KEGG   ENZYME: 1.1.1.378
Entry
EC 1.1.1.378                Enzyme                                 
Name
L-rhamnose 1-dehydrogenase [NAD(P)+]
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-rhamnose:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
L-rhamnose + NAD(P)+ = L-rhamnono-1,4-lactone + NAD(P)H + H+ [RN:R10788 R10995]
Reaction(KEGG)
R10788 R10995
Substrate
L-rhamnose [CPD:C00507];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
L-rhamnono-1,4-lactone [CPD:C02991];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which occurs in the bacteria Azotobacter vinelandii and Sphingomonas sp. SKA58, is part of the non-phosphorylative degradation pathway for L-rhamnose. The enzyme differs in cofactor specificity from EC 1.1.1.173, L-rhamnose 1-dehydrogenase, which is specific for NAD+ and EC 1.1.1.377, L-rhamnose 1-dehydrogenase (NADP+).
History
EC 1.1.1.378 created 2014
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18337  L-rhamnose 1-dehydrogenase
Genes
QSU111990061 112003557 112030403
PPAPAS_chr4_0338
DHADEHA2E01100g
PICPICST_50944(DHG2)
PGUPGUG_03591
CTENCANTEDRAFT_113935
CLUCLUG_02926
CLUSA9F13_18g00385
CAURCJI97_002171
SLBAWJ20_4952(SPS19)
BNNFOA43_001971(DHG2)
NCRNCU09035
NTENEUTE1DRAFT102514(NEUTE1DRAFT_102514)
SMPSMAC_05850
PANPODANSg706
TTTTHITE_2111000
MTMMYCTH_102290
CTHRCTHT_0045640
MGRMGG_08318
TMNUCRPA7_3732 UCRPA7_5029
SSCKSPSK_02647
FGRFGSG_09882
FPUFPSE_10199
FVRFVEG_02597
FOXFOXG_05543
NHENECHADRAFT_37021 NECHADRAFT_41350
TRETRIREDRAFT_65588
TRRM419DRAFT_36736
MAJMAA_08254
CMTCCM_06363
PLJVFPFJ_09562
VALVDBG_07058
VDAVDAG_06700
CFJCFIO01_07064 CFIO01_09199
ELAUCREL1_2272 UCREL1_7808
PFYPFICI_03100 PFICI_06510 PFICI_13970
SSLSS1G_10326
BFUBCIN_14g04170
MBEMBM_02654
PSCOLY89DRAFT_684259 LY89DRAFT_707448
GLZGLAREA_03301
ANIAN1886.2 AN4186.2
AFMAFUA_7G04360
ACTACLA_006060
NFINFIA_025330
AORAO090005000123
ANGANI_1_132114(An13g00930) ANI_1_256044(An05g02050)
AFVAFLA_002906
ALUCAKAW2_20117A(DHG2) AKAW2_81349A
ACHEACHE_31306A ACHE_40186A(DHG2)
APUUAPUU_21191A APUU_50081S APUU_60465A(DHG2) APUU_60792A
PCSPc21g04410 Pc22g09480
PDPPDIP_82370
TMFPMAA_069180
TRGTRUGW13939_06749 TRUGW13939_09624
ABEARB_00929
TVETRV_00758
PNOSNOG_14192(SNOG_14191)
PTEPTT_09742
BZECOCCADRAFT_36707
BSCCOCSADRAFT_40878
BORCOCMIDRAFT_4863
AALTCC77DRAFT_1054497
ZTRMYCGRDRAFT_83548
PFJMYCFIDRAFT_39072
BCOMBAUCODRAFT_64509
NPAUCRNP2_3170
TMLGSTUM_00003021001 GSTUM_00009300001
CNECNB05760
CNBCNBB0030
CGICGB_A0020C
TASAA1Q1_01844
PPLPOSPLDRAFT_87849
TVSTRAVEDRAFT_159063
DSQDICSQDRAFT_131032
PCOPHACADRAFT_247452
SHSSTEHIDRAFT_89569
HIRHETIRDRAFT_456869
PSQPUNSTDRAFT_48714
ADLAURDEDRAFT_80943
FMEFOMMEDRAFT_81776
GTRGLOTRDRAFT_53059
MPRMPER_11191
MRRMoror_17215
SCMSCHCODRAFT_80931
ABPAGABI1DRAFT31987(AGABI1DRAFT_31987)
