Entry
Name
hydroxymethylglutaryl-CoA reductase (NADPH);
hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate);
3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous);
beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous);
hydroxymethylglutaryl CoA reductase (NADPH);
S-3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous);
NADPH-hydroxymethylglutaryl-CoA reductase;
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA);
3-hydroxy-3-methylglutaryl CoA reductase (NADPH);
hydroxymethylglutaryl-CoA reductase (NADPH2)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ [RN:
R02082 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme is inactivated by EC
2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC
3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
History
EC 1.1.1.34 created 1961
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K00021 hydroxymethylglutaryl-CoA reductase (NADPH)
Genes
RRO : 104653755(HMGCR) 115895907 115896021 115896068
PLEU : 114687932 114694656(Hmgcr)
MFOT : 126496070 126508518
NPO : 129503361 129507793 129521048(HMGCR)
HHV : 120226596 120240725(HMGCR)
BACU : 103000968 103010372(HMGCR) 103020890
ACHC : 115336962(HMGCR) 121232774
AGEN : 126035249 126035717
HHAR : 128136126 128137056(HMGCR)
NNI : 104013038(HMGCR) 104017611
CVF : 104285757(HMGCR) 104295812
RTD : 128901989 128902471(HMGCR)
TGT : 104567556(HMGCR) 104571572
XLA : 108707262(hmgcr.S) 397750(hmgcr.L)
BBUF : 120992439 120992442 120992446
BGAR : 122924719 122924720 122935929 122935954 122935962
DRE : 541479(hmgcrb) 559054(hmgcra)
SRX : 107713481 107720287 107731091 107756298
SANH : 107653362 107675784 107699716 107703249
SGH : 107555490 107568540 107585692 107587518
CCAR : 109055857 109056491 109067925 109070312
CAUA : 113038995 113039106 113049089 113049608 113080269
CGIB : 127958121 127985512 127998847
PTET : 122332519 122345041(hmgcra)
LROH : 127152779(hmgcrb) 127165704(hmgcra)
OMC : 131528310(hmgcrb) 131540343(hmgcra)
PPRM : 120471286(hmgcrb) 120471903(hmgcra)
RKG : 130072736(hmgcra) 130073040(hmgcrb)
MAMB : 125252378 125252751(hmgcrb) 125267502(hmgcra)
CIDE : 127503285 127512176
CERY : 137013331(hmgcrb) 137034537(hmgcra)
MASI : 127424367 127429240 127430821 127440097
TROS : 130550344(hmgcra) 130569927(hmgcrb)
TDW : 130407552(hmgcrb) 130419877(hmgcra)
IPU : 108255489(hmgcra) 108278928(hmgcrb)
IFU : 128622029 128625564(hmgcra)
PHYP : 113535726 113536911(hmgcr)
SMEO : 124380523(hmgcra) 124397681(hmgcrb)
TFD : 113642276(hmgcra) 113646450(hmgcrb)
TVC : 132854985(hmgcra) 132859902(hmgcrb)
TRN : 134330193(hmgcrb) 134335066(hmgcra)
AMEX : 103033046(hmgcra) 103037085(hmgcrb)
CMAO : 118819954(hmgcrb) 118827647(hmgcra)
EEE : 113573726 113574964(hmgcr)
TRU : 101066905(hmgcr) 101078757
TNG : GSTEN00007211G001 GSTEN00025237G001
LCO : 104926606 104937871(hmgcr)
NCC : 104951831 104964565(hmgcr)
TBEN : 117472804(hmgcra) 117476808
CGOB : 115013403(hmgcr) 115016396
PGEO : 117452762 117456259
GACU : 117534986 117561391
EMAC : 134868509 134874020
ELY : 117252815(hmgcra) 117269947
EFO : 125878674 125890946(hmgcra)
SLUC : 116050416(hmgcra) 116063008
ECRA : 117945081 117959134
PFLV : 114555718(hmgcr) 114571423
PPUG : 119224957 119226451
CLUM : 117736344 117740793
PSWI : 130196519 130205072
CANA : 137783938 137799444
CVE : 137866790(hmgcra) 137869235
MSAM : 119891223(hmgcra) 119914994
SCHU : 122865699 122876893(hmgcra)
CUD : 121509299(hmgcra) 121525459
SPUL : 138601748 138610221(hmgcra)
ALAT : 119019401 119029640
