KEGG ENZYME: 1.1.1.372

ENZYME: 1.1.1.372

Entry

EC 1.1.1.372                Enzyme

Name

D/L-glyceraldehyde reductase;
gld1 (gene name);
gaaD (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)

Reaction(IUBMB)

(1) glycerol + NADP+ = L-glyceraldehyde + NADPH + H+ [RN:R10563];
(2) glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ [RN:R01041]

Reaction(KEGG)

R01041 R10563

Substrate

glycerol [CPD:C00116];
NADP+ [CPD:C00006]

Product

L-glyceraldehyde [CPD:C02426];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-glyceraldehyde [CPD:C00577]

Comment

The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.

History

EC 1.1.1.372 created 2014

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K18107

L-glyceraldehyde reductase

Genes

SLB:	AWJ20_926(YPR1)

TMN:	UCRPA7_7092

FGR:	FGSG_04223 FGSG_12483

FPU:	FPSE_05953 FPSE_10427

FPOA:

FPOAC1_005580(GLD1_1) FPOAC1_006677(GLD1_2)

FVN:	FVRRES_06153 FVRRES_07296

FVR:	FVEG_10413 FVEG_13481

FOX:	FOXG_11406 FOXG_14656

NHE:	NECHADRAFT_100823 NECHADRAFT_36240 NECHADRAFT_51740 NECHADRAFT_55099 NECHADRAFT_56237

FFC:	NCS54_00355700 NCS54_00800700

FKR:	NCS57_00361300 NCS57_00843500

FMU:	J7337_011141(GLD1_2) J7337_011689(GLD1_3)

TRE:	TRIREDRAFT_120911

TRR:	M419DRAFT_136373

TATV:

25778859(TrAtP1_013345) 25786024(TrAtP1_008116)

TASP:

36612552(GLD1_3) 36616029(GLD1_1)

MAW:	19245915(GLD1)

MAJ:

MAA_02439

MBRN:

26240041(gld1_1)

PCHM:

VFPPC_01202

CMT:

CCM_08044

AMUS:

LMH87_010717

PLJ:	28884578(PLICBS_005812)

PTKZ:

JDV02_003551(GLD1)

VAL:	VDBG_01436 VDBG_02764

VDA:	VDAG_03683 VDAG_07810

CFJ:	CFIO01_04162

CLUP:

CLUP02_15606

CHIG:

CH63R_05076

CDET:

87942146(CDEST_05643)

SAPO:

SAPIO_CDS9455

PFY:	PFICI_10674

PSCO:

LY89DRAFT_648285

ANI:	ANIA_07193

AFM:	AFUA_6G10260

ACT:	ACLA_083990

NFI:	NFIA_055980

AOR:	AO090023000264

ANG:	An11g01120

AFV:	AFLA_006624

ALUC:

AKAW2_80108A(GLD1)

ACHE:

ACHE_80800A(GLD1)

APUU:

APUU_20887S(GLD1)

PCS:	N7525_009925

PDP:	PDIP_47240

POU:	POX_e07311

TMF:	EYB26_004297

TRG:	TRUGW13939_08392

PBL:	PAAG_03765

PBN:	PADG_03268

AJE:	HCAG_07199

BGH:	BDBG_00706

PNO:	SNOG_02188 SNOG_13518

PTE:

PTT_13265

PTRR:

6344821(PtrM4_050630)

BZE:	COCCADRAFT_104160

BSC:	COCSADRAFT_89350

BOR:	COCMIDRAFT_86997

AALT:

CC77DRAFT_1057777 CC77DRAFT_443074

ADAC:

96080754(ACET3X_000432) 96081913(ACET3X_001591)

ARAB:

EKO05_0001903 EKO05_0002790

BCOM:

BAUCODRAFT_31372

CNE:

CNB04710

CNB:

CNBB1050

CNG:	CNAG_03983

CGI:	CGB_A1300W CGB_L0040C

CDEU:

CNBG_4493 CNBG_5487

KMG:	30165171(I203_108462)

KNE:	92177419(IAR55_000159)

TMS:	TREMEDRAFT_62643 TREMEDRAFT_69577

TASA:

A1Q1_07976

CCAC:

CcaHIS019_0208360(CcaverHIS019_0208360)

TVS:	TRAVEDRAFT_31299

DSQ:	DICSQDRAFT_107106

PCO:	PHACADRAFT_260185

SHS:	STEHIDRAFT_105307

HIR:	HETIRDRAFT_442642

PSQ:	PUNSTDRAFT_121656

ADL:	AURDEDRAFT_117506 AURDEDRAFT_117507 AURDEDRAFT_146377

GTR:	GLOTRDRAFT_41862

LBC:	LACBIDRAFT_291410

CCI:	CC1G_06822

ABP:	AGABI1DRAFT112884(AGABI1DRAFT_112884) AGABI1DRAFT84126(AGABI1DRAFT_84126)

ABV:	AGABI2DRAFT151116(AGABI2DRAFT_151116) AGABI2DRAFT192853(AGABI2DRAFT_192853)

PCUB:

JR316_0002526

MPR:	MPER_10102

MRR:	Moror_11319 Moror_7401

E1B28_010334

SCM:	SCHCO_02511616(SCHCODRAFT_02511616) SCHCO_02628264(SCHCODRAFT_02628264) SCHCO_02630637(SCHCODRAFT_02630637)

CPUT:

CONPUDRAFT_82716

SLA:	SERLADRAFT_462889

UMA:	UMAG_11741

PFP:	PFL1_00964

SGRA:

EX895_001429

MGL:

MGL_4016

MRT:

MRET_4251

MSYM:

MSY001_2183

PGR:	PGTG_08701

PTRC:

PtA15_7A660

PSTR:

Pst134EA_013694

MLR:	MELLADRAFT_114173 MELLADRAFT_70461

» show all

Reference

1 [PMID:16930134]

Authors

Liepins J, Kuorelahti S, Penttila M, Richard P

Title

Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina.

Journal

FEBS J 273:4229-35 (2006)
DOI:10.1111/j.1742-4658.2006.05423.x

Sequence

[tre:TRIREDRAFT_120911]

Reference

2 [PMID:18768163]

Authors

Martens-Uzunova ES, Schaap PJ

Title

An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.

Journal

Fungal Genet Biol 45:1449-57 (2008)
DOI:10.1016/j.fgb.2008.08.002

Sequence

[ang:An11g01120]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.372

IUBMB Enzyme Nomenclature:

1.1.1.372

ExPASy - ENZYME nomenclature database:

1.1.1.372

BRENDA, the Enzyme Database:

1.1.1.372

DBGET integrated database retrieval system