KEGG   ENZYME: 1.1.1.384Help
Entry
EC 1.1.1.384                Enzyme                                 

Name
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase;
KijD10;
dTDP-4-keto-2,6-dideoxy-D-glucose 3-oxidoreductase;
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose 3-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose:NADP+ 3-oxidoreductase
Reaction(IUBMB)
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP+ = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + NADPH + H+ [RN:R05526]
Reaction(KEGG)
Substrate
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose [CPD:C11922];
NADP+ [CPD:C00006]
Product
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose [CPD:C06620];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in the biosynthesis of several deoxysugars, including L-digitoxose, L- and D-olivose, L-oliose, D-mycarose and forosamine.
History
EC 1.1.1.384 created 2015
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K13327  dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase
Genes
VCX: VAA049_3443
SDE: Sde_2126
GUR: Gura_4277
DMA: DMR_07590
DSA: Desal_3611
BGZ: XH91_11585
LYG: C1N55_04680
LBW: C3V36_01185
DMI: Desmer_4106
ERB: A4V01_21325
TPR: Tpau_3482
SBH: SBI_06875
SVE: SVEN_5995
SALS: SLNWT_0707
SFI: SFUL_5283
SALU: DC74_6605
SALL: SAZ_34340
STRE: GZL_01617
SLD: T261_6843
SAMB: SAM23877_5610(srm27)
SRW: TUE45_01311(gfo_2)
SLX: SLAV_40170(afr2)
SFK: KY5_6078
NDA: Ndas_4698
NAL: B005_1464
PSEH: XF36_05040
PHH: AFB00_29745(selSVI)
SESP: BN6_58940(sam33)
AHG: AHOG_15155(afr3) AHOG_15190(gfo1)
SAQ: Sare_1266
MIL: ML5_4431
OBG: Verru16b_02068(gfo_5)
BFR: BF0810
BCEL: BcellWH2_00544(gfo_1) BcellWH2_04966(gfo_2)
GFO: GFO_2034
PROC: Ptc2401_00808(afr)
NBV: T478_0168
 » show all
Taxonomy
Reference
1  [PMID:10770761]
  Authors
Aguirrezabalaga I, Olano C, Allende N, Rodriguez L, Brana AF, Mendez C, Salas JA.
  Title
Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.
  Journal
Antimicrob Agents Chemother 44:1266-75 (2000)
DOI:10.1128/AAC.44.5.1266-1275.2000
  Sequence
Reference
2  [PMID:11932454]
  Authors
Wang L, White RL, Vining LC
  Title
Biosynthesis of the dideoxysugar component of jadomycin B: genes in the jad cluster of Streptomyces venezuelae ISP5230 for L-digitoxose assembly and transfer to the angucycline aglycone.
  Journal
Microbiology 148:1091-103 (2002)
DOI:10.1099/00221287-148-4-1091
  Sequence
Reference
3  [PMID:18345667]
  Authors
Hong L, Zhao Z, Melancon CE 3rd, Zhang H, Liu HW.
  Title
In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa.
  Journal
J Am Chem Soc 130:4954-67 (2008)
DOI:10.1021/ja0771383
Reference
4  [PMID:21598943]
  Authors
Kubiak RL, Holden HM
  Title
Combined structural and functional investigation of a C-3''-ketoreductase involved in the biosynthesis of dTDP-L-digitoxose.
  Journal
Biochemistry 50:5905-17 (2011)
DOI:10.1021/bi200514b
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.384
IUBMB Enzyme Nomenclature: 1.1.1.384
ExPASy - ENZYME nomenclature database: 1.1.1.384
BRENDA, the Enzyme Database: 1.1.1.384

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