KEGG   ENZYME: 1.1.1.349Help
Entry
EC 1.1.1.349                Enzyme                                 

Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K17644  norsolorinic acid ketoreductase
Genes
QSU: 111983631 111989788 112014326
SMP: SMAC_00337
PAN: PODANSg8549 PODANSg8566
TTT: THITE_2089433 THITE_2147584
MGR: MGG_10910
TMN: UCRPA7_6053 UCRPA7_8840
FVR: FVEG_09885 FVEG_13322
FOX: FOXG_15212
NHE: NECHADRAFT_19049 NECHADRAFT_44851 NECHADRAFT_94977
TRE: TRIREDRAFT_103113 TRIREDRAFT_105884
CMT: CCM_08014
ANI: AN7821.2
ANG: ANI_1_1648104(An12g03210) ANI_1_1984104(An12g06400)
 » show all
Taxonomy
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl Environ Microbiol 59:2486-92 (1993)
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus  parasiticus.
  Journal
Appl Environ Microbiol 65:5639-41 (1999)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.349
IUBMB Enzyme Nomenclature: 1.1.1.349
ExPASy - ENZYME nomenclature database: 1.1.1.349
BRENDA, the Enzyme Database: 1.1.1.349

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