KEGG   ENZYME: 1.1.1.350
Entry
EC 1.1.1.350                Enzyme                                 
Name
ureidoglycolate dehydrogenase (NAD+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-ureidoglycolate:NAD+ oxidoreductase
Reaction(IUBMB)
(S)-ureidoglycolate + NAD+ = N-carbamoyl-2-oxoglycine + NADH + H+ [RN:R02935]
Reaction(KEGG)
R02935
Substrate
(S)-ureidoglycolate [CPD:C00603];
NAD+ [CPD:C00003]
Product
N-carbamoyl-2-oxoglycine [CPD:C00802];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in catabolism of purines. The enzyme from the bacterium Escherichia coli is specific for NAD+ [2]. cf. EC 1.1.1.154, ureidoglycolate dehydrogenase [NAD(P)+].
History
EC 1.1.1.350 created 2013
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00073  ureidoglycolate dehydrogenase (NAD+)
Genes
ECOb0517(allD)
ECJJW0505(allD)
ECDECDH10B_0473(allD)
EBWBWG_0393(allD)
ECOKECMDS42_0410(allD)
ECEZ0672(ylbC)
ECSECs_0579(allD)
ECFECH74115_0618(allD)
ETWECSP_0591(allD)
ELXCDCO157_0562
EOIECO111_0549(allD)
EOJECO26_0550(allD)
EOHECO103_0489(allD)
ECOOECRM13514_0319(ylbC)
ECOHECRM13516_0506(ylbC)
ESLO3K_18915
ESOO3O_06380
ESMO3M_18890
ECKEC55989_0531(allD)
ECGE2348C_0450(allD)
EOKG2583_0637(allD)
ELRECO55CA74_03110
ELHETEC_0569
ECWEcE24377A_0555(allD)
EUNUMNK88_567(allD)
ECPECP_0577 ECP_3102
ENAECNA114_0494(allD) ECNA114_3100
ECOSEC958_0655(allD) EC958_3411
ECVAPECO1_1498(allD)
ECOAAPECO78_06080
ECXEcHS_A0591(allD)
ECMEcSMS35_0562(allD)
ECYECSE_0542
ECRECIAI1_0519(allD)
ECQECED1_0536(allD)
EUMECUMN_0557(allD)
ECTECIAI39_0480(allD)
EOCCE10_0491(allD)
EBRECB_00467(allD)
EBLECD_00467(allD)
EBEB21_00472(allD)
EBDECBD_3141
ECIUTI89_C0545(allD)
EIHECOK1_0499(allD) ECOK1_3436(allD)
ECZECS88_0516(allD)
ECCc0631
ELOEC042_0560(allD)
ELNNRG857_02445 NRG857_14970
ESEECSF_0479 ECSF_2848
ECLEcolC_3105
EKOEKO11_3330
EKFKO11_21005(allD)
EABECABU_c05960(allD) ECABU_c34220
EDHEcDH1_3096
EDJECDH1ME8569_0501(allD)
ELUUM146_01275 UM146_14775
ELWECW_m0588(allD)
ELLWFL_02915(allD)
ELCi14_0607 i14_3445
ELDi02_0607 i02_3445
ELPP12B_c0530(allD)
ELFLF82_0071(allD) LF82_494
ECOLLY180_02915
ECOIECOPMV1_00505(allD_1) ECOPMV1_03321(allD_2)
ECOJP423_02630 P423_17025
EALEAKF1_ch2916c(allD)
EMAC1192_09985
ESZFEM44_17155(allD)
STYSTY0576(allD)
STTt2333(allD)
SEXSTBHUCCB_24670
SENTTY21A_11820
STMSTM0528(allD)
SEOSTM14_0618(allD)
