KEGG   ENZYME: 1.1.1.372Help
Entry
EC 1.1.1.372                Enzyme                                 

Name
D/L-glyceraldehyde reductase;
gld1 (gene name);
gaaD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
Reaction(IUBMB)
(1) glycerol + NADP+ = L-glyceraldehyde + NADPH + H+ [RN:R10563];
(2) glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ [RN:R01041]
Reaction(KEGG)
Substrate
glycerol [CPD:C00116];
NADP+ [CPD:C00006]
Product
L-glyceraldehyde [CPD:C02426];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.
History
EC 1.1.1.372 created 2014
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K18107  L-glyceraldehyde reductase
Genes
TMN: UCRPA7_7092
FGR: FGSG_04223 FGSG_12483
FPU: FPSE_05953 FPSE_10427
FVR: FVEG_10413 FVEG_13481
FOX: FOXG_11406 FOXG_14656
NHE: NECHADRAFT_100823 NECHADRAFT_36240 NECHADRAFT_51740 NECHADRAFT_55099 NECHADRAFT_56237
TRE: TRIREDRAFT_120911
MAW: MAC_01604
MAJ: MAA_02439
CMT: CCM_08044
PLJ: VFPFJ_02445
VAL: VDBG_01436 VDBG_02764 VDBG_03238
VDA: VDAG_03683 VDAG_07810
CFJ: CFIO01_04162
PFY: PFICI_10674
PSCO: LY89DRAFT_648285
ANI: AN4829.2 AN7193.2
AFM: AFUA_6G10260
AOR: AO090023000264
ANG: ANI_1_172094(An11g01120)
AFV: AFLA_106880 AFLA_111590
ACT: ACLA_083990
NFI: NFIA_055980
PCS: Pc20g15580
PDP: PDIP_47240
PBL: PAAG_03765
PBN: PADG_03268
AJE: HCAG_07199
PNO: SNOG_02188 SNOG_13518
PTE: PTT_13265
BZE: COCCADRAFT_104160
BSC: COCSADRAFT_89350
BOR: COCMIDRAFT_86997
AALT: CC77DRAFT_1057777 CC77DRAFT_443074
BCOM: BAUCODRAFT_31372
CNE: CNB04710
CNB: CNBB1050
CGI: CGB_A1300W CGB_L0040C
TMS: TREMEDRAFT_62643 TREMEDRAFT_69577
TVS: TRAVEDRAFT_31299
DSQ: DICSQDRAFT_107106
PCO: PHACADRAFT_260185
SHS: STEHIDRAFT_105307
HIR: HETIRDRAFT_442642
PSQ: PUNSTDRAFT_121656
ADL: AURDEDRAFT_117506 AURDEDRAFT_117507 AURDEDRAFT_146377
GTR: GLOTRDRAFT_41862
LBC: LACBIDRAFT_291410
MPR: MPER_10102
MRR: Moror_11319 Moror_7401
CCI: CC1G_06822
SCM: SCHCODRAFT_77290 SCHCODRAFT_82845 SCHCODRAFT_85627
ABP: AGABI1DRAFT112884(AGABI1DRAFT_112884) AGABI1DRAFT84126(AGABI1DRAFT_84126)
ABV: AGABI2DRAFT151116(AGABI2DRAFT_151116) AGABI2DRAFT192853(AGABI2DRAFT_192853)
CPUT: CONPUDRAFT_82716
SLA: SERLADRAFT_462889
UMA: UMAG_11741
PFP: PFL1_00964
MGL: MGL_4016
PGR: PGTG_08701
MLR: MELLADRAFT_114173 MELLADRAFT_70461
 » show all
Taxonomy
Reference
1  [PMID:16930134]
  Authors
Liepins J, Kuorelahti S, Penttila M, Richard P
  Title
Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina.
  Journal
FEBS J 273:4229-35 (2006)
DOI:10.1111/j.1742-4658.2006.05423.x
  Sequence
Reference
2  [PMID:18768163]
  Authors
Martens-Uzunova ES, Schaap PJ
  Title
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.
  Journal
Fungal Genet Biol 45:1449-57 (2008)
DOI:10.1016/j.fgb.2008.08.002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.372
IUBMB Enzyme Nomenclature: 1.1.1.372
ExPASy - ENZYME nomenclature database: 1.1.1.372
BRENDA, the Enzyme Database: 1.1.1.372

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (203)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (86)   
   KEGG MGENES (50)   
   RefGene (66)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (219)   

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