ABVAGABI2DRAFT182285(AGABI2DRAFT_182285)
CPUTCONPUDRAFT_86700
SLASERLADRAFT_467003
UMAUMAG_11693
PFPPFL1_03743
PLUMA4R40_11700
PFNHZ99_04550
PTVAA957_01200
PAZOAYR47_21440
PFXA7318_11935
PYMAK972_2741
PEZHWQ56_16160
PTRTHU722_0013875
AVNAvin_09160
AVLAvCA_09160
AVDAvCA6_09160
ABERBSR55_00550
HELHELO_4213(rhaD)
HHUAR456_20000
SALNSALB1_2836
AMAHDLM_0709
AQSDKK66_01665
BCNBcen_6402
BCHBcen2424_6635
BCMBcenmc03_6233
BAMBamb_3400
BACBamMC406_1208
BPYRABD05_31635
BSEMWJ12_16075
BUGBC1001_3863
BGFBC1003_5545
BYIBYI23_B007530
BUEBRPE67_BCDS10610
BUQAC233_21650
BGPBGL_2c06950(fabG4)
BPLAbpln_2g07800
BUMAXG89_17635
BUIAX768_27415
BURKDM992_37155
BXEBxe_B1031
BXBDR64_6352
BPHBphy_3467
BGEBC1002_4237
BPXBUPH_00437
BPYBphyt_5688
BFNOI25_6825
BCAIK788_0008513
PSPWBJG93_25610
PARABTO02_31830
PARBCJU94_23860
PHSC2L64_22530
PTERC2L65_25100
PGPCUJ91_21880
PCJCUJ87_23065
PTSCUJ90_29530
PMEGFNZ07_09785
PTROG5S35_23015
PGISI6I06_24295
PACPFAZ97_21155
PACSFAZ98_17345
PEWKZJ38_34630
PPULRO07_24905
PNRAT302_22510
CABASBC2_60260
BUOBRPE64_BCDS05710
VPDVAPA_2c00520
MALIEYF70_08165
MUMFCL38_10600
MPLIE1742_17255
MESPC1M53_17345
RPODE0E05_15250
SMKSinme_6600
SMQSinmeB_6525
SMXSM11_pC0375
SMIBN406_03597(fabG1)
SMELSM2011_a0335
SMERDU99_18905
SMDSmed_5223
SIXBSY16_5763
EAHFA04_28460
AGRAGROH133_14217
ATFAch5_46630
BOFFQV39_05180
CSECseg_1768 Cseg_2740
CFHC1707_14155
BSBBresu_2867
BRDJL11_06990
BRGA4249_07690
BREVE7T10_08375
BNDKWG56_07380
AEXAstex_2133
PTPRCA23_c23450(fabG4)
HBAHbal_2755
STAXMC45_07230 MC45_07285
SPHITS85_02230
SSANNX02_22785
SNJA7E77_11680
SMYBJP26_16645
SPANAWL63_05960
SKRBRX40_01540
SPLMBXU08_17995
SPHCCVN68_10795
SARIH5J25_00325
SSUAFPZ54_00310
SPHRBSY17_3168
SYAA6768_21720
SPYGYGS_C1P2522
BLASBSY18_1707
BFWB5J99_17915
SPHSETR14_07025
TFVIDJ81_03365
ABGAsbog_01342
ROSCTJ15_21290
NAOY958_05065
NCBC0V82_24320
PPSCEHS13_31275
PBKBack11_16610(fabG_2)
PAUTPdca_50300(fabG_11)
PMADBAY61_19440
ATLAthai_30200
ASERAsera_44360
SACISinac_3785
TACTa0747
TVOTVG0436799(TVG0436799)
FACFACI_IFERC01G0497
 » show all
Reference
1  [PMID:18505728]
  Authors
Watanabe S, Saimura M, Makino K
  Title
Eukaryotic and bacterial gene clusters related to an alternative pathway of nonphosphorylated L-rhamnose metabolism.
  Journal
J Biol Chem 283:20372-82 (2008)
DOI:10.1074/jbc.M801065200
  Sequence
Reference
2  [PMID:19187228]
  Authors
Watanabe S, Makino K
  Title
Novel modified version of nonphosphorylated sugar metabolism--an alternative L-rhamnose pathway of Sphingomonas sp.
  Journal
FEBS J 276:1554-67 (2009)
DOI:10.1111/j.1742-4658.2009.06885.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.378
IUBMB Enzyme Nomenclature: 1.1.1.378
ExPASy - ENZYME nomenclature database: 1.1.1.378
BRENDA, the Enzyme Database: 1.1.1.378

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