KEGG   ENZYME: 1.1.1.370Help
Entry
EC 1.1.1.370                Enzyme                                 

Name
scyllo-inositol 2-dehydrogenase (NAD+);
iolX (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
scyllo-inositol:NAD+ 2-oxidoreductase
Reaction(IUBMB)
scyllo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ [RN:R09953]
Reaction(KEGG)
Substrate
scyllo-inositol [CPD:C06153];
NAD+ [CPD:C00003]
Product
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC 1.1.1.371, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA.
History
EC 1.1.1.370 created 2014
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16043  scyllo-inositol 2-dehydrogenase (NAD+)
Genes
BSU: BSU10850(yisS)
BSR: I33_1220
BSL: A7A1_0901
BSH: BSU6051_10850(yisS)
BSY: I653_05490
BSUT: BSUB_01182(iolX)
BSUL: BSUA_01182(iolX)
BSUS: Q433_06135
BSS: BSUW23_05500(yisS)
BST: GYO_1391
BSO: BSNT_07532(yisS)
BSQ: B657_10850(yisS)
BSX: C663_1108(yisS)
BLI: BL01338(yisS)
BLD: BLi01181(yisS)
BLH: BaLi_c13090(yisS)
BAQ: BACAU_1058(yisS)
BYA: BANAU_1002(yisS)
BAMB: BAPNAU_2698(yisS)
BMP: NG74_01107(idhA)
BAO: BAMF_1169(yisS)
BAZ: BAMTA208_05090(yisS)
BQL: LL3_01173(yisS)
BXH: BAXH7_01068(yisS)
BQY: MUS_1133(yisS)
BAMI: KSO_014360
BAMF: U722_05590
BCL: ABC0429
BJS: MY9_1184
BACB: OY17_08180
BACY: QF06_04360
BACL: BS34A_11990(yisS)
BALM: BsLM_1130
BGY: BGLY_1207
GKA: GK1897
KBS: EPA93_23570(iolG)
 » show all
Taxonomy
Reference
1  [PMID:20133360]
  Authors
Morinaga T, Ashida H, Yoshida K.
  Title
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis.
  Journal
Microbiology 156:1538-46 (2010)
DOI:10.1099/mic.0.037499-0
  Sequence
[bsu:BSU10850]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.370
IUBMB Enzyme Nomenclature: 1.1.1.370
ExPASy - ENZYME nomenclature database: 1.1.1.370
BRENDA, the Enzyme Database: 1.1.1.370

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