KEGG   ENZYME: 1.1.1.350Help
Entry
EC 1.1.1.350                Enzyme                                 

Name
ureidoglycolate dehydrogenase (NAD+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-ureidoglycolate:NAD+ oxidoreductase
Reaction(IUBMB)
(S)-ureidoglycolate + NAD+ = N-carbamoyl-2-oxoglycine + NADH + H+ [RN:R02935]
Reaction(KEGG)
Substrate
(S)-ureidoglycolate [CPD:C00603];
NAD+ [CPD:C00003]
Product
N-carbamoyl-2-oxoglycine [CPD:C00802];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Involved in catabolism of purines. The enzyme from the bacterium Escherichia coli is specific for NAD+ [2]. cf. EC 1.1.1.154, ureidoglycolate dehydrogenase [NAD(P)+].
History
EC 1.1.1.350 created 2013
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00073  ureidoglycolate dehydrogenase (NAD+)
Genes
ECO: b0517(allD)
ECJ: JW0505(allD)
ECD: ECDH10B_0473(allD)
EBW: BWG_0393(allD)
ECOK: ECMDS42_0410(allD)
ECE: Z0672(ylbC)
ECS: ECs0579
ECF: ECH74115_0618(allD)
ETW: ECSP_0591(allD)
ELX: CDCO157_0562
EOJ: ECO26_0550(allD)
EOI: ECO111_0549(allD)
EOH: ECO103_0489(allD)
ECOO: ECRM13514_0319(ylbC)
ECOH: ECRM13516_0506(ylbC)
ECG: E2348C_0450(allD)
EOK: G2583_0637(allD)
ESO: O3O_06380
ESM: O3M_18890
ESL: O3K_18915
ECW: EcE24377A_0555(allD)
ELH: ETEC_0569
EUN: UMNK88_567(allD)
ECC: c0631
ECP: ECP_0577
ECI: UTI89_C0545(allD)
ECV: APECO1_1498(allD)
ECX: EcHS_A0591(allD)
ECM: EcSMS35_0562(allD)
ECY: ECSE_0542
ECR: ECIAI1_0519(allD)
ECQ: ECED1_0536(allD)
ECK: EC55989_0531(allD)
ECT: ECIAI39_0480(allD)
EOC: CE10_0491(allD)
EUM: ECUMN_0557(allD)
ECZ: ECS88_0516(allD)
ELO: EC042_0560(allD)
ESE: ECSF_0479
EBR: ECB_00467(allD)
EBD: ECBD_3141
EKF: KO11_21005(allD)
EAB: ECABU_c05960(allD)
EDJ: ECDH1ME8569_0501(allD)
EIH: ECOK1_0499(allD)
ENA: ECNA114_0494(allD)
ELW: ECW_m0588(allD)
ELL: WFL_02915(allD)
ELC: i14_0607
ELD: i02_0607
ELP: P12B_c0530(allD)
EBL: ECD_00467(allD)
EBE: B21_00472(allD)
ELF: LF82_0071(allD)
ECOI: ECOPMV1_00505(allD_1)
ECOJ: P423_02630
ECOS: EC958_0655(allD)
STY: STY0576(allD)
STT: t2333(allD)
STM: STM0528(allD)
SEO: STM14_0618(allD)
SEY: SL1344_0521(allD)
SEJ: STMUK_0535(allD)
SEB: STM474_0549(allD)
SEF: UMN798_0574(allD)
SENR: STMDT2_05231(allD)
SPT: SPA2195(allD)
SEK: SSPA2040
SEI: SPC_0542(allD)
SEC: SCH_0567(allD)
SEH: SeHA_C0635(allD)
SHB: SU5_01221
SEE: SNSL254_A0581(allD)
SEA: SeAg_B0574(allD)
SENS: Q786_02605
SED: SeD_A0576(allD)
SEG: SG0540(allD)
SET: SEN0509(allD)
SENA: AU38_02595
SENO: AU37_02590
SENV: AU39_02595
SENQ: AU40_02850
SENL: IY59_02645
SENB: BN855_5270(allD)
SENE: IA1_02785
KPU: KP1_1373(ylbC)
KPP: A79E_3790
YIN: CH53_61(allD)
SMW: SMWW4_v1c11190(allD)
SMAR: SM39_0495(allD)
SERF: L085_22955
RAA: Q7S_01500
TPTY: NCTC11468_00687(allD)
PMR: PMI0702(allD)
PMIB: BB2000_0774(allD)
PHAU: PH4a_13000
LRI: NCTC12151_02780(allD)
MHAT: B824_16610
MHAM: J450_02305
MVE: X875_8750
BSR: I33_1387
BSL: A7A1_0241
BSH: BSU6051_12320(yjmC)
BSUT: BSUB_01341(yjmC)
BSUL: BSUA_01341(yjmC)
BSUS: Q433_07025
BSS: BSUW23_06275(yjmC)
BSO: BSNT_07705(yjmC)
BSQ: B657_12320(yjmC)
BSX: C663_1264(yjmC)
BLI: BL01097 BL01098(yjmC)
BCL: ABC4048
BJS: MY9_1346
BACY: QF06_05155
BACL: BS34A_13640(yjmC)
BALM: BsLM_1298
LSP: Bsph_2900
SCA: SCA_2053(allD) SCA_2054(allD)
SXO: SXYL_02492(allD1) SXYL_02493(allD2)
AAD: TC41_0695
LFE: LAF_0163
LFR: LC40_0123
EFA: EF0388(allD)
EFL: EF62_0721(allD)
EFI: OG1RF_10276(allD)
EFS: EFS1_0271
EFN: DENG_00376(allD)
EFQ: DR75_2381(allD)
ENE: ENT_25980
EGA: AL523_00065(allD) AL523_17300(allD)
EGV: EGCR1_17800(allD) EGCR1_17820(allD)
TOO: C7K38_01850(allD) C7K38_01865(allD)
CRN: CAR_c17740(allD)
CML: BN424_1730(allD) BN424_1731(allD)
JDA: BW727_101585(allD)
JEH: EJN90_04090(allD)
CSQ: CSCA_5012
EHL: EHLA_2826
PUF: UFO1_0268
OLS: Olsu_1381
BRM: Bmur_1791
BPO: BP951000_1198(allD)
BPJ: B2904_orf2667(yjmC)
BPW: WESB_2623(yjmC)
BIP: Bint_0179(yjmC)
 » show all
Taxonomy
Reference
1  [PMID:10601204]
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
  Sequence
[eco:b0517]
Reference
2  [PMID:23284870]
  Authors
Kim MI, Shin I, Cho S, Lee J, Rhee S
  Title
Structural and functional insights into (S)-ureidoglycolate dehydrogenase, a metabolic branch point enzyme in nitrogen utilization.
  Journal
PLoS One 7:e52066 (2012)
DOI:10.1371/journal.pone.0052066
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.350
IUBMB Enzyme Nomenclature: 1.1.1.350
ExPASy - ENZYME nomenclature database: 1.1.1.350
BRENDA, the Enzyme Database: 1.1.1.350

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