KEGG ENZYME: 1.1.1.372

ENZYME: 1.1.1.372

Entry

EC 1.1.1.372 Enzyme

Name

D/L-glyceraldehyde reductase;
gld1 (gene name);
gaaD (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)

Reaction(IUBMB)

(1) glycerol + NADP+ = L-glyceraldehyde + NADPH + H+ [RN:R10563];
(2) glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ [RN:R01041]

Reaction(KEGG)

R01041 R10563

Substrate

glycerol [CPD:C00116];
NADP+ [CPD:C00006]

Product

L-glyceraldehyde [CPD:C02426];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-glyceraldehyde [CPD:C00577]

Comment

The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.

History

EC 1.1.1.372 created 2014

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K18107

L-glyceraldehyde reductase

Genes

TMN:	UCRPA7_7092

FGR:	FGSG_04223 FGSG_12483

FPU:	FPSE_05953 FPSE_10427

FVR:	FVEG_10413 FVEG_13481

FOX:	FOXG_11406 FOXG_14656

NHE:	NECHADRAFT_100823 NECHADRAFT_36240 NECHADRAFT_51740 NECHADRAFT_55099 NECHADRAFT_56237

TRE:	TRIREDRAFT_120911

TRR:	M419DRAFT_136373

MAW:

MAC_01604

MAJ:

MAA_02439

CMT:

CCM_08044

PLJ:	VFPFJ_02445

VAL:	VDBG_01436 VDBG_02764 VDBG_03238

VDA:	VDAG_03683 VDAG_07810

CFJ:	CFIO01_04162

PFY:	PFICI_10674

PSCO:

LY89DRAFT_648285

ANI:	AN4829.2 AN7193.2

AFM:	AFUA_6G10260

AOR:	AO090023000264

ANG:	ANI_1_172094(An11g01120)

AFV:	AFLA_106880 AFLA_111590

ACT:	ACLA_083990

NFI:	NFIA_055980

PCS:	Pc20g15580

PDP:	PDIP_47240

PBL:	PAAG_03765

PBN:	PADG_03268

AJE:	HCAG_07199

PNO:	SNOG_02188 SNOG_13518

PTE:

PTT_13265

BZE:	COCCADRAFT_104160

BSC:	COCSADRAFT_89350

BOR:	COCMIDRAFT_86997

AALT:

CC77DRAFT_1057777 CC77DRAFT_443074

BCOM:

BAUCODRAFT_31372

CNE:

CNB04710

CNB:

CNBB1050

CGI:	CGB_A1300W CGB_L0040C

TMS:	TREMEDRAFT_62643 TREMEDRAFT_69577

TVS:	TRAVEDRAFT_31299

DSQ:	DICSQDRAFT_107106

PCO:	PHACADRAFT_260185

SHS:	STEHIDRAFT_105307

HIR:	HETIRDRAFT_442642

PSQ:	PUNSTDRAFT_121656

ADL:	AURDEDRAFT_117506 AURDEDRAFT_117507 AURDEDRAFT_146377

GTR:	GLOTRDRAFT_41862

LBC:	LACBIDRAFT_291410

MPR:	MPER_10102

MRR:	Moror_11319 Moror_7401

CCI:	CC1G_06822

SCM:	SCHCODRAFT_77290 SCHCODRAFT_82845 SCHCODRAFT_85627

ABP:	AGABI1DRAFT112884(AGABI1DRAFT_112884) AGABI1DRAFT84126(AGABI1DRAFT_84126)

ABV:	AGABI2DRAFT151116(AGABI2DRAFT_151116) AGABI2DRAFT192853(AGABI2DRAFT_192853)

CPUT:

CONPUDRAFT_82716

SLA:	SERLADRAFT_462889

UMA:	UMAG_11741

PFP:	PFL1_00964

MGL:

MGL_4016

MRT:

MRET_4251

PGR:	PGTG_08701

MLR:	MELLADRAFT_114173 MELLADRAFT_70461

» show all

Reference

1 [PMID:16930134]

Authors

Liepins J, Kuorelahti S, Penttila M, Richard P

Title

Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina.

Journal

FEBS J 273:4229-35 (2006)
DOI:10.1111/j.1742-4658.2006.05423.x

Sequence

[tre:TRIREDRAFT_120911]

Reference

2 [PMID:18768163]

Authors

Martens-Uzunova ES, Schaap PJ

Title

An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.

Journal

Fungal Genet Biol 45:1449-57 (2008)
DOI:10.1016/j.fgb.2008.08.002

Sequence

[ang:ANI_1_172094]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.372

IUBMB Enzyme Nomenclature:

1.1.1.372

ExPASy - ENZYME nomenclature database:

1.1.1.372

BRENDA, the Enzyme Database:

1.1.1.372

DBGET integrated database retrieval system