KEGG   ENZYME: 1.1.1.380Help
Entry
EC 1.1.1.380                Enzyme                                 

Name
L-gulonate 5-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-gulonate:NAD+ 5-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = D-fructuronate + NADH + H+ [RN:R10848]
Reaction(KEGG)
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
D-fructuronate [CPD:C00905];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Halomonas elongata, participates in a pathway for L-gulonate degradation.
History
EC 1.1.1.380 created 2014
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K08322  L-gulonate 5-dehydrogenase
Genes
ECO: b1580(rspB)
ECJ: JW1572(rspB)
ECD: ECDH10B_1713(rspB)
EBW: BWG_1394(rspB)
ECOK: ECMDS42_1250(rspB)
EOJ: ECO26_2282(rspB)
EOI: ECO111_2047(rspB)
EOH: ECO103_1719(rspB)
ECOO: ECRM13514_2068(rspB)
ECOH: ECRM13516_1973(rspB)
ECG: E2348C_1664(rspB)
EOK: G2583_1974(rspB)
ESO: O3O_12915
ESM: O3M_12680
ESL: O3K_12720
ECW: EcE24377A_1787(rspB)
ELH: ETEC_1614
ECC: c1970(rspB)
ECP: ECP_1528
ECI: UTI89_C1767(rspB)
ECV: APECO1_663(rspB)
ECM: EcSMS35_1620(rspB)
ECY: ECSE_1701
ECR: ECIAI1_1630(rspB)
ECQ: ECED1_1748(rspB)
ECT: ECIAI39_1478(rspB)
EOC: CE10_1850(rspB)
EUM: ECUMN_1865(rspB)
ECZ: ECS88_1625(rspB)
ELO: EC042_1727(rspB)
ESE: ECSF_1439
EBR: ECB_01549(rspB)
EBD: ECBD_2066
EKF: KO11_14855(rspB)
EAB: ECABU_c17760(rspB)
EDJ: ECDH1ME8569_1523(rspB)
EIH: ECOK1_1697(rspB)
ENA: ECNA114_1625(rspB)
ELW: ECW_m1745(rspB)
ELL: WFL_08545(rspB)
ELC: i14_1793(rspB)
ELD: i02_1793(rspB)
ELP: P12B_c1501(rspB)
EBL: ECD_01549(rspB)
EBE: B21_01539(rspB)
ELF: LF82_2029(rspB)
ECOI: ECOPMV1_01675(tdh_1)
ECOJ: P423_08465
ECOS: EC958_1798(rspB)
EFE: EFER_1526(rspB)
STY: STY1555(rspB)
STT: t1427(rspB)
STM: STM1506(rspB)
SEO: STM14_1819(rspB)
SEY: SL1344_1436(rspB)
SEJ: STMUK_1469(rspB)
SEB: STM474_1516(rspB)
SEF: UMN798_1569(rspB)
SENR: STMDT2_14331(rspB)
SEND: DT104_14761(rspB)
SENI: CY43_07670
SPT: SPA1349(rspB)
SEK: SSPA1254
SEI: SPC_2223(rspB)
SEC: SCH_1523(rspB)
SHB: SU5_02117
SENS: Q786_07715
SEG: SG1614(rspB)
SEL: SPUL_1322(rspB)
SEGA: SPUCDC_1322(rspB)
SET: SEN1544(rspB)
SENA: AU38_07980
SENO: AU37_07980
SENV: AU39_07990
SENQ: AU40_08940
SENL: IY59_08175
SEEP: I137_06125
SENE: IA1_07450
SBG: SBG_1333(rspB)
SBZ: A464_1526
ENC: ECL_02182
ECLO: ENC_12060
ECLX: LI66_10090
ECLY: LI62_10875
ECLZ: LI64_10240
EEC: EcWSU1_02016(rspB)
CTU: CTU_22010(rspB)