ASTR : 137592466 137608559
OAU : 116315906 116316679(hmgcra)
OML : 112137795(hmgcra) 112162813
CSAI : 133450784(hmgcra) 133455072
XMA : 102229336 102237239(hmgcr)
XCO : 114149006 114155192(hmgcr)
XHE : 116724027 116729469(hmgcr)
PRET : 103470679(hmgcr) 103473284
PFOR : 103132185 103135855 103155668(hmgcr)
PLAI : 106935197 106942092 106943151
PMEI : 106910235 106912233 106928741
PPRL : 129355319 129355378 129374174
CVG : 107090374 107093682(hmgcr)
CTUL : 119788290 119795598
KMR : 108244757 108250729(hmgcra)
ALIM : 106531768 106536933
AOCE : 111575348 111579328
EJA : 138198473(hmgcra) 138207675
MCEP : 124997022 125012064
CSEM : 103389902 103397369(hmgcr)
POV : 109626244 109640161(hmgcr)
SSEN : 122758554 122762082(hmgcra)
HHIP : 117767822 117771485
PPLT : 128438388 128462286
SMAU : 118300401 118314132(hmgcra)
LCF : 108873800 108878542(hmgcra)
SLAL : 111647996(hmgcr) 111666845
XGL : 120805848(hmgcra) 120806513
HCQ : 109510552(hmgcr) 109525561
SSCV : 125979273 125994742(hmgcra)
SBIA : 133490806 133499409
PTAO : 133475443 133490102
BPEC : 110157405 110172435(hmgcr)
MALB : 109959666 109967764
BSPL : 114845428 114866612
SASA : 100380797(hmdh) 106570829(hmgcr)
STRU : 115159718 115200549(hmgcr)
OMY : 100135848(hmgcra) 110523461
OGO : 124036620(hmgcra) 124049075
ONE : 115121148 115140349(hmgcr)
OKI : 109868044 109896210(hmgcr)
SALP : 111957595 111961745
SNH : 120026347 120063420(hmgcra)
CCLU : 121530724(hmgcra) 121582634
ELS : 105009321(hmgcr) 105015131
AANG : 118206679(hmgcra) 118212698
PSPA : 121305348 121313494
ARUT : 117403715 117973436
SCLV : 120331473 120331474
DSI : Dsimw501_GD21034(Dsim_GD21034)
AALB : 109430221 115257652
SOC : 105197351 105202303 105203277
AGRG : 126748370 126750170
CSET : 123306661 123321602
PPYR : 116165087 116165442 116165673
BTAB : 109033237 109043605
CLEC : 106662464 106665424
HHAL : 106681606 106683368(Hmgcr)
DPX : DAPPUDRAFT_346929(Hmgcr)
PMOO : 119569787 119591446
LPOL : 106465812 106468291 106472382
PMEO : 129587202 129590750
CEL : CELE_F08F8.2(hmgr-1)
ATH : AT1G76490(HMG1) AT2G17370(HMG2)
CRB : 17891091 17891700 17894738
CSAT : 104702412 104713314 104747554 104751544 104767040 104791012
EUS : EUTSA_v10018320mg EUTSA_v10022614mg
BRP : 103832111 103845964 103853029
BNA : 106381415 106393352 106397583 106413095 106421619 106447170 111206800
BOE : 106298164 106302431 106327567
RSZ : 108806082 108815848 108817716 108823330
THJ : 104807413 104809909 104812013 104819699
CPAP : 110818015 110822502 110826423
CIC : CICLE_v10000761mg CICLE_v10028082mg
PVY : 116125840 116127722 116128530
MINC : 123199305 123203268 123213049 123229190
TCC : 18592079 18608389 18610613
GRA : 105762693 105773783 105780523 105783325 105785336 105795019 105795020 105795021 105795022
GHI : 107894010 107898896 107900974 107908970 107908971 107908972 107908973 107920223 107921012 107928879 107929696 107939227 107939234 107939235 107942380 107949229 121203148
GAB : 108464595 108464823 108472665 108474412 108476033 108476034 108476102 108478449 108483316
HSYR : 120123805 120128061 120133880 120149648 120151081 120153680 120160409 120161963 120171390 120171763 120175361 120178064 120178707 120188478 120214975
DZI : 111282133 111294897 111295040 111309162
EGR : 104415928 104415929 104419056 104419554 104448961 104450349
RARG : 115732107 115736489 115738540 115740130 115744704 115747453 115747454 115756849
GMX : 100777317 100779932 100784330 100786956 100790033 100811237 100815480
GSJ : 114368900 114372874 114384333 114390548 114400556 114403720 114418926
