KEGG   ENZYME: 1.1.1.380
Entry
EC 1.1.1.380                Enzyme                                 
Name
L-gulonate 5-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-gulonate:NAD+ 5-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = D-fructuronate + NADH + H+ [RN:R10848]
Reaction(KEGG)
R10848
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
D-fructuronate [CPD:C00905];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Halomonas elongata, participates in a pathway for L-gulonate degradation.
History
EC 1.1.1.380 created 2014
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K08322  L-gulonate 5-dehydrogenase
Genes
ONE115119961
ECOb1580(rspB)
ECJJW1572(rspB)
ECDECDH10B_1713(rspB)
EBWBWG_1394(rspB)
ECOKECMDS42_1250(rspB)
EOIECO111_2047(rspB)
EOJECO26_2282(rspB)
EOHECO103_1719(rspB)
ECOOECRM13514_2068(rspB)
ECOHECRM13516_1973(rspB)
ESLO3K_12720 O3K_24485
ESOO3O_00850 O3O_12915
ESMO3M_12680 O3M_24405
ECKEC55989_4355
ECGE2348C_1664(rspB) E2348C_4182
EOKG2583_1974(rspB)
ELRECO55CA74_09690
ELHETEC_1614
ECWEcE24377A_1787(rspB)
EUNUMNK88_2034
ECPECP_1528
ENAECNA114_1625(rspB) ECNA114_3977
ECOSEC958_1798(rspB) EC958_4356
ECVAPECO1_2586 APECO1_663(rspB)
ECOAAPECO78_11700
ECXEcHS_A1653 EcHS_A4106
ECMEcSMS35_1620(rspB)
ECYECSE_1701
ECRECIAI1_1630(rspB)
ECQECED1_1748(rspB)
EUMECUMN_1865(rspB)
ECTECIAI39_1478(rspB)
EOCCE10_1850(rspB)
EBRECB_01549(rspB)
EBLECD_01549(rspB)
EBEB21_01539(rspB)
EBDECBD_2066
ECIUTI89_C1767(rspB)
EIHECOK1_1697(rspB) ECOK1_4348
ECZECS88_1625(rspB) ECS88_4326
ECCc1970(rspB) c4828
ELOEC042_1727(rspB)
ELNNRG857_07910 NRG857_19360
ESEECSF_1439
ECLEcolC_2050 EcolC_4137
EKOEKO11_2198
EKFKO11_14855(rspB)
EABECABU_c17760(rspB) ECABU_c43830
EDHEcDH1_2063
EDJECDH1ME8569_1523(rspB)
ELUUM146_09270 UM146_19620
ELWECW_m1745(rspB)
ELLWFL_08545(rspB)
ELCi14_1793(rspB) i14_4422
ELDi02_1793(rspB) i02_4422
ELPP12B_c1501(rspB) P12B_c3999(rspB)
ELFLF82_2029(rspB) LF82_612
ECOLLY180_08230
ECOIECOPMV1_01675(tdh_1) ECOPMV1_04239(gutB_5)
ECOJP423_08465 P423_21520
EFEEFER_1526(rspB)
EALEAKF1_ch4474
EMAC1192_04370 C1192_16085
ESZFEM44_09210 FEM44_22830
STYSTY1555(rspB)
STTt1427(rspB)
SEXSTBHUCCB_15150 STBHUCCB_15530
SENTTY21A_07225 TY21A_07410
STMSTM1506(rspB)
SEOSTM14_1819(rspB)
SEVSTMMW_15061 STMMW_15411
SEYSL1344_1436(rspB) SL1344_1471
SEMSTMDT12_C15200 STMDT12_C15580
SEJSTMUK_1469(rspB) STMUK_1508
SEBSTM474_1516(rspB) STM474_1553
SEFUMN798_1569(rspB) UMN798_1612
SETUSTU288_03845 STU288_04030
SETCCFSAN001921_09410 CFSAN001921_09600
SENRSTMDT2_14331(rspB) STMDT2_14681
SENDDT104_14761(rspB) DT104_15111
SENICY43_07670 CY43_07855
