KEGG   ENZYME: 1.1.1.385
Entry
EC 1.1.1.385                Enzyme                                 
Name
dihydroanticapsin dehydrogenase;
BacC;
ywfD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-dihydroanticapsin:NAD+ oxidoreductase
Reaction(IUBMB)
L-dihydroanticapsin + NAD+ = L-anticapsin + NADH + H+ [RN:R10917]
Reaction(KEGG)
R10917
Substrate
L-dihydroanticapsin [CPD:C20940];
NAD+ [CPD:C00003]
Product
L-anticapsin [CPD:C20941];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin.
History
EC 1.1.1.385 created 2015
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19548  dihydroanticapsin dehydrogenase
Genes
ALKALEK_2272
AVMJQX13_36925
KAIK32_05950(fabG2) K32_25800 K32_49770
BVZBRAD3257_2813
SKTIGS68_30855
BSUBSU37720(bacC)
BSRI33_3920
BSLA7A1_0191
BSHBSU6051_37720(bacC)
BSYI653_18505
BSUTBSUB_04008(bacC)
BSULBSUA_04008(bacC)
BSUSQ433_20775
BSOBSNT_10430(ywfD)
BSNBSn5_09850
BSQB657_37720(bacC)
BSXC663_3677(bacC)
BSPU712_19010
BSSBSUW23_18630(bacC)
BSTGYO_4158
BAYRBAM_034910(bacC)
BAQBACAU_3520(bacC)
BYABANAU_3673(bacC)
BAMPB938_17915(bacC)
BQYMUS_4150(bacC3)
BAMLBAM5036_3421(bacC)
BAMARBAU_3629(bacC)
BAMNBASU_3405(bacC)
BAMBBAPNAU_3687(bacC)
BAMTAJ82_19700
BAMYV529_37630(bacC)
BMPNG74_03666(gdhIV_2)
BAOBAMF_3605(bacC)
BAZBAMTA208_19090(bacC)
BQLLL3_03916(bacC)
BXHBAXH7_03908(bacC)
BAMIKSO_001605
BAMCU471_36360
BAMFU722_18650
BSIACWD84_01670
BVMB9C48_17865
BHTDIC78_12115(bacC)
BMOJHC660_36800(bacC)
BTEQG4P54_19450(bacC)
BIQAN935_19105
BPUBPUM_3422
BPUMBW16_18170
BPUSUP12_17615
BJSMY9_3863
BACWQR42_17170
BACPSB24_11240
BACBOY17_01120
BACYQF06_17300
BACLBS34A_40900(bacC)
BALMBsLM_3802
BALTCFN77_18075
BACSAUL54_12240
BSAFBSL056_18715
BITBIS30_08575
BGIBGM20_13120
BMURABE28_019125
PSOPKP014_17250
AFXJZ786_23520
MAUUNCTC10437_02787(cpnA_3)
MMAGMMAD_18390(bacC)
NIEKV110_23495
SPHVF9278_21500
BSUEBS3272_08590
PPIOCE91St28_02330
NLIG3M70_12375
ALAMRT761_01341(bacC_5)
 » show all
Reference
1  [PMID:23317005]
  Authors
Parker JB, Walsh CT
  Title
Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.
  Journal
Biochemistry 52:889-901 (2013)
DOI:10.1021/bi3016229
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.385
IUBMB Enzyme Nomenclature: 1.1.1.385
ExPASy - ENZYME nomenclature database: 1.1.1.385
BRENDA, the Enzyme Database: 1.1.1.385

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