KPN: KPN_03621
KPU: KP1_4933
KPP: A79E_0492
KPE: KPK_0500
KPR: KPR_4813(rspB)
KPJ: N559_0543
KPX: PMK1_01129(yjmD)
KPNU: LI86_02610
KPNK: BN49_0499(rspB)
KVA: Kvar_0478
KOX: KOX_21515
KOE: A225_3174
EAE: EAE_18425
EAR: CCG30205
CKO: CKO_01574
CRO: ROD_46081(rspB)
CAMA: F384_06810
EBT: EBL_c22150(rspB)
EBF: D782_2223
PSTS: E05_03230
SPE: Spro_3564
SRL: SOD_c34860(rspB)
SPLY: Q5A_018880(rspB)
SMAF: D781_3318
SMW: SMWW4_v1c36750(rspB)
SMAC: SMDB11_2957(rspB)
RAA: Q7S_05130
ECA: ECA0918(rspB)
PATR: EV46_04240
PATO: GZ59_08560
PCT: PC1_0803
PEC: W5S_0931
SOD: Sant_0032
DDD: Dda3937_01655(rspB)
DDQ: DDI_2839
EBI: EbC_29610
EGE: EM595_2411(rspB)
PVA: Pvag_2005(rspB)
PHEI: NCTC12003_03944(gutB_4)
LRI: NCTC12151_00325(gutB_1)
ASU: Asuc_0369
CSA: Csal_2975
HEL: HELO_1147(rspB)
HAM: HALO3082
AMAH: DLM_0674
REH: H16_A1934(tdh)
CTI: RALTA_A2841(rspB)
BMA: BMAA0765
BMAL: DM55_4675
BMAE: DM78_3382
BMAQ: DM76_3628
BMAI: DM57_11775
BMAF: DM51_4465
BMAZ: BM44_4668
BMAB: BM45_3190
BPS: BPSS1478a(rspB)
BPM: BURPS1710b_A0512(rspB)
BPL: BURPS1106A_A2002(rspB)
BPSE: BDL_4787
BPSM: BBQ_4669
BPSU: BBN_4924
BPSD: BBX_3949
BPZ: BP1026B_II1569(rspB)
BPK: BBK_4090
BPSH: DR55_3795
BPSA: BBU_4557
BPSO: X996_3582
BUT: X994_5638
BAM: Bamb_4598
BCT: GEM_3242
BTEI: WS51_09190
BGU: KS03_3459
BGO: BM43_6943
BGP: BGL_2c01570(rspB)
ARA: Arad_8888
NEN: NCHU2750_49590(rspB)
BBT: BBta_2119
AOL: S58_57410
BRO: BRAD285_5486(rspB)
MNO: Mnod_0981
AZL: AZL_e02200(rspB)
ALI: AZOLI_p50105(rspB)
HLI: HLI_12600
CBEI: LF65_03927
BPRO: PMF13cell1_01379(yjmD_2) PMF13cell1_04771(yjmD_5)
CBAR: PATL70BA_2575(rspB)
SVE: SVEN_6716
SFK: KY5_0710
 » show all
Taxonomy
Reference
1  [PMID:6993236]
  Authors
Cooper RA
  Title
The pathway for L-gulonate catabolism in Escherichia coli K-12 and Salmonella typhimurium LT-2.
  Journal
FEBS Lett 115:63-7 (1980)
DOI:10.1016/0014-5793(80)80727-7
Reference
2  [PMID:25145794]
  Authors
Wichelecki DJ, Vendiola JA, Jones AM, Al-Obaidi N, Almo SC, Gerlt JA
  Title
Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism  of L-gulonate and L-idonate.
  Journal
Biochemistry 53:5692-9 (2014)
DOI:10.1021/bi500837w
  Sequence
[csa:Csal_2975]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.380
IUBMB Enzyme Nomenclature: 1.1.1.380
ExPASy - ENZYME nomenclature database: 1.1.1.380
BRENDA, the Enzyme Database: 1.1.1.380

DBGET integrated database retrieval system