Entry |
|
Name |
(R)-mandelate dehydrogenase;
ManDH2;
D-ManDH2;
D-mandelate dehydrogenase (ambiguous)
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
Sysname |
(R)-mandelate:NAD+ 2-oxidoreductase
|
Reaction(IUBMB) |
(R)-mandelate + NAD+ = phenylglyoxylate + NADH + H+ [RN: R03790]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme, found in bacteria and fungi, can also accept a number of substituted mandelate derivatives, such as 3-hydroxymandelate, 4-hydroxymandelate, 2-methoxymandelate, 4-hydroxy-3-methoxymandelate and 3-hydroxy-4-methoxymandelate. The enzyme has no activity with (S)-mandelate (cf. EC 1.1.99.31, (S)-mandelate dehydrogenase) [1,2]. The enzyme transfers the pro-R-hydrogen from NADH [2].
|
History |
EC 1.1.1.379 created 2014
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Reference |
1 |
Authors |
Baker, D.P. and Fewson, C.A. |
Title |
Purification and characterization of D(-)-mandelate dehydrogenase from Rhodotorula graminis. |
Journal |
Microbiology 135:2035-2044 (1989) |
Reference |
|
Authors |
Baker DP, Kleanthous C, Keen JN, Weinhold E, Fewson CA |
Title |
Mechanistic and active-site studies on D(--)-mandelate dehydrogenase from Rhodotorula graminis. |
Journal |
Biochem J 281 ( Pt 1):211-8 (1992) |
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.379 |
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