KEGG   ENZYME: 1.1.1.358Help
Entry
EC 1.1.1.358                Enzyme                                 

Name
2-dehydropantolactone reductase;
2-oxopantoyl lactone reductase;
2-ketopantoyl lactone reductase;
ketopantoyl lactone reductase;
2-dehydropantoyl-lactone reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-pantolactone:NADP+ oxidoreductase
Reaction(IUBMB)
(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ [RN:R03155]
Reaction(KEGG)
Substrate
(R)-pantolactone [CPD:C01012];
NADP+ [CPD:C00006]
Product
2-dehydropantolactone [CPD:C01125];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B5). This entry covers enzymes whose stereo specificity for NADP+ is not known. cf. EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific) and EC 1.1.1.214, 2-dehydropantolactone reductase (Si-specific).
History
EC 1.1.1.358 created 2013
Orthology
K19654  2-dehydropantolactone reductase
Genes
LEL: LELG_05161
CTP: CTRG_05139
COT: CORT_0G03830
CDU: CD36_73000(CPR-C2)
Taxonomy
Reference
1  [PMID:2644973]
  Authors
Hata H, Shimizu S, Hattori S, Yamada H
  Title
Ketopantoyl-lactone reductase from Candida parapsilosis: purification and characterization as a conjugated polyketone reductase.
  Journal
Biochim Biophys Acta 990:175-81 (1989)
DOI:10.1016/S0304-4165(89)80031-5
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.358
IUBMB Enzyme Nomenclature: 1.1.1.358
ExPASy - ENZYME nomenclature database: 1.1.1.358
BRENDA, the Enzyme Database: 1.1.1.358

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