Entry |
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Name |
D/L-glyceraldehyde reductase;
gld1 (gene name);
gaaD (gene name)
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
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Reaction(IUBMB) |
(1) glycerol + NADP+ = L-glyceraldehyde + NADPH + H+ [RN: R10563];
(2) glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ [RN: R01041]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.
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History |
EC 1.1.1.372 created 2014
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Pathway |
ec00040 | Pentose and glucuronate interconversions |
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Orthology |
K18107 | L-glyceraldehyde reductase |
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Genes |
» show all
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Reference |
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Authors |
Liepins J, Kuorelahti S, Penttila M, Richard P |
Title |
Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina. |
Journal |
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Sequence |
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Reference |
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Authors |
Martens-Uzunova ES, Schaap PJ |
Title |
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.372 |
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