KEGG   ENZYME: 1.1.1.357
Entry
EC 1.1.1.357                Enzyme                                 
Name
3alpha-hydroxysteroid 3-dehydrogenase;
3alpha-hydroxysteroid dehydrogenase;
AKR1C4 (gene name);
AKR1C2 (gene name);
hsdA (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]
Reaction(KEGG)
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. This entry stands for enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known. [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) and EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)].
History
EC 1.1.1.357 created 2013
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
K00089  3alpha-hydroxysteroid 3-dehydrogenase
K00212  20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
K04119  aldo-keto reductase family 1 member C3
K19811  3alpha-hydroxysteroid 3-dehydrogenase
Genes
HSA1109(AKR1C4) 1645(AKR1C1) 1646(AKR1C2) 8644(AKR1C3)
PTR100607996 100612191(AKR1C2) 100612718(AKR1C3) 100612887 450274(AKR1C4) 746545
PPS100971300 100986388(AKR1C3) 100986729 100987632 100987989(AKR1C4) 100988315 103783188
GGO101144878(AKR1C3) 101146324 101147265(AKR1C8) 101148343 101152195 115936027
PON100171658(AKR1C1) 100174617(AKR1C3) 100189776 100432652 100434557(AKR1C4) 100461633 100462259
PPYG129006137 129006867 129006869 129006872 129006873 129006874(AKR1C8) 129006876(AKR1C4)
NLE100593325 100603603 100604844 100605385 100605934 100606512
HMH116457046 116457717 116460197(AKR1C8) 116461800(AKR1C4)
SSYN129491830 129491831 129491832 129491834 129491837 129491838
MCC100430336 711198(AKR1C1) 711360(AKR1C2) 711440 722483 722485 722490(AKR1C4) 722496
MCF101865536(AKR1C1) 102116465 102116844 102117205 102141103 102142023(HSD17B5) 102143072 102144231
MTHB126963005 126963006 126963007 126963008 126963009 126963422
MNI105490778 105490779 105490780 105490781 105490782 105490783 105494391 112428206
CSAB103237807 103237808 103237812 103237813 103237814 103237816
CATY105587685 105587688 105587690 105597444 105597446 105597447 105597481
PANU100997485 101022585 101022938 101023297 101024707
TGE112631307 112631308 112631309 112631314 112631750
MLEU105532487 105532488 105532490 105532496 105535734 105535762 105535763
RRO104674747 104674748 104678924 104678925
RBB108521035 108521036 108532990 108532991 108532992
TFN117082052 117082118 117082119 117082359 117083437 117083548 117083560 117087703 117087714
PTEH111528130 111528985 113224919
CANG105521699 105521700 105521701 105521702 105521704 105521705
CJC100404656(AKR1C1) 100405255 100405615(AKR1C4) 100406962 100409025 100409384
SBQ101041594 101041915 101042225 101042532 101049957
CIMI108285104 108285106 108292323 108292324(AKR1C4) 108292325 108292357
ANAN105710839 105710841 105710885 105710886 105710887 105710891
CSYR103261879 103261880 103261882 103261883 103263298 103263300
MMUR105858219 105858220 105858221 105858224
LCAT123623042 123623043 123623044 123623047
PCOQ105826891 105826910 105826913
OGA100940488 100942491 100967071
MMU77337(Akr1c21)
MCAL110308148 110308710
MPAH110315750 110333790 110333839 110333848
RNO291283(Akr1c2) 307092(Akr1c1) 361267(Akr1c15)
MCOC116081731 116081947
ANU117713832 117713854
MUN110539888 110540933 110542801 110560700 132649305
CGE100768090 100768376 100770100 100770388
MAUA101839651 101841267 101843587
PROB127229800 127229804
PLEU114707814 114708002 114708030 114708096
MORG121432600 121432606 121432658 121432668
MFOT126501679 126501680 126501681 126501693 126506800
AAMP119816160 119816243 119817583 119826549
NGI103725884 103725890 103725892 103725895 103746652
HGL101702106 101716553
CPOC100722094 100724342 100724620 100727454
CCAN109678869 109680334 109680485 109680990
DSP122113031
PLOP125366785
NCAR124961142 124961655
MMMA107134068 107150202 107150203
OCU100348607(PGER1) 100352716 108176284
OPI101524567 101525116 101525279 101525842 101526245 101526664 101526901 101527313 101527569 101527977 118759111
TUP102478063 102478495 102491222 102491650
GVR103581518 103602898 103610229 103610426
CFA497070(AKR1C3)
CLUD112658979
VVP112933725
VLG121496638
NPO129514265
AML100483758
UMR103676234
UAH113241124
UAR123802294(AKR1C8)
ELK111158636
LLV125107753
MPUF101678776
MNP132020017
MLK131838054
NVS122891768(AKR1C4)
ORO101377633 101379669
EJU114217720
ZCA113921662
MLX118021623 118021905
LWW102748666 102748964
FCA100510801(AKR1C3)
PYU121014878
PCOO112867557
PBG122473163
PVIV125169528
LRUF124502362
PTG102963188
PPAD109273789
PUC125918575
AJU106988139
HHV120237198
BTA100139386(20ALPHA-HSD) 112441538 112449293 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 782884
BOM102267155 102269337 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205
BIU109567627 109568074 109568076 109568077 109568079 109568080 109568087