SEVSTMMW_05961 STMMW_30421
SEYSL1344_0521(allD) SL1344_3057
SEMSTMDT12_C05920 STMDT12_C31340
SEJSTMUK_0535(allD) STMUK_3069
SEBSTM474_0549(allD) STM474_3228
SEFUMN798_0574(allD) UMN798_3350
SETUSTU288_11730 STU288_15590
SETCCFSAN001921_01625 CFSAN001921_14390
SENRSTMDT2_05231(allD) STMDT2_29771
SENDDT104_30781
SENICY43_16065
SEENSE451236_08665 SE451236_21520
SPTSPA2195(allD)
SEKSSPA2040
SPQSPAB_03036
SEISPC_0542(allD)
SECSCH_0567(allD)
SEHSeHA_C0635(allD)
SHBSU5_01221 SU5_03582
SENHCFSAN002069_06200 CFSAN002069_16750
SEEHSEEH1578_01525 SEEH1578_12075
SEESNSL254_A0581(allD)
SENNSN31241_15330 SN31241_42030
SEASeAg_B0574(allD)
SENSQ786_02605 Q786_14925
SEDSeD_A0576(allD)
SEGSG0540(allD)
SELSPUL_3083
SEGASPUCDC_3069
SETSEN0509(allD)
SENAAU38_02595 AU38_14860
SENOAU37_02590 AU37_14870
SENVAU39_02595 AU39_14865
SENQAU40_02850 AU40_16765
SENLIY59_02645 IY59_15465
SEECCFSAN002050_09250 CFSAN002050_21760
SEEBSEEB0189_004480 SEEB0189_016660
SEEPI137_14720
SENBBN855_31510 BN855_5270(allD)
SENEIA1_02785 IA1_14860
SENCSEET0819_09595 SEET0819_22385
SALZEOS98_03965 EOS98_16460
SHQA0259_06250
ECLEECNIH2_00250
ECLZLI64_00045
EHMAB284_02455
KPUKP1_1373(ylbC)
KPPA79E_3790
KOCAB185_29050
KLWDA718_04185
KGRJJJ10_20955(allD)
CFDCFNIH1_12730
CBRAA6J81_10550
CIEAN232_23700
CARSE1B03_07350(allD)
LAXAPT61_22045
LEHC3F35_11575
BAGEBADSM9389_31190
EBUCUC76_09105
YINCH53_61(allD)
SMARSM39_0495(allD)
SMWSMWW4_v1c11190(allD)
SRYM621_05540
SERFL085_22955
SFWWN53_14690
SFGAV650_10210
SSURATE40_002310
SURIJ0X03_18265(allD)
SFOZ042_06890
RAHRahaq_0302
RACEJHW33_18115(allD)
RAQRahaq2_0319
RAAQ7S_01500
EAMEGXP68_18225(allD)
ERWIGN242_15840(allD)
TCIA7K98_20490
TPTYNCTC11468_00687(allD)
PMRPMI0702(allD)
PMIBBB2000_0774(allD)
PVLAOB99_05905
PVGCRN77_16325
PHAUPH4a_13000
PROTBTA34_04755
PCOLF1325_05980(allD)
PCIBF9282_05750(allD)
PPEEI6G31_03530(allD)
PFQQQ39_10725
LRINCTC12151_02780(allD)
MHATB824_16610
MHAMJ450_02305
MVIX808_13020
MVGX874_12010
MVEX875_8750
MANNGM695_08175(allD)
MGRAA4G16_03105
MBOSICJ55_06420(allD)
MPEGHV560_08520(allD)
AVTNCTC3438_00702(allD)
VEJVEJY3_09395
VNIVIBNI_B2041
VASGT360_06820
PGBH744_1c1498
EMODM558_12020
GAIIMCC3135_30305(yjmC)
HAKKO116_00829
HAMHALO0839
HHUAR456_08900
HCOLOKO_03157(yjmC)
HALOBWR19_08260
HOLHORIV_59680
HSRHSBAA_57300
HTTHZS52_09030
HCAMI4484_11555
HAAA5892_02585
GAPGAPWK_1756
SALNSALB1_0157
