KEGG   ENZYME: 1.1.1.354Help
Entry
EC 1.1.1.354                Enzyme                                 

Name
farnesol dehydrogenase (NAD+);
NAD+-farnesol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2E,6E)-farnesol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+ [RN:R10412]
Reaction(KEGG)
Substrate
(2E,6E)-farnesol [CPD:C01126];
NAD+ [CPD:C00003]
Product
(2E,6E)-farnesal [CPD:C03461];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
History
EC 1.1.1.354 created 2013
Pathway
ec00900  Terpenoid backbone biosynthesis
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K15891  NAD+-dependent farnesol dehydrogenase
Genes
ATH: AT4G33360(FLDH)
ALY: ARALYDRAFT_656688
CRB: 17878851
CSAT: 104716825 104721483 104729924
EUS: EUTSA_v10025657mg
BRP: 103862234
BNA: 106411435 111207928
BOE: 106302011
RSZ: 108848622
THJ: 104819464
CPAP: 110815277
CIT: 102617063
TCC: 18591229
GRA: 105769201
GAB: 108450623
DZI: 111315425
EGR: 104449340
GMX: 100792747
VRA: 106762372
VAR: 108343368
VUN: 114196187
CCAJ: 109801757
CAM: 101492439
LJA: Lj1g3v1649010.1(Lj1g3v1649010.1) Lj1g3v1649010.2(Lj1g3v1649010.2) Lj1g3v2584610.1(Lj1g3v2584610.1) Lj1g3v2584640.1(Lj1g3v2584640.1)
ADU: 107460435
AIP: 107605825
FVE: 101307656
PPER: 109949998
PMUM: 103320321
PAVI: 110761929
MDM: 103428773
ZJU: 107420927
CSV: 101223178
CMO: 103493529
MCHA: 111026159
CMAX: 111481147
CMOS: 111446335
CPEP: 111789148
RCU: 8278896
JCU: 105633659
HBR: 110664353
MESC: 110605974
JRE: 108987634
VVI: 100266013
SLY: 101264803
SPEN: 107005370
SOT: 102604685
NSY: 104212650
INI: 109149773
SIND: 105166261
HAN: 110913581
CCAV: 112511479
BVG: 104898527
SOE: 110776702
NNU: 104610585
DOSA: Os03t0184550-01(Os03g0184550)
BDI: 100829741
ATS: 109735166
ZMA: 100272889
PDA: 103701809
EGU: 105048681
MUS: 103971350
DCT: 110101245
PEQ: 110027609
AOF: 109848345
ATR: 18425069
PPP: 112293999
MBAS: ALGA_3274
MUC: MuYL_4365
 » show all
Taxonomy
Reference
1  [PMID:18422649]
  Authors
Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y
  Title
Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae).
  Journal
FEBS J 275:2807-17 (2008)
DOI:10.1111/j.1742-4658.2008.06421.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.354
IUBMB Enzyme Nomenclature: 1.1.1.354
ExPASy - ENZYME nomenclature database: 1.1.1.354
BRENDA, the Enzyme Database: 1.1.1.354

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