BBUB102389138 102395293 102395635 102396460 102396772 102400645 102404780 102415234 102416534
BBIS104985980 104985985 104985990 104985991 104985992 104985994 104985995 104985998 104985999 104986133
CHX102176340 102176622 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102189109 102189495 102190498
OAS101107119 101107541 101107809 101109111 101109377 101110434 101110693 105614315 106990122 114108656
BTAX128058197 128058202 128058203 128058208 128058211 128058212 128058213 128058216
ODA120860627 120868601 120869467 120869469 120869471
CCAD122447956 122447958 122447959 122448269 122448454 122448455 122448456 122448511 122448512
MBEZ129547517 129555459 129559457 129559483 129559564 129559569 129559578 129559602 129559618 129559630 129559646
SSC654406(AKR1CL1) 733634(AKR1C1) 733635 733694(AKR1C1)
CFR102511678 116656624 116661570
CBAI105074137 105074417 105074427 105074728
CDK105104488 105104489 105105880
VPC102531609 102541232 102541486
BACU103002145 103003050
BMUS118891073 118891271
LVE103069218
OOR101273575 101281536
DLE111170128 111170129
PCAD102978533
PSIU116748968 116749098
NASI112407550 112407551
ECB100057212 100057251 100070491 100070501 100070509 100070570 100070616 111771771 111771772
EPZ103540777 103540778 103541472 103541473 103542048
EAI106824650 106827241 106827243 106827244 106827468 106846832 106846833 106846834 123281999
MYB102254990 102255491
MYD102751586 102763642
MMYO118672630 118672665
MLF102421358 102428982
PKL118702292 118702295
EFUS103300835 103300840
MNA107542430 107542432
DRO112321159 112323007
SHON118977133
AJM119057712
PDIC114492418
PHAS123824859 123831227(AKR1C8)
MMF118632067 118632135
PPAM129084610 129084627
HAI109378613
PALE102889546
PGIG120608988
PVP105299187
MJV108384939 108393830 108407235 108407237 108407238
TOD119244650 119245260
SARA101543981 101545704 101551007 101551999 101555320 101555749
SETR126013285
LAV100659630 100659914 100660861
TMU101342771 101360332
ETF101653259 101653576
DNM101426998 101428157 101429786 101433437 101433871 101435315
GAS123247018 123248678
AFZ127564339
TVP118850247 118850334
OAA100085065 100085983
PSS102446010 102446253 102446483
CMY102946053 119563672
CCAY125625831
DCC119843778 119849865
CPIC101940001 101940260 101940524
TST117882842
CABI116815619
MRV120395343 120395491 120395494 120395542
PVT110070400 110071420 110088827
PMUA114590236 114604979 114604980 114604981 114605230 114605592
PRAF128421905 128421906 128421907 128421908 128421909 128422029
ZVI118090693 118090694 118090915
GJA107108026
EMC129335705
XLA100049750(XB5895996.L) 108712557(akr1c4.S) 443571(akr1c3.L)
XTR100127714(akr1c1) 100490956 100494522 101733893 116406435 116409681 496490(akr1c4) 734139 779627(akr1c3)
NPR108789947 108789949 108799287 108799288 108799289 108799290 108799291 108799292
RTEM120921832 120932840 120932842
BBUF121003666
BGAR122926607
MUO115477556
GSH117364122
CPLA122559456
HOC132825023
BBEL109473367
PPYR116168970
DMK116918341
PMEO129593135
PVUL126823863 130010387
PMAX117329343 117329344 117331065
MCAF127727738
MMER123536211
CTTCtCNB1_1322
CTESO987_07590
CRJQMY55_06895
SMIOCATMQ487_31860
NTCKHQ06_28825
NHUH0264_27905
NYALTV02_06370
NYUD7D52_11570
AACDLWP59_16945
ATHML1857_34415
AMOGQRX60_45535
ACYNORV05_17285
 » show all
Reference
1  [PMID:8172617]
  Authors
Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A
  Title
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.
  Journal
Biochem J 299 ( Pt 2):545-52 (1994)
DOI:10.1042/bj2990545
  Sequence
[hsa:1645 1109]
Reference
2  [PMID:7650035]
  Authors
Khanna M, Qin KN, Wang RW, Cheng KC
  Title
Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 270:20162-8 (1995)
DOI:10.1074/jbc.270.34.20162
  Sequence
[hsa:8644]
Reference
3  [PMID:8944761]
  Authors
Oppermann UC, Maser E
  Title
Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the gram-negative bacterium Comamonas testosteroni.
  Journal
Eur J Biochem 241:744-9 (1996)
DOI:10.1111/j.1432-1033.1996.00744.x
  Sequence
Reference
4  [PMID:9812981]
  Authors
Mobus E, Maser E
  Title
Molecular cloning, overexpression, and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. A novel member of the short-chain dehydrogenase/reductase superfamily.
  Journal
J Biol Chem 273:30888-96 (1998)
DOI:10.1074/jbc.273.47.30888
  Sequence
Reference
5  [PMID:11514561]
  Authors
Nahoum V, Gangloff A, Legrand P, Zhu DW, Cantin L, Zhorov BS, Luu-The V, Labrie F, Breton R, Lin SX
  Title
Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.
  Journal
J Biol Chem 276:42091-8 (2001)
DOI:10.1074/jbc.M105610200
  Sequence
[hsa:1646]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.357
IUBMB Enzyme Nomenclature: 1.1.1.357
ExPASy - ENZYME nomenclature database: 1.1.1.357
BRENDA, the Enzyme Database: 1.1.1.357

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