KEGG   ENZYME: 1.1.1.359Help
Entry
EC 1.1.1.359                Enzyme                                 

Name
aldose 1-dehydrogenase [NAD(P)+]
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
an aldopyranose:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
an aldopyranose + NAD(P)+ = an aldono-1,5-lactone + NAD(P)H + H+ [RN:R10428 R10429]
Reaction(KEGG)
Substrate
aldopyranose [CPD:C20655];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
aldono-1,5-lactone [CPD:C20616];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.
History
EC 1.1.1.359 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K18125  aldose 1-dehydrogenase [NAD(P)+]
Genes
PTO: PTO0639
FAC: FACI_IFERC01G0109
FAI: FAD_1034
STO: STK_17040(gdh)
SSO: SSO3003(dhg-1) SSO3042(dhg-2) SSO3204(dhg-3)
SOL: Ssol_0792 Ssol_0941
SSOA: SULA_0783 SULA_0820 SULA_0974
SSOL: SULB_0785 SULB_0822 SULB_0976
SSOF: SULC_0783 SULC_0820 SULC_0975
SAI: Saci_1079
MSE: Msed_1301
MCN: Mcup_0902
AHO: Ahos_2067
CMA: Cmaq_1714
 » show all
Taxonomy
Reference
1  [PMID:3827812]
  Authors
Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V
  Title
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus.
  Journal
Biochem J 239:517-22 (1986)
Reference
2  [PMID:2803257]
  Authors
Smith LD, Budgen N, Bungard SJ, Danson MJ, Hough DW
  Title
Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum.
  Journal
Biochem J 261:973-7 (1989)
Reference
3  [PMID:12824170]
  Authors
Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ
  Title
Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase.
  Journal
J Biol Chem 278:34066-72 (2003)
DOI:10.1074/jbc.M305818200
  Sequence
[sso:SSO3003]
Reference
4  [PMID:16508107]
  Authors
Theodossis A, Milburn CC, Heyer NI, Lamble HJ, Hough DW, Danson MJ, Taylor GL
  Title
Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:112-5 (2005)
DOI:10.1107/S174430910403101X
Reference
5  [PMID:16556607]
  Authors
Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL
  Title
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.
  Journal
J Biol Chem 281:14796-804 (2006)
DOI:10.1074/jbc.M601334200
  Sequence
[sso:SSO3003]
Reference
6  [PMID:21265750]
  Authors
Haferkamp P, Kutschki S, Treichel J, Hemeda H, Sewczyk K, Hoffmann D, Zaparty M, Siebers B
  Title
An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of  sugar degradation?
  Journal
Biochem Soc Trans 39:77-81 (2011)
DOI:10.1042/BST0390077
  Sequence
[sso:SSO3003]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.359
IUBMB Enzyme Nomenclature: 1.1.1.359
ExPASy - ENZYME nomenclature database: 1.1.1.359
BRENDA, the Enzyme Database: 1.1.1.359

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