SEENSE451236_13405 SE451236_13595
SPTSPA1349(rspB)
SEKSSPA1254
SPQSPAB_01804
SEISPC_2223(rspB)
SECSCH_1523(rspB)
SEHSeHA_C1676
SHBSU5_02117 SU5_02151
SENHCFSAN002069_01285 CFSAN002069_01465
SEEHSEEH1578_16750 SEEH1578_16925
SEESNSL254_A1617
SENNSN31241_25770 SN31241_26140
SEWSeSA_A1608
SEASeAg_B1666
SENSQ786_07535 Q786_07715
SEGSG1614(rspB)
SELSPUL_1322(rspB) SPUL_1359
SEGASPUCDC_1322(rspB) SPUCDC_1359
SETSEN1544(rspB)
SENAAU38_07800 AU38_07980
SENOAU37_07800 AU37_07980
SENVAU39_07810 AU39_07990
SENQAU40_08745 AU40_08940
SENLIY59_07995 IY59_08175
SENJCFSAN001992_03875 CFSAN001992_04050
SEECCFSAN002050_13930 CFSAN002050_14110
SEEBSEEB0189_011815 SEEB0189_011995
SEEPI137_06125 I137_06300
SENBBN855_15460 BN855_15840
SENEIA1_07450 IA1_07630
SENCSEET0819_14195 SEET0819_14375
SESSARI_01442
SBGSBG_1333(rspB)
SBZA464_1526 A464_1566
SBVN643_06380 N643_06560
SALZEOS98_11725 EOS98_11910
SSNSSON_4050(rspB)
SBOSBO_3891(rspB)
SBCSbBS512_E4352
SHQA0259_11920
ENCECL_02182
ENLA3UG_10210
ECLGEC036_19820
ECLEECNIH2_10740
ECLNECNIH4_12535
ECLIECNIH5_09870
ECLXLI66_10090
ECLYLI62_10875
ECLZLI64_10240
ECLOENC_12060
EHMAB284_14920
EXFBFV63_10275
ECLAECNIH3_09880
ECLCECR091_09855
EAUDI57_08715
ENOECENHK_10190
EECEcWSU1_02016(rspB)
ELGBH714_06370
ECANCWI88_12345
ERNBFV67_09710
ECLSLI67_015620
ECHGFY206_11615
ESHC1N69_10415
ENTEnt638_1933
EASEntas_2007
ENXNI40_010310
LNICWR52_01950
EBGFAI37_19045
ENDA4308_14825
ENZG0034_09940
ENSHWQ15_18740
ENKLOC22_20535
CTUCTU_22010(rspB)
KPNKPN_03621
KPUKP1_4933
KPMKPHS_47610
KPPA79E_0492
KPHKPNIH24_05110
KPZKPNIH27_22745
KPVKPNIH29_23655
KPWKPNIH30_23980
KPYKPNIH31_23095
KPGKPNIH32_24860
KPCKPNIH10_23690
KPQKPR0928_23210
KPTVK055_3856
KPOKPN2242_21180
KPRKPR_4813(rspB)
KPJN559_0543
KPID364_18585
KPAKPNJ1_00530
KPSKPNJ2_00568
KPXPMK1_01129(yjmD)
KPBFH42_14475
KPNEKU54_002605
KPNULI86_02610
KPNKBN49_0499(rspB)
KVAKvar_0478
KPEKPK_0500 KPK_B0038
KPKA593_08300
KVDKR75_05645
KVQSP68_12260
KOXKOX_21515
KOEA225_3174
KOYJ415_16070
KOMHR38_19815
KMIVW41_10435
KOKKONIH1_15565
KOCAB185_20330
KQUAVR78_01960
EAEEAE_18425
EARCCG30205
KQVB8P98_02595
KLLBJF97_15695
KLWDA718_13560
KARLGL98_02535
KGRJJJ10_13140
RORRORB6_05610
RONTE10_15635
RPLNB1209_12270
RAODSD31_12085
RTGNCTC13098_03452(tdh_2)
REEelectrica_02379(yjmD)
CROROD_46081(rspB)
CKOCKO_01574
CFDCFNIH1_05080 CFNIH1_17600
CYOCD187_12365
CFQC2U38_12375
CSEDJY391_11495
CAMAF384_06810
CIFAL515_00060 AL515_11910 AL515_22165
CFARCI104_12755
CIEAN232_05755 AN232_18230
CPARCUC49_07620 CUC49_18045
CTELGBC03_17795
CITZE4Z61_04815 E4Z61_16325 E4Z61_18205
CARSE1B03_12980
EBTEBL_c22150(rspB)
PGELG71_16460
