| Entry |
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| Name |
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase;
WbjC;
Cap5F
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
UDP-2-acetamido-2,6-dideoxy-L-talose:NADP+ oxidoreductase
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| Reaction(IUBMB) |
UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NAD(P)+ = UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose + NAD(P)H + H+ [RN: R10665]
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| Reaction(KEGG) |
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| Substrate |
UDP-2-acetamido-2,6-dideoxy-beta-L-talose [CPD: C20768];
NAD+ [CPD: C00003];
NADP+ [CPD: C00006]
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| Product |
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose;
NADH [CPD: C00004];
NADPH [CPD: C00005];
H+ [CPD: C00080]
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| Comment |
Part of the biosynthesis of UDP-N-acetyl-L-fucosamine. Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus.
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| History |
EC 1.1.1.367 created 2014
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| Pathway |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
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| Orthology |
| K19068 | UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase |
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| Genes |
» show all
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| Reference |
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| Authors |
Kneidinger B, O'Riordan K, Li J, Brisson JR, Lee JC, Lam JS |
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| Title |
Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Mulrooney EF, Poon KK, McNally DJ, Brisson JR, Lam JS |
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| Title |
Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11. |
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| Journal |
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| Reference |
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| Authors |
Miyafusa T, Tanaka Y, Kuroda M, Ohta T, Tsumoto K |
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| Title |
Expression, purification, crystallization and preliminary diffraction analysis of CapF, a capsular polysaccharide-synthesis enzyme from Staphylococcus aureus. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.367 |
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