CNCCNE_2c04180
CUHBJN34_32535
BCEWDM40_5589
BLATWK25_18155
BGDbgla_1g20640
BGOBM43_3408
PGPCUJ91_23860
BBROBAU06_02950
BFZBAU07_03020 BAU07_19850
BOHAKI39_02660
AXYAXYL_05544
AXNAX27061_3547
AXXERS451415_03551(allD_2)
ADTAPT56_16870
ASWCVS48_11110
ACHBDVB37_23730
ADYHLG70_26295
BOZDBV39_04595
PACRFXN63_25555
RTARta_12460
URUDSM104443_01686(yjmC_3)
UPLDSM104440_01607(yjmC)
BEBABWI17_18540
MAMOA6B35_25115
HOEIMCC20628_00173
ORMHTY61_17775
SMKSinme_2599
SMQSinmeB_2378
SMXSM11_chr2702
SMIBN406_02396
SMEGC770_GR4Chr2649
SMELSM2011_c02035
SMERDU99_14145
SFHSFHH103_02433
SAMESAMCFNEI73_Ch2906(mdh)
ESJSJ05684_b58510
REPIE4803_PC00139
REIIE4771_PD00139
RHKKim5_PC00148
NGGRG540_PA12830
KAIK32_05860
STARG3545_12760 G3545_13570
MIVC4E04_19670
MICOGDR74_01980
BIDBind_2541
RHZRHPLAN_09850
DEIC4375_12670
DEAFPZ08_11055
AALAIGS74_14145
RPONG3256_12755
GXYGLX_23380
KNAB0W47_16895
AOTAcetOri_orf02513
NTND5366_09920
AOZHUE56_26200
BSRI33_1387
BSLA7A1_0241
BSHBSU6051_12320(yjmC)
BSYI653_06285
BSUTBSUB_01341(yjmC)
BSULBSUA_01341(yjmC)
BSUSQ433_07025
BSOBSNT_07705(yjmC)
BSNBSn5_18130
BSQB657_12320(yjmC)
BSXC663_1264(yjmC)
BSPU712_06400
BSSBSUW23_06275(yjmC)
BSTGYO_1541
BLIBL01097 BL01098(yjmC)
BLDBLi01129 BLi01130
BLHBaLi_c12540 BaLi_c12550
BSONS101395_03699(allD) S101395_03700
BHTDIC78_03325
BMOJHC660_12940(yjmC)
BIQAN935_06390
BIFN288_22470
BITBIS30_16895
BCABEFK13_06890(allD)
BRYM0696_06735(allD)
BJSMY9_1346
BACYQF06_05155
BACLBS34A_13640(yjmC)
BALMBsLM_1298
BEOBEH_12660
BCLABC4048
BLEBleG1_0301
BGIBGM20_00440
BONA361_26100
CSOALIS82_01135(allD)
GELIB49_01645
LSPBsph_2900
LFUHR49_12215
LYSLBYS11_21790
HLIHLI_12580
VNECFK40_17830 CFK40_17835
LAOAOX59_07645 AOX59_07650
APAKAP3564_06155
BMURABE28_012515
PBUTDTO10_00720
PFRIL8956_13620(allD)
SALEEPH95_13705
AIAAWH56_012085(allD)
BOUI5818_06520(allD) I5818_06525(allD)
SCASCA_2053(allD) SCA_2054(allD)
SXYBE24_13540 BE24_13545
SXLSXYLSMQ121_2325 SXYLSMQ121_2326
SXOSXYL_02492(allD1) SXYL_02493(allD2)
SSIFAL483_12085 AL483_12090(allD)
SCOHBZ166_03585
SNLBJD96_12915 BJD96_12920
SARLSAP2_02420(allD_1) SAP2_02430(allD_2)
SSIMSAMEA4384339_0261(allD_1) SAMEA4384339_0262(allD_2)
SPSDJMB28_12670(allD) JMB28_12675(allD)
SSCUCEP64_13225 CEP64_13230(allD)
SSTESAMEA4384403_0162(allD_1) SAMEA4384403_0163(allD_2)
SHVAAT16_12735
JEAJEM45_03075(allD) JEM45_03080(allD)
LWIUE46_03775 UE46_03780