ESCEntcl_1243 Entcl_2319
KLEAO703_10625
KORAWR26_13650
KRDA3780_10365
KOTEH164_12150
KIENCTC12125_01399(gutB_1)
KASKATP_21140
LAXAPT61_11715
LEIC2U54_15695
LEEDVA44_12640
LERGNG29_10540
LEAGNG26_10670
LAZA8A57_09915
LEFLJPFL01_1980
LEWDAI21_16285
BUFD8682_03880
BAGEBADSM9389_19720
METYMRY16398_26790
AHNNCTC12129_04953(gutB)
YREHEC60_05855
SGOEA8O29_011250
KINAB182_24950
PDZHHA33_14175
IZHFEM41_12890 FEM41_17000
EBFD782_2223
EBCC2U52_22195
EBUCUC76_18195
PSTSE05_03230
SMACSMDB11_2957(rspB)
SMWSMWW4_v1c36750(rspB)
SPESpro_3564
SRRSerAS9_3770
SRLSOD_c34860(rspB)
SRYM621_18945
SPLYQ5A_018880(rspB)
SRSSerAS12_3771
SRASerAS13_3771
SMAFD781_3318
SLQM495_18345
SFWWN53_00495
SFGAV650_23210
SRZAXX16_1748
SERASer39006_020895
SERQCWC46_20900
SERMCLM71_17500
SQUE4343_22890
SFJSAMEA4384070_3681(gutB_3)
SOFNCTC11214_03100(gutB_2)
SURIJ0X03_05550
SRHZFO014_16720
RAHRahaq_1072
RACEJHW33_22075
RAQRahaq2_1143
RAAQ7S_05130
ROXBV494_00630
RVCJ9880_13185
GQUAWC35_18345
EAMEGXP68_05435
RBADH2866_02510
ECAECA0918(rspB)
PATREV46_04240
PATOGZ59_08560
PCTPC1_0803
PCCPCC21_008290
PCVBCS7_04110
PWAPecwa_1037
PPARA8F97_13750
PECW5S_0931
PWSA7983_12485
PPOABJK05_20985
PBRAB5S52_17545
PAQUDMB82_0016155
PVZOA04_09230(rspB)
PPAVLOZ86_05410
DDDDda3937_01655(rspB)
DZEDd1591_1269
DDQDDI_2839
DDADd703_2636
BGJAWC36_14045
BNGEH206_17950
BIZHC231_18880
SODSant_0032
EBIEbC_29610
EGEEM595_2411(rspB)
EPECI789_03895
ERWIGN242_07010
PVAPvag_2005(rspB)
PAGGAL522_16915
PAOPat9b_2614
KLNLH22_09450
PANPPSNIH2_04965
PAGCBEE12_00625
PALHB1H58_14375
PANSFCN45_12650
PEYEE896_06650
PDISD8B20_11215
PGZC2E15_13730
PCDC2E16_13830
MINTC7M51_01908(rspB)
MTHIC7M52_00899(rspB) C7M52_01006(yjmD)
PHEINCTC12003_03944(gutB_4)
PRQCYG50_16300
HAVAT03_16150
HPARAL518_10565
OPODSM2777_19295
LPVHYN51_08265
PFQQQ39_01485
PRAGEKN56_14655 EKN56_18700
LRINCTC12151_00325(gutB_1) NCTC12151_00813(gutB_3)
MVIX808_19840
ASUAsuc_0369
VSRVspart_03580(yjmD)
PORAPT59_12555
PLULFOB45_15545
PBAPSEBR_a2372
PBCCD58_17075
PPSYAOC04_01185
PPSHG5J76_07200
PVKEPZ47_17235
PBZGN234_00765
PALVKSS97_16655
CSACsal_2975
HELHELO_1147(rspB)
HAKKO116_02821
HAMHALO3082
HHUAR456_15715
HAXIHAALTHF_10510n
HTTHZS52_19960
HSVHNO53_06380
HTXEKK97_06760
MMWMmwyl1_0038
MPCMar181_0029
MARDIBG28_00195
MFOIJSY38_09480
MARSA8C75_12295
GAPGAPWK_0541
AMAHDLM_0674
AQSDKK66_01835
REHH16_A1934(tdh)
CUHBJN34_10215
CTIRALTA_A2841(rspB)
COXE0W60_25915
BMABMAA0765
BMVBMASAVP1_0584
BMLBMA10229_0695
BMNBMA10247_A1649
BMALDM55_4675
BMAEDM78_3382
BMAQDM76_3628
BMAIDM57_11775
BMAFDM51_4465
BMAZBM44_4668
BMABBM45_3190
BPSBPSS1478a(rspB)
BPMBURPS1710b_A0512(rspB)
BPLBURPS1106A_A2002(rspB)