PVU : 137808545 137811056 137816906 137827284
VRA : 106765004 106769498 106775852 106777775
VAR : 108323852 108336049 108338409 108343207
VUN : 114166587 114178197 114188075 114194282
VUM : 124820624 124835565 124844661
CCAJ : 109789279 109807923 109809026 109817020
APRC : 113846336 113856008 113868520
MTR : 11407896 11409457 11410653 11415590 11416526 11416581 11432311 11435433 11441531 120580464 120580466
TPRA : 123881442 123907437 123907438 123907439 123907456 123921307
CAM : 101499627 101506157 101507469
PSAT : 127074798 127117940 127119955 127119956
VVO : 131615967 131624615 131641374 131641424 131641540 131643031 131651938 131651939 131651940 131651941
ADU : 107475678 107487384 107496702 127743928
AHF : 112702186 112747624 112766610 112786654 112797557 112800231
LANG : 109331148 109332949 109333207 109340936 109348976 109360654
PCIN : 129297237 129303705
QSA : O6P43_016400 O6P43_018800 O6P43_024982 O6P43_033488
FVE : 101292247 101308137 101308723 101309304 101314281 105349649
AANS : 126782176 126783784 126783785 126783786 126784868 126784869 126784870 126795606
RCN : 112169394 112170031 112170480 112170950 112172112 112173409 112187592
PPER : 18766576 18769510 18770980
PMUM : 103334636 103340474 103340524 103340675
PAVI : 110748888 110748889 110753313
PDUL : 117634036 117634124 117634319 117636586
MDM : 103406991 103410649 103412133 103420907 103421562 103455059 114823477 114827471
MSYL : 126584724 126603659 126608760 126608765 126621351 126621687
PXB : 103949512 103950192 103959146 103959147
ZJU : 107416066 107424303 107425621
CSAV : 115702836 115711722
CSV : 101210779 101213994 101219178
CMO : 103490442 103492557 103502601
BHJ : 120069047 120075609 120078703
MCHA : 111007941 111011297 111022898
CMAX : 111468156 111469777 111483921 111486441 111493947
CMOS : 111435117 111448960 111450384 111451663 111455316
CPEP : 111777784 111786647 111792545 111795892 111805274 111811700
RCU : 8258747 8273668 8285370
MEAN : 126655495 126676938 126677268
JCU : 105635170 105636809 105646344
HBR : 110632308 110639682 110659189 110666401 110669274
MESC : 110602324 110609571 110610776 110611890 110615710
POP : 18098173 7463352 7474548 7480368 7489052 7494728
PEU : 105108290 105130080 105132797 105135092 105137286
PALZ : 118032272 118038875 118040723 118042028 118049007 118049008 118061881
PNZ : 133679553 133691539 133694789 133696353 133699780 133702972
JRE : 108997419 109006674 109007712
CILL : 122310732 122313723 122314005 122316648
CAVE : 132166922 132172388 132189614
AGLU : 133851869 133870427 133880978
QSU : 112003066 112029959 136063819
TWL : 120002099 120009517 120010889
VVI : 100243051 100245191 100265082
VRI : 117906950 117911449 117913554
SLY : 101265292(HMG2) 101266490(HMG3) 101266800(HMGR4) 543702(HMGR)
SPEN : 107009176 107011154 107013488 107014402 107014404
SOT : 102577467(HMG3) 102577654(HMGR) 102577889(HMG2) 102577899 102585007 102599791(hmg1)
SSTN : 125847643 125849310 125856126 125856209 125858547 125862908
SDUL : 129873330 129873690 129895646 129902939
CANN : 107857553 107859749 107866760 107868268
LBB : 132606360 132616896 132625211 132628261
NTA : 107759218 107765219 107770799 107772124 107772411 107777769(HMGR2) 107832729(HMGR1)
NSY : 104229786 104230282 104234010
NTO : 104085779 104095021 104096414
NAU : 109212119 109212162 109214780
INI : 109156531 109156539 109157709 109157710 109157803 109157858 109163672 109166302 109167689 109172644 109177861 109179200 109179210 109179221
