KEGG   ENZYME: 1.1.1.372
Entry
EC 1.1.1.372                Enzyme                                 
Name
D/L-glyceraldehyde reductase;
gld1 (gene name);
gaaD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
Reaction(IUBMB)
(1) glycerol + NADP+ = L-glyceraldehyde + NADPH + H+ [RN:R10563];
(2) glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ [RN:R01041]
Reaction(KEGG)
R01041 R10563
Substrate
glycerol [CPD:C00116];
NADP+ [CPD:C00006]
Product
L-glyceraldehyde [CPD:C02426];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.
History
EC 1.1.1.372 created 2014
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K18107  L-glyceraldehyde reductase
Genes
SLBAWJ20_926(YPR1)
TMNUCRPA7_7092
FGRFGSG_04223 FGSG_12483
FPUFPSE_05953 FPSE_10427
FVRFVEG_10413 FVEG_13481
FOXFOXG_11406 FOXG_14656
NHENECHADRAFT_100823 NECHADRAFT_36240 NECHADRAFT_51740 NECHADRAFT_55099 NECHADRAFT_56237
TRETRIREDRAFT_120911
TRRM419DRAFT_136373
MAWMAC_01604
MAJMAA_02439
CMTCCM_08044
PLJVFPFJ_02445
VALVDBG_01436 VDBG_02764 VDBG_03238
VDAVDAG_03683 VDAG_07810 VDAG_09651
CFJCFIO01_01165 CFIO01_04162
SAPOSAPIO_CDS9455
PFYPFICI_10674
PSCOLY89DRAFT_615112 LY89DRAFT_648285
ANIAN4829.2 AN7193.2
AFMAFUA_6G10260
ACTACLA_083990
NFINFIA_055980 NFIA_107950
AORAO090023000264
ANGANI_1_172094(An11g01120) ANI_1_236144(An16g01720)
AFVAFLA_006624
ALUCAKAW2_70136A AKAW2_80108A(GLD1)
ACHEACHE_80800A(GLD1)
APUUAPUU_20887S(GLD1) APUU_31050A
PCSPc20g15580
PDPPDIP_47240
TMFPMAA_082530
TRGTRUGW13939_08392
PBLPAAG_03765
PBNPADG_03268
AJEHCAG_07199
BGHBDBG_00706
PNOSNOG_02188 SNOG_13518
PTEPTT_13265
BZECOCCADRAFT_104160
BSCCOCSADRAFT_89350
BORCOCMIDRAFT_86997
AALTCC77DRAFT_1057777 CC77DRAFT_443074
BCOMBAUCODRAFT_31372
NPAUCRNP2_7896
CNECNB04710
CNBCNBB1050
CGICGB_A1300W CGB_L0040C
TMSTREMEDRAFT_62643 TREMEDRAFT_69577
TASAA1Q1_07976
TVSTRAVEDRAFT_31299
DSQDICSQDRAFT_107106
PCOPHACADRAFT_260185
SHSSTEHIDRAFT_105307
HIRHETIRDRAFT_442642
PSQPUNSTDRAFT_121656
ADLAURDEDRAFT_117506 AURDEDRAFT_117507 AURDEDRAFT_146377
GTRGLOTRDRAFT_41862
LBCLACBIDRAFT_291410
MPRMPER_10102
MRRMoror_11319 Moror_7401
CCICC1G_06822
SCMSCHCODRAFT_77290 SCHCODRAFT_82845 SCHCODRAFT_85627
ABPAGABI1DRAFT112884(AGABI1DRAFT_112884) AGABI1DRAFT84126(AGABI1DRAFT_84126)
ABVAGABI2DRAFT151116(AGABI2DRAFT_151116) AGABI2DRAFT192853(AGABI2DRAFT_192853)
CPUTCONPUDRAFT_82716
SLASERLADRAFT_462889
UMAUMAG_11741
PFPPFL1_00964
MGLMGL_4016
MRTMRET_4251
MSYMMSY001_2183
PGRPGTG_08701
MLRMELLADRAFT_114173 MELLADRAFT_70461
 » show all
Reference
1  [PMID:16930134]
  Authors
Liepins J, Kuorelahti S, Penttila M, Richard P
  Title
Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina.
  Journal
FEBS J 273:4229-35 (2006)
DOI:10.1111/j.1742-4658.2006.05423.x
  Sequence
Reference
2  [PMID:18768163]
  Authors
Martens-Uzunova ES, Schaap PJ
  Title
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.
  Journal
Fungal Genet Biol 45:1449-57 (2008)
DOI:10.1016/j.fgb.2008.08.002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.372
IUBMB Enzyme Nomenclature: 1.1.1.372
ExPASy - ENZYME nomenclature database: 1.1.1.372
BRENDA, the Enzyme Database: 1.1.1.372

DBGET integrated database retrieval system