_15725
NENNCHU2750_38690(comC)
SHZshn_13285
SZOK8M09_11885
SOJK6301_10535
OCAOCAR_7551
OCGOCA5_c05890
OCOOCA4_c05880
VGOGJW-30_1_00128(comC_1)
BOPAXW83_05590 AXW83_16725 AXW83_22765
BOSBSY19_2613
BVVBHK69_06980 BHK69_18045
BOIBLM15_06695
BOFFQV39_06440
AZCAZC_1795
LNEFZC33_10280
ANCGBB76_08720
APRAG3A50_05870
APOLK9D25_10450
MRDMrad2831_5976
MNOMnod_3707
METIDK427_02125
MMESMMSR116_04760
RVARvan_2276
FILBN1229_v1_1880(comC)
FIYBN1229_v1_1883(comC)
RHZRHPLAN_09770
CMETK6K41_04855
HDIHDIA_2769(comC)
MEYTM49_04085
AUZSa4125_38850
AUBLXB15_20880
PSFPSE_2587
PPHRAPZ00_23875
LABRCHH27_12015
LABPFJ695_09900
SIWGH266_22245
PHRC6569_06525
PSTGE8M01_20055 E8M01_21820
SILSPO3187(comC)
SITTM1040_3386
RUAD1823_14280
RUTFIU92_16940(comC2)
JANJann_2141
RDERD1_2049
RLIRLO149_c011950
RPONG3256_04620
DSHDshi_2039
PGLPGA2_239p1590
PGDGal_03878
PHPPhaeoP97_03708
PPICPhaeoP14_03602
PHQD1820_17760
OATOAN307_c11640
OAROA238_c06130
OTMOSB_22100(comC)
OCTFTO60_04615
LMDMETH_04595
LEJETW24_05715
LAQUR2C4_12835
LEVETW23_13980
REDroselon_00573
MALGMALG_01235
TPROGa0080559_TMP3622
SUAMBOO69_05270
SULZC1J03_16430
SULIC1J05_05125 C1J05_17400
SMEDJNX03_07670
TOMBWR18_04315
RMMROSMUCSMR3_03370(comC)
ROKRAK1035_2264
RIDRIdsm_03387(comC)
ROMEI983_05780
AHTANTHELSMS3_02624(comC)
THAACFI11_16630
MARUFIU81_03610(comC)
MALUKU6B_15290
PTPRCA23_c28070
RSUNHU_04237
RHMB5V46_17735
DONBSK21_09390
RBGBG454_07280 BG454_15345
SEDIEBB79_05885
BOOE2K80_00685
PPRUFDP22_15055
PAEDG5B38_00025
MONG8E03_11005
PSHQF3W81_14630
POZI0K15_17265
PALWPSAL_021170(comC_1) PSAL_028040(comC_2)
PGVSL003B_2798
CACTHZ995_04875 HZ995_04905
CMAGCBW24_05865 CBW24_15885
GCEKYE46_09860
ACROK3J57_06480
FAQG5B39_15425
AMAQGO499_07050
RGIRGI145_14315
ROSCTJ15_21625
RMUCFOB66_16340
SRFLHU95_02160
SHUMSTHU_20860
SVCSTVA_23970
STELSTAQ_18750
NAOY958_25125
NCBC0V82_01495
RCERC1_0266
TXITH3_01035
THACCSC3H3_12430
TIIDY252_20595
THAIIT893_00945
ELIOKO353_01265 KO353_13150
NACINUH88_09415
APCHIMB59_00001300
SNEANBZ79_15985
PVOPVOR_16914
PCHIPC41400_01795
COHNKCTCHS21_60970
CGYCGLY_02555
CFKCFRA_01855
CEECENDO_00120(comC)
CSANE3227_04380
CRLNCTC7448_00063(allD)
CYZC3B44_10085
CLIAC3E79_10890
RHARHA1_ro08843
RKOJWS14_29120 JWS14_47740
GPDGII33_21655
PSEYGU243_03165
SATKSA2016_2196
BKIM4486_12640
CETB8281_12080
CCEUCBR64_19660
BLINBLSMQ_0125
MPHMLP_09960 MLP_21640
PLANA1s21148_06275
PVNA7sIIA15_00855
MRBMrub_2460
MREK649_10230
MSVMesil_1014
MTAIMtai_v1c20750
 » show all
Reference
1  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology 156:967-74 (2010)
DOI:10.1099/mic.0.034736-0
  Sequence
[csa:Csal_1771]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.338
IUBMB Enzyme Nomenclature: 1.1.1.338
ExPASy - ENZYME nomenclature database: 1.1.1.338
BRENDA, the Enzyme Database: 1.1.1.338
CAS: 81210-65-3

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