ITR : 115998205 115998206 115999126 115999210 115999417 115999661 116013453 116020998 116025432 116031547
SIND : 105158861 105172989
OEU : 111376622 111387406 111387692 111396504 111396750 111401248 111409359 111410512
EGT : 105953664 105954672 105959439
SSPL : 121746493 121750355 121755257 121759913 121761201 121761327 121762577 121763864 121763865 121763866 121763867 121765864 121792911
SMIL : 130995288 131011022 131020849 131020852
SHIS : 125188964 125198417 125198418 125201139 125201391 125221166 125222005
APAN : 127242677 127246395 127248373 127252564
HAN : 110872304 110877312 110892686 110911984 110915593 110926479
ECAD : 122580131 122586774 122596882 122602162 122606915
LSV : 111876391 111878449 111887736 111896566 111903696 111903697 111903698 111916003
CCAV : 112509112 112510297 112510721 112512356 112522594 112523899 112524109 112524280 112524499 112525038 112525047
DCR : 108211606 108221269 108223417
CSIN : 114258298 114278875 114283426 114303870 114310350 114313128 114314342
RVL : 131299050 131304380 131307834 131330784
AEW : 130758818 130775973 130777253 130777463 130778431 130784651 130785155
CQI : 110682124 110682133 110695305 110696360 110718708
MING : 122074500 122084512
PSOM : 113279850 113283586 113289689 113296423 113299434 113305346 113325202 113326281 113343154 113356776
OSA : 4346017(HMG3) 4347443 9272427(HMG1)
DOSA : Os08g0512700 Os09g0492700
OBR : 102709438 102714400 102718298
OGL : 127761214 127782400 127784566
BDI : 100828238 100832962 100840327
ATS : 109746630 109752372 109782286
TDC : 119302075 119309763 119317635 119320070 119329263 119337418
TAES : 123104204 123112452 123121961 123128173 123137982 123145269 123151295 123159445 123165516
TUA : 125514343 125519905 125530574
LPER : 127302135 127306435 127316790
LRD : 124649117 124654551 124681478 124688160
SBI : 8054742 8057903 8071789
ZMA : 100191922 100280335 100383280 103627645
MFLO : 136476804 136476881 136500727 136500932 136542097 136549954
SITA : 101754923 101777103 101777901
SVS : 117844885 117860868 117863085
PVIR : 120650124 120654228 120661101 120680035 120683379 120712834
PHAI : 112873522 112881963 112896992
PAUA : 133895844 133897642 133898822 133901833
PDA : 103698006 103702268 103711741 103713865
EGU : 105036971 105039425 105049376 105050594 105052870
MUS : 103973856 103981049 135599138 135617651
ZOF : 121969888 121974998 121980478 121981507 121984392 122008140 122016369 122038097
DCT : 110098248 110104601 110110287 110115939
MSIN : 131219180 131222354
ACAK : 137945666 137949596
NCOL : 116256633 116259657
CJF : 131029588 131059432 131070955 131070957 131071026 131071045 131071046 131071051 131071052 131071053 131071054 131071055 131071058 131071059 131071060 131071063 131071064 131073318 131073319
SMO : SELMODRAFT_177513 SELMODRAFT_272011
PPP : 112276414 112278455 112288197
SCE : YLR450W(HMG2) YML075C(HMG1)
SEUB : DI49_3943 DI49_4014
SPAO : SPAR_L04530 SPAR_M00560
VPO : Kpol_1001p4 Kpol_520p23
CGR : 2890968(GVI51_L11451)
NCS : NCAS_0A06180(NCAS0A06180)
NDI : NDAI_0D03170(NDAI0D03170)
TPF : TPHA_0B00420(TPHA0B00420) TPHA_0B01590(TPHA0B01590)
TBL : TBLA_0E04740(TBLA0E04740)
TDL : TDEL_0D00740(TDEL0D00740)
KAF : KAFR_0E04250(KAFR0E04250) KAFR_0I00290(KAFR0I00290)
KNG : KNAG_0B06690(KNAG0B06690) KNAG_0E04090(KNAG0E04090)
LBG : 92208258(LODBEIA_P30620)
CAL : CAALFM_C103780CA(HMG1)
YLI : 2912214(YALI2_E00109g)
NTE : NEUTE1DRAFT89746(NEUTE1DRAFT_89746)
SMP : 10810184(SMAC4_01392)
NHE : NECHADRAFT_105420(NhHMR1)
TATV : 25775746(TrAtP1_000156)
