KEGG   ENZYME: 1.1.1.378Help
Entry
EC 1.1.1.378                Enzyme                                 

Name
L-rhamnose 1-dehydrogenase [NAD(P)+]
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-rhamnose:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
L-rhamnose + NAD(P)+ = L-rhamnono-1,4-lactone + NAD(P)H + H+ [RN:R10788 R10995]
Reaction(KEGG)
Substrate
L-rhamnose [CPD:C00507];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
L-rhamnono-1,4-lactone [CPD:C02991];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which occurs in the bacteria Azotobacter vinelandii and Sphingomonas sp. SKA58, is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+ and EC 1.1.1.377, L-rhamnose 1-dehydrogenase (NADP+).
History
EC 1.1.1.378 created 2014
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18337  L-rhamnose 1-dehydrogenase
Genes
QSU: 111990061 112003557 112030403
PPA: PAS_chr4_0338
DHA: DEHA2E01100g
PIC: PICST_50944(DHG2)
PGU: PGUG_03591
CTEN: CANTEDRAFT_113935
CLU: CLUG_02926
CLUS: A9F13_18g00385
CAUR: CJI97_002171
SLB: AWJ20_4952(SPS19)
NCR: NCU09035
NTE: NEUTE1DRAFT102514(NEUTE1DRAFT_102514)
MGR: MGG_08318
SSCK: SPSK_02647
MAJ: MAA_08254
CMT: CCM_06363
MBE: MBM_02654
ANG: ANI_1_132114(An13g00930)
ABE: ARB_00929
TVE: TRV_00758
PNO: SNOG_14192(SNOG_14191)
PTE: PTT_09742
CNE: CNB05760
CNB: CNBB0030
ABP: AGABI1DRAFT31987(AGABI1DRAFT_31987)
ABV: AGABI2DRAFT182285(AGABI2DRAFT_182285)
HEL: HELO_4213(rhaD)
SALN: SALB1_2836
AMAH: DLM_0709
BCN: Bcen_6402
BAM: Bamb_3400
BSEM: WJ12_16075
BGP: BGL_2c06950(fabG4)
BXE: Bxe_B1031
BXB: DR64_6352
BPH: Bphy_3467
BFN: OI25_6825
CSE: Cseg_1768
PTP: RCA23_c23450(fabG4)
HBA: Hbal_2755
SPHI: TS85_02230
SSAN: NX02_22785
SPHR: BSY17_3168
BLAS: BSY18_1707
SACI: Sinac_3785
TAC: Ta0747
TVO: TVG0436799(TVG0436799)
 » show all
Taxonomy
Reference
1  [PMID:18505728]
  Authors
Watanabe S, Saimura M, Makino K
  Title
Eukaryotic and bacterial gene clusters related to an alternative pathway of nonphosphorylated L-rhamnose metabolism.
  Journal
J Biol Chem 283:20372-82 (2008)
DOI:10.1074/jbc.M801065200
  Sequence
Reference
2  [PMID:19187228]
  Authors
Watanabe S, Makino K
  Title
Novel modified version of nonphosphorylated sugar metabolism--an alternative L-rhamnose pathway of Sphingomonas sp.
  Journal
FEBS J 276:1554-67 (2009)
DOI:10.1111/j.1742-4658.2009.06885.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.378
IUBMB Enzyme Nomenclature: 1.1.1.378
ExPASy - ENZYME nomenclature database: 1.1.1.378
BRENDA, the Enzyme Database: 1.1.1.378

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