KEGG   ENZYME: 1.1.1.350
Entry
EC 1.1.1.350                Enzyme                                 
Name
ureidoglycolate dehydrogenase (NAD+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-ureidoglycolate:NAD+ oxidoreductase
Reaction(IUBMB)
(S)-ureidoglycolate + NAD+ = N-carbamoyl-2-oxoglycine + NADH + H+ [RN:R02935]
Reaction(KEGG)
R02935
Substrate
(S)-ureidoglycolate [CPD:C00603];
NAD+ [CPD:C00003]
Product
N-carbamoyl-2-oxoglycine [CPD:C00802];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in catabolism of purines. The enzyme from the bacterium Escherichia coli is specific for NAD+ [2]. cf. EC 1.1.1.154, ureidoglycolate dehydrogenase [NAD(P)+].
History
EC 1.1.1.350 created 2013
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00073  ureidoglycolate dehydrogenase (NAD+)
Genes
ECOb0517(allD)
ECJJW0505(allD)
ECDECDH10B_0473(allD)
EBWBWG_0393(allD)
ECOKECMDS42_0410(allD)
ECOCC3026_02535
ECEZ0672(ylbC)
ECSECs_0579(allD)
ECFECH74115_0618(allD)
ETWECSP_0591(allD)
ELXCDCO157_0562
EOIECO111_0549(allD)
EOJECO26_0550(allD)
EOHECO103_0489(allD)
ECOOECRM13514_0319(ylbC)
ECOHECRM13516_0506(ylbC)
ESLO3K_18915
ESOO3O_06380
ESMO3M_18890
ECKEC55989_0531(allD)
ECGE2348C_0450(allD)
EOKG2583_0637(allD)
ELRECO55CA74_03110
ELHETEC_0569
ECWEcE24377A_0555(allD)
EUNUMNK88_567(allD)
ECPECP_0577
ENAECNA114_0494(allD)
ECOSEC958_0655(allD)
ECVAPECO1_1498(allD)
ECOAAPECO78_06080
ECXEcHS_A0591(allD)
ECMEcSMS35_0562(allD)
ECYECSE_0542
ECRECIAI1_0519(allD)
ECQECED1_0536(allD)
EUMECUMN_0557(allD)
ECTECIAI39_0480(allD)
EOCCE10_0491(allD)
EBRECB_00467(allD)
ECOBC3029_06185
EBLECD_00467(allD)
EBEB21_00472(allD)
EBDECBD_3141
ECIUTI89_C0545(allD)
EIHECOK1_0499(allD)
ECZECS88_0516(allD)
ECCc0631
ELOEC042_0560(allD)
ELNNRG857_02445
ESEECSF_0479
ECLEcolC_3105
EKOEKO11_3330
EKFKO11_21005(allD)
EABECABU_c05960(allD)
EDHEcDH1_3096
EDJECDH1ME8569_0501(allD)
ELUUM146_14775
ELWECW_m0588(allD)
ELLWFL_02915(allD)
ELCi14_0607
ELDi02_0607
ELPP12B_c0530(allD)
ELFLF82_0071(allD)
ECOLLY180_02915
ECOIECOPMV1_00505(allD_1)
ECOJP423_02630
EMAC1192_09985
ESZFEM44_17155(allD)
ERUYOSH18_06890(allD)
STYSTY0576(allD)
STTt2333(allD)
SEXSTBHUCCB_24670
SENTTY21A_11820
STMSTM0528(allD)
SEOSTM14_0618(allD)
SEVSTMMW_05961
SEYSL1344_0521(allD)
SEMSTMDT12_C05920
SEJSTMUK_0535(allD)
SEBSTM474_0549(allD)
SEFUMN798_0574(allD)
SETUSTU288_11730
SETCCFSAN001921_14390
SENRSTMDT2_05231(allD)
SEENSE451236_08665
SPTSPA2195(allD)
SEKSSPA2040
SPQSPAB_03036
SEISPC_0542(allD)
SECSCH_0567(allD)
SEHSeHA_C0635(allD)
SHBSU5_01221
SENHCFSAN002069_06200
SEEHSEEH1578_12075
SEESNSL254_A0581(allD)
SENNSN31241_15330
SEASeAg_B0574(allD)
SENSQ786_02605
SEDSeD_A0576(allD)
SEGSG0540(allD)
SETSEN0509(allD)
SENAAU38_02595
SENOAU37_02590
SENVAU39_02595
SENQAU40_02850
SENLIY59_02645
SEECCFSAN002050_09250
SEEBSEEB0189_016660
SENBBN855_5270(allD)
SENEIA1_02785
SENCSEET0819_09595
SALZEOS98_16460
SHQA0259_06250
KPUKP1_1373(ylbC)
KPPA79E_3790
KOCAB185_29050
KGRJJJ10_20955(allD)
KPASLUW96_13565(allD)
KLCK7H21_21260(allD)
KLMBWI76_07040
CFDCFNIH1_12730
CBRAA6J81_10550
CIEAN232_23700
CARSE1B03_07350(allD)
CIXM4I31_17310(allD)
BAGEBADSM9389_31190
EBUCUC76_09105
YINCH53_61(allD)
SMARSM39_0495(allD)
SMWSMWW4_v1c11190(allD)
SRYM621_05540
SERFL085_22955
SFWWN53_14690
SFGAV650_10210
SSURATE40_002310
SURIJ0X03_18265(allD)
SNEVOI978_01085(allD)
SFOZ042_06890
RAHRahaq_0302
RACEJHW33_18115(allD)
RAQRahaq2_0319
RAAQ7S_01500
EAMEGXP68_18225(allD)