TASP : 36611988(TrAFT101_002173)
MAW : 19247102(HMG1_1) 90963495(HMG1_2)
PLJ : 28892300(PLICBS_009952)
PTKZ : JDV02_002825(HMG1_1) JDV02_008855(HMG1_2)
CHIG : CH63R_05417 CH63R_10650
CDET : 87943724(CDEST_07221) 87948382(CDEST_11882)
AFM : AFUA_1G11230 AFUA_2G03700
NFI : NFIA_009850 NFIA_014400 NFIA_036050
AOR : AO090103000311 AO090120000217
ANG : An04g00610 An07g08280
AFV : AFLA_009435 AFLA_013213
ALUC : AKAW2_11444A(HMG1_1) AKAW2_51101A(HMG1_2)
APUU : APUU_20079S(HMG1_1) APUU_40582S(HMG1_2)
PTRR : 6349013(PtrM4_081330)
ZTR : MYCGRDRAFT_64888(HMG1)
CBET : CB0940_02342 CB0940_07492
NPA : UCRNP2_4660 UCRNP2_6917
CDEP : 91088346(L203_104136)
KMG : 30162276(I203_107714)
KNE : 92182898(IAR55_005640)
CCAC : CcaHIS019_0109720(HMG1)
PCO : PHACADRAFT_201693 PHACADRAFT_202359 PHACADRAFT_207672 PHACADRAFT_253538 PHACADRAFT_253580
LBC : LACBIDRAFT_165672 LACBIDRAFT_184183
ABP : AGABI1DRAFT64187(AGABI1DRAFT_64187)
ABV : AGABI2DRAFT208992(AGABI2DRAFT_208992)
PCUB : JR316_0010214 JR316_0011137
SCM : SCHCO_02637526(SCHCODRAFT_02637526)
DDI : DDB_G0269142(hmgA) DDB_G0276615(hmgB)
DPP : DICPUDRAFT_149815 DICPUDRAFT_38386
DFA : DFA_02965(hmgB) DFA_07220
ACAN : ACA1_063120 ACA1_275640
LMAT : 92513985(LSCM1_03943)
LOI : 92358214(LSCM4_02246)
LEIS : 94178389(GH5_02888)
LENR : 94170479(CUR178_03233)
LEIN : 94187289(JIQ42_03613)
PHET : 94289208(JKF63_03110)
NGR : NAEGRDRAFT_54929 NAEGRDRAFT_81695
EHX : EMIHUDRAFT_438210(HMGR2) EMIHUDRAFT_444446(HMGR3) EMIHUDRAFT_462270(HMGR1) EMIHUDRAFT_471368
VCE : Vch1786_II0408(hmgA)
VNI : VIBNI_A3467 VIBNI_B1293
VAU : VANGNB10_cII0695(hmgA)
VPL : SA104470976_03471(hmgA)
AMC : MADE_1004060 MADE_1018245
AMAA : amad1_03765 amad1_18215
AMAL : I607_03660 I607_17150
AMAE : I876_03870 I876_17535
AMAO : I634_04025 I634_17350
AMAD : I636_03755 I636_17420
AMAI : I635_03730 I635_18180
AMAG : I533_03595 I533_17100
AMAC : MASE_03270 MASE_17135
AMB : AMBAS45_03525 AMBAS45_17525
AMG : AMEC673_03470 AMEC673_17255
AMK : AMBLS11_03435 AMBLS11_16635
ASP : AOR13_3918 AOR13_3978
ASQ : AVL57_18825 AVL57_19105
AAW : AVL56_17615 AVL56_17925
ALE : AV939_17795 AV939_18075
ALZ : AV940_17495 AV940_17775
ALTE : ALT761_03680 ALT761_03738
ALTM : BM527_03260 BM527_16995
ALTR : BM528_03495 BM528_16205
LAL : AT746_06285 AT746_15995
PAEW : KIH87_09385 KIH87_14665
ALII : QR722_02155 QR722_07790 QR722_17615 QR722_19305
PMAW : MACH26_16240 MACH26_18470 MACH26_24340
CBS : COXBURSA331_A0723(hmgA) COXBURSA331_A2174
CBD : CBUD_0151 CBUD_0622(hmgA)
CBG : CbuG_0298 CbuG_1393(hmgA)
CBC : CbuK_0218 CbuK_1440(hmgA)
GPB : HDN1F_02380 HDN1F_32470
HNV : DDQ68_16370 DDQ68_17100
NBR : O3I_007950 O3I_033255
NAH : F5544_04350 F5544_24665
SQZ : FQU76_00360 FQU76_32140 FQU76_33380
MJK : N2V74_00960(hmgA) N2V74_04900(hmgA)
NPH : NP_0368A(hmgA2) NP_2422A(hmgA1)
NHO : HWV23_05615 HWV23_13980(hmgA)
HALA : Hrd1104_06135(hmgA)
HALI : BV210_09730 BV210_12520
HSN : DV733_04170(hmgA) DV733_04175(hmgA)
HDS : HSR122_0368(hmg1) HSR122_0753(hmg12)
HALQ : Hrr1229_009810(hmgA)
HACB : Hbl1158_07135(hmgA)
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Taxonomy
Reference
Authors
BUCHER NL, OVERATH P, LYNEN F
Title
beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver.
Journal
Reference
Authors
DURR IF, RUDNEY H.
Title
The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid.
Journal
J Biol Chem 235:2572-8 (1960)
Reference
Authors
Kawachi T, Rudney H.
Title
Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.34
ExPASy - ENZYME nomenclature database: 1.1.1.34