KEGG   ENZYME: 1.1.1.370
Entry
EC 1.1.1.370                Enzyme                                 
Name
scyllo-inositol 2-dehydrogenase (NAD+);
iolX (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
scyllo-inositol:NAD+ 2-oxidoreductase
Reaction(IUBMB)
scyllo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ [RN:R09953]
Reaction(KEGG)
R09953
Substrate
scyllo-inositol [CPD:C06153];
NAD+ [CPD:C00003]
Product
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC 1.1.1.371, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA.
History
EC 1.1.1.370 created 2014
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16043  scyllo-inositol 2-dehydrogenase (NAD+)
Genes
BSUBSU10850(yisS)
BSRI33_1220
BSLA7A1_0901
BSHBSU6051_10850(yisS)
BSYI653_05490
BSUTBSUB_01182(iolX)
BSULBSUA_01182(iolX)
BSUSQ433_06135
BSOBSNT_07532(yisS)
BSNBSn5_17320
BSQB657_10850(yisS)
BSXC663_1108(yisS)
BSPU712_05555
BSSBSUW23_05500(yisS)
BSTGYO_1391
BLIBL01338(yisS)
BLDBLi01181(yisS)
BLHBaLi_c13090(yisS)
BAQBACAU_1058(yisS)
BYABANAU_1002(yisS)
BQYMUS_1133(yisS)
BAMBBAPNAU_2698(yisS)
BMPNG74_01107(idhA)
BAOBAMF_1169(yisS)
BAZBAMTA208_05090(yisS)
BQLLL3_01173(yisS)
BXHBAXH7_01068(yisS)
BAMIKSO_014360
BAMFU722_05590
BAEBATR1942_03040
BSONS101395_03659(iolX)
BHTDIC78_04175
BMOJHC660_11400(iolX)
BIQAN935_05625
BGYBGLY_1207
BITBIS30_16135
BCABEFK13_06110(iolX)
BRYM0696_06020(iolX)
BJSMY9_1184
GSTHW35_12510
BACBOY17_08180
BACYQF06_04360
BACLBS34A_11990(yisS)
BALMBsLM_1130
BHKB4U37_04040
BCLABC0429
BLEBleG1_0261
BKWBkAM31D_22510(iolG_2)
BGIBGM20_20705
GKAGK1897
GTKGT3570_09015
GLIGLN3_02705
GMCGY4MC1_2179
GSEGT50_18790
GSRGS3922_07080
GEJA0V43_07035
PTBDER53_15280(iolG)
PARGPspKH34_20940(iolX)
ASEDIRT44_18970
VILCFK37_00015
FPNABE65_005640
FARABE41_005725
APAKAP3564_07140
GRCGI584_22385
MDGK8L98_05290
PIBBBD41_01830
PRZGZH47_19315
ACURJZ785_21235
SPSYAZE41_09830
NTRB0W44_10810
BYLA4V09_21140
BPROPMF13cell1_00615(iolX_1)
DRUDesru_3855
DKUDesku_1639
ASDAS9A_3975
MYLC3E77_13865
XYLET495_07535
PBROHOP40_25485
ACTTDDD63_03625
ERZER308_10415
CAPCLDAP_32050 CLDAP_32890
KBSEPA93_23570(iolG)
TTRTter_1925 Tter_2247
PMETG4Y79_16900(iolG)
DEINDAAJ005_09565
TRATrad_1233
MRBMrub_1694
MREK649_14090
MTAIMtai_v1c12640
MHDMarky_0949
SSMSpirs_1664
SCCSpico_0080
LBJLBJ_1125
LBLLBL_1179
LKMEFP84_17975
ABACLuPra_01804(afr_2)
SALIL593_11080
THFMA03_04635
THELIG193_02645
 » show all
Reference
1  [PMID:20133360]
  Authors
Morinaga T, Ashida H, Yoshida K
  Title
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis.
  Journal
Microbiology 156:1538-46 (2010)
DOI:10.1099/mic.0.037499-0
  Sequence
[bsu:BSU10850]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.370
IUBMB Enzyme Nomenclature: 1.1.1.370
ExPASy - ENZYME nomenclature database: 1.1.1.370
BRENDA, the Enzyme Database: 1.1.1.370

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