BPDBURPS668_A2097
BPSEBDL_4787
BPSMBBQ_4669
BPSUBBN_4924
BPSDBBX_3949
BPZBP1026B_II1569(rspB)
BPQBPC006_II1983
BPKBBK_4090
BPSHDR55_3795
BPSABBU_4557
BPSOX996_3582
BUTX994_5638
BUUWS70_24985
BSAVWS86_26535
BAMBamb_4598
BACBamMC406_5131
BCTGEM_3242
BPYRABD05_23395
BTEIWS51_09190
BANNJFN94_16460
BGLbglu_2g01920
BGUKS03_3459
BGOBM43_6943
BGPBGL_2c01570(rspB)
BPLAbpln_2g01550
BURKDM992_23805
HYFDTO96_101051
DTIDesti_0094
ARAArad_8888
AVIAvi_7076
ARUIG6M88_15670
RJGCCGE525_31380
RLSHB780_08025
NENNCHU2750_49590(rspB)
BBTBBta_2119
AOLS58_57410
BROBRAD285_5486(rspB)
RPCRPC_1044
MNOMnod_0981
MEEDA075_30595
PGAPGA1_c07730
PPICPhaeoP14_00694
PHQD1820_16940
LEJETW24_02315
LAQUR2C4_00640
AZLAZL_e02200(rspB)
ALIAZOLI_p50105(rspB)
ATIAL072_28950
AHUA6A40_13165
AZMDM194_25700
AOZHUE56_22520
PSONJI735_33985
PPSCEHS13_16575 EHS13_34980
PBKBack11_43850(adh_4)
COHNKCTCHS21_33010(adh_4)
LFELAF_1827
LFFLBFF_2016
LORAYI71_09545
LPARFAM21731_01161
LKFDNL43_04210
OOEOEOE_1707
CBEILF65_03927
CPATCLPA_c27070
CPAECPAST_c27070
BYLA4V09_03455
BPROPMF13cell1_04771(yjmD_5)
LACYA4V08_34390
ARFAR1Y2_0264
ACACEYQ97_15370
STHRBXT84_13465
CBARPATL70BA_2575(rspB)
HALSD7D81_03675 D7D81_03725
MMCMmcs_2784
MKMMkms_2828
CGYCGLY_14840
ROPROP_21300
ROAPd630_LPD06623
RTMG4H71_11900
SVLStrvi_5395
SFASfla_4421
STRPF750_2270
SFKKY5_0710
SKACP970_06645 CP970_39445
SGXH4W23_33820
SBATG4Z16_18465
SROIIAG44_03100
MHOSCXR34_05700
MPRTET475_04335
SALCC2138_11905 C2138_12180
ARQBWQ92_13445
ACRYAC20117_06585
ARTPE5206_05330
NOWGBF35_20975
AABA4R43_26040
AACDLWP59_35755
APRECNX65_22305
AMIAmir_4479
ACTAC1701_23190
PMADBAY61_18785 BAY61_24675
MTUACSH63_05710
AFSAFR_10705
BSOLFSW04_08095
CAPCLDAP_16530
TSCTSC_c17790
THCTCCBUS3UF1_15730
TOSTheos_1066
TBCA0O31_00441
MHDMarky_0606
STASTHERM_c06020
STQSpith_0616
DRCG0Q07_09300
MCOSGM418_31165
STAEHNV11_16735
ALAMRT761_01142(rspB)
 » show all
Reference
1  [PMID:6993236]
  Authors
Cooper RA
  Title
The pathway for L-gulonate catabolism in Escherichia coli K-12 and Salmonella typhimurium LT-2.
  Journal
FEBS Lett 115:63-7 (1980)
DOI:10.1016/0014-5793(80)80727-7
Reference
2  [PMID:25145794]
  Authors
Wichelecki DJ, Vendiola JA, Jones AM, Al-Obaidi N, Almo SC, Gerlt JA
  Title
Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate.
  Journal
Biochemistry 53:5692-9 (2014)
DOI:10.1021/bi500837w
  Sequence
[csa:Csal_2975]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.380
IUBMB Enzyme Nomenclature: 1.1.1.380
ExPASy - ENZYME nomenclature database: 1.1.1.380
BRENDA, the Enzyme Database: 1.1.1.380

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