Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy

L-allo-threonine:NADP+ 3-oxidoreductase

L-allo-threonine + NADP+ = aminoacetone + CO2 + NADPH + H+ (overall reaction) [RN:R10852];
(1a) L-allo-threonine + NADP+ = L-2-amino-3-oxobutanoate + NADPH + H+ [RN:R10851];
(1b) L-2-amino-3-oxobutanoate = aminoacetone + CO2 (spontaneous) [RN:R03758]

R03758 R10851 R10852
Reaction

L-allo-threonine [CPD:C05519];
NADP+ [CPD:C00006];
L-2-amino-3-oxobutanoate [CPD:C03508]

The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase).

EC 1.1.1.381 created 2014, modified 2015