KEGG   ENZYME: 1.1.1.374
Entry
EC 1.1.1.374                Enzyme                                 

Name
UDP-N-acetylglucosamine 3-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
UDP-N-acetyl-alpha-D-glucosamine:NAD+ 3-oxidoreductase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + NAD+ = UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+ [RN:R10785]
Reaction(KEGG)
R10785
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
NAD+ [CPD:C00003]
Product
UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose [CPD:C20849];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Methanococcus maripaludis is activated by KCl (200 mM).
History
EC 1.1.1.374 created 2014
Orthology
K18855  UDP-N-acetylglucosamine 3-dehydrogenase
Genes
HIA: H733_0577(aidA)
TDN: Suden_0901
SULN: FJR47_04075
SULC: CVO_05540
CJU: C8J_0468
CJI: CJSA_0474
CJM: CJM1_0482
CJS: CJS3_0497
CJP: A911_02460
CJER: H730_03410
CJY: QZ67_00514(idhA)
CJQ: UC78_0491(idhA)
CJR: CJE0611
CLA: CLA_1070
CCQ: N149_0495
CCF: YSQ_07325
CCY: YSS_02330
CCOI: YSU_06335
CCOF: VC76_02645(pht4)
CCOO: ATE51_03196(pht4)
CIS: CINS_1034
CVO: CVOL_1044
CPEL: CPEL_1174
CGRA: CGRAC_0964
CURE: CUREO_0588
CCUN: CCUN_0149
CAVI: CAV_0738
HEBR: AEBR_2920
SULJ: SJPD1_2063
NIS: NIS_1316
DFL: DFE_1681
DAS: Daes_2344
DPI: BN4_11043
PPRF: DPRO_2915
BRS: S23_23370
AOL: S58_25400
BRAD: BF49_5729
RPB: RPB_1608
RPC: RPC_1434
RPD: RPD_1619
RPE: RPE_1455
RPT: Rpal_4502
NHA: Nham_1304
OCA: OCAR_5339
VGO: GJW-30_1_02195(afr_2)
XAU: Xaut_2339
AZC: AZC_3960
SNO: Snov_2267
BVR: BVIR_931
BLAG: BLTE_28750
BHA: BH1248
BCQ: BCQ_0392(idh)
BNC: BCN_0339
BCL: ABC3439
BMEG: BG04_4458
BEO: BEH_17540
BBEV: BBEV_3070(gfo)
ANL: GFC29_594
AXL: AXY_03850
HLI: HLI_14690
MCL: MCCL_0358
PPM: PPSC2_24645(yobV11)
PPO: PPM_4897
PPOL: X809_41205
PPOY: RE92_12640
PSAB: PSAB_09135
PSWU: SY83_02095
JEO: JMA_32020
CGJ: AR0_02355
CAQU: CAQU_12170
SGB: WQO_10760
SFA: Sfla_4282
STRP: F750_2427
SFI: SFUL_2169
SRN: A4G23_01675(ligC)
ARM: ART_1662
AAU: AAur_2677
LMOI: VV02_09915
SERJ: SGUI_0550
DCO: SAMEA4475696_1941(iolG)
PAW: PAZ_c01480(iolG1)
PACC: PAC1_00740
PACH: PAGK_0141
CACN: RN83_01135
CGRN: 4412665_00510(iolG)
ACIJ: JS278_02848(iolX_3)
MPH: MLP_25770
NCA: Noca_4211
NDK: I601_1769(iolG)
PSIM: KR76_03360
PAUT: Pdca_01400
SAQ: Sare_1684
MIL: ML5_2193
ASE: ACPL_7750
ACTS: ACWT_7619
CAI: Caci_7629
TPYO: X956_02580
TBW: NCTC13354_00626(yvaA)
AHW: NCTC11636_02346(iolG_2)
CWO: Cwoe_5494
RCA: Rcas_3975
CAG: Cagg_0831
TTR: Tter_2603
ALUS: STSP2_02703(gfo_2)
LBF: LBF_1972
TLE: Tlet_0392
MMP: MMP0352
MVO: Mvol_0228
MTH: MTH_875
METC: MTCT_0793
METE: tca_00840(iolX)
MST: Msp_1333
MRU: mru_1747
MSI: Msm_0882
MEB: Abm4_0457
MMIL: sm9_1833
MEYE: TL18_08545
MOL: YLM1_1201
METH: MBMB1_0357
MFC: BRM9_1907
MCUB: MCBB_0333
MFV: Mfer_1207
MKA: MK0248
PFU: PF0766
PFI: PFC_02985
PHO: PH1882(PH1882)
PAB: PAB0775
PYN: PNA2_0470
PYS: Py04_0017
THE: GQS_09545
THM: CL1_0826
PPAC: PAP_05155
MBAR: MSBR2_3374
MBAK: MSBR3_3343
MAC: MA_4448(idh)
MTHR: MSTHT_1686
MTHE: MSTHC_1603
MMET: MCMEM_0690
MPY: Mpsy_0709
RCI: RCIX1923(idhA)
IAG: Igag_1264
HBU: Hbut_1413
PYR: P186_2329
POG: Pogu_2396
TNE: Tneu_0084
TTN: TTX_1867
TUZ: TUZN_1623
VDI: Vdis_0790
VMO: VMUT_1637
TPE: Tpen_0717
NMR: Nmar_0247
NCT: NMSP_1463
NEV: NTE_02307
TAA: NMY3_00953(iolG)
NFN: NFRAN_1913(iolG)
NCV: NCAV_0867
NBV: T478_1203
NDV: NDEV_1854
KCR: Kcr_1479
CCAI: NAS2_1630
 » show all
Reference
1  [PMID:18634748]
  Authors
Namboori SC, Graham DE
  Title
Enzymatic analysis of uridine diphosphate N-acetyl-D-glucosamine.
  Journal
Anal Biochem 381:94-100 (2008)
DOI:10.1016/j.ab.2008.06.034
  Sequence
[mmp:MMP0352]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.374
IUBMB Enzyme Nomenclature: 1.1.1.374
ExPASy - ENZYME nomenclature database: 1.1.1.374
BRENDA, the Enzyme Database: 1.1.1.374

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