ERWIGN242_15840(allD)
TCIA7K98_20490
TPTYNCTC11468_00687(allD)
PMRPMI0702(allD)
PMIBBB2000_0774(allD)
PVLAOB99_05905
PVGCRN77_16325
PHAUPH4a_13000
PROTBTA34_04755
PCOLF1325_05980(allD)
PCIBF9282_05750(allD)
PPEEI6G31_03530(allD)
PAPPQQS39_06255(allD)
PFQQQ39_10725
LRINCTC12151_02780(allD)
MHATB824_16610
MHAMJ450_02305
MVIX808_13020
MVGX874_12010
MVEX875_8750
MGRAA4G16_03105
MBOSICJ55_06420(allD)
MPEGHV560_08520(allD)
MANNGM695_08175(allD)
AVTNCTC3438_00702(allD)
PGBH744_1c1498
EMODM558_12020
HAAA5892_02585
GAPGAPWK_1756
GAQRAM11_06065(allD)
BLIBL01097 BL01098(yjmC)
BLDBLi01129 BLi01130
BLHBaLi_c12540 BaLi_c12550
BSONS101395_03699(allD) S101395_03700
CSOALIS82_01135(allD)
LSPBsph_2900
LFUHR49_12215
VNECFK40_17830 CFK40_17835
LAOAOX59_07645 AOX59_07650
NNVQNH39_21420(allD) QNH39_21425(allD)
BOUI5818_06520(allD) I5818_06525(allD)
SCASCA_2053(allD) SCA_2054(allD)
SXYBE24_13540 BE24_13545
SXLSXYLSMQ121_2325 SXYLSMQ121_2326
SXOSXYL_02492(allD1) SXYL_02493(allD2)
SSIFAL483_12085 AL483_12090(allD)
SCOHBZ166_03585
SNLBJD96_12915 BJD96_12920
SARLSAP2_02420(allD_1) SAP2_02430(allD_2)
SSIMSAMEA4384339_0261(allD_1) SAMEA4384339_0262(allD_2)
SPSDJMB28_12670(allD) JMB28_12675(allD)
SURYMUA21_12110(allD) MUA21_12115(allD)
SCAQQMO72_12310(allD) QMO72_12315(allD)
SSCUCEP64_13225 CEP64_13230(allD)
SSTESAMEA4384403_0162(allD_1) SAMEA4384403_0163(allD_2)
JEAJEM45_03075(allD) JEM45_03080(allD)
LWIUE46_03775 UE46_03780
LNWOTR81_01125(allD) OTR81_01130(allD)
BLRBRLA_c022460 BRLA_c022470
BRWGOP56_04135(allD) GOP56_04140(allD)
PTAHPL003_13020
PKBB4V02_20120
PLUTEI981_02235
PTHINDS46_06670(allD)
PDYQJQ58_15845(allD)
SPOOJ3U78_13330(allD)
STHOQNH10_06975(allD) QNH10_06980(allD)
RSTATY39_05550 ATY39_05555
LFELAF_0163
LFRLC40_0123
LHILG8J22_00247(allD)
LZYLZ3411_0459
EFAEF0388(allD)
EFLEF62_0721(allD)
EFIOG1RF_10276(allD)
EFDEFD32_0322
EFSEFS1_0271
EFNDENG_00376(allD)
EFQDR75_2381(allD)
ENEENT_25980
ECASECBG_00215 ECBG_00233
EGAAL523_00065(allD) AL523_17300(allD)
ESSATZ33_08475 ATZ33_08480
EGVEGCR1_17800(allD) EGCR1_17820(allD)
EIEENLAB_08150 ENLAB_08330
TOOC7K38_01850(allD) C7K38_01865(allD)
VTEBHY08_06460
VPIBW732_07880
VCPH9L18_06540(allD)
VHYG7082_14395(allD)
VLUM2919_06885(allD)
AUIAPT62_03875
ABAECL176_02815
FCTNRE15_06660(allD)
FHMR0V13_09215(allD)
CRNCAR_c17740(allD)
CMLBN424_1730(allD) BN424_1731(allD)
CARCNY10_1796 NY10_821
CDJBFC22_07250 BFC22_07255
JDABW727_101585(allD)
JEHEJN90_04090(allD)
CSQCSCA_5012
CCKCcar_15715
CARGRSJ17_17100
CDRKB9W14_19750
BLIQINP51_01735(allD)
LACYA4V08_02865
CHYLCE91St63_15320(allD)
CBOLCGC65_17075
DFMNQ560_10850(allD)
SINTK5I26_04190(allD)
MDVC5Q96_03700
MNLQU661_05250(allD)
PUFUFO1_0268
STEDSPTER_11400(allD)
OLSOlsu_1381
CGOCorgl_1632
COLLKPC83_02180(allD)
LLUTK1X41_00900
LGOJCM16774_0854
 » show all
Reference
1  [PMID:10601204]
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
  Sequence
[eco:b0517]
Reference
2  [PMID:23284870]
  Authors
Kim MI, Shin I, Cho S, Lee J, Rhee S
  Title
Structural and functional insights into (S)-ureidoglycolate dehydrogenase, a metabolic branch point enzyme in nitrogen utilization.
  Journal
PLoS One 7:e52066 (2012)
DOI:10.1371/journal.pone.0052066
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.350
IUBMB Enzyme Nomenclature: 1.1.1.350
ExPASy - ENZYME nomenclature database: 1.1.1.350
BRENDA, the Enzyme Database: 1.1.1.350

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