BLRBRLA_c022460 BRLA_c022470
BRWGOP56_04135(allD) GOP56_04140(allD)
PTAHPL003_13020
PKBB4V02_20120
PLUTEI981_02235
PALBEJC50_18150
PLNPlano_0201
PLLI858_006370
SURESporoP32a_11200
SPOOJ3U78_13330(allD)
RSTATY39_05550 ATY39_05555
PLAYDNR44_005565(allD)
LFELAF_0163
LFRLC40_0123
LHILG8J22_00247(allD)
LZYLZ3411_0459
EFAEF0388(allD)
EFLEF62_0721(allD)
EFIOG1RF_10276(allD)
EFDEFD32_0322
EFSEFS1_0271
EFNDENG_00376(allD)
EFQDR75_2381(allD)
ENEENT_25980
ECASECBG_00215 ECBG_00233
EGAAL523_00065(allD) AL523_17300(allD)
ESSATZ33_08475 ATZ33_08480
EGVEGCR1_17800(allD) EGCR1_17820(allD)
EIEENLAB_08150 ENLAB_08330
TOOC7K38_01850(allD) C7K38_01865(allD)
VTEBHY08_06460
VPIBW732_07880
VCPH9L18_06540(allD)
VHYG7082_14395(allD)
VLUM2919_06885(allD)
AUIAPT62_03875
ABAECL176_02815
CRNCAR_c17740(allD)
CMLBN424_1730(allD) BN424_1731(allD)
CARCNY10_1796 NY10_821
CDJBFC22_07250 BFC22_07255
JDABW727_101585(allD)
JEHEJN90_04090(allD)
CSQCSCA_5012
CCKCcar_15715
CARGRSJ17_17100
CDRKB9W14_19750
BLIQINP51_01735(allD)
LACYA4V08_02865
EHLEHLA_2826
CBOLCGC65_17075
SINTK5I26_04190(allD)
MDVC5Q96_03700
PUFUFO1_0268
STEDSPTER_11400(allD)
SSXSACTE_6070
SNQCP978_01540
MALKMalAC0309_2479
LLUTK1X41_00900
AGGC1N71_11390
CELZE5225_11030
OLSOlsu_1381
CGOCorgl_1632
TTJTTHB078(TTHB078)
TTSThthe16_2289
TTLTtJL18_2250
AAGGETAA8_00550(yjmC)
LPAVPLANPX_3331
AMUCPan181_28410(yjmC)
GMRGmarT_15850(yjmC_1)
GIMF1728_07080
GPNPan110_15230(yjmC_1)
STASTHERM_c02180
STQSpith_0202
BHDBHYOB78_07835
BRMBmur_1791
BPOBP951000_1198(allD)
BPJB2904_orf2667(yjmC)
BPIPBPP43_09125
BPWWESB_2623(yjmC)
BIPBint_0179(yjmC)
BHPBHAMNSH16_06490
LGOJCM16774_0854
HABSG26_03140
HALQHrr1229_017415
SRUBC2R22_13085
HALUHUG12_04625 HUG12_04630
 » show all
Reference
1  [PMID:10601204]
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
  Sequence
[eco:b0517]
Reference
2  [PMID:23284870]
  Authors
Kim MI, Shin I, Cho S, Lee J, Rhee S
  Title
Structural and functional insights into (S)-ureidoglycolate dehydrogenase, a metabolic branch point enzyme in nitrogen utilization.
  Journal
PLoS One 7:e52066 (2012)
DOI:10.1371/journal.pone.0052066
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.350
IUBMB Enzyme Nomenclature: 1.1.1.350
ExPASy - ENZYME nomenclature database: 1.1.1.350
BRENDA, the Enzyme Database: 1.1.1.350

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