KEGG   ENZYME: 1.1.1.372Help
Entry
EC 1.1.1.372                Enzyme                                 

Name
D/L-glyceraldehyde reductase;
gld1 (gene name);
gaaD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
Reaction(IUBMB)
(1) glycerol + NADP+ = L-glyceraldehyde + NADPH + H+ [RN:R10563];
(2) glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ [RN:R01041]
Reaction(KEGG)
Substrate
glycerol [CPD:C00116];
NADP+ [CPD:C00006]
Product
L-glyceraldehyde [CPD:C02426];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.
History
EC 1.1.1.372 created 2014
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K18107  L-glyceraldehyde reductase
Genes
TMN: UCRPA7_7092
FGR: FGSG_04223 FGSG_12483
FPU: FPSE_05953 FPSE_10427
FVR: FVEG_10413 FVEG_13481
FOX: FOXG_11406 FOXG_14656
NHE: NECHADRAFT_100823 NECHADRAFT_36240 NECHADRAFT_51740 NECHADRAFT_55099 NECHADRAFT_56237
TRE: TRIREDRAFT_120911
MAW: MAC_01604
MAJ: MAA_02439
CMT: CCM_08044
ANG: ANI_1_172094(An11g01120)
PTE: PTT_13265
CNE: CNB04710
CNB: CNBB1050
ABP: AGABI1DRAFT112884(AGABI1DRAFT_112884) AGABI1DRAFT84126(AGABI1DRAFT_84126)
ABV: AGABI2DRAFT151116(AGABI2DRAFT_151116) AGABI2DRAFT192853(AGABI2DRAFT_192853)
MGL: MGL_4016
 » show all
Taxonomy
Reference
1  [PMID:16930134]
  Authors
Liepins J, Kuorelahti S, Penttila M, Richard P
  Title
Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina.
  Journal
FEBS J 273:4229-35 (2006)
DOI:10.1111/j.1742-4658.2006.05423.x
  Sequence
Reference
2  [PMID:18768163]
  Authors
Martens-Uzunova ES, Schaap PJ
  Title
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.
  Journal
Fungal Genet Biol 45:1449-57 (2008)
DOI:10.1016/j.fgb.2008.08.002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.372
IUBMB Enzyme Nomenclature: 1.1.1.372
ExPASy - ENZYME nomenclature database: 1.1.1.372
BRENDA, the Enzyme Database: 